| 1 |
Trastuzumab Emtansine for Residual Invasive HER2-Positive Breast Cancer
Gϋnter von Minckwitz et al. · New England Journal of Medicine
Open access |
5 Dec 2018 |
2,689 |
| 2 |
Self-expandable metal stents for obstructing colonic and extracolonic cancer: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2020
Jeanin Elise van Hooft, Joyce Valerie Veld, Dirk Arnold et al. · Endoscopy
Open access |
7 Apr 2020 |
375 |
| 3 |
Stepwise engineering to produce high yields of very long-chain polyunsaturated fatty acids in plants
Guohai Wu, Martin Truksa, Nagamani Datla et al. · Nature Biotechnology
|
12 Jun 2005 |
310 |
| 4 |
DNA methylation dynamics during early plant life
Daniel Bouyer, Amira Kramdi, Mohamed Kassam et al. · Genome biology
Open access |
19 Sep 2017 |
259 |
| 5 |
Die Gutenberg Gesundheitsstudie
Philipp Sebastian Wild, Tanja Zeller, Manfred Elmar Beutel et al. · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz
|
Jun 2012 |
243 |
| 6 |
Tumor mutational burden and immune infiltration as independent predictors of response to neoadjuvant immune checkpoint inhibition in early TNBC in GeparNuevo
Thomas Karn et al. · Annals of Oncology
Open access |
24 May 2020 |
241 |
| 7 |
MitraClip Therapy in Daily Clinical Practice: Initial Results from the German Transcatheter Mitral Valve Interventions (TRAMI) Registry
Stephan Ernst Baldus, Wolfgang Schillinger, Olaf Walter Franzen et al. · European Journal of Heart Failure
Open access |
8 Jun 2012 |
229 |
| 8 |
Specific microRNA signatures in exosomes of triple-negative and HER2-positive breast cancer patients undergoing neoadjuvant therapy within the GeparSixto trial
Ines Stevic, Volkmar Müller, Karsten Ernst Weber et al. · BMC Medicine
Open access |
26 Sep 2018 |
212 |
| 9 |
Fertility preservation in women—a practical guide to preservation techniques and therapeutic strategies in breast cancer, Hodgkin’s lymphoma and borderline ovarian tumours by the fertility preservation network FertiPROTEKT
Michael von Wolff, Markus H. M. Montag, Ralf Dittrich et al. · Archives of Gynecology and Obstetrics
Open access |
23 Mar 2011 |
197 |
| 10 |
The human action recognition system and its relationship to Broca’s area: an fMRI study
Farsin Hamzei, Michel Rijntjes, Christian Dettmers et al. · NeuroImage
|
12 May 2003 |
189 |
| 11 |
Sirolimus-Eluting Stents for Treatment of Infrapopliteal Arteries Reduce Clinical Event Rate Compared to Bare-Metal Stents
Aljoscha Rastan, Klaus Brechtel, Hans Krankenberg et al. · Journal of the American College of Cardiology
Open access |
Aug 2012 |
182 |
| 12 |
Fixed-dose combination of pertuzumab and trastuzumab for subcutaneous injection plus chemotherapy in HER2-positive early breast cancer (FeDeriCa): a randomised, open-label, multicentre, non-inferiority, phase 3 study
Antoinette R. Tan, Seock‐Ah Im, André P. L. Mattar et al. · The Lancet Oncology
|
21 Dec 2020 |
175 |
| 13 |
Distributed form of constraint-induced movement therapy improves functional outcome and quality of life after stroke
Christian Dettmers, Ulrike Teske, Farsin Hamzei et al. · Archives of Physical Medicine and Rehabilitation
|
Feb 2005 |
164 |
| 14 |
The SBRT database initiative of the German Society for Radiation Oncology (DEGRO): patterns of care and outcome analysis of stereotactic body radiotherapy (SBRT) for liver oligometastases in 474 patients with 623 metastases
Nicolaus H. Andratschke, H. Alheid, Michael Allgäuer et al. · BMC Cancer
Open access |
13 Mar 2018 |
154 |
| 15 |
Safety and Efficacy of Atorvastatin-Induced Very Low-Density Lipoprotein Cholesterol Levels in Patients With Coronary Heart Disease (a Post Hoc Analysis of the Treating to New Targets [TNT] Study)††Conflicts of interest: Dr. LaRosa has served as a consultant to Pfizer, Inc., New York, New York; Merck Whitehouse Station, New Jersey; Bristol-Myers Squibb, New York, New York; and AstraZeneca, Wilming
John C. LaRosa, Scott M. Grundy, John J.P. Kastelein et al. · The American Journal of Cardiology
|
31 Jul 2007 |
148 |
| 16 |
The plant‐specific CDKB1‐CYCB1 complex mediates homologous recombination repair in Arabidopsis
Annika K. Weimer, Sascha Biedermann, Hirofumi Harashima et al. · The EMBO Journal
Open access |
6 Aug 2016 |
141 |
| 17 |
Life on the edge: hydrogen sulfide and the fish communities of a Mexican cave and surrounding waters
Michael Tobler, Ingo Schlupp, Katja U. Heubel et al. · Extremophiles
Open access |
20 Jun 2006 |
139 |
| 18 |
Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients
Jens Panse, Kay Friedrichs, Alexander Marx et al. · British Journal of Cancer
Open access |
Sep 2008 |
134 |
| 19 |
Radiotherapy for non-malignant disorders: state of the art and update of the evidence-based practice guidelines
M. Heinrich Seegenschmiedt, Oliver Micke, Ralph Muecke et al. · British Journal of Radiology
Open access |
8 May 2015 |
132 |
| 20 |
Treatment of bifurcation lesions with a drug-eluting balloon: the PEPCAD V (Paclitaxel Eluting PTCA Balloon in Coronary Artery Disease) trial
Detlef G. Mathey, Imke Wendig, Michael Boxberger et al. · EuroIntervention
|
May 2011 |
127 |
| 21 |
From transplant to novel cellular therapies in multiple myeloma: European Myeloma Network guidelines and future perspectives
Francesca Gay et al. · Haematologica
Open access |
7 Dec 2017 |
124 |
| 22 |
Immunomodulatory Properties and Molecular Effects in Inflammatory Diseases of Low-Dose X-Irradiation
Franz Rödel, Benjamin Frey, Katrin Manda et al. · Frontiers in Oncology
Open access |
2012 |
119 |
| 23 |
Mastectomy trends for early-stage breast cancer: A report from the EUSOMA multi-institutional European database
Carlos A. Garcia‐Etienne, Mariano Tomatis, Joerg Heil et al. · European Journal of Cancer
|
5 Apr 2012 |
114 |
| 24 |
An IQ Domain Mediates the Interaction with Calmodulin in a Plant Cyclic Nucleotide-Gated Channel
Cornelia Fischer, Annette Kugler, Stefan Hoth et al. · Plant and Cell Physiology
Open access |
6 Feb 2013 |
113 |
| 25 |
Stereotactic body radiotherapy for oligo-metastatic liver disease – Influence of pre-treatment chemotherapy and histology on local tumor control
Rainer J. Klement, Matthias Gückenberger, H. Alheid et al. · Radiotherapy and Oncology
|
6 Mar 2017 |
111 |
| 26 |
Proximal Endovascular Flow Blockage for Cerebral Protection During Carotid Artery Stenting: Results From a Prospective Multicenter Registry
Bernhard Reimers et al. · Journal of Endovascular Therapy
Open access |
Apr 2005 |
111 |
| 27 |
Long-term trends in cellulose 13 C and water-use efficiency of tropical Cedrela and Swietenia from Brazil
Peter Hietz, Wolfgang Wanek, Oliver Dünisch · Tree Physiology
|
Jun 2005 |
108 |
| 28 |
Reduction of Excitability (“Inhibition”) in the Ipsilateral Primary Motor Cortex Is Mirrored by fMRI Signal Decreases
Farsin Hamzei, Christian Dettmers, R. Rzanny et al. · NeuroImage
|
Sep 2002 |
106 |
| 29 |
Association of RAD51 with homologous recombination deficiency (HRD) and clinical outcomes in untreated triple-negative breast cancer (TNBC): analysis of the GeparSixto randomized clinical trial
Alba Llop‐Guevara et al. · Annals of Oncology
Open access |
11 Sep 2021 |
105 |
| 30 |
Increased excitability in the primary motor cortex and supplementary motor area in patients with phantom limb pain after upper limb amputation
Christian Dettmers, Torsten Adler, R. Rzanny et al. · Neuroscience Letters
|
Jul 2001 |
104 |
| 31 |
Treatment and outcomes of patients in the Brain Metastases in Breast Cancer Network Registry
Isabell Witzel, Elena Laakmann, Rudolf Weide et al. · European Journal of Cancer
Open access |
9 Aug 2018 |
99 |
| 32 |
The impact of local control on overall survival after stereotactic body radiotherapy for liver and lung metastases from colorectal cancer: a combined analysis of 388 patients with 500 metastases
Rainer J. Klement et al. · BMC Cancer
Open access |
26 Feb 2019 |
97 |
| 33 |
PAR and UVBR effects on photosynthesis, viability, growth and DNA in different life stages of coexisting Gigartinales: implications for recruitment and zonation pattern
MY Roleda, Willem H. van de Poll, Dieter Hanelt et al. · Marine Ecology Progress Series
Open access |
2004 |
97 |
| 34 |
Catheter Ablation of Atrial Fibrillation: State of the Art and Future Perspectives
Laura Rottner, Barbara Bellmann, Tina Lin et al. · Cardiology and Therapy
Open access |
2 Jan 2020 |
95 |
| 35 |
The retinoblastoma homolog RBR1 mediates localization of the repair protein RAD51 to DNA lesions in Arabidopsis
Sascha Biedermann, Hirofumi Harashima, Po‐Yu Chen et al. · The EMBO Journal
Open access |
20 Mar 2017 |
90 |
| 36 |
Possible Fruit Protein Effects on Primate Communities in Madagascar and the Neotropics
Jörg Ulrich Ganzhorn, Summer J. Arrigo‐Nelson, Sue Boinski et al. · PLoS ONE
Open access |
15 Dec 2009 |
88 |
| 37 |
Clinical Application of Trans-Arterial Radioembolization in Hepatic Malignancies in Europe: First Results from the Prospective Multicentre Observational Study CIRSE Registry for SIR-Spheres Therapy (CIRT)
Thomas K. Helmberger et al. · CardioVascular and Interventional Radiology
Open access |
21 Sep 2020 |
85 |
| 38 |
Giredestrant for Estrogen Receptor–Positive, HER2-Negative, Previously Treated Advanced Breast Cancer: Results From the Randomized, Phase II acelERA Breast Cancer Study
Miguel Martín et al. · Journal of Clinical Oncology
Open access131 authors |
27 Mar 2024 |
76 |
| 39 |
?-tricalcium phosphate as a bone substitute for dorsal spinal fusion in adolescent idiopathic scoliosis: preliminary results of a prospective clinical study
M. Muschik, Ralph Ludwig, Kathrin Bursche et al. · European Spine Journal
Open access |
Oct 2001 |
76 |
| 40 |
Beyond second-line therapy in patients with metastatic colorectal cancer: a systematic review
Dirk Arnold, Gerald W. Prager, ADRIELY OLIVEIRA QUINTELA et al. · Annals of Oncology
ReviewOpen access |
13 Feb 2018 |
75 |
| 41 |
Treatment of Photosensitivity
Athanasios Covanis, Stefan R. G. Stodieck, Arnold Jonathan Wilkins · Epilepsia
|
2004 |
68 |
| 42 |
Visuomotor control within a distributed parieto-frontal network
Farsin Hamzei, Christian Dettmers, Michel Rijntjes et al. · Experimental Brain Research
|
17 Aug 2002 |
65 |
| 43 |
NY‐CO‐58/KIF2C is overexpressed in a variety of solid tumors and induces frequent T cell responses in patients with colorectal cancer
Sacha Gnjatic et al. · International Journal of Cancer
Open access |
23 Nov 2009 |
64 |
| 44 |
Rationale and current perspective for early rhythm control therapy in atrial fibrillation
Isabelle C. Van Gelder, Laurent Haegeli, Axel Brandes et al. · EP Europace
Open access |
22 Jul 2011 |
62 |
| 45 |
Autologous minced cartilage repair for chondral and osteochondral lesions of the knee joint demonstrates good postoperative outcomes and low reoperation rates at minimum five‐year follow‐up
Armin Runer, Robert Ossendorff, Felix Conrad Oettl et al. · Knee Surgery Sports Traumatology Arthroscopy
Open access |
27 Aug 2023 |
61 |
| 46 |
Inflammatory Bowel Disease in Juvenile Idiopathic Arthritis Patients Treated with Biologics
Deborah Barthel, Gerd Ganser, Rolf‐Michael Kuester et al. · The Journal of Rheumatology
Open access |
15 Sep 2015 |
60 |
| 47 |
211MO Giredestrant (GDC-9545) vs physician choice of endocrine monotherapy (PCET) in patients (pts) with ER+, HER2– locally advanced/metastatic breast cancer (LA/mBC): Primary analysis of the phase II, randomised, open-label acelERA BC study
M. Martín Jiménez, Elgene Lim, M. Chavez Mac Gregor et al. · Annals of Oncology
Open access |
Sep 2022 |
59 |
| 48 |
The effect of estrogen synthesis inhibition on hippocampal memory
Janine Bayer, Gabriele M. Rune, Heidrun Schultz et al. · Psychoneuroendocrinology
|
2 Apr 2015 |
57 |
| 49 |
Severe heart failure and the need for mechanical circulatory support and heart transplantation in pediatric patients with myocarditis: Results from the prospective multicenter registry “MYKKE”
Stephan Schubert et al. · Pediatric Transplantation
Open access |
11 Jul 2019 |
56 |
| 50 |
Targeted therapy for metastatic colorectal cancer
Timothy Jay Price, Mónica Tang, Peter Gibbs et al. · Expert Review of Anticancer Therapy
|
18 Jul 2018 |
55 |