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CRISPR-Cas9 gene repair of hematopoietic stem cells from patients with X-linked chronic granulomatous disease
Suk See De Ravin, Linhong Li, Xiaolin Wu et al. · Science Translational Medicine
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11 Jan 2017 |
262 |
| 2 |
Targeted gene addition in human CD34+ hematopoietic cells for correction of X-linked chronic granulomatous disease
Suk See De Ravin et al. · Nature Biotechnology
Open access |
7 Mar 2016 |
195 |
| 3 |
Expression of chimeric antigen receptors in natural killer cells with a regulatory-compliant non-viral method
Lin Li, L N Liu, Stephanie Feller et al. · Cancer Gene Therapy
Open access |
11 Sep 2009 |
141 |
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Selective Field Effects on Intracellular Vacuoles and Vesicle Membranes with Nanosecond Electric Pulses
Ephrem Tekle, Hammou Oubrahim, Sergey M. Dzekunov et al. · Biophysical Journal
Open access |
8 Apr 2005 |
137 |
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Efficient mRNA-Based Genetic Engineering of Human NK Cells with High-Affinity CD16 and CCR7 Augments Rituximab-Induced ADCC against Lymphoma and Targets NK Cell Migration toward the Lymph Node-Associated Chemokine CCL19
Mattias Carlsten, Emily Ruth Levy, Amrita D. Karambelkar et al. · Frontiers in Immunology
Open access |
21 Mar 2016 |
119 |
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CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide
Mark E. Gurney, Arwen Stikvoort, Emma Nolan et al. · Haematologica
Open access |
30 Dec 2020 |
113 |
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Development of Anti-Human Mesothelin-Targeted Chimeric Antigen Receptor Messenger RNA–Transfected Peripheral Blood Lymphocytes for Ovarian Cancer Therapy
Chien‐Fu Hung, Xuequn Xu, Linhong Li et al. · Human Gene Therapy
Open access |
16 Jan 2018 |
81 |
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Enhanced homology-directed repair for highly efficient gene editing in hematopoietic stem/progenitor cells
Suk See De Ravin et al. · Blood
Open access |
24 Feb 2021 |
76 |
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A roadmap for cost-of-goods planning to guide economic production of cell therapy products
Yonatan Y. Lipsitz, William D. Milligan, Ian FitzPatrick et al. · Cytotherapy
Open access |
19 Sep 2017 |
76 |
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Highly Efficient, Large Volume Flow Electroporation
Linhong Li, Rama Shivakumar, Stephanie Feller et al. · Technology in Cancer Research & Treatment
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Oct 2002 |
63 |
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CHO-S Antibody Titers >1 Gram/Liter Using Flow Electroporation-Mediated Transient Gene Expression followed by Rapid Migration to High-Yield Stable Cell Lines
Krista K. Steger, James P. Brady, Weili Wang et al. · SLAS DISCOVERY
Open access |
18 Dec 2014 |
53 |
| 12 |
Preclinical Evaluation of CRISPR-Edited CAR-NK-92 Cells for Off-the-Shelf Treatment of AML and B-ALL
Guillermo Ureña-Bailén, Jérôme-Maurice Dobrowolski, Yujuan Hou et al. · International Journal of Molecular Sciences
Open access |
24 Oct 2022 |
50 |
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Assessing the gang-level and community-level effects of the Philadelphia Focused Deterrence strategy
Caterina G. Roman, Nathan W. Link, Jordan M. Hyatt et al. · Journal of Experimental Criminology
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22 Jun 2018 |
48 |
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Homology-independent targeted insertion (HITI) enables guided CAR knock-in and efficient clinical scale CAR-T cell manufacturing
Hyatt Balke‐Want, Vimal Keerthi, Nikolaos Gkitsas-Long et al. · Molecular Cancer
Open access |
26 Jun 2023 |
46 |
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Cutting Edge: TCR-Induced NAB2 Enhances T Cell Function by Coactivating IL-2 Transcription
Samuel L. Collins, Lawrence A. Wolfraim, Charles G. Drake et al. · The Journal of Immunology
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Dec 2006 |
43 |
| 16 |
Simulated evidence on the prospects of treating more drug-involved offenders
Avinash Singh Bhati, John Roman · Journal of Experimental Criminology
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Mar 2010 |
33 |
| 17 |
Efficient Large Volume Lentiviral Vector Production Using Flow Electroporation
Scott R. Witting, Lin-Hong Li, Aparna C. Jasti et al. · Human Gene Therapy
Open access |
21 Sep 2011 |
32 |
| 18 |
Heterologous survey of 130 DNA transposons in human cells highlights their functional divergence and expands the genome engineering toolbox
Tongtong Zhang et al. · Cell
Open access |
5 Jun 2024 |
28 |
| 19 |
Preclinical evaluation for engraftment of CD34+ cells gene-edited at the sickle cell disease locus in xenograft mouse and non-human primate models
Naoya Uchida, Linhong Li, Tina Nassehi et al. · Cell Reports Medicine
Open access |
Apr 2021 |
27 |
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Optimized electroporation of CRISPR-Cas9/gRNA ribonucleoprotein complex for selection-free homologous recombination in human pluripotent stem cells
Huaigeng Xu, Yuto Kita, Uikyu Bang et al. · STAR Protocols
Open access |
16 Nov 2021 |
25 |
| 21 |
Large Volume Flow Electroporation of mRNA: Clinical Scale Process
Linhong Li, Cornell Allen, Rama Shivakumar et al. · Methods in molecular biology
Book chapter |
8 Nov 2012 |
25 |
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A non-viral gene delivery system designed for clinical use
Joseph C. Fratantoni, Sergey M. Dzekunov, Vin Singh et al. · Cytotherapy
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2003 |
23 |
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Rapid, in vivo, evaluation of antiangiogenic and antineoplastic gene products by nonviral transfection of tumor cells
Jonathan M. Weiss, Rama Shivakumar, Stephanie Feller et al. · Cancer Gene Therapy
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19 Mar 2004 |
22 |
| 24 |
Delivery of Whole Tumor Lysate into Dendritic Cells for Cancer Vaccination
Linda N. Liu, Rama Shivakumar, Cornell Allen et al. · Methods in molecular biology
Book chapter |
2008 |
22 |
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Efficient electroporation of neuronal cells using synthetic oligonucleotides: identifying duplex RNA and antisense oligonucleotide activators of human frataxin expression
Xiulong Shen, Sharon Beasley, Jennifer N. Putman et al. · RNA
Open access |
31 May 2019 |
21 |
| 26 |
Non-viral TRAC-knocked-in CD19KICAR-T and gp350KICAR-T cells tested against Burkitt lymphomas with type 1 or 2 EBV infection: In vivo cellular dynamics and potency
Tobias Braun, Alina Pruene, Milita Darguzyte et al. · Frontiers in Immunology
Open access |
24 Mar 2023 |
20 |
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Rapid and efficient nonviral gene delivery of CD154 to primary chronic lymphocytic leukemia cells
Letai Li, Eleonora Biagi, Cornell Allen et al. · Cancer Gene Therapy
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5 Aug 2005 |
20 |
| 28 |
Clinical scale electroloading of mature dendritic cells with melanoma whole tumor cell lysate is superior to conventional lysate co-incubation in triggering robust in vitro expansion of functional antigen-specific CTL
Lawrence A. Wolfraim, Masashi Takahara, Angelia M. Viley et al. · International Immunopharmacology
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8 Feb 2013 |
18 |
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CRISPR-Cas9-Based Gene Knockout of Immune Checkpoints in Expanded NK Cells
Tahereh Mohammadian Gol, Miso Kim, Ralph Sinn et al. · International Journal of Molecular Sciences
Open access |
8 Nov 2023 |
16 |
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MAGT1 messenger RNA-corrected autologous T and natural killer cells for potential cell therapy in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia disease
Julie Brault, Ronald J. Meis, Linhong Li et al. · Cytotherapy
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10 Oct 2020 |
15 |
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Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips
Sayaka Deguchi, Kaori Kosugi, Rina Hashimoto et al. · PNAS Nexus
Open access |
Mar 2023 |
14 |
| 32 |
Final overall survival analysis of the phase 3 HERITAGE study demonstrates equivalence of trastuzumab-dkst to trastuzumab in HER2-positive metastatic breast cancer
Hope S. Rugo et al. · Breast Cancer Research and Treatment
Open access |
14 Jun 2021 |
14 |
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Comparison of two CD40-ligand/interleukin-2 vaccines in patients with chronic lymphocytic leukemia
Fatma Visal Okur, Eric S. Yvon, Ettore Biagi et al. · Cytotherapy
Open access |
12 Jul 2011 |
14 |
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Efficient Responses in a Murine Renal Tumor Model by Electroloading Dendritic Cells With Whole-Tumor Lysate
Jonathan M. Weiss, Cornell Allen, Rama Shivakumar et al. · Journal of Immunotherapy
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13 Oct 2005 |
13 |
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SARS-CoV-2-induced disruption of a vascular bed in a microphysiological system caused by type-I interferon from bronchial organoids
Kazuya Fujimoto, Yoshikazu Kameda, Yuta Nagano et al. · Lab on a Chip
Open access |
2024 |
12 |
| 36 |
Challenges in Gene Therapy for Somatic Reverted Mosaicism in X-Linked Combined Immunodeficiency by CRISPR/Cas9 and Prime Editing
Yujuan Hou, Guillermo Ureña-Bailén, Tahereh Mohammadian Gol et al. · Genes
Open access |
13 Dec 2022 |
12 |
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Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence
Nianbin Song, Srona Sengupta, Stanislav Khoruzhenko et al. · Cellular Immunology
Open access |
6 Sep 2020 |
12 |
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Bioprocessing considerations for generation of iPSCs intended for clinical application: perspectives from the ISCT Emerging Regenerative Medicine Technology working group
Hannah W. Song, Jennifer N. Solomon, Fernanda Masri et al. · Cytotherapy
Open access |
Jun 2024 |
11 |
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Selecting a Cell Engineering Methodology During Cell Therapy Product Development
Lauren M. Timmins, Alexandra Burr, Kristina Carroll et al. · Cell Transplantation
Open access |
2021 |
10 |
| 40 |
CGMP-compliant, clinical scale, non-viral platform for efficient gene editing using CRISPR/Cas9
L. Li, P. Natarajan, Cornell Allen et al. · Cytotherapy
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14 Mar 2014 |
10 |
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Supporting the Manufacturing of Medical Supplies in Africa: Collaboration Between Africa CDC, Partners, and Member States
Mohammed Abdulaziz, Hanna Idris-Dantata, Tochi Joy Okwor et al. · Global Health Science and Practice
Open access |
15 Sep 2023 |
9 |
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Clinical-Grade mRNA Electroporation of NK Cells: A Novel and Highly Efficient Method to Genetically Reprogram Human NK Cells for Cancer Immunotherapy
Mattias Carlsten, Linhong Li, Su Su et al. · Blood
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6 Dec 2014 |
9 |
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Accelerated generation of gene‐engineered monoclonal CHO cell lines using FluidFM nanoinjection and CRISPR/Cas9
Justin S. Antony, Anabel Migenda Herranz, Tahereh Mohammadian Gol et al. · Biotechnology Journal
Open access |
Apr 2024 |
8 |
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Mass balance, routes of excretion, and pharmacokinetics of investigational oral [14C]-alisertib (MLN8237), an Aurora A kinase inhibitor in patients with advanced solid tumors
Xiaofei Zhou, Sandeepraj Pusalkar, Swapan K. Chowdhury et al. · Investigational New Drugs
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6 Nov 2018 |
7 |
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ORAOV1 , CCND1 , and MIR548K Are the Driver Oncogenes of the 11q13 Amplicon in Squamous Cell Carcinoma
Céline I. Mahieu, Andrew G. Mancini, Ellee Pisey Vikram et al. · Molecular Cancer Research
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6 Nov 2023 |
6 |
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Enrichment of Allelic Editing Outcomes by Prime Editing in Induced Pluripotent Stem Cells
Ryo Niwa, Tomoko Matsumoto, Alexander Y. Liu et al. · The CRISPR Journal
Open access |
Oct 2024 |
5 |
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Preparation of NanoMEDIC Extracellular Vesicles to Deliver CRISPR-Cas9 Ribonucleoproteins for Genomic Exon Skipping
Kei Watanabe, Peter Gee, Akitsu Hotta · Methods in molecular biology
Book chapter |
18 Nov 2022 |
5 |
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NADPH oxidase correction by mRNA transfection of apheresis granulocytes in chronic granulomatous disease
Suk See De Ravin et al. · Blood Advances
Open access |
7 Dec 2020 |
4 |
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Highly efficient gene knockout in tumor-infiltrating lymphocytes by adenine base editing
Morteza Hafezi, Raphaël Genolet, Leila Hadadi et al. · Molecular Therapy Oncology
Open access |
22 Aug 2025 |
3 |
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A phase I study of intraperitoneal MCY-M11 Anti-mesothelin CAR for women with platinum resistant high grade serous adenocarcinoma of the ovary, primary peritoneum, or fallopian tube, or subjects with peritoneal mesothelioma with recurrence after prior chemotherapy
Christina M. Annunziata, C. Dansky-Ullmann, Armin Ghobadi et al. · Annals of Oncology
Open access |
Oct 2019 |
3 |