| 1 |
Mapping the human genetic architecture of COVID-19
COVID-19 Host Genetics Initiative et al. · Nature
Open access3,896 authors |
8 Jul 2021 |
1,130 |
| 2 |
SARS-CoV-2 evolution during treatment of chronic infection
Steven A. Kemp et al. · Nature
Open access1,134 authors |
5 Feb 2021 |
1,091 |
| 3 |
Randomized Trial of Complete Versus Lesion-Only Revascularization in Patients Undergoing Primary Percutaneous Coronary Intervention for STEMI and Multivessel Disease
Anthony Gershlick, Jamal Nasir Khan, Damian J. Kelly et al. · Journal of the American College of Cardiology
Open access |
Mar 2015 |
814 |
| 4 |
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
Brian J. Willett et al. · Nature Microbiology
Open access692 authors |
7 Jul 2022 |
739 |
| 5 |
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies
Dami A. Collier et al. · Nature
Open access1,136 authors |
11 Mar 2021 |
717 |
| 6 |
Reliability and Validity of the Subjective Component of the American Orthopaedic Foot and Ankle Society Clinical Rating Scales
Talal Ibrahim, Almoghera Beiri, Mohamed Azzabi et al. · The Journal of Foot & Ankle Surgery
|
28 Feb 2007 |
620 |
| 7 |
Difficult Airway Society Guidelines for the management of tracheal extubation
Membership of the Difficult Airway Society Extubation Guidelines Group: M. Popat, Viki Mitchell, R. M. Dravid et al. · Anaesthesia
|
9 Feb 2012 |
559 |
| 8 |
Effectiveness of early orthodontic treatment with the twin-block appliance: A multicenter, randomized, controlled trial. Part 1: Dental and skeletal effects
Kevin D O'Brien et al. · American Journal of Orthodontics and Dentofacial Orthopedics
|
Sep 2003 |
375 |
| 9 |
Subtotal Cholecystectomy for “Difficult Gallbladders”
Mohamed Mahmoud Abdelrahim Elshaer, Gianpiero Gravante, Katie B. Thomas et al. · JAMA Surgery
|
30 Dec 2014 |
373 |
| 10 |
Revised guidelines for the control of methicillin-resistant Staphylococcus aureus infection in hospitals
Professor G.A.J. Ayliffe, Ms A Buckles, M.W. Casewell et al. · Journal of Hospital Infection
|
Aug 1998 |
371 |
| 11 |
Quality in screening colonoscopy: position statement of the European Society of Gastrointestinal Endoscopy (ESGE)
Bjorn J. Rembacken, Cesare Hassan, J�rgen F. Riemann et al. · Endoscopy
|
17 Sep 2012 |
334 |
| 12 |
Colonoscopy quality measures: experience from the NHS Bowel Cancer Screening Programme
Thomas J.W. Lee, Matthew D. Rutter, R G Blanks et al. · Gut
|
22 Sep 2011 |
327 |
| 13 |
What is the pipeline for future medications for obesity?
Eka Melson, Uzma Ashraf, Dimitris Papamargaritis et al. · International Journal of Obesity
Open access |
Feb 2024 |
316 |
| 14 |
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
Heather Jane Cordell et al. · Nature Communications
Open access462 authors |
22 Sep 2015 |
313 |
| 15 |
British Society of Gastroenterology guidelines for the management of iron deficiency anaemia in adults
Jonathon A Snook, Neeraj B. Bhala, Ian Beales et al. · Gut
Open access |
8 Sep 2021 |
304 |
| 16 |
An early rehabilitation intervention to enhance recovery during hospital admission for an exacerbation of chronic respiratory disease: randomised controlled trial
Neil J. Greening, Johanna E. Williams, Sana Hussain et al. · BMJ
Open access |
8 Jul 2014 |
292 |
| 17 |
Total Hip Arthroplasty – over 100 years of operative history
Stephen Richard Knight, Randeep Singh Aujla, Satya Prasad Biswas · Orthopedic Reviews
Open access |
6 Sep 2011 |
288 |
| 18 |
Infliximab is associated with attenuated immunogenicity to BNT162b2 and ChAdOx1 nCoV-19 SARS-CoV-2 vaccines in patients with IBD
Nicholas Alexander Kennedy et al. · Gut
Open access |
26 Apr 2021 |
281 |
| 19 |
Effectiveness of treatment for class II malocclusion with the herbst or twin-block appliances: a randomized, controlled trial
Kevin D O'Brien et al. · American Journal of Orthodontics and Dentofacial Orthopedics
|
Aug 2003 |
275 |
| 20 |
A major outbreak of methicillin-resistant Staphylococcus aureus caused by a new phage-type (EMRSA-16)
R.A. Cox, C. Conquest, C. Mallaghan et al. · Journal of Hospital Infection
|
Feb 1995 |
261 |
| 21 |
Treatment of active Crohn's disease by exclusion diet: East Anglian Multicentre Controlled Trial
A.M. Riordan, John O. Hunter, John R. Crampton et al. · The Lancet
|
Nov 1993 |
207 |
| 22 |
Effectiveness of early orthodontic treatment with the twin-block appliance: a multicenter, randomized, controlled trial. Part 2: psychosocial effects
Kevin D O'Brien, Jean L. Wright, Frances Conboy et al. · American Journal of Orthodontics and Dentofacial Orthopedics
Open access |
Nov 2003 |
193 |
| 23 |
Blood Eosinophils and Outcomes in Severe Hospitalized Exacerbations of COPD
Mona Bafadhel, Neil J. Greening, Theresa C. Harvey‐Dunstan et al. · CHEST Journal
Open access |
3 Feb 2016 |
168 |
| 24 |
British Society of Gastroenterology guidelines on inflammatory bowel disease in adults: 2025
Gordon William Moran et al. · Gut
Open access |
Jun 2025 |
161 |
| 25 |
Longer mean colonoscopy withdrawal time is associated with increased adenoma detection: evidence from the Bowel Cancer Screening Programme in England
Tom Lee, R G Blanks, Colin John Rees et al. · Endoscopy
|
19 Dec 2012 |
155 |
| 26 |
British Society of Gastroenterology guidelines on sedation in gastrointestinal endoscopy
Reena Sidhu, David Turnbull, Hasan Haboubi et al. · Gut
Open access |
10 Oct 2023 |
150 |
| 27 |
Clinical, MRI, and arthroscopic correlation in meniscal and anterior cruciate ligament injuries
F. Rayan, Sachin Bhonsle, Divyang D. Shukla · International Orthopaedics
Open access |
22 Feb 2008 |
142 |
| 28 |
The Kidney Failure Risk Equation for prediction of end stage renal disease in UK primary care: An external validation and clinical impact projection cohort study
Rupert Major, David J. Shepherd, James F. Medcalf et al. · PLoS Medicine
Open access |
6 Nov 2019 |
136 |
| 29 |
Prediction of amblyopia and squint by means of refraction at age 1 year.
R M Ingram, C.F. Walker, Jessica M. Wilson et al. · British Journal of Ophthalmology
Open access |
1986 |
135 |
| 30 |
Relationship Between Focal and Diffuse Fibrosis Assessed by CMR and Clinical Outcomes in Heart Failure With Preserved Ejection Fraction
Prathap Kanagala, Adrian S. H. Cheng, Anvesha Singh et al. · JACC. Cardiovascular imaging
Open access |
13 Feb 2019 |
127 |
| 31 |
Changes in refraction between the ages of 1 and 3 1/2 years.
R M Ingram, A Barr · British Journal of Ophthalmology
Open access |
May 1979 |
126 |
| 32 |
Fascination and Isolation: A Grounded Theory Exploration of Unusual Sensory Experiences in Adults with Asperger Syndrome
Richard Scott Smith, Jonathan Sharp · Journal of Autism and Developmental Disorders
|
24 Aug 2012 |
125 |
| 33 |
Population-based cohort study of outcomes following cholecystectomy for benign gallbladder diseases
Ravinder Vohra et al. · British journal of surgery
Open access641 authors |
26 Aug 2016 |
122 |
| 34 |
Genomic reconstruction of the SARS-CoV-2 epidemic in England
Harald S. Vöhringer et al. · Nature
Open access1,017 authors |
14 Oct 2021 |
120 |
| 35 |
Ambulatory management of primary spontaneous pneumothorax: an open-label, randomised controlled trial
Rob Hallifax et al. · The Lancet
Open access |
Jul 2020 |
117 |
| 36 |
Polymorphisms Near TBX5 and GDF7 Are Associated With Increased Risk for Barrett’s Esophagus
Claire Palles et al. · Gastroenterology
Open access |
5 Nov 2014 |
114 |
| 37 |
Validation of international consensus equation for acute serum total tryptase in mast cell activation: A perioperative perspective
Richard L. Baretto, Sandra Trevisan Beck, Jane Heslegrave et al. · Allergy
|
13 Jun 2017 |
110 |
| 38 |
Metatarsus primus varus. A statistical study
TE Kilmartin, RL Barrington, William Angus Wallace · Journal of Bone and Joint Surgery - British Volume
|
Nov 1991 |
107 |
| 39 |
British Thoracic Society Clinical Statement on pleural procedures
Rachelle Asciak, Eihab O. Bedawi, Rahul Bhatnagar et al. · Thorax
Open access |
Jul 2023 |
106 |
| 40 |
Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision
G Zaffaroni et al. · British journal of surgery
Open access |
8 Apr 2024 |
104 |
| 41 |
Diagnostic approach to patients with suspected vasculitis
Ernest Suresh · Postgraduate Medical Journal
Open access |
Aug 2006 |
104 |
| 42 |
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
Felicity Liew et al. · Nature Immunology
Open access1,462 authors |
Apr 2024 |
103 |
| 43 |
Iron overload in the Asian community
Chun Yu Lok et al. · Blood
|
3 Apr 2009 |
103 |
| 44 |
Chemoprevention of Oesophageal Cancer and the AspECT Trial
Debasish Das, Andrew Chilton, Janusz A. Jankowski · Recent results in cancer research/Recent Results in Cancer Research
Book chapter |
27 Nov 2008 |
102 |
| 45 |
Emmetropisation, squint, and reduced visual acuity after treatment.
R M Ingram, P. E. Arnold, S Dally et al. · British Journal of Ophthalmology
Open access |
Jul 1991 |
101 |
| 46 |
Peripherally Inserted Central Catheter (PICC)-Related Thrombosis in Critically Ill Patients
Vasileios Zochios, Imraan Umar, Nicola Simpson et al. · The Journal of Vascular Access
|
25 Apr 2014 |
100 |
| 47 |
Systematic review and meta-analysis of the epidemiology of polyautoimmunity in Sjögren’s syndrome (secondary Sjögren’s syndrome) focusing on autoimmune rheumatic diseases
Haya H. Al-Ani, Julian Henty, N.L. Thompson et al. · Scandinavian Journal of Rheumatology
ReviewOpen access |
20 Sep 2017 |
99 |
| 48 |
Comparison of exercise testing and CMR measured myocardial perfusion reserve for predicting outcome in asymptomatic aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in Aortic Stenosis (PRIMID AS) Study
Anvesha Singh et al. · European Heart Journal
Open access |
30 Jan 2017 |
99 |
| 49 |
Screening for refractive errors at age 1 year: a pilot study.
R M Ingram, M J Traynar, C.F. Walker et al. · British Journal of Ophthalmology
Open access |
Apr 1979 |
99 |
| 50 |
MDMA induced hyperthermia: Report of a fatality and review of current therapy
Khavar J. Dar, M. E. McBrien · Intensive Care Medicine
|
Sep 1996 |
99 |