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Institution · Lexicon Pharmaceuticals (United States)

Most cited papers from Lexicon Pharmaceuticals (United States)

Lexicon Pharmaceuticals (United States)

What are the most cited papers from Lexicon Pharmaceuticals (United States)?

The most cited paper from Lexicon Pharmaceuticals (United States) is "Deep learning applications and challenges in big data analytics" (Maryam Mousaarab Najafabadi, Flavio Villanustre, Taghi M. Khoshgoftaar et al., 2015), with 2,613 citations. Next come "The Sketch Engine" (2,106) and "Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure" (1,872).

Showing 50 of 60 papers. Every paper with more than 170 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Deep learning applications and challenges in big data analytics Maryam Mousaarab Najafabadi, Flavio Villanustre, Taghi M. Khoshgoftaar et al. · Journal Of Big Data Open access 23 Feb 2015 2,613
2 The Sketch Engine Adam Kilgarriff, Vít Baisa, Jan Bušta et al. · Lexicography Open access Jul 2014 2,106
3 Sotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure Deepak L. Bhatt, Michael J. Szarek, Philippe Gabríel Steg et al. · New England Journal of Medicine Open access 16 Nov 2020 1,872
4 Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance William L. Holland, Joseph T. Brozinick, Liping Wang et al. · Cell Metabolism Open access Mar 2007 1,231
5 Sotagliflozin in Patients with Diabetes and Chronic Kidney Disease Deepak L. Bhatt, Michael J. Szarek, Bertram Pitt et al. · New England Journal of Medicine Open access 16 Nov 2020 1,206
6 Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2 Shyam K. Sharan, Masami Morimatsu, Urs Albrecht et al. · Nature Open access Apr 1997 1,080
7 NCCN Guidelines Insights: Colon Cancer, Version 2.2018 Al B. Benson et al. · Journal of the National Comprehensive Cancer Network Open access Apr 2018 1,045
8 The Knockout Mouse Project Christopher P. Austin et al. · Nature Genetics Open access 31 Aug 2004 620
9 The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice. Steven Xanthoudakis, Richard Jay Smeyne, James D. Wallace et al. · Proceedings of the National Academy of Sciences Open access 20 Aug 1996 513
10 Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system Michael P. Matise, Douglas J. Epstein, Heidi L. Park et al. · Development Aug 1998 495
11 Glycosylphosphatidylinositol-Anchored High-Density Lipoprotein-Binding Protein 1 Plays a Critical Role in the Lipolytic Processing of Chylomicrons Anne P. Beigneux, Brandon S.J. Davies, Peter Gin et al. · Cell Metabolism Open access Apr 2007 471
12 Lrp5 functions in bone to regulate bone mass Yajun Cui et al. · Nature Medicine Open access 22 May 2011 455
13 Cutting Edge: Induced Indoleamine 2,3 Dioxygenase Expression in Dendritic Cell Subsets Suppresses T Cell Clonal Expansion Andrew L. Mellor, Babak Baban, Phillip Chandler et al. · The Journal of Immunology Open access Aug 2003 455
14 Proteinuria and Perinatal Lethality in Mice Lacking NEPH1, a Novel Protein with Homology to NEPHRIN Dorit B. Donoviel, Deon D. Freed, Hannes Vogel et al. · Molecular and Cellular Biology Open access Jul 2001 453
15 Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells Brian Zambrowicz, Glenn A. Friedrich, Eric C. Buxton et al. · Nature Apr 1998 438
16 Effects of Sotagliflozin Added to Insulin in Patients with Type 1 Diabetes Satish K. Garg, Robert R. Henry, Phillip Lee Banks et al. · New England Journal of Medicine Open access 13 Sep 2017 421
17 Essential Roles of Enteric Neuronal Serotonin in Gastrointestinal Motility and the Development/Survival of Enteric Dopaminergic Neurons Zhiqing Li, Alcmène Chalazonitis, Yuan Huang et al. · Journal of Neuroscience Open access 15 Jun 2011 411
18 Knockouts model the 100 best-selling drugs—will they model the next 100? Brian Zambrowicz, Arthur Sands · Nature Reviews Drug Discovery Review 31 Dec 2002 396
19 TSPAN12 Regulates Retinal Vascular Development by Promoting Norrin- but Not Wnt-Induced FZD4/β-Catenin Signaling Harald J. Junge, Stacey C. Yang, Jeremy B. Burton et al. · Cell Open access Oct 2009 392
20 The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates Jeffrey A. Kramer, John E. Sagartz, Dale L. Morris · Nature Reviews Drug Discovery Review 13 Jul 2007 378
21 Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus Volker Vallon, Michael A. Rose, Maria Gerasimova et al. · American Journal of Physiology-Renal Physiology Open access 14 Nov 2012 370
22 A Meta-analysis of Quantitative EEG Power Associated With Attention-Deficit Hyperactivity Disorder Steven M. Snyder, James Richard Hall · Journal of Clinical Neurophysiology Review 8 Sep 2006 352
23 A mouse knockout library for secreted and transmembrane proteins Tracy Tang et al. · Nature Biotechnology 20 Jun 2010 341
24 Essential Role of MAPK Phosphatase-1 in the Negative Control of Innate Immune Responses Konstantin V. Salojin, Iris B. Owusu, Karen A. Millerchip et al. · The Journal of Immunology Feb 2006 337
25 Wnk1 kinase deficiency lowers blood pressure in mice: A gene-trap screen to identify potential targets for therapeutic intervention Brian Zambrowicz et al. · Proceedings of the National Academy of Sciences Open access 10 Nov 2003 334
26 Diverse Psychotomimetics Act Through a Common Signaling Pathway Per Svenningsson, Eleni T. Tzavara, Robert L. Carruthers et al. · Science 21 Nov 2003 313
27 Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia Timo Rieg, Takahiro Masuda, Maria Gerasimova et al. · American Journal of Physiology-Renal Physiology Open access 14 Nov 2013 311
28 WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk Hou‐Feng Zheng et al. · PLoS Genetics Open access 5 Jul 2012 299
29 Disruption of Ini1 Leads to Peri-Implantation Lethality and Tumorigenesis in Mice Cynthia J. Guidi, Arthur Sands, Brian Zambrowicz et al. · Molecular and Cellular Biology Open access May 2001 295
30 Genetic Disruption of Both Tryptophan Hydroxylase Genes Dramatically Reduces Serotonin and Affects Behavior in Models Sensitive to Antidepressants Katerina V. Savelieva, Shulei Zhao, Vladimir M. Pogorelov et al. · PLoS ONE Open access 14 Oct 2008 261
31 Regulation of PKD by the MAPK p38δ in Insulin Secretion and Glucose Homeostasis Grzegorz Sumara, Ivan Formentini, Stephan C. Collins et al. · Cell Open access 2009 246
32 LX4211, a Dual SGLT1/SGLT2 Inhibitor, Improved Glycemic Control in Patients With Type 2 Diabetes in a Randomized, Placebo-Controlled Trial Brian Zambrowicz, J Freiman, Phil Brown et al. · Clinical Pharmacology & Therapeutics Open access 27 Jun 2012 244
33 Requirement of the paraxis gene for somite formation and musculoskeletal patterning Rob Burgess, Alan Rawls, Doris R. Brown et al. · Nature Dec 1996 237
34 A rapid learning and dynamic stepwise updating algorithm for flat neural networks and the application to time-series prediction C. L. Philip Chen, Jiaoxia Wan · IEEE Transactions on Systems Man and Cybernetics Part B (Cybernetics) 1999 235
35 Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3) Creg J. Workman, Dennis S. Rice, Kari J. Dugger et al. · European Journal of Immunology Open access Aug 2002 235
36 Sotagliflozin in Combination With Optimized Insulin Therapy in Adults With Type 1 Diabetes: The North American inTandem1 Study John B. Buse, Satish K. Garg, Julio Rosenstock et al. · Diabetes Care Open access 24 Jun 2018 233
37 BGEM: An In Situ Hybridization Database of Gene Expression in the Embryonic and Adult Mouse Nervous System Susan M. Magdaleno, Patricia Jensen, Craig L. Brumwell et al. · PLoS Biology Open access 22 Mar 2006 227
38 Sotagliflozin, a Dual SGLT1 and SGLT2 Inhibitor, as Adjunct Therapy to Insulin in Type 1 Diabetes Arthur Sands, Brian Zambrowicz, Julio Rosenstock et al. · Diabetes Care Open access 7 Jun 2015 221
39 A DVANCES IN M OLECULAR -B ASED D IAGNOSTICS IN M EETING C ROP B IOSECURITY AND P HYTOSANITARY I SSUES Norman W. Schaad, Reid D. Frederick, Joe Shaw et al. · Annual Review of Phytopathology Review Sep 2003 214
40 Thenob2mouse, a null mutation inCacna1f: Anatomical and functional abnormalities in the outer retina and their consequences on ganglion cell visual responses Bo Chang, John R. Heckenlively, Philippa R. Bayley et al. · Visual Neuroscience Open access 2006 206
41 Transglutaminase and Polyamination of Tubulin: Posttranslational Modification for Stabilizing Axonal Microtubules Yuyu Song, Laura Kirkpatrick, Alexander B. Schilling et al. · Neuron Open access Apr 2013 206
42 KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation Laura R. Pearce et al. · Cell Open access 24 Oct 2013 205
43 Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice Urvi S. Desai, E-Chiang Lee, Kyu Hyuck Chung et al. · Proceedings of the National Academy of Sciences Open access 3 Jul 2007 197
44 mdmx is a negative regulator of p53 activity in vivo. Rick A. Finch, Dorit B. Donoviel, David Potter et al. · PubMed Jun 2002 195
45 Blockade of the αvβ3 Integrin Adversely Affects Implantation in the Mouse1 Maria Jose Illera, Emily B. Cullinan, Yaoting Gui et al. · Biology of Reproduction May 2000 194
46 The semantic priming project Keith A. Hutchison, David A. Balota, James H. Neely et al. · Behavior Research Methods Open access 23 Jan 2013 192
47 Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine Kara Gross Margolis, Korey D. Stevanovic, Zhishan Li et al. · Gut Open access 7 Jun 2013 191
48 A novel variant of the immunoglobulin fold in surface adhesins of Staphylococcus aureus: crystal structure of the fibrinogen‐binding MSCRAMM, clumping factor A Champion C. S. Deivanayagam, Elisabeth R. Wann, Wei Chen et al. · The EMBO Journal Open access 16 Dec 2002 191
49 EGFL7 regulates the collective migration of endothelial cells by restricting their spatial distribution Maike Schmidt, Kim Paes, Ann De Mazière et al. · Development 12 Jul 2007 189
50 Defect in neutrophil killing and increased susceptibility to infection with nonpathogenic gram-positive bacteria in peptidoglycan recognition protein-S (PGRP-S)–deficient mice Roman Dziarski, Kenneth A. Platt, Eva Gelius et al. · Blood Open access 24 Mar 2003 187

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.