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Institution · Lonza (United Kingdom)

Most cited papers from Lonza (United Kingdom)

Lonza (United Kingdom)

What are the most cited papers from Lonza (United Kingdom)?

The most cited paper from Lonza (United Kingdom) is "Aggregates in monoclonal antibody manufacturing processes" (María Vázquez‐Rey, Dietmar Lang, 2011), with 486 citations. Next come "Antibody production" (475) and "On the Optimal Ratio of Heavy to Light Chain Genes for Efficient Recombinant Antibody Production by CHO Cells" (237).

Showing 50 of 60 papers. Every paper with more than 29 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Aggregates in monoclonal antibody manufacturing processes María Vázquez‐Rey, Dietmar Lang · Biotechnology and Bioengineering 7 Apr 2011 486
2 Antibody production John R. Birch, Andrew J. Racher · Advanced Drug Delivery Reviews Review 23 May 2006 475
3 On the Optimal Ratio of Heavy to Light Chain Genes for Efficient Recombinant Antibody Production by CHO Cells Stefan Schlatter, Scott H. Stansfield, Diane M. Dinnis et al. · Biotechnology Progress 4 Feb 2005 237
4 Reactor design for large scale suspension animal cell culture Julie Varley, John R. Birch · Cytotechnology Open access Mar 1999 159
5 Taking immunogenicity assessment of therapeutic proteins to the next level Isabel Büttel et al. · Biologicals 25 Feb 2011 140
6 Functional proteomic analysis of GS‐NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate Diane M. Dinnis, Scott H. Stansfield, Stefan Schlatter et al. · Biotechnology and Bioengineering 17 Feb 2006 139
7 Generation of T-cell-redirecting bispecific antibodies with differentiated profiles of cytokine release and biodistribution by CD3 affinity tuning Lauric Haber et al. · Scientific Reports Open access 13 Jul 2021 122
8 Comparative proteomic analysis of GS‐NS0 murine myeloma cell lines with varying recombinant monoclonal antibody production rate Christopher Mark Smales, Diane M. Dinnis, Scott H. Stansfield et al. · Biotechnology and Bioengineering 30 Sep 2004 120
9 Scale-up of monoclonal antibody purification processes Suzanne Aldington, Julian R. Bonnerjea · Journal of Chromatography B 17 Jan 2007 118
10 Shear stress analysis of mammalian cell suspensions for prediction of industrial centrifugation and its verification Nicholas Hutchinson, N. S. Bingham, NJ Murrell et al. · Biotechnology and Bioengineering 9 Jun 2006 114
11 Aggregation risk prediction for antibodies and its application to biotherapeutic development Olga Obrezanova, Andreas Arnell, Ramón Gómez de la Cuesta et al. · mAbs Open access 4 Mar 2015 111
12 Cell line‐specific control of recombinant monoclonal antibody production by CHO cells Peter M. O’Callaghan, Jane McLeod, Leon P. Pybus et al. · Biotechnology and Bioengineering 16 Apr 2010 102
13 Recombinase‐mediated cassette exchange ( RMCE ) for monoclonal antibody expression in the commercially relevant CHOK1SV cell line Lin Zhang, Mara C. Inniss, Shu Han et al. · Biotechnology Progress 24 Sep 2015 99
14 Control of Culture Environment for Improved Polyethylenimine-Mediated Transient Production of Recombinant Monoclonal Antibodies by CHO Cells D.J. Galbraith, A. Sasha Tait, Andrew J. Racher et al. · Biotechnology Progress 2 Jun 2006 99
15 Functional heterogeneity and heritability in CHO cell populations Sarah L. Davies, Clare S. Lovelady, Rhian K. Grainger et al. · Biotechnology and Bioengineering 25 Jul 2012 96
16 Separation-based Glycoprofiling Approaches using Fluorescent Labels Paula Jane Domann, Ana Carmen Pardos-Pardos, Daryl L. Fernandes et al. · PROTEOMICS Sep 2007 92
17 Human health hazard assessment of quaternary ammonium compounds: Didecyl dimethyl ammonium chloride and alkyl (C12–C16) dimethyl benzyl ammonium chloride Anthony L. Luz, Paul C. DeLeo, Nathan Pechacek et al. · Regulatory Toxicology and Pharmacology Open access 5 Jul 2020 85
18 Process analytics for purification of monoclonal antibodies STEPHEN FLATMAN, Imtiaz Alam, Jeffery M. Gerard et al. · Journal of Chromatography B 13 Dec 2006 79
19 Development of generic raman models for a GS‐KO TM CHO platform process Thaddaeus A. Webster, Brian C. Hadley, William Hilliard et al. · Biotechnology Progress 31 Mar 2018 78
20 Strategies for selecting recombinant CHO cell lines for cGMP manufacturing: Improving the efficiency of cell line generation Alison J. Porter, Andrew J. Racher, Richard F. Preziosi et al. · Biotechnology Progress 22 Apr 2010 74
21 Glycosylation of immunoglobulin light chains associated with amyloidosis L. A. Omtvedt, David Stanley Bailey, David V. Renouf et al. · Amyloid 2000 74
22 An Industry Perspective on Forced Degradation Studies of Biopharmaceuticals: Survey Outcome and Recommendations Jennifer Halley, Yite Robert Chou, Crystal Cicchino et al. · Journal of Pharmaceutical Sciences Open access 26 Sep 2019 73
23 Extending the half-life of a fab fragment through generation of a humanized anti-human serum albumin Fv domain: An investigation into the correlation between affinity and serum half-life Ralph Adams, Laura Griffin, Joanne E. Compson et al. · mAbs Open access 17 Jun 2016 70
24 Catalytic Asymmetric Hydrogenation in the Manufacture of d-Biotin and Dextromethorphan René Imwinkelried · CHIMIA International Journal for Chemistry Open access 25 Jun 1997 69
25 The development, benefits and disadvantages of serum-free media. Froud Sj · PubMed 1999 69
26 A glutamic acid 3‐methyltransferase encoded by an accessory gene locus important for daptomycin biosynthesis in Streptomyces roseosporus Kien Trung Nguyen, DAVID A. KAU, Jian‐Qiao Gu et al. · Molecular Microbiology 25 Jul 2006 68
27 Early Implementation of QbD in Biopharmaceutical Development: A Practical Example Jesús Zurdo, Andreas Arnell, Olga Obrezanova et al. · BioMed Research International Open access 2015 66
28 The response of GS‐NS0 myeloma cells to single and multiple pH perturbations Jason J. Osman, John R. Birch, Julie Varley · Biotechnology and Bioengineering 12 Jun 2002 63
29 Assay format diversity in pre-clinical immunogenicity risk assessment: Toward a possible harmonization of antigenicity assays Axel Ducret, Chloé Ackaert, Juliana Bessa et al. · mAbs Open access 20 Dec 2021 60
30 Engineering of Chinese hamster ovary cell lipid metabolism results in an expanded ER and enhanced recombinant biotherapeutic protein production James D. Budge, Tanya J. Knight, Jane F. Povey et al. · Metabolic Engineering Open access 2 Dec 2019 56
31 Toward More Efficient Protein Expression: Keep the Message Simple Stephan A. Kalwy, James Rance, Robert J. Young · Molecular Biotechnology 2006 53
32 FTIR markers of methionine oxidation for early detection of oxidized protein therapeutics Jascindra Ravi, Anna E. Hills, Eleonora Cerasoli et al. · European Biophysics Journal 12 Jan 2011 53
33 Metabolic Rates, Growth Phase, and mRNA Levels Influence Cell-Specific Antibody Production Levels from In Vitro-Cultured Mammalian Cells at Sub-Physiological Temperatures Rosalyn J. Marchant, Mohamed B. Al‐Fageeh, Michèle F. Underhill et al. · Molecular Biotechnology 5 Feb 2008 52
34 The response of GS‐NS0 myeloma cells to pH shifts and pH perturbations Jason J. Osman, John R. Birch, Julie Varley · Biotechnology and Bioengineering 13 Aug 2001 52
35 Strategies for selecting Recombinant CHO cell lines for cGMP manufacturing: Realizing the potential in bioreactors Alison J. Porter, Alan James Dickson, Andrew J. Racher · Biotechnology Progress 22 Apr 2010 51
36 Proteomic analysis of enriched microsomal fractions from GS‐NS0 murine myeloma cells with varying secreted recombinant monoclonal antibody productivities Daniel E. Alete, Andrew J. Racher, John R. Birch et al. · PROTEOMICS 24 Oct 2005 50
37 Rapid high-throughput characterisation, classification and selection of recombinant mammalian cell line phenotypes using intact cell MALDI-ToF mass spectrometry fingerprinting and PLS-DA modelling Jane F. Povey, Christopher J. O'Malley, Tracy Root et al. · Journal of Biotechnology Open access 20 May 2014 49
38 Comparison of spectroscopy technologies for improved monitoring of cell culture processes in miniature bioreactors Ruth C. Rowland‐Jones, Frans W.J. van den Berg, Andrew J. Racher et al. · Biotechnology Progress Open access Mar 2017 48
39 Automated Large-Scale Culture and Medium-Throughput Chemical Screen for Modulators of Proliferation and Viability of Human Induced Pluripotent Stem Cell–Derived Neuroepithelial-like Stem Cells Donna McLaren, Thorsten Gorba, Anita Marguerie de Rotrou et al. · SLAS DISCOVERY Open access 6 Oct 2012 47
40 Novel Endogenous Engineering Platform for Robust Loading and Delivery of Functional mRNA by Extracellular Vesicles Antje Maria Zickler, Xiuming Liang, Dhanu Gupta et al. · Advanced Science Open access 9 Sep 2024 45
41 Dynamic analysis of GS‐NS0 cells producing a recombinant monoclonal antibody during fed‐batch culture Scott H. Stansfield, Emma E. Allen, Diane M. Dinnis et al. · Biotechnology and Bioengineering 17 Nov 2006 44
42 GTR-Mediated Radial Import Directs Accumulation of Defensive Glucosinolates to Sulfur-Rich Cells in the Phloem Cap of Arabidopsis Inflorescence Stem Deyang Xu, Pascal Hunziker, Olga Koroleva et al. · Molecular Plant Open access 28 Jun 2019 43
43 Rapid whole monoclonal antibody analysis by mass spectrometry: An Ultra scale‐down study of the effect of harvesting by centrifugation on the post‐translational modification profile Charles Reid, A. Sasha Tait, Helen Baldascini et al. · Biotechnology and Bioengineering 7 May 2010 41
44 Improving the accuracy of flux balance analysis through the implementation of carbon availability constraints for intracellular reactions Maximilian Lularevic, Andrew J. Racher, Colin M. Jaques et al. · Biotechnology and Bioengineering Open access 21 May 2019 38
45 Impact of gene vector design on the control of recombinant monoclonal antibody production by chinese hamster ovary cells Sarah L. Davies, Peter M. O’Callaghan, Jane McLeod et al. · Biotechnology Progress 4 Aug 2011 38
46 Engineering of the CMV promoter for controlled expression of recombinant genes in HEK293 cells Yusuf B. Johari, Joseph M. Scarrott, Thilo H. Pohle et al. · Biotechnology Journal Open access 28 Apr 2022 37
47 Network and pathway expansion of genetic disease associations identifies successful drug targets Aidan MacNamara, Nikolina Nakić, Ali Amin Al Olama et al. · Scientific Reports Open access Dec 2020 37
48 High‐throughput screening techniques for rapid PEG‐based precipitation of IgG4 mAb from clarified cell culture supernatant Carol Knevelman, Jim Davies, Lee Allen et al. · Biotechnology Progress 11 Dec 2009 37
49 Best Practices in Bioassay Development to Support Registration of Biopharmaceuticals John Robert White, Marla Abodeely, Sammina Ahmed et al. · BioTechniques Open access 5 Aug 2019 36
50 Biopharmaceutical Proteins: Opportunities and Challenges John R. Birch, Yemi Onakunle · Humana Press eBooks Book chapter 4 Aug 2005 35

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.