Institution · Lead Discovery Center (Germany)

Most cited papers from Lead Discovery Center (Germany)

Lead Discovery Center (Germany)

What are the most cited papers from Lead Discovery Center (Germany)?

The most cited paper from Lead Discovery Center (Germany) is "Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer" (Jonathan M. Weiss et al., 2010), with 830 citations. Next come "Gasdermin D plays a vital role in the generation of neutrophil extracellular traps" (773) and "Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression" (516).

Published TypeFieldAccessAuthorsCitations

Showing 50 of 60 papers. Every paper with more than 55 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer Jonathan M. Weiss et al. · Science Translational Medicine Open access	15 Dec 2010	830
2	Gasdermin D plays a vital role in the generation of neutrophil extracellular traps Gabriel Sollberger, Axel Choidas, Garth Lawrence Burn et al. · Science Immunology	3 Aug 2018	773
3	Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression Peter P. Reinhardt et al. · Cell stem cell Open access	Mar 2013	516
4	The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells Magdalena Paolino et al. · Nature Open access	19 Feb 2014	464
5	Multiple Sclerosis: MicroRNA Expression Profiles Accurately Differentiate Patients with Relapsing-Remitting Disease from Healthy Controls Andreas Keller, Petra Leidinger, Julia Lange et al. · PLoS ONE Open access	12 Oct 2009	371
6	Toward the blood-borne miRNome of human diseases Andreas Keller et al. · Nature Methods	4 Sep 2011	366
7	Interference with Bile Salt Export Pump Function Is a Susceptibility Factor for Human Liver Injury in Drug Development Ryan E. Morgan, Michael A Trauner, Carlo J. van Staden et al. · Toxicological Sciences Open access	9 Sep 2010	335
8	Small-molecule inhibitors of human mitochondrial DNA transcription Nina A. Bonekamp et al. · Nature	16 Dec 2020	296
9	Modulators of 14-3-3 Protein–Protein Interactions Loes M. Stevers, Eline Sijbesma, Maurizio Botta et al. · Journal of Medicinal Chemistry Open access	2 Oct 2017	293
10	MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction Benjamin Meder, Andreas Keller, Britta Vogel et al. · Basic Research in Cardiology	30 Sep 2010	274
11	Selective inhibitors of the FK506-binding protein 51 by induced fit S. Gaali, Alexander Kirschner, Serena Cuboni et al. · Nature Chemical Biology	Dec 2014	252
12	Amorfrutins are potent antidiabetic dietary natural products Christopher Weidner, Jens C. de Groot, AJ Mahadesh Prasad et al. · Proceedings of the National Academy of Sciences Open access	16 Apr 2012	210
13	An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms David Rauh, Frank Fischer, M. Gertz et al. · Nature Communications Open access	2 Sep 2013	207
14	A specific miRNA signature in the peripheral blood of glioblastoma patients Patrick A. Roth, Jörg Wischhusen, Caroline Happold et al. · Journal of Neurochemistry Open access	12 May 2011	200
15	Identification of Atuveciclib (BAY 1143572), the First Highly Selective, Clinical PTEFb/CDK9 Inhibitor for the Treatment of Cancer Ulrich Lücking et al. · ChemMedChem Open access	29 Sep 2017	192
16	Stabilization of protein-protein interactions in drug discovery Sebastian A. Andrei, Eline Sijbesma, Michael M. Hann et al. · Expert Opinion on Drug Discovery Open access	11 Jul 2017	172
17	Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth Elena S. Reckzeh, George Karageorgis, Melanie Schwalfenberg et al. · Cell chemical biology Open access	11 Jul 2019	164
18	Identification of pyrazolopyridazinones as PDEδ inhibitors Bjoern Papke, Sandip Murarka, Holger A. Vogel et al. · Nature Communications Open access	20 Apr 2016	164
19	Genome‐wide miRNA signatures of human longevity Abdou ElSharawy, Andreas Keller, Friederike Flachsbart et al. · Aging Cell Open access	26 Apr 2012	156
20	Stable serum miRNA profiles as potential tool for non-invasive lung cancer diagnosis Andreas Keller, Petra Leidinger, Randi Elin Gislefoss et al. · RNA Biology Open access	May 2011	139
21	BIGCHEM: Challenges and Opportunities for Big Data Analysis in Chemistry Igor V. Tetko, Ola Engkvist, Uwe Koch et al. · Molecular Informatics Open access	28 Jul 2016	128
22	Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels Hussein N. Rubaiy et al. · Journal of Biological Chemistry Open access	22 Mar 2017	126
23	Characterization of molecular and cellular functions of the cyclin‐dependent kinase CDK9 using a novel specific inhibitor Thomas Albert, Caroline Rigault, Jan Eickhoff et al. · British Journal of Pharmacology Open access	8 Oct 2013	124
24	Diagnosis of Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis by Measurement of microRNA Abundance in Blood and Tissue Andrea S. Bauer, Andreas Keller, Eithne Costello et al. · PLoS ONE Open access	12 Apr 2012	122
25	Multivariate miRNA signatures as biomarkers for non-ischaemic systolic heart failure Britta Vogel, Andreas Keller, Karen Frese et al. · European Heart Journal Open access	17 Jul 2013	115
26	Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties Jakob Hartmann, Klaus V. Wagner, S. Gaali et al. · Journal of Neuroscience Open access	17 Jun 2015	115
27	Natural product–inspired cascade synthesis yields modulators of centrosome integrity Heiko Dückert, Verena Pries, Vivek Khedkar et al. · Nature Chemical Biology Open access	25 Dec 2011	114
28	Targeting Drug Resistance in EGFR with Covalent Inhibitors: A Structure-Based Design Approach Julian Engel et al. · Journal of Medicinal Chemistry Open access	14 Aug 2015	114
29	A Novel CDK7 Inhibitor of the Pyrazolotriazine Class Exerts Broad-Spectrum Antiviral Activity at Nanomolar Concentrations Corina Hutterer, Jan Eickhoff, Jens Milbradt et al. · Antimicrobial Agents and Chemotherapy Open access	27 Jan 2015	108
30	Small-molecule inhibitors binding to protein kinase. Part II: the novel pharmacophore approach of type II and type III inhibition AC Backes, Birgit Zech, Béatrice Felber et al. · Expert Opinion on Drug Discovery	Dec 2008	107
31	Specific peripheral miRNA profiles for distinguishing lung cancer from COPD Petra Leidinger, Andreas Keller, Anne Borries et al. · Lung Cancer	9 Mar 2011	104
32	Covalent Protein Labeling at Glutamic Acids Pablo Martín‐Gago, Eyad K. Fansa, Michael Winzker et al. · Cell chemical biology Open access	20 Apr 2017	100
33	Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer Jörn Weisner et al. · Cancer Research	11 Mar 2019	94
34	Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models Wolfgang B. Fischer, Heike Franke, Ute Krügel et al. · PLoS ONE Open access	9 Jun 2016	94
35	Towards Personalized Cardiology: Multi-Scale Modeling of the Failing Heart Elham Kayvanpour, Tommaso Mansi, Farbod Sedaghat‐Hamedani et al. · PLoS ONE Open access	31 Jul 2015	93
36	Expansion of chemical space for collaborative lead generation and drug discovery: the European Lead Factory Perspective Anna Karawajczyk, Fabrizio Giordanetto, Jorg C. J. Benningshof et al. · Drug Discovery Today Open access	Oct 2015	91
37	A PDE6δ‐KRas Inhibitor Chemotype with up to Seven H‐Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2 Pablo Martín‐Gago, Eyad K. Fansa, Christian H. Klein et al. · Angewandte Chemie International Edition	20 Jan 2017	90
38	Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein Susanne Höing et al. · Cell chemical biology Open access	26 Jan 2018	87
39	Total Synthesis and Biological Evaluation of (−)‐Englerin A and B: Synthesis of Analogues with Improved Activity Profile Lea Radtke, Matthieu Willot, Hongyan Sun et al. · Angewandte Chemie International Edition	29 Mar 2011	85
40	Small-molecule inhibitors binding to protein kinases. Part I: exceptions from the traditional pharmacophore approach of type I inhibition AC Backes, Birgit Zech, Béatrice Felber et al. · Expert Opinion on Drug Discovery	Dec 2008	83
41	Cyclin-Dependent Kinase 7 Controls mRNA Synthesis by Affecting Stability of Preinitiation Complexes, Leading to Altered Gene Expression, Cell Cycle Progression, and Survival of Tumor Cells Timothy W. R. Kelso, Karen Baumgart, Jan Eickhoff et al. · Molecular and Cellular Biology Open access	22 Jul 2014	81
42	Cloning and Characterization of an Armillaria gallica cDNA Encoding Protoilludene Synthase, Which Catalyzes the First Committed Step in the Synthesis of Antimicrobial Melleolides Benedikt Engels, Uwe Heinig, Torsten Grothe et al. · Journal of Biological Chemistry Open access	11 Dec 2010	77
43	TEAD–YAP Interaction Inhibitors and MDM2 Binders from DNA‐Encoded Indole‐Focused Ugi Peptidomimetics Verena B. K. Kunig et al. · Angewandte Chemie International Edition Open access	15 Jun 2020	75
44	Dual Inhibition of GSK3β and CDK5 Protects the Cytoskeleton of Neurons from Neuroinflammatory-Mediated Degeneration In Vitro and In Vivo Lydia Reinhardt et al. · Stem Cell Reports Open access	14 Feb 2019	72
45	SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia Patricia Johansson, Ludger Klein‐Hitpaß, Axel Choidas et al. · Blood Cancer Journal Open access	19 Jan 2018	69
46	Importance of secondary metabolites in the Xylariaceae as parameters for Marc Stadler · Current Research in Environmental & Applied Mycology Open access	29 Oct 2011	69
47	Price-Focused Analysis of Commercially Available Building Blocks for Combinatorial Library Synthesis Tuomo Kalliokoski · ACS Combinatorial Science	15 Sep 2015	69
48	DYRK1B as therapeutic target in Hedgehog/GLI-dependent cancer cells with Smoothened inhibitor resistance Wolfgang Gruber, Martin Hutzinger, Dominik Patrick Elmer et al. · Oncotarget Open access	13 Jan 2016	65
49	Insight into the Inhibition of Drug‐Resistant Mutants of the Receptor Tyrosine Kinase EGFR Julian Engel, Christian Becker, Jonas Lategahn et al. · Angewandte Chemie International Edition	5 Aug 2016	63
50	Increasing the Efficiency of Ligands for FK506-Binding Protein 51 by Conformational Control Yansong Wang, Alexander Kirschner, A. Fabian et al. · Journal of Medicinal Chemistry Open access	6 May 2013	63

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.