Most cited papers from Khondrion (Netherlands)

Khondrion (Netherlands)

What are the most cited papers from Khondrion (Netherlands)?

The most cited paper from Khondrion (Netherlands) is "Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy" (Eligio F. Iannetti, Jan A.M. Smeitink, Julien Beyrath et al., 2016), with 100 citations. Next come "Mitochondrial disorders in children: toward development of small‐molecule treatment strategies" (92) and "Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses" (81).

Published TypeFieldAccess

Showing 48 of 48 papers. Every paper is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Multiplexed high-content analysis of mitochondrial morphofunction using live-cell microscopy Eligio F. Iannetti, Jan A.M. Smeitink, Julien Beyrath et al. · Nature Protocols Open access	18 Aug 2016	100
2	Mitochondrial disorders in children: toward development of small‐molecule treatment strategies Werner J.H. Koopman, Julien Beyrath, Cheuk‐Wing Fung et al. · EMBO Molecular Medicine Open access	7 Mar 2016	92
3	Inducing cancer indolence by targeting mitochondrial Complex I is potentiated by blocking macrophage-mediated adaptive responses Ivana Kurelac et al. · Nature Communications Open access	22 Feb 2019	81
4	KH176 Safeguards Mitochondrial Diseased Cells from Redox Stress-Induced Cell Death by Interacting with the Thioredoxin System/Peroxiredoxin Enzyme Machinery Julien Beyrath, Mina Pellegrini, G. Herma Renkema et al. · Scientific Reports Open access	20 Apr 2018	75
5	The KHENERGY Study: Safety and Efficacy of KH 176 in Mitochondrial m.3243A>G Spectrum Disorders Mirian C. H. Janssen, Saskia Koene, Paul de Laat et al. · Clinical Pharmacology & Therapeutics Open access	30 Jul 2018	58
6	The histone methyltransferase G9a regulates tolerance to oxidative stress–induced energy consumption Human Riahi, Carlijn Brekelmans, Sarah Foriel et al. · PLoS Biology Open access	12 Mar 2019	54
7	Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease Ria de Haas, Devashish Das, Alejandro Garanto et al. · Scientific Reports Open access	11 Sep 2017	50
8	SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans Inge E. Krabbendam, Birgit Honrath, Benjamin Dilberger et al. · Cell Death and Disease Open access	23 Apr 2020	48
9	KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers Saskia Koene, Edwin Spaans, Luc Van Bortel et al. · Orphanet Journal of Rare Diseases Open access	16 Oct 2017	48
10	Rescue from galactose-induced death of Leigh Syndrome patient cells by pyruvate and NAD+ Eligio F. Iannetti, Jan A.M. Smeitink, Peter H.G.M. Willems et al. · Cell Death and Disease Open access	14 Nov 2018	46
11	Therapy-Induced Senescence Enhances the Efficacy of HER2-Targeted Antibody–Drug Conjugates in Breast Cancer Santiago Duro‐Sánchez, Mercedes Nadal‐Serrano, Marta Lalinde-Gutiérrez et al. · Cancer Research Open access	12 Oct 2022	45
12	Quantifying small molecule phenotypic effects using mitochondrial morpho-functional fingerprinting and machine learning Lionel Blanchet, Jan A.M. Smeitink, Sjenet E. van Emst - de Vries et al. · Scientific Reports Open access	26 Jan 2015	43
13	Hypothesis: mPGES-1-Derived Prostaglandin E2, a So Far Missing Link in COVID-19 Pathophysiology? Jan A.M. Smeitink, Xiaolan Jiang, S. A. Pecheritsyna et al. · Preprints.org PreprintOpen access	12 Apr 2020	36
14	To be or not to be pink(1): contradictory findings in an animal model for Parkinson’s disease Ria de Haas, Lisa C M W Heltzel, Denise Tax et al. · Brain Communications Open access	2019	35
15	Toward high-content screening of mitochondrial morphology and membrane potential in living cells Eligio F. Iannetti, Peter H.G.M. Willems, Mina Pellegrini et al. · The International Journal of Biochemistry & Cell Biology Open access	8 Feb 2015	35
16	Process analytical technique ( PAT ) miniaturization for monoclonal antibody aggregate detection in continuous downstream processing Mariana N. São Pedro, Marieke E. Klijn, Michel H. M. Eppink et al. · Journal of Chemical Technology & Biotechnology Open access	15 Sep 2021	34
17	Oxidative switch drives mitophagy defects in dopaminergic parkin mutant patient neurons Aurélie Schwartzentruber, Camilla Boschian, Fernanda Martins Lopes et al. · Scientific Reports Open access	23 Sep 2020	32
18	Dissecting Drug-Induced Cytotoxicity and Metabolic Dysfunction in Conditionally Immortalized Human Proximal Tubule Cells Charlotte A. Hoogstraten, Jan A.M. Smeitink, Frans G. M. Rüssel et al. · Frontiers in Toxicology Open access	28 Feb 2022	30
19	Sonlicromanol improves neuronal network dysfunction and transcriptome changes linked to m.3243A>G heteroplasmy in iPSC-derived neurons Teun M. Klein Gunnewiek, Anouk H. A. Verboven, Iris Pelgrim et al. · Stem Cell Reports Open access	29 Jul 2021	29
20	Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE2 biosynthesis by sonlicromanol’s metabolite KH176m Xiaoying Jiang, G. Herma Renkema, Bas Pennings et al. · Scientific Reports Open access	13 Jan 2021	29
21	Mitochondrial diseases: Drosophila melanogaster as a model to evaluate potential therapeutics Sarah Foriel, Peter H.G.M. Willems, Jan A.M. Smeitink et al. · The International Journal of Biochemistry & Cell Biology	7 Feb 2015	26
22	Live-Imaging Readouts and Cell Models for Phenotypic Profiling of Mitochondrial Function Eligio F. Iannetti, Alessandro Prigione, Jan A.M. Smeitink et al. · Frontiers in Genetics Open access	28 Feb 2019	23
23	Natural history, outcome measures and trial readiness in LAMA2-related muscular dystrophy and SELENON-related myopathy in children and adults: protocol of the LAST STRONG study Karlijn Bouman et al. · BMC Neurology Open access	12 Aug 2021	22
24	Mitochondrial Migraine: Disentangling the angiopathy paradigm in m.3243A>G patients Jan A.M. Smeitink, Saskia Koene, Julien Beyrath et al. · JIMD Reports Open access	Mar 2019	21
25	Feeding difficulties, a key feature of the Drosophila NDUFS4 mitochondrial disease model Sarah Foriel, Julien Beyrath, Ilse Eidhof et al. · Disease Models & Mechanisms Open access	2018	20
26	Time to Change: A Systems Pharmacology Approach to Disentangle Mechanisms of Drug-Induced Mitochondrial Toxicity Charlotte A. Hoogstraten, Jonathan J. Lyon, Jan A.M. Smeitink et al. · Pharmacological Reviews Open access	10 Jan 2023	18
27	Cognitive functioning and mental health in mitochondrial disease: A systematic scoping review Inge‐Lot Klein, Kim F. E. van de Loo, Jan A.M. Smeitink et al. · Neuroscience & Biobehavioral Reviews Open access	11 Feb 2021	18
28	A Drosophila Mitochondrial Complex I Deficiency Phenotype Array Sarah Foriel, G. Herma Renkema, Yvonne Lasarzewski et al. · Frontiers in Genetics Open access	27 Mar 2019	18
29	The Redox Modulating Sonlicromanol Active Metabolite KH176m and the Antioxidant MPG Protect Against Short-Duration Cardiac Ischemia-Reperfusion Injury Yang Xiao, Karen Yim, Hong Zhang et al. · Cardiovascular Drugs and Therapy Open access	29 Apr 2021	17
30	Phase 2b program with sonlicromanol in patients with mitochondrial disease due to m.3243A>G mutation Jan A.M. Smeitink, Just van Es, Brigitte Bosman et al. · Brain Open access	28 Aug 2024	16
31	A randomised placebo-controlled, double-blind phase II study to explore the safety, efficacy, and pharmacokinetics of sonlicromanol in children with genetically confirmed mitochondrial disease and motor symptoms (“KHENERGYC”) Jan A.M. Smeitink, Rob van Maanen, Lonneke de Boer et al. · BMC Neurology Open access	27 Apr 2022	14
32	Synthetic ligands of death receptor 5 display a cell-selective agonistic effect at different oligomerization levels Julien Beyrath, Neïla Chekkat, Cristian Roberto Smulski et al. · Oncotarget Open access	9 Jul 2016	14
33	Real‐time detection of mAb aggregates in an integrated downstream process Mariana N. São Pedro, Madelène Isaksson, Joaquín Gomis‐Fons et al. · Biotechnology and Bioengineering Open access	13 Jun 2023	13
34	Metabolic impact of genetic and chemical ADP/ATP carrier inhibition in renal proximal tubule epithelial cells Charlotte A. Hoogstraten, Maaike M. E. Jacobs, Guido de Boer et al. · Archives of Toxicology Open access	8 May 2023	9
35	Natural variability of daily physical activity measured by accelerometry in children with a mitochondrial disease Pascal R. de Vries, Mariska M. H. P. Janssen, Edwin Spaans et al. · Mitochondrion	20 Apr 2019	9
36	Design of a microfluidic mixer channel: First steps into creating a fluorescent dye‐based biosensor for mAb aggregate detection Mariana N. São Pedro, Mafalda S. Santos, Michel H. M. Eppink et al. · Biotechnology Journal Open access	4 Nov 2022	8
37	Application of a fluorescent dye‐based microfluidic sensor for real‐time detection of mAb aggregates Mariana N. São Pedro, Michel H. M. Eppink, Marcel Ottens · Biotechnology Progress Open access	10 May 2023	6
38	Sonlicromanol’s active metabolite KH176m normalizes prostate cancer stem cell mPGES-1 overexpression and inhibits cancer spheroid growth Xiaolan Jiang, G. Herma Renkema, Jan A.M. Smeitink et al. · PLoS ONE Open access	9 Jul 2021	6
39	Sensitivity of primary mitochondrial disease fibroblasts to ferroptosis: The role of intracellular iron S. A. Pecheritsyna, Melisa Emel Ermert, Emina Podhumljak et al. · Mitochondrion Open access	24 Jan 2026	3
40	Restoring cellular NAD(P)H levels by PPARα and LXRα stimulation to improve mitochondrial complex I deficiency Sanne J.C.M. Frambach, Ria de Haas, Jan A.M. Smeitink et al. · Life Sciences Open access	22 Apr 2022	3
41	Community Consensus Guidelines to Support FAIR Data Standards in Clinical Research Studies in Primary Mitochondrial Disease Amel Karaa, Laura E. MacMullen, John C. Campbell et al. · Advanced Genetics Open access	19 Dec 2021	3
42	A qualitative study assessing content validity of Neuro-QoL fatigue and PROMIS mental fatigue in m.3243A>G primary mitochondrial disease Jan Smeitink, Charlotte A. Hoogstraten, Mirian C. H. Janssen et al. · Orphanet Journal of Rare Diseases Open access	26 Aug 2026	0
43	Digital Cognitive Testing in Mitochondrial Disease: Validity and Challenges for Clinical Trial Use Oksana Pogoryelova, Jan Smeitink, Herma Renkema et al. · Annals of Clinical and Translational Neurology Open access	31 Jul 2026	0
44	The goal attainment scale in primary mitochondrial disease: Construct validity and lessons learned from a randomized controlled trial Kristofoor E Leeuwenberg, Joanna IntHout, Jan T. Groothuis et al. · Molecular Genetics and Metabolism Open access	3 Mar 2026	0
45	Restoring oxidative phosphorylation enhances osteogenesis in mitochondrial DNA translation defective human bone marrow stromal cells Paula Fernandez Guerra, Pernille Kirkegaard Kjær, Simone Karlsson Terp et al. · bioRxiv (Cold Spring Harbor Laboratory) PreprintOpen access	24 Dec 2024	0
46	Pyruvate dehydrogenase is a potential mitochondrial off-target for gentamicin based on in silico predictions and in vitro inhibition studies Charlotte A. Hoogstraten, Jan B. Koenderink, Carolijn E. van Straaten et al. · Toxicology in Vitro Open access	28 Nov 2023	0
47	CONGENITAL MUSCULAR DYSTROPHIES Karlijn Bouman, Jan T. Groothuis, Jonne Doorduin et al. · Neuromuscular Disorders	18 Sep 2021	0
48	Exogenous NAD+ prevents galactose-induced death of Leigh Syndrome patient fibroblasts with isolated complex I deficiency Werner J.H. Koopman, Eligio F. Iannetti, Jan A.M. Smeitink et al. · Biochimica et Biophysica Acta (BBA) - Bioenergetics Open access	Sep 2018	0

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.