| 1 |
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky et al. · Autophagy
Open access2,467 authors |
2 Jan 2016 |
6,023 |
| 2 |
Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C
Yasuhito Tanaka et al. · Nature Genetics
|
13 Sep 2009 |
2,144 |
| 3 |
Negative Fluid-Attenuated Inversion Recovery- Based Intravenous Thrombolysis Using Recombinant Tissue Plasminogen Activator in Acute Stroke Patients with Unknown Onset Time
Junya Aoki, Kazumi Kimura, Kensaku Shibazaki et al. · Cerebrovascular Diseases Extra
Open access |
23 Mar 2013 |
1,934 |
| 4 |
The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2019)
Satoshi Umemura et al. · Hypertension Research
Open access |
2 Aug 2019 |
1,903 |
| 5 |
Kyoto global consensus report on Helicobacter pylori gastritis
Kentaro Sugano, Jan F. Tack, Ernst Johan Kuipers et al. · Gut
Open access |
17 Jul 2015 |
1,823 |
| 6 |
Autologous Induced Stem-Cell–Derived Retinal Cells for Macular Degeneration
Michiko Mandai et al. · New England Journal of Medicine
Open access |
15 Mar 2017 |
1,561 |
| 7 |
Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholecystitis (with videos)
Masamichi Yokoe et al. · Journal of Hepato-Biliary-Pancreatic Sciences
Open access |
15 Oct 2017 |
1,544 |
| 8 |
Interferon Therapy Reduces the Risk for Hepatocellular Carcinoma: National Surveillance Program of Cirrhotic and Noncirrhotic Patients with Chronic Hepatitis C in Japan
Haruhiko Yoshida, Yasushi Shiratori, Mitsuhiko Moriyama et al. · Annals of Internal Medicine
|
3 Aug 1999 |
1,103 |
| 9 |
WFUMB Guidelines and Recommendations for Clinical Use of Ultrasound Elastography: Part 1: Basic Principles and Terminology
Tsuyoshi Shiina et al. · Ultrasound in Medicine & Biology
Open access |
11 Apr 2015 |
964 |
| 10 |
International clinical harmonization of glycated hemoglobin in Japan: From Japan Diabetes Society to National Glycohemoglobin Standardization Program values
Atsunori Kashiwagi et al. · Journal of Diabetes Investigation
Open access |
Feb 2012 |
909 |
| 11 |
WFUMB Guidelines and Recommendations for Clinical Use of Ultrasound Elastography: Part 3: Liver
Giovanna Ferraioli et al. · Ultrasound in Medicine & Biology
Open access |
31 Mar 2015 |
882 |
| 12 |
Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness
Takayuki Kondo et al. · Cell stem cell
Open access |
21 Feb 2013 |
758 |
| 13 |
Tokyo Guidelines 2018: diagnostic criteria and severity grading of acute cholangitis (with videos)
Seiki Kiriyama et al. · Journal of Hepato-Biliary-Pancreatic Sciences
Open access |
15 Oct 2017 |
752 |
| 14 |
Randomised, multicentre prospective trial of transarterial chemoembolisation (TACE) plus sorafenib as compared with TACE alone in patients with hepatocellular carcinoma: TACTICS trial
Masatoshi Kudo et al. · Gut
Open access |
4 Dec 2019 |
739 |
| 15 |
SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations
Hiroyuki Unoki‐Kubota et al. · Nature Genetics
|
17 Aug 2008 |
733 |
| 16 |
Japan Society of Hepatology guidelines for sarcopenia in liver disease (1st edition): Recommendation from the working group for creation of sarcopenia assessment criteria
Hiroki Nishikawa, Makoto Shiraki, Akira Hiramatsu et al. · Hepatology Research
|
3 Aug 2016 |
673 |
| 17 |
Characterization of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Sheets Aiming for Clinical Application
Hiroyuki Kamao, Michiko Mandai, Satoshi Okamoto et al. · Stem Cell Reports
Open access |
23 Jan 2014 |
605 |
| 18 |
Assessment of Coronary Arterial Plaque by Optical Coherence Tomography
Teruyoshi Kume, Takashi Akasaka, Takahiro Kawamoto et al. · The American Journal of Cardiology
|
10 Mar 2006 |
576 |
| 19 |
The mesenchymal factor, FGF10, initiates and maintains the outgrowth of the chick limb bud through interaction with FGF8, an apical ectodermal factor
Hideyo Ohuchi, Takashi Nakagawa, Atsuyo Yamamoto et al. · Development
|
Jun 1997 |
557 |
| 20 |
Current status of boron neutron capture therapy of high grade gliomas and recurrent head and neck cancer
Rolf F. Barth, MGraca H Vicente, O. K. Harling et al. · DOAJ (DOAJ: Directory of Open Access Journals)
Open access |
Aug 2012 |
536 |
| 21 |
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms
Yoshihiro Onouchi et al. · Nature Genetics
Open access |
16 Dec 2007 |
525 |
| 22 |
Tokyo Guidelines 2018: Initial Management of Acute Biliary Infection and Flowchart for Acute Cholangitis
Fumihiko Miura et al. · Journal of Hepato-Biliary-Pancreatic Sciences
Open access |
23 Sep 2017 |
484 |
| 23 |
WFUMB Guidelines and Recommendations for Clinical Use of Ultrasound Elastography: Part 2: Breast
R. Graham Barr et al. · Ultrasound in Medicine & Biology
Open access |
25 Mar 2015 |
479 |
| 24 |
Oxidative Stress in Diabetic Nephropathy
Naoki Kashihara, Yoshisuke Haruna, Vinay Kondeti et al. · Current Medicinal Chemistry
Open access |
13 Nov 2010 |
469 |
| 25 |
Diagnostic criteria for primary osteoporosis: year 2000 revision
Hajime Orimo, Yasufumi Hayashi, Masao Fukunaga et al. · Journal of Bone and Mineral Metabolism
|
Nov 2001 |
466 |
| 26 |
Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high-fat-diet-induced obese mice
Noriaki Kawanishi, Hiromi Yano, Yuka Yokogawa et al. · PubMed
Open access |
15 Jul 2026 |
457 |
| 27 |
Free Anterolateral Thigh Flaps for Reconstruction of Head and Neck Defects
Isao Koshima, Hiroshi Fukuda, Hidekazu Yamamoto et al. · Plastic & Reconstructive Surgery
|
Sep 1993 |
454 |
| 28 |
Supermicrosurgical Lymphaticovenular Anastomosis for the Treatment of Lymphedema in the Upper Extremities
Isao Koshima, Kiichi Inagawa, Katsuyuki Urushibara et al. · Journal of Reconstructive Microsurgery
|
2000 |
447 |
| 29 |
Assessment of Coronary Arterial Thrombus by Optical Coherence Tomography
Teruyoshi Kume, Takashi Akasaka, Takahiro Kawamoto et al. · The American Journal of Cardiology
|
25 Apr 2006 |
445 |
| 30 |
Optical coherence tomography in coronary atherosclerosis assessment and intervention
Makoto Araki et al. · Nature Reviews Cardiology
ReviewOpen access114 authors |
21 Apr 2022 |
428 |
| 31 |
Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages
Anthony J. Covarrubias et al. · Nature Metabolism
Open access |
16 Nov 2020 |
426 |
| 32 |
Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma
Kohichiroh Yasui, Etsuko Hashimoto, Yasuji Komorizono et al. · Clinical Gastroenterology and Hepatology
Open access |
13 Feb 2011 |
426 |
| 33 |
[Helicobacter pylori infection and development of gastric cancer].
Tomoari Kamada, Hiroaki Kusunoki, Jiro Hata et al. · PubMed
|
Jun 2005 |
425 |
| 34 |
Targeting LDH enzymes with a stiripentol analog to treat epilepsy
Nagisa Sada, Sai Peck Lee, Takashi Katsu et al. · Science
|
19 Mar 2015 |
418 |
| 35 |
TG13 diagnostic criteria and severity grading of acute cholecystitis (with videos)
Masamichi Yokoe et al. · Journal of Hepato-Biliary-Pancreatic Sciences
|
2013 |
409 |
| 36 |
Thoracic and cardiovascular surgery in Japan during 2014
Munetaka Masuda, Meinoshin Okumura, Yuichiro� Doki et al. · General Thoracic and Cardiovascular Surgery
Open access |
2 Sep 2016 |
401 |
| 37 |
Gastroparesis
Michael Camilleri, Victor G Chedid, Alexander Charles Ford et al. · Nature Reviews Disease Primers
Review |
Nov 2018 |
391 |
| 38 |
Effects of Size and Shape (Aspect Ratio) on the Hemodynamics of Saccular Aneurysms: A Possible Index for Surgical Treatment of Intracranial Aneurysms
Hiroshi Ujiié, Hiroyuki Tachi, Osamu Hiramatsu et al. · Neurosurgery
|
Jul 1999 |
370 |
| 39 |
Semaglutide versus placebo in people with obesity-related heart failure with preserved ejection fraction: a pooled analysis of the STEP-HFpEF and STEP-HFpEF DM randomised trials
Javed Butler et al. · The Lancet
Open access |
Apr 2024 |
364 |
| 40 |
Japanese 2011 guidelines for prevention and treatment of osteoporosis—executive summary
Hajime Orimo, Toshitaka Nakamura, Takayuki Hosoi et al. · Archives of Osteoporosis
Open access |
30 Nov 2012 |
363 |
| 41 |
Diagnostic criteria for primary osteoporosis: year 2012 revision
Satoshi Soen, Masao Fukunaga, Toshitsugu Sugimoto et al. · Journal of Bone and Mineral Metabolism
|
3 Apr 2013 |
360 |
| 42 |
New concepts of resistance in the treatment of Helicobacter pylori infections
David Yates Graham, Akiko Shiotani · Nature Clinical Practice Gastroenterology & Hepatology
Open access |
29 Apr 2008 |
359 |
| 43 |
NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy
Minoru Satoh, Sohachi Fujimoto, Yoshisuke Haruna et al. · American Journal of Physiology-Renal Physiology
|
Feb 2005 |
355 |
| 44 |
Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy
Jay C. Jha, Stephen P. Gray, David Barit et al. · Journal of the American Society of Nephrology
Open access |
8 Feb 2014 |
355 |
| 45 |
A genome-wide association study identifies three new risk loci for Kawasaki disease
Yoshihiro Onouchi et al. · Nature Genetics
|
25 Mar 2012 |
341 |
| 46 |
The Gluteal Perforator-based Flap for Repair of Sacral Pressure Sores
Isao Koshima, Takahiko Moriguchi, Shugo Soeda et al. · Plastic & Reconstructive Surgery
|
Apr 1993 |
338 |
| 47 |
The JRS Guidelines for the Management of Community-acquired Pneumonia in Adults:An Update and New Recommendations
Naoyuki Miyashita, Toshiharu Matsushima, Mikio Oka · Internal Medicine
Open access |
2006 |
338 |
| 48 |
Clinical Correlations With Dermatomyositis-Specific Autoantibodies in Adult Japanese Patients With Dermatomyositis
Yasuhito Hamaguchi et al. · Archives of Dermatology
|
11 Apr 2011 |
335 |
| 49 |
Role of hyaluronic acid glycosaminoglycans in shear-induced endothelium-derived nitric oxide release
Seiichi Mochizuki, Hans Vink, Osamu Hiramatsu et al. · American Journal of Physiology-Heart and Circulatory Physiology
|
Aug 2003 |
333 |
| 50 |
New diagnostic criteria and severity assessment of acute cholangitis in revised Tokyo guidelines
Seiki Kiriyama et al. · Journal of Hepato-Biliary-Pancreatic Sciences
Open access |
23 Jul 2012 |
332 |