| 1 |
Afatinib versus cisplatin plus gemcitabine for first-line treatment of Asian patients with advanced non-small-cell lung cancer harbouring EGFR mutations (LUX-Lung 6): an open-label, randomised phase 3 trial
Yi-Long Lung Cancer Wu, Caicun Zhou, Chengping Hu et al. · The Lancet Oncology
|
14 Jan 2014 |
1,992 |
| 2 |
Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct
Xiaochuan Huo et al. · New England Journal of Medicine
|
10 Feb 2023 |
893 |
| 3 |
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3
Zi‐Jiang Chen et al. · Nature Genetics
|
12 Dec 2010 |
863 |
| 4 |
Endovascular Thrombectomy with or without Intravenous Alteplase in Acute Stroke
Pengfei Yang et al. · New England Journal of Medicine
Open access |
6 May 2020 |
850 |
| 5 |
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Simon I Hay et al. · The Lancet
Open access2,780 authors |
Oct 2025 |
762 |
| 6 |
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome
Yongyong Shi et al. · Nature Genetics
|
12 Aug 2012 |
753 |
| 7 |
CRISPR/Cas9 therapeutics: progress and prospects
Tianxiang Li, Yanyan Yang, Hongzhao Qi et al. · Signal Transduction and Targeted Therapy
Open access |
16 Jan 2023 |
725 |
| 8 |
Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion
Chunrong Tao et al. · New England Journal of Medicine
Open access |
12 Oct 2022 |
681 |
| 9 |
Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (BEST): an open-label, randomised controlled trial
Xinfeng Liu et al. · The Lancet Neurology
143 authors |
9 Dec 2019 |
657 |
| 10 |
Dietary patterns and depression risk: A meta-analysis
Ye Li, Mei-Rong Lv, Yan-Jin Wei et al. · Psychiatry Research
Review |
11 Apr 2017 |
605 |
| 11 |
Toripalimab plus chemotherapy in treatment-naïve, advanced esophageal squamous cell carcinoma (JUPITER-06): A multi-center phase 3 trial
Zixian Wang et al. · Cancer Cell
Open access |
Mar 2022 |
592 |
| 12 |
Oral bioavailability of curcumin: problems and advancements
Weidong Liu, Yingjie Zhai, Xueyuan Heng et al. · Journal of drug targeting
|
4 Mar 2016 |
567 |
| 13 |
Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Mohsen Naghavi et al. · The Lancet
Open access2,463 authors |
Oct 2025 |
500 |
| 14 |
Exosomes from bone marrow mesenchymal stem cells enhance fracture healing through the promotion of osteogenesis and angiogenesis in a rat model of nonunion
Lu Zhang, Guangjun Jiao, Shanwu Ren et al. · Stem Cell Research & Therapy
Open access |
28 Jan 2020 |
376 |
| 15 |
Global, regional, and national burden of chronic kidney disease in adults, 1990–2023, and its attributable risk factors: a systematic analysis for the Global Burden of Disease Study 2023
Patrick B Mark et al. · The Lancet
Open access597 authors |
Nov 2025 |
366 |
| 16 |
Assessment of Endovascular Treatment for Acute Basilar Artery Occlusion via a Nationwide Prospective Registry
Writing Group for the BASILAR Group et al. · JAMA Neurology
Open access |
21 Feb 2020 |
363 |
| 17 |
Uncontrolled hypertension increases risk of all-cause and cardiovascular disease mortality in US adults: the NHANES III Linked Mortality Study
Donghao Zhou, Bo Xi, Min Zhao et al. · Scientific Reports
Open access |
14 Jun 2018 |
362 |
| 18 |
2020 Chinese guidelines for ultrasound malignancy risk stratification of thyroid nodules: the C-TIRADS
Jianqiao Zhou et al. · Endocrine
239 authors |
21 Aug 2020 |
348 |
| 19 |
Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage
Huimin Zhu, Zhiqiang Wang, Jixu Yu et al. · Progress in Neurobiology
|
25 Mar 2019 |
343 |
| 20 |
Camrelizumab Plus Carboplatin and Paclitaxel as First-Line Treatment for Advanced Squamous NSCLC (CameL-Sq): A Phase 3 Trial
Shengxiang Ren et al. · Journal of Thoracic Oncology
Open access |
16 Dec 2021 |
326 |
| 21 |
Tenecteplase versus alteplase in acute ischaemic cerebrovascular events (TRACE-2): a phase 3, multicentre, open-label, randomised controlled, non-inferiority trial
Yongjun Wang et al. · The Lancet
|
Feb 2023 |
313 |
| 22 |
circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis
Jianzhen Xu, Changchun Shao, Xiaojia Wang et al. · Cell Death and Disease
Open access |
20 Feb 2019 |
311 |
| 23 |
Therapeutic potentials of gene silencing by RNA interference: Principles, challenges, and new strategies
Yan Ping Deng, Chi Chiu Wang, Kwong Wai Choy et al. · Gene
|
6 Jan 2014 |
304 |
| 24 |
Sugar-sweetened beverages and risk of hypertension and CVD: a dose–response meta-analysis
Bo Xi, Yubei Huang, Kathleen H. Reilly et al. · British Journal Of Nutrition
Open access |
4 Mar 2015 |
300 |
| 25 |
Safety and Efficacy of Atorvastatin for Chronic Subdural Hematoma in Chinese Patients
Rongcai Jiang et al. · JAMA Neurology
Open access |
30 Jul 2018 |
294 |
| 26 |
A genome-wide association study identifies two new risk loci for Graves' disease
Xun Chu et al. · Nature Genetics
|
14 Aug 2011 |
284 |
| 27 |
Intensive blood pressure control after endovascular thrombectomy for acute ischaemic stroke (ENCHANTED2/MT): a multicentre, open-label, blinded-endpoint, randomised controlled trial
Pengfei Yang et al. · The Lancet
Open access |
28 Oct 2022 |
264 |
| 28 |
Prevalence of metabolic syndrome and its influencing factors among the Chinese adults: The China Health and Nutrition Survey in 2009
Bo Xi, Dan He, Yuehua Hu et al. · Preventive Medicine
Open access |
5 Oct 2013 |
262 |
| 29 |
Short sleep duration predicts risk of metabolic syndrome: A systematic review and meta-analysis
Bo Xi, Dan He, Min Zhang et al. · Sleep Medicine Reviews
Review |
24 Jul 2013 |
259 |
| 30 |
MALAT1 Is Associated with Poor Response to Oxaliplatin-Based Chemotherapy in Colorectal Cancer Patients and Promotes Chemoresistance through EZH2
Peilong Li, Xin Zhang, Haiyan Wang et al. · Molecular Cancer Therapeutics
Open access |
9 Jan 2017 |
251 |
| 31 |
Zinc Silicate/Nano-Hydroxyapatite/Collagen Scaffolds Promote Angiogenesis and Bone Regeneration via the p38 MAPK Pathway in Activated Monocytes
Yue Song, Hao Wu, Yi Gao et al. · ACS Applied Materials & Interfaces
|
17 Mar 2020 |
229 |
| 32 |
Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials
Charles B.L.M. Majoie et al. · The Lancet
ReviewOpen access133 authors |
25 Aug 2023 |
225 |
| 33 |
Preparation and evaluation of quercetin-loaded lecithin-chitosan nanoparticles for topical delivery
Guangxi Zhai, Guanlun Guo, Tan et al. · International Journal of Nanomedicine
Open access |
Aug 2011 |
220 |
| 34 |
CD4+ and CD8+ T cells have opposing roles in breast cancer progression and outcome
Yi Huang, Chunling Ma, Qunyuan Zhang et al. · Oncotarget
Open access |
29 Apr 2015 |
219 |
| 35 |
Efficacy and safety of a novel anti‐HER2 therapeutic antibody RC48 in patients with HER2‐overexpressing, locally advanced or metastatic gastric or gastroesophageal junction cancer: a single‐arm phase II study
Zhi Peng et al. · 癌症:英文版
Open access |
19 Oct 2021 |
211 |
| 36 |
Long noncoding RNA-MEG3 is involved in diabetes mellitus-related microvascular dysfunction
Gui-Zhen Qiu, Wei Tian, Haitao Fu et al. · Biochemical and Biophysical Research Communications
|
Feb 2016 |
197 |
| 37 |
VEGF and BMP-2 promote bone regeneration by facilitating bone marrow stem cell homing and differentiation
Wenjie Zhang, Chao Zhu, Yi‐Lei Wu et al. · European Cells and Materials
Open access |
15 Jan 2014 |
196 |
| 38 |
Prognostic prediction of systemic immune-inflammation index for patients with gynecological and breast cancers: a meta-analysis
Yongfang Ji, Haiyan Wang · World Journal of Surgical Oncology
ReviewOpen access |
7 Aug 2020 |
180 |
| 39 |
Global, regional, and national burdens of hip osteoarthritis from 1990 to 2019: estimates from the 2019 Global Burden of Disease Study
Ming Fu, Hongming Zhou, Yushi Li et al. · Arthritis Research & Therapy
Open access |
3 Jan 2022 |
179 |
| 40 |
Treatment guidelines of lymphatic malformations of the head and neck
Qin Zhou, Jia Wei Zheng, Hua Ming et al. · Oral Oncology
|
10 Sep 2011 |
167 |
| 41 |
TLR8 signaling enhances tumor immunity by preventing tumor‐induced T‐cell senescence
Jian Ye, Chunling Ma, Eddy C. Hsueh et al. · EMBO Molecular Medicine
Open access |
17 Sep 2014 |
166 |
| 42 |
The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, and Blood Markers
Bao‐Zhen Wei, Lin Li, Cheng‐Wen Dong et al. · American Journal of Clinical Nutrition
Open access |
5 Apr 2023 |
163 |
| 43 |
Intake of Fruit Juice and Incidence of Type 2 Diabetes: A Systematic Review and Meta-Analysis
Bo Xi, Shuangshuang Li, Zhaolu Liu et al. · PLoS ONE
ReviewOpen access |
28 Mar 2014 |
163 |
| 44 |
Study of Microbiomes in Aseptically Collected Samples of Human Breast Tissue Using Needle Biopsy and the Potential Role of in situ Tissue Microbiomes for Promoting Malignancy
Meng Shen, Bin Chen, Junjie Yang et al. · Frontiers in Oncology
Open access |
17 Aug 2018 |
154 |
| 45 |
Efficacy of Aumolertinib (HS-10296) in Patients With Advanced EGFR T790M+ NSCLC: Updated Post-National Medical Products Administration Approval Results From the APOLLO Registrational Trial
Shun Lü et al. · Journal of Thoracic Oncology
Open access |
19 Nov 2021 |
152 |
| 46 |
Global impact of COVID-19 on stroke care
Raul G. Nogueira et al. · International Journal of Stroke
Open access273 authors |
18 Jan 2021 |
152 |
| 47 |
Dysbiosis of the gut microbiome is associated with thyroid cancer and thyroid nodules and correlated with clinical index of thyroid function
Jiaming Zhang, Fanghua Zhang, Changying Zhao et al. · Endocrine
|
24 Dec 2018 |
144 |
| 48 |
Nut consumption in relation to cardiovascular disease risk and type 2 diabetes: a systematic review and meta-analysis of prospective studies
Donghao Zhou, Haibing Yu, Fang He et al. · American Journal of Clinical Nutrition
ReviewOpen access |
8 May 2014 |
144 |
| 49 |
Association between Common Polymorphism near the MC4R Gene and Obesity Risk: A Systematic Review and Meta-Analysis
Bo Xi, Giriraj R. Chandak, Yue Shen et al. · PLoS ONE
ReviewOpen access |
25 Sep 2012 |
144 |
| 50 |
Detection and characterization of bacterial nucleic acids in culture-negative synovial tissue and fluid samples from rheumatoid arthritis or osteoarthritis patients
Yan Zhao, Bin Chen, Shufeng Li et al. · Scientific Reports
Open access |
18 Sep 2018 |
139 |