| 1 |
Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis
Jin‐Wen Song et al. · Cell Metabolism
Open access |
24 Jun 2020 |
548 |
| 2 |
Integration of lipidomics and metabolomics for in-depth understanding of cellular mechanism and disease progression
Raoxu Wang, Bowen Li, Sin Man Lam et al. · Journal of genetics and genomics/Journal of Genetics and Genomics
|
18 Dec 2019 |
343 |
| 3 |
A multi-omics investigation of the composition and function of extracellular vesicles along the temporal trajectory of COVID-19
Sin Man Lam et al. · Nature Metabolism
Open access |
22 Jun 2021 |
313 |
| 4 |
RIPK3 Orchestrates Fatty Acid Metabolism in Tumor-Associated Macrophages and Hepatocarcinogenesis
Lei Wu, Xiao Zhang, Lu Zheng et al. · Cancer Immunology Research
|
2 Mar 2020 |
285 |
| 5 |
Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury
Zhongyuan Bao, Yinlong Liu, Binglin Chen et al. · Nature Communications
Open access |
9 Jul 2021 |
147 |
| 6 |
Hsp90 induces Acsl4-dependent glioma ferroptosis via dephosphorylating Ser637 at Drp1
Zong Miao, Wei Tian, Yangfan Ye et al. · Cell Death and Disease
Open access |
13 Jun 2022 |
128 |
| 7 |
The Attenuation of Diabetic Nephropathy by Annexin A1 via Regulation of Lipid Metabolism Through the AMPK/PPARα/CPT1b Pathway
Liang Wu, Changjie Liu, Dong‐Yuan Chang et al. · Diabetes
Open access |
8 Jun 2021 |
127 |
| 8 |
Precise Metabolomics Reveals a Diversity of Aging‐Associated Metabolic Features
He Tian, Ni Zhen, Sin Man Lam et al. · Small Methods
|
8 May 2022 |
101 |
| 9 |
Lithocholic acid phenocopies anti-ageing effects of calorie restriction
Qi Qu et al. · Nature
Open access |
18 Dec 2024 |
100 |
| 10 |
Lipidomics, en route to accurate quantitation
Sin Man Lam, He Tian, Guanghou Shui · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
|
17 Feb 2017 |
97 |
| 11 |
Low-input lipidomics reveals lipid metabolism remodelling during early mammalian embryo development
Ling Zhang et al. · Nature Cell Biology
|
Feb 2024 |
93 |
| 12 |
Stepwise selection of natural variations at CTB2 and CTB4a improves cold adaptation during domestication of japonica rice
Ji‐Long Li et al. · New Phytologist
Open access |
23 Apr 2021 |
92 |
| 13 |
Identification and Validation of Plasma Metabolomic Signatures in Precancerous Gastric Lesions That Progress to Cancer
Sha Huang, Yang Guo, Zhongwu Li et al. · JAMA Network Open
Open access |
22 Jun 2021 |
84 |
| 14 |
Membrane-Lipid Therapy in Operation: The HSP Co-Inducer BGP-15 Activates Stress Signal Transduction Pathways by Remodeling Plasma Membrane Rafts
Imre Gombos et al. · PLoS ONE
Open access |
12 Dec 2011 |
80 |
| 15 |
PAFAH2 suppresses synchronized ferroptosis to ameliorate acute kidney injury
Qianping Zhang et al. · Nature Chemical Biology
|
29 Jan 2024 |
65 |
| 16 |
Hydroximic Acid Derivatives: Pleiotropic Hsp Co-Inducers Restoring Homeostasis and Robustness
Tim Crul et al. · Current Pharmaceutical Design
Open access |
4 Dec 2012 |
64 |
| 17 |
Quantitative Lipidomics and Spatial MS-Imaging Uncovered Neurological and Systemic Lipid Metabolic Pathways Underlying Troglomorphic Adaptations in Cave-Dwelling Fish
Sin Man Lam, Jie Li, Huan Sun et al. · Molecular Biology and Evolution
Open access |
8 Mar 2022 |
63 |
| 18 |
High-coverage lipidomics for functional lipid and pathway analyses
Sin Man Lam, Zehua Wang, Bowen Li et al. · Analytica Chimica Acta
|
25 Nov 2020 |
63 |
| 19 |
Neuronal lipolysis participates in PUFA‐mediated neural function and neurodegeneration
Leilei Yang, Jingjing Liang, Sin Man Lam et al. · EMBO Reports
Open access |
9 Oct 2020 |
61 |
| 20 |
Lipidome Atlas of the Developing Heart Uncovers Dynamic Membrane Lipid Attributes Underlying Cardiac Structural and Metabolic Maturation
Huan Miao, Bowen Li, Zehua Wang et al. · Research
Open access |
2022 |
55 |
| 21 |
Phosphatidylserine synthase regulates cellular homeostasis through distinct metabolic mechanisms
Xiao Na Yang, Jingjing Liang, Long Ding et al. · PLoS Genetics
Open access |
23 Dec 2019 |
52 |
| 22 |
Targeted lipidomics and transcriptomics profiling reveal the heterogeneity of visceral and subcutaneous white adipose tissue
Biyu Hou, Yan Zhao, Ping He et al. · Life Sciences
Open access |
29 Jan 2020 |
49 |
| 23 |
AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway
Hoi Yin Mak, Qian Ouyang, Sergey Tumanov et al. · Nature Communications
Open access |
25 Nov 2021 |
46 |
| 24 |
Lipid droplets sequester palmitic acid to disrupt endothelial ciliation and exacerbate atherosclerosis in male mice
Yanjie Tan, Zhenzhou Huang, Yi Jin et al. · Nature Communications
Open access |
27 Sep 2024 |
45 |
| 25 |
Daytime-restricted feeding enhances running endurance without prior exercise in mice
Haoran Xin, Rongfeng Huang, Meiyu Zhou et al. · Nature Metabolism
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26 Jun 2023 |
45 |
| 26 |
Emerging roles and therapeutic potentials of sphingolipids in pathophysiology: emphasis on fatty acyl heterogeneity
Jinming Mu, Sin Man Lam, Guanghou Shui · Journal of genetics and genomics/Journal of Genetics and Genomics
Open access |
25 Jun 2023 |
45 |
| 27 |
Precise Metabolomics Defines Systemic Metabolic Dysregulation Distinct to Acute Myocardial Infarction Associated With Diabetes
Jinggang Xia, Bowen Li, Hao Zhang et al. · Arteriosclerosis Thrombosis and Vascular Biology
Open access |
2 Feb 2023 |
44 |
| 28 |
A robust, integrated platform for comprehensive analyses of acyl-coenzyme As and acyl-carnitines revealed chain length-dependent disparity in fatty acyl metabolic fates across Drosophila development
Sin Man Lam, Tianxing Zhou, Jie Li et al. · 中国科学通报:英文版
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11 Jul 2020 |
42 |
| 29 |
Plasma lipids signify the progression of precancerous gastric lesions to gastric cancer: a prospective targeted lipidomics study
Zongchao Liu, Wenhui Wu, Sha Huang et al. · Theranostics
Open access |
2022 |
41 |
| 30 |
Multi-omics profiling reveals rhythmic liver function shaped by meal timing
Rongfeng Huang, Jianghui Chen, Meiyu Zhou et al. · Nature Communications
Open access |
29 Sep 2023 |
38 |
| 31 |
Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function
Linbo Chen et al. · EMBO Reports
Open access |
27 Feb 2023 |
37 |
| 32 |
Non-invasive lipid panel of MASLD fibrosis transition underscores the role of lipoprotein sulfatides in hepatic immunomodulation
Sin Man Lam, Zehua Wang, Jin‐Wen Song et al. · Cell Metabolism
Open access |
4 Nov 2024 |
36 |
| 33 |
Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards
Federico Tesio Torta et al. · Nature Communications
Open access |
3 Oct 2024 |
35 |
| 34 |
Integration of Metabolomics and Transcriptomics Reveals Ketone Body and Lipid Metabolism Disturbance Related to ER Stress in the Liver
Peng Ma, Zijing Wang, Yisa Wang et al. · Journal of Proteome Research
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16 Jul 2021 |
30 |
| 35 |
Embracing lipidomics at single-cell resolution: Promises and pitfalls
Zehua Wang, Mingjun Cao, Sin Man Lam et al. · TrAC Trends in Analytical Chemistry
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10 Feb 2023 |
27 |
| 36 |
GBA1-dependent membrane glucosylceramide reprogramming promotes liver cancer metastasis via activation of the Wnt/β-catenin signalling pathway
Zhidong Qiu, Xuehong Wang, Zebin Yang et al. · Cell Death and Disease
Open access |
30 May 2022 |
27 |
| 37 |
Metabolomics-Based Frailty Biomarkers in Older Chinese Adults
Yiming Pan, Yun Li, Pan Liu et al. · Frontiers in Medicine
Open access |
26 Jan 2022 |
27 |
| 38 |
The role of glutathione-mediated triacylglycerol synthesis in the response to ultra-high cadmium stress in Auxenochlorella protothecoides
Chao Xing, Jinyu Li, Sin Man Lam et al. · Journal of Environmental Sciences
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28 Feb 2021 |
27 |
| 39 |
Localized increases in CEPT1 and ATGL elevate plasmalogen phosphatidylcholines in HDLs contributing to atheroprotective lipid profiles in hyperglycemic GCK-MODY
Xiaojing Wang, Sin Man Lam, Mingjun Cao et al. · Redox Biology
Open access |
10 Jan 2021 |
26 |
| 40 |
An integrated method for direct interrogation of sphingolipid homeostasis in the heart and brain tissues of mice through postnatal development up to reproductive senescence
Sin Man Lam, Raoxu Wang, Huan Miao et al. · Analytica Chimica Acta
|
3 Feb 2018 |
26 |
| 41 |
Heat therapy shows benefit in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
Judit Sebők, Zsófia Édel, Szilárd Váncsa et al. · International Journal of Hyperthermia
ReviewOpen access |
2021 |
25 |
| 42 |
Metabolomics through the lens of precision cardiovascular medicine
Sin Man Lam, Yuan Wang, Bowen Li et al. · Journal of genetics and genomics/Journal of Genetics and Genomics
|
Mar 2017 |
25 |
| 43 |
The ER calcium channel Csg2 integrates sphingolipid metabolism with autophagy
Shiyan Liu, Mutian Chen, Yi-Chang Wang et al. · Nature Communications
Open access |
22 Jun 2023 |
24 |
| 44 |
Rebaudioside A Enhances Resistance to Oxidative Stress and Extends Lifespan and Healthspan in Caenorhabditis elegans
Pan Li, Zehua Wang, Sin Man Lam et al. · Antioxidants
Open access |
8 Feb 2021 |
22 |
| 45 |
Skeletal muscle-secreted DLPC orchestrates systemic energy homeostasis by enhancing adipose browning
Xiaodi Hu et al. · Nature Communications
Open access |
30 Nov 2023 |
21 |
| 46 |
Global determination of reaction rates and lipid turnover kinetics in Mus musculus
Qishan Chen, Hu Li, He Tian et al. · Cell Metabolism
Open access |
Apr 2023 |
19 |
| 47 |
Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural–glial coupling in Drosophila
Xiupeng Chen, Jie Li, Zhongbao Gao et al. · National Science Review
Open access |
27 Jul 2022 |
18 |
| 48 |
Untargeted metabolomics and transcriptomics identified glutathione metabolism disturbance and PCS and TMAO as potential biomarkers for ER stress in lung
Zijing Wang, Peng Ma, Yisa Wang et al. · Scientific Reports
Open access |
19 Jul 2021 |
17 |
| 49 |
RICE ACYL-COA-BINDING PROTEIN6 Affects Acyl-CoA Homeostasis and Growth in Rice
Wei Meng, Lijian Xu, Zhiyan Du et al. · Rice
Open access |
6 Nov 2020 |
17 |
| 50 |
Untargeted LC–MS Data Preprocessing in Metabolomics
He Tian, Bowen Li, Guanghou Shui · Journal of Analysis and Testing
|
Jul 2017 |
17 |