| 1 |
DNA methylation-based classification of central nervous system tumours
David Capper et al. · Nature
Open access143 authors |
13 Mar 2018 |
3,228 |
| 2 |
HRS/EHRA Expert Consensus Statement on the State of Genetic Testing for the Channelopathies and Cardiomyopathies
Michael John Ackerman et al. · Heart Rhythm
|
26 Jul 2011 |
1,483 |
| 3 |
Early Use of TIPS in Patients with Cirrhosis and Variceal Bleeding
Juan Carlos García‐Pagán, Karel Caca, Christophe Bureau et al. · New England Journal of Medicine
Open access |
23 Jun 2010 |
1,249 |
| 4 |
Endoscopic biliary stenting: indications, choice of stents, and results: European Society of Gastrointestinal Endoscopy (ESGE) Clinical Guideline – Updated October 2017
Jean‐Marc Dumonceau, Andrea Tringali, Ioannis S. Papanikolaou et al. · Endoscopy
Open access |
7 Aug 2018 |
796 |
| 5 |
Histopathological regression after neoadjuvant docetaxel, oxaliplatin, fluorouracil, and leucovorin versus epirubicin, cisplatin, and fluorouracil or capecitabine in patients with resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4-AIO): results from the phase 2 part of a multicentre, open-label, randomised phase 2/3 trial
Salah‐Eddin Al‐Batran et al. · The Lancet Oncology
|
22 Oct 2016 |
751 |
| 6 |
Prolonged Bacterial Culture to Identify Late Periprosthetic Joint Infection: A Promising Strategy
Peter H Schafer, Bernd Fink, Dieter Sandow et al. · Clinical Infectious Diseases
Open access |
20 Oct 2008 |
548 |
| 7 |
Effect of Neoadjuvant Chemotherapy Followed by Surgical Resection on Survival in Patients With Limited Metastatic Gastric or Gastroesophageal Junction Cancer
Salah‐Eddin Al‐Batran et al. · JAMA Oncology
Open access |
27 Apr 2017 |
485 |
| 8 |
CMR Imaging Predicts Death and Other Adverse Events in Suspected Cardiac Sarcoidosis
Simon Greulich, Claudia Christina Deluigi, Steffen Gloekler et al. · JACC. Cardiovascular imaging
Open access |
13 Mar 2013 |
462 |
| 9 |
Mutations in the cardiac L-type calcium channel associated with inherited J-wave syndromes and sudden cardiac death
Elena Burashnikov et al. · Heart Rhythm
Open access |
4 Sep 2010 |
435 |
| 10 |
The continuum of spreading depolarizations in acute cortical lesion development: Examining Leão’s legacy
Jed A. Hartings et al. · Journal of Cerebral Blood Flow & Metabolism
Open access |
22 Jun 2016 |
401 |
| 11 |
Federated learning enables big data for rare cancer boundary detection
Sarthak Pati et al. · Nature Communications
Open access279 authors |
5 Dec 2022 |
390 |
| 12 |
Drug Induced Interstitial Lung Disease
Martin Schwaiblmair, Werner Behr, Thomas Haeckel et al. · The Open Respiratory Medicine Journal
Open access |
27 Jul 2012 |
375 |
| 13 |
Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group
Jens Peter Dreier et al. · Journal of Cerebral Blood Flow & Metabolism
Open access |
17 Jun 2016 |
362 |
| 14 |
High‐dose ursodeoxycholic acid therapy for nonalcoholic steatohepatitis
U. Leuschner, Birgit Lindenthal, Günter Herrmann et al. · Hepatology
|
23 Apr 2010 |
318 |
| 15 |
Colonoscopic full-thickness resection using an over-the-scope device: a prospective multicentre study in various indications
Arthur Robert Schmidt, Torsten Beyna, Brigitte M. Schumacher et al. · Gut
|
10 Aug 2017 |
295 |
| 16 |
Use of early-TIPS for high-risk variceal bleeding: Results of a post-RCT surveillance study
Juan Carlos García‐Pagán, Marco Di Pascoli, Karel Caca et al. · Journal of Hepatology
|
30 Aug 2012 |
282 |
| 17 |
European cardiovascular magnetic resonance (EuroCMR) registry – multi national results from 57 centers in 15 countries
Oliver Bruder et al. · Journal of Cardiovascular Magnetic Resonance
Open access |
2013 |
278 |
| 18 |
Prevention of Rebleeding From Esophageal Varices in Patients With Cirrhosis Receiving Small-Diameter Stents Versus Hemodynamically Controlled Medical Therapy
Tilman Sauerbruch, Martin A. Mengel, Matthias M. Dollinger et al. · Gastroenterology
Open access |
16 May 2015 |
261 |
| 19 |
Fluid status telemedicine alerts for heart failure: a randomized controlled trial
Michael C Böhm, Helmut Drexler, Hanno Oswald et al. · European Heart Journal
Open access |
16 Mar 2016 |
257 |
| 20 |
Plasma atrial natriuretic peptide and brain natriuretic peptide are increased in septic shock: impact of interleukin-6 and sepsis-associated left ventricular dysfunction
Rochus Witthaut, Christian Busch, Peter Fraunberger et al. · Intensive Care Medicine
|
Oct 2003 |
245 |
| 21 |
The value of synovial biopsy, joint aspiration and C-reactive protein in the diagnosis of late peri-prosthetic infection of total knee replacements
Bernd Fink, C. Makowiak, M. Fuerst et al. · Journal of Bone and Joint Surgery - British Volume
Open access |
30 Jun 2008 |
243 |
| 22 |
Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders
Alexander S. Hatoum et al. · Nature Mental Health
ReviewOpen access174 authors |
22 Mar 2023 |
242 |
| 23 |
The RENAISSANCE (AIO-FLOT5) trial: effect of chemotherapy alone vs. chemotherapy followed by surgical resection on survival and quality of life in patients with limited-metastatic adenocarcinoma of the stomach or esophagogastric junction – a phase III trial of the German AIO/CAO-V/CAOGI
Salah‐Eddin Al‐Batran et al. · BMC Cancer
Open access |
Dec 2017 |
235 |
| 24 |
Antiarrhythmic drugs–clinical use and clinical decision making: a consensus document from the European Heart Rhythm Association (EHRA) and European Society of Cardiology (ESC) Working Group on Cardiovascular Pharmacology, endorsed by the Heart Rhythm Society (HRS), Asia-Pacific Heart Rhythm Society (APHRS) and International Society of Cardiovascular Pharmacotherapy (ISCP)
Gheorghe‐Andrei Dan et al. · EP Europace
Open access |
9 Feb 2018 |
231 |
| 25 |
Antithrombotic treatment with direct‐acting oral anticoagulants in patients with splanchnic vein thrombosis and cirrhosis
Andrea De Gottardi et al. · Liver International
Open access |
25 Oct 2016 |
231 |
| 26 |
Chromoendoscopy with Indigocarmine Improves the Detection of Adenomatous and Nonadenomatous Lesions in the Colon
Ralf Kießlich, M. von Bergh, Maryrose Hahn et al. · Endoscopy
|
Dec 2001 |
230 |
| 27 |
Perioperative Atezolizumab Plus Fluorouracil, Leucovorin, Oxaliplatin, and Docetaxel for Resectable Esophagogastric Cancer: Interim Results From the Randomized, Multicenter, Phase II/III DANTE/IKF-s633 Trial
Sylvie Lorenzen et al. · Journal of Clinical Oncology
|
14 Nov 2023 |
224 |
| 28 |
Caesarean section on request: a comparison of obstetricians’ attitudes in eight European countries
Marwan A Habiba, Monique Kaminski, Monica Da Frè et al. · BJOG An International Journal of Obstetrics & Gynaecology
|
2 May 2006 |
224 |
| 29 |
Guidelines for Neuroprognostication in Comatose Adult Survivors of Cardiac Arrest
Venkatakrishna Rajajee et al. · Neurocritical Care
Open access |
22 Mar 2023 |
215 |
| 30 |
Endoscopic full-thickness resection in the colorectum with a novel over-the-scope device: first experience
Arthur Robert Schmidt, Peter Bauerfeind, Christoph Gubler et al. · Endoscopy
Open access |
12 Mar 2015 |
196 |
| 31 |
Over-the-Scope Clips Are More Effective Than Standard Endoscopic Therapy for Patients With Recurrent Bleeding of Peptic Ulcers
Arthur Robert Schmidt, Stefan Karl Gölder, Martin Goetz et al. · Gastroenterology
|
24 May 2018 |
193 |
| 32 |
Cyanide poisoning by fire smoke inhalation
Kurt Anseeuw, Nicolas Delvau, Guillermo Burillo Putze et al. · European Journal of Emergency Medicine
|
24 Jul 2012 |
190 |
| 33 |
EuroCMR (European Cardiovascular Magnetic Resonance) Registry
Oliver Bruder, Steffen Schneider, Detlef Nothnagel et al. · Journal of the American College of Cardiology
Open access |
27 Aug 2009 |
187 |
| 34 |
Remifentanil versus fentanyl for analgesia based sedation to provide patient comfort in the intensive care unit: a randomized, double-blind controlled trial [ISRCTN43755713]
Bernd Muellejans, Ángel Crespo López, Michael H. Cross et al. · Critical Care
Open access |
20 Nov 2003 |
183 |
| 35 |
Diverse Functional Properties of Wilson Disease ATP7B Variants
Dominik Hüster, Angelika Kühne, Ashima Bhattacharjee et al. · Gastroenterology
Open access |
10 Jan 2012 |
182 |
| 36 |
German Cancer Society Neuro‐Oncology Working Group NOA‐03 multicenter trial of single‐agent high‐dose methotrexate for primary central nervous system lymphoma
Ulrich Herrlinger, Martin Schabet, Wolfram Brugger et al. · Annals of Neurology
|
31 Jan 2002 |
182 |
| 37 |
Short-term versus long-term antiarrhythmic drug treatment after cardioversion of atrial fibrillation (Flec-SL): a prospective, randomised, open-label, blinded endpoint assessment trial
Paulus F. Kirchhof, Dietrich Andresen, RALPH F. BOSCH et al. · The Lancet
|
18 Jun 2012 |
176 |
| 38 |
Molecular genetic and functional association of Brugada and early repolarization syndromes with S422L missense mutation in KCNJ8
Héctor Barajas-Martínez, Dan Hu, Tania Ferrer et al. · Heart Rhythm
Open access |
4 Nov 2011 |
170 |
| 39 |
The feasibility of triple-drug chemotherapy combination in older adult patients with oesophagogastric cancer: A randomised trial of the Arbeitsgemeinschaft Internistische Onkologie (FLOT65+)
Salah‐Eddin Al‐Batran, Claudia Pauligk, Nils Homann et al. · European Journal of Cancer
|
11 Oct 2012 |
168 |
| 40 |
Effects of Early Placement of Transjugular Portosystemic Shunts in Patients With High-Risk Acute Variceal Bleeding: a Meta-analysis of Individual Patient Data
Oana Nicoară-Farcău et al. · Gastroenterology
ReviewOpen access139 authors |
24 Sep 2020 |
167 |
| 41 |
Refining prediction of survival after TIPS with the novel Freiburg index of post-TIPS survival
Dominik Bettinger et al. · Journal of Hepatology
|
25 Jan 2021 |
165 |
| 42 |
Apixaban for treatment of embolic stroke of undetermined source (ATTICUS randomized trial): Rationale and study design
Tobias Geisler et al. · International Journal of Stroke
Open access |
23 Nov 2016 |
164 |
| 43 |
Endoscopic Full-Thickness Plication for the Treatment of Gastroesophageal Reflux Disease: A Randomized, Sham-Controlled Trial
Richard Ira Rothstein, Charles J. Filipi, Karel Caca et al. · Gastroenterology
Open access |
Sep 2006 |
159 |
| 44 |
Serological and clinical aspects of granulocyte antibodies leading to alloimmune neonatal neutropenia
Jürgen Bux, K. D. Jung, Thomas Kauth et al. · Transfusion Medicine
|
Jun 1992 |
141 |
| 45 |
The Diagnosis and Treatment of Optic Neuritis
Helmut M. Wilhelm, Martin Schabet · Deutsches Ärzteblatt international
Open access |
11 Sep 2015 |
139 |
| 46 |
A randomised controlled trial comparing sugammadex and neostigmine at different depths of neuromuscular blockade in patients undergoing laparoscopic surgery*
Götz Geldner, M. Niskanen, Päivi Laurila et al. · Anaesthesia
Open access |
14 Jun 2012 |
137 |
| 47 |
Influence of stent design on 1-year outcome after coronary stent placement: A randomized comparison of five stent types in 1,147 unselected patients
Adnan Kastrati, Josef Dirschinger, Peter Boekstegers et al. · Catheterization and Cardiovascular Interventions
|
2000 |
134 |
| 48 |
Definition, clinical classification and initial diagnosis of pulmonary hypertension: Updated recommendations from the Cologne Consensus Conference 2018
Gábor Kovács, Daniel Dumitrescu, Andreas Barner et al. · International Journal of Cardiology
|
27 Aug 2018 |
130 |
| 49 |
Endoscopic full-thickness resection for early colorectal cancer
Armin Kuellmer, Julius Mueller, Karel Caca et al. · Gastrointestinal Endoscopy
|
14 Jan 2019 |
129 |
| 50 |
German S3 guidelines: anal abscess and fistula (second revised version)
A. Ommer, Alexander Herold, E. Berg et al. · Langenbeck s Archives of Surgery
|
Mar 2017 |
126 |