Institution · La Roche College
Most cited papers from La Roche College
What are the most cited papers from La Roche College?
The most cited paper from La Roche College is "Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation" (Paul B. Chapman et al., 2011), with 7,801 citations. Next come "In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2" (4,741) and "Prone Positioning in Severe Acute Respiratory Distress Syndrome" (4,142).
Showing 50 of 60 papers. Every paper with more than 842 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation Paul B. Chapman et al. · New England Journal of Medicine | 5 Jun 2011 | 7,801 |
| 2 | In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2 Lyubomir T. Vassilev, Binh Thanh Vu, Bradford J. Graves et al. · Science | 5 Jan 2004 | 4,741 |
| 3 | Prone Positioning in Severe Acute Respiratory Distress Syndrome Claude Guérin et al. · New England Journal of Medicine | 20 May 2013 | 4,142 |
| 4 | Inhibition of Mutated, Activated BRAF in Metastatic Melanoma Keith T. Flaherty, Igor J. Puzanov, Kevin B. Kim et al. · New England Journal of Medicine | 25 Aug 2010 | 3,581 |
| 5 | Identification and expression cloning of a leptin receptor, OB-R Louis A. Tartaglia, Marlene Dembski, Xun Weng et al. · Cell | Dec 1995 | 3,513 |
| 6 | Recombinant Mouse OB Protein: Evidence for a Peripheral Signal Linking Adiposity and Central Neural Networks L. Arthur Campfield, Françoise J. Smith, Yves Guisez et al. · Science | 28 Jul 1995 | 3,280 |
| 7 | Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice Dennis Huszar, Catherine A. Lynch, Victoria Fairchild-Huntress et al. · Cell | 1997 | 3,071 |
| 8 | Peginterferon-α2a and Ribavirin Combination Therapy in Chronic Hepatitis C Stephanos J. Hadziyannis, Hoel Sette, Timothy R. Morgan et al. · Annals of Internal Medicine | 2 Mar 2004 | 2,842 |
| 9 | Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun James I. Morgan, Tom Curran · Annual Review of Neuroscience | Mar 1991 | 2,674 |
| 10 | Fluorescamine: A Reagent for Assay of Amino Acids, Peptides, Proteins, and Primary Amines in the Picomole Range Sidney Udenfriend, Stanley J. Stein, Peter Böhlen et al. · Science | 24 Nov 1972 | 2,660 |
| 11 | Histone modifications at human enhancers reflect global cell-type-specific gene expression Nathaniel D. Heintzman et al. · Nature | 18 Mar 2009 | 2,649 |
| 12 | Efficacy of B-Cell–Targeted Therapy with Rituximab in Patients with Rheumatoid Arthritis Jonathan Edwards, Leszek Szczepanski, Jacek Szechiński et al. · New England Journal of Medicine | 16 Jun 2004 | 2,640 |
| 13 | A Prospective, Randomized Trial of Autologous Bone Marrow Transplantation and Chemotherapy in Multiple Myeloma Michel Attal, Jean-Luc Harousseau, Anne-Marie Stoppa et al. · New England Journal of Medicine | 11 Jul 1996 | 2,583 |
| 14 | Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity Yann Echelard, Douglas J. Epstein, Benoit St‐Jacques et al. · Cell | Dec 1993 | 2,185 |
| 15 | Survival in BRAF V600–Mutant Advanced Melanoma Treated with Vemurafenib Jeffrey Alan Sosman et al. · New England Journal of Medicine | 22 Feb 2012 | 2,170 |
| 16 | Cancer immunotherapy via dendritic cells Karolina Palucka, Jacques Banchereau · Nature reviews. Cancer | 22 Mar 2012 | 2,050 |
| 17 | Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor Colin L. Stewart, Petr Kašpar, Lisa J. Brunet et al. · Nature | Sep 1992 | 2,050 |
| 18 | XENical in the Prevention of Diabetes in Obese Subjects (XENDOS) Study Jarl Torgerson, Jonathan B. Hauptman, Mark N. Boldrin et al. · Diabetes Care | 2004 | 1,920 |
| 19 | Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma Gideon E. Bollag et al. · Nature | Sep 2010 | 1,850 |
| 20 | Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation Thomas N. Sato, Yuzuru Tozawa, Urban Deutsch et al. · Nature | Jul 1995 | 1,833 |
| 21 | Mapping Patterns of c- fos Expression in the Central Nervous System After Seizure James I. Morgan, Donna Cohén, James L. Hempstead et al. · Science | 10 Jul 1987 | 1,817 |
| 22 | A protein related to extracellular matrix proteins deleted in the mouse mutant reeler Gabriella D’Arcangelo, Graham G. Miao, Shu‐Cheng Chen et al. · Nature | Apr 1995 | 1,767 |
| 23 | B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy Vijay Kumar Kuchroo, Mercy Prabhu Das, Julia A. Brown et al. · Cell | Mar 1995 | 1,662 |
| 24 | Fluorometric assay of proteins in the nanogram range Peter Böhlen, Stanley J. Stein, Wallace M. Dairman et al. · Archives of Biochemistry and Biophysics | Mar 1973 | 1,635 |
| 25 | Fos and jun: The AP-1 connection Tom Curran, B. Robert Franza · Cell | Nov 1988 | 1,597 |
| 26 | Liver regeneration: from myth to mechanism Rebecca A. Taub · Nature Reviews Molecular Cell Biology | Oct 2004 | 1,592 |
| 27 | The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain Andrew P. McMahon, Allan Bradley · Cell | Sep 1990 | 1,545 |
| 28 | Induction of c-fos gene and protein by growth factors precedes activation of c-myc Rolf Müller, Rodrigo Bravo, Jean Burckhardt et al. · Nature | Dec 1984 | 1,419 |
| 29 | Analysis of Variance for Gene Expression Microarray Data Kathleen F. Kerr, Mitchell Martin, Gary A. Churchill · Journal of Computational Biology | Dec 2000 | 1,329 |
| 30 | A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization Vikas P. Sukhatme, Xinmin Cao, Louise C. Chang et al. · Cell | Apr 1988 | 1,296 |
| 31 | Validity and Reliability of the Observer??s DORIS A. CHERNIK, Dennis B. Gillings, HARRIET LAINE et al. · Journal of Clinical Psychopharmacology | Aug 1990 | 1,262 |
| 32 | THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses Maurice K. Gately, Louis M. Renzetti, Jeanne Magram et al. · Annual Review of Immunology | Apr 1998 | 1,252 |
| 33 | 9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα Arthur Aaron Levin, Laurie J. Sturzenbecker, Sonja Kazmer et al. · Nature | 1992 | 1,248 |
| 34 | Randomised placebo-controlled trial of orlistat for weight loss and prevention of weight regain in obese patients Lars Sjöström, Aila Rissanen, Teis Andersen et al. · The Lancet | Jul 1998 | 1,243 |
| 35 | Peginterferon Alfa-2a plus Ribavirin for Chronic Hepatitis C Virus Infection in HIV-Infected Patients Francesca J. Torriani, Maribel Rodriguez‐Torres, Jürgen Kurt Rockstroh et al. · New England Journal of Medicine | 28 Jul 2004 | 1,238 |
| 36 | Antitumor and antimetastatic activity of interleukin 12 against murine tumors. Michael J. Brunda, Leopoldo L. Luistro, Rajeev R. Warrier et al. · The Journal of Experimental Medicine | Oct 1993 | 1,212 |
| 37 | Free radical tissue damage: protective role of antioxidant nutrients 1 Lawrence J. Machlin, Adrianne Bendich · The FASEB Journal | Dec 1987 | 1,192 |
| 38 | Capping of eucaryotic mRNAs Aaron J. Shatkin · Cell | Dec 1976 | 1,175 |
| 39 | Identity of tumour necrosis factor and the macrophage-secreted factor cachectin Bruce Beutler, David A. Greenwald, J D Hulmes et al. · Nature | Aug 1985 | 1,138 |
| 40 | Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors Timothy Richard Wilson, Jane Fridlyand, Yibing Yan et al. · Nature | Jul 2012 | 1,136 |
| 41 | IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial Paul E. Emery, Edward Clark Keystone, Hans‐Peter Tony et al. · Annals of the Rheumatic Diseases | 14 Jul 2008 | 1,121 |
| 42 | Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus Alexander Figurov, Lucas D. Pozzo‐Miller, Pétur Olafsson et al. · Nature | Jun 1996 | 1,120 |
| 43 | The reporting odds ratio and its advantages over the proportional reporting ratio Kenneth Jay Rothman, Stephan Lanes, Susan T. Sacks · Pharmacoepidemiology and Drug Safety | Aug 2004 | 1,118 |
| 44 | Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. Nobuyuki Marui, M K Offermann, Robert A. Swerlick et al. · Journal of Clinical Investigation | Oct 1993 | 1,080 |
| 45 | An improved staining procedure for the detection of the peroxidase activity of cytochrome P-450 on sodium dodecyl sulfate polyacrylamide gels Paul E. Thomas, Dene E. Ryan, Wayne Levin · Analytical Biochemistry | Sep 1976 | 1,069 |
| 46 | Induced Pluripotent Stem Cells and Embryonic Stem Cells Are Distinguished by Gene Expression Signatures Mark H. Chin et al. · Cell stem cell | Jul 2009 | 1,044 |
| 47 | RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors Fei Su et al. · New England Journal of Medicine | 18 Jan 2012 | 1,038 |
| 48 | Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells Susanne J. Szabo, Anand S. Dighe, Ueli Gubler et al. · The Journal of Experimental Medicine | 3 Mar 1997 | 1,010 |
| 49 | Role of ion flux in the control of c-fos expression James I. Morgan, Tom Curran · Nature | Aug 1986 | 1,009 |
| 50 | IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses Jeanne Magram, Suzanne E. Connaughton, Rajeev R. Warrier et al. · Immunity | May 1996 | 996 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.