Most cited papers from Kyowa Kirin (Japan)

Kyowa Kirin (Japan)

What are the most cited papers from Kyowa Kirin (Japan)?

The most cited paper from Kyowa Kirin (Japan) is "Mutation of the mouse klotho gene leads to a syndrome resembling ageing" (Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al., 1997), with 3,876 citations. Next come "Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase" (2,475) and "Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche" (1,960).

Published TypeFieldAccessAuthorsCitations

Showing 50 of 60 papers. Every paper with more than 275 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Mutation of the mouse klotho gene leads to a syndrome resembling ageing Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature	6 Nov 1997	3,876
2	Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase Tatsuya Tamaoki, Hisayo Nomoto, ISAMI TAKAHASHI et al. · Biochemical and Biophysical Research Communications	Mar 1986	2,475
3	Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche Fumio Arai, Atsushi Hirao, Masako Ohmura et al. · Cell Open access	Jul 2004	1,960
4	Klotho converts canonical FGF receptor into a specific receptor for FGF23 Itaru Urakawa, Yuji Yamazaki, Takashi Shimada et al. · Nature	29 Oct 2006	1,855
5	The Absence of Fucose but Not the Presence of Galactose or Bisecting N-Acetylglucosamine of Human IgG1 Complex-type Oligosaccharides Shows the Critical Role of Enhancing Antibody-dependent Cellular Cytotoxicity Toyohide Shinkawa, Kazuyasu Nakamura, Naoko Yamane et al. · Journal of Biological Chemistry Open access	2003	1,422
6	Induction of Midbrain Dopaminergic Neurons from ES Cells by Stromal Cell–Derived Inducing Activity Hiroshi Kawasaki, Kenji Mizuseki, Satomi Nishikawa et al. · Neuron Open access	Oct 2000	1,281
7	Genome sequencing and analysis of Aspergillus oryzae Masayuki Machida et al. · Nature Open access	Dec 2005	1,272
8	Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells Keisuke Ito, Atsushi Hirao, Fumio Arai et al. · Nature	Oct 2004	1,173
9	Calphostin C (UCN-1028C), a novel microbial compound, is a highly potent and specific inhibitor of protein kinase C Eiji Kobayashi, Hirofumi Nakano, Makoto Morimoto et al. · Biochemical and Biophysical Research Communications	Mar 1989	1,117
10	K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases Hiroshi Kase, Kazuyuki Iwahashi, Satoshi Nakanishi et al. · Biochemical and Biophysical Research Communications	1987	944
11	Complete sequencing and characterization of 21,243 full-length human cDNAs Toshio Ota et al. · Nature Genetics 157 authors	21 Dec 2003	934
12	NELF, a Multisubunit Complex Containing RD, Cooperates with DSIF to Repress RNA Polymerase II Elongation Yuki Yamaguchi, Toshiyuki Takagi, Tadashi Wada et al. · Cell Open access	Apr 1999	853
13	Cloning and expression of a complementary DNA encoding a bovine adrenal angiotensin II type-1 receptor Katsutoshi Sasaki, Yoshiaki Yamano, Smriti Bardhan et al. · Nature	May 1991	814
14	Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche Hiroki Yoshihara, Fumio Arai, Kentaro Hosokawa et al. · Cell stem cell Open access	Dec 2007	812
15	DSIF, a novel transcription elongation factor that regulates RNA polymerase II processivity, is composed of human Spt4 and Spt5 homologs Takuro Wada, Toshiyuki Takagi, Yuki Yamaguchi et al. · Genes & Development Open access	Feb 1998	762
16	Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. Hiroshi Yano, Shinobu Nakanishi, Koutarou D. Kimura et al. · Journal of Biological Chemistry Open access	Dec 1993	740
17	Identification of the HumanKlothoGene and Its Two Transcripts Encoding Membrane and SecretedKlothoProtein Yutaka Matsumura, Hiroki Aizawa, Takako Shiraki-Iida et al. · Biochemical and Biophysical Research Communications	1998	697
18	A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes Naoaki Ishii, Michihiko Fujii, Philip S. Hartman et al. · Nature	Aug 1998	695
19	Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium Kyung‐Ah Kim, Makoto Kakitani, Jingsong Zhao et al. · Science	18 Aug 2005	592
20	Establishment of FUT8 knockout Chinese hamster ovary cells: An ideal host cell line for producing completely defucosylated antibodies with enhanced antibody‐dependent cellular cytotoxicity Naoko Yamane‐Ohnuki, Satoko Kinoshita, Miho Inoue‐Urakubo et al. · Biotechnology and Bioengineering	17 Aug 2004	580
21	Saturated Fatty Acid and TLR Signaling Link β Cell Dysfunction and Islet Inflammation Kosei Eguchi, Ichiro Manabe, Yumiko Tanaka et al. · Cell Metabolism Open access	29 Mar 2012	523
22	The Corynebacterium glutamicum genome: features and impacts on biotechnological processes Masato Ikeda, Satoru Nakagawa · Applied Microbiology and Biotechnology	Aug 2003	519
23	Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes Kouichi Kimura et al. · Genome Research Open access	12 Dec 2005	512
24	Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans Asako Sakaue-Sawano, Shinobu Iwai, Yoshiko Sakurai et al. · Blood	Feb 2001	505
25	Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects Y. Yamazaki et al. · Biochemical and Biophysical Research Communications Open access	Jul 2010	502
26	Severely Reduced Production of Klotho in Human Chronic Renal Failure Kidney Noritoshi Koh, Toshihiko Fujimori, Shuhei Nishiguchi et al. · Biochemical and Biophysical Research Communications	Feb 2001	498
27	Stomagen positively regulates stomatal density in Arabidopsis Shigeo S. Sugano, Tomoo Shimada, Yu Imai et al. · Nature Open access	9 Dec 2009	497
28	TIM-3 Is a Promising Target to Selectively Kill Acute Myeloid Leukemia Stem Cells Yoshikane Kikushige, Takahiro Shima, Shin‐ichiro Takayanagi et al. · Cell stem cell Open access	Dec 2010	488
29	A role for fungal β-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice Hiroyuki Yoshitomi, Noriko Sakaguchi, Katsuya Kobayashi et al. · The Journal of Experimental Medicine Open access	21 Mar 2005	454
30	Wortmannin, a microbial product inhibitor of myosin light chain kinase. Shinobu Nakanishi, Shingo Kakita, ISAMI TAKAHASHI et al. · Journal of Biological Chemistry Open access	Feb 1992	431
31	Expression of chimeric receptor composed of immunoglobulin-derived V resions and T-cell receptor-derived C regions Yoshihisa Kuwana, Yoshihiro Asakura, Naoko Utsunomiya et al. · Biochemical and Biophysical Research Communications	Dec 1987	428
32	Large-scale identification of protein–protein interaction of Escherichia coli K-12 Mohammad Arifuzzaman et al. · Genome Research Open access	10 Apr 2006	406
33	M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis Yoshiaki Kubota, Keiyo Takubo, Takatsune Shimizu et al. · The Journal of Experimental Medicine Open access	27 Apr 2009	390
34	Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types Yutaka Kanda, Tsuyoshi Yamada, Katsuhiro Mori et al. · Glycobiology	29 Sep 2006	379
35	Inhibition of protein kinase C by calphostin C is light-dependent Robert F. Bruns, Freeman D. Miller, Ronald L. Merriman et al. · Biochemical and Biophysical Research Communications	Apr 1991	369
36	Adenosine A2A Antagonist: A novel antiparkinsonian agent that does not provoke dyskinesia in Parkinsonian monkeys Tomoyuki Kanda, Michael John Jackson, Lance A. Smith et al. · Annals of Neurology	Apr 1998	356
37	R-spondin1 plays an essential role in ovarian development through positively regulating Wnt-4 signaling Kazuma Tomizuka, Kaori Horikoshi, Rina Kitada et al. · Human Molecular Genetics	4 Feb 2008	355
38	Adenosine A 2A receptor antagonist istradefylline (KW‐6002) reduces “off” time in Parkinson's disease: A double‐blind, randomized, multicenter clinical trial (6002‐US‐005) Peter A. LeWitt, Mark Guttman, James W. Tetrud et al. · Annals of Neurology	27 Feb 2008	354
39	Fucose Depletion from Human IgG1 Oligosaccharide Enhances Binding Enthalpy and Association Rate Between IgG1 and FcγRIIIa Akira Okazaki, Emi Shoji-Hosaka, Kazuyasu Nakamura et al. · Journal of Molecular Biology	27 Jan 2004	341
40	Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease Hisashi Hasegawa, Nobuo Nagano, Itaru Urakawa et al. · Kidney International Open access	15 Sep 2010	338
41	K-252a, a potent inhibitor of protein kinase C from microbial origin. Hiroshi Kase, Kazuyuki Iwahashi, Yuzuru Matsuda · The Journal of Antibiotics Open access	1986	334
42	Amino Acid Production Processes Masato Ikeda · Advances in biochemical engineering, biotechnology Book chapter	13 Nov 2002	334
43	Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones Tadashi Imanishi et al. · PLoS Biology Open access158 authors	19 Apr 2004	332
44	Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes. Keisuke Sasaki, Keigo Kurata, Kikuko Funayama et al. · Journal of Biological Chemistry Open access	May 1994	331
45	Defucosylated Chimeric Anti-CC Chemokine Receptor 4 IgG1 with Enhanced Antibody-Dependent Cellular Cytotoxicity Shows Potent Therapeutic Activity to T-Cell Leukemia and Lymphoma Rinpei Niwa, Emi Shoji-Hosaka, Mikiko Sakurada et al. · Cancer Research	15 Mar 2004	326
46	Deregulation of DUX4 and ERG in acute lymphoblastic leukemia Jinghui Zhang et al. · Nature Genetics Open access	24 Oct 2016	322
47	Tumor angiogenesis is an independent prognostic indicator in primary breast carcinoma Masakazu Toi, Takeshi Tominaga, Jitsuo Kashitani · International Journal of Cancer	30 Sep 1993	317
48	A novel methodology employing Corynebacterium glutamicum genome information to generate a new L -lysine-producing mutant Shizen Ohnishi · Applied Microbiology and Biotechnology	2002	311
49	Structure of the mouse klotho gene and its two transcripts encoding membrane and secreted protein 1 Takako Shiraki-Iida, Hiroki Aizawa, Yutaka Matsumura et al. · FEBS Letters	6 Mar 1998	310
50	Rescue of Hearing, Auditory Hair Cells, and Neurons by CEP-1347/KT7515, an Inhibitor of c-Jun N-Terminal Kinase Activation Ulla Pirvola, Liang Xing-Qun, Jussi Virkkala et al. · Journal of Neuroscience Open access	2000	308

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.