Most cited papers from Maxygen (United States)

Maxygen (United States)

What are the most cited papers from Maxygen (United States)?

The most cited paper from Maxygen (United States) is "In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship." (Dirk B. Mendel et al., 2003), with 1,971 citations. Next come "High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis" (1,957) and "Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions" (1,420).

Published TypeFieldAccessCitations

Showing 50 of 60 papers. Every paper with more than 179 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Dirk B. Mendel et al. · PubMed	2003	1,971
2	High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis Birgit Millauer, Susanne Wizigmann-Voos, Harald Schnürch et al. · Cell	Mar 1993	1,957
3	Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions Sima Lev, Herman Moreno, Ronny Martínez et al. · Nature	Aug 1995	1,420
4	Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant Birgit Millauer, Laura K. Shawver, Karl Heinz Plate et al. · Nature	Feb 1994	1,234
5	A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers James Robert Bischoff, Lee Anderson, Yingfang Zhu et al. · The EMBO Journal Open access	Jun 1998	1,226
6	Structures of the Tyrosine Kinase Domain of Fibroblast Growth Factor Receptor in Complex with Inhibitors Moosa Mohammadi, Gerald McMahon, Li Sun et al. · Science Open access	9 May 1997	1,114
7	A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation Ivan Đikić, George Y. Tokiwa, Sima Lev et al. · Nature	Oct 1996	976
8	A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway Haruhiko Kouhara, Yaron R. Hadari, Taly R. Spivak-Kroizman et al. · Cell Open access	May 1997	877
9	DNA shuffling of a family of genes from diverse species accelerates directed evolution Andreas Crameri, Sun-Ai Raillard, Ericka Bermudez et al. · Nature	1998	840
10	A family of proteins that inhibit signalling through tyrosine kinase receptors Alexei Kharitonenkov, Zhengjun Chen, Irmi Sures et al. · Nature	Mar 1997	667
11	Role of Melanopsin in Circadian Responses to Light Norman F. Ruby, Thomas J. Brennan, Xinmin Xie et al. · Science	12 Dec 2002	649
12	The Signal Recognition Particle Robert J. Keenan, Douglas M. Freymann, R. M. Stroud et al. · Annual Review of Biochemistry Review	Jun 2001	648
13	Immunocytochemical Localization of trkA Receptors in Chemically Identified Subgroups of Adult Rat Sensory Neurons Sharon Averill, Stephen Brendan McMahon, D O Clary et al. · European Journal of Neuroscience Open access	Jul 1995	627
14	The Knockout Mouse Project Christopher P. Austin et al. · Nature Genetics Open access	31 Aug 2004	620
15	Genome shuffling leads to rapid phenotypic improvement in bacteria Yingxin Zhang, Kim Perry, Victor A. Vinci et al. · Nature	Feb 2002	565
16	Knockout Analysis of Arabidopsis Transcription Factors TGA2 , TGA5 , and TGA6 Reveals Their Redundant and Essential Roles in Systemic Acquired Resistance Yuelin Zhang, Mark J. Tessaro, Michael Lassner et al. · The Plant Cell Open access	23 Oct 2003	522
17	Synthesis and Biological Evaluations of 3-Substituted Indolin-2-ones: A Novel Class of Tyrosine Kinase Inhibitors That Exhibit Selectivity toward Particular Receptor Tyrosine Kinases Li Sun, Ngoc Quang Tran, Flora L. M. Tang et al. · Journal of Medicinal Chemistry Open access	9 Jun 1998	493
18	The protein kinases of budding yeast: six score and more Tony R. Hunter, Gregory D. Plowman · Trends in Biochemical Sciences Review	1997	472
19	Identification of a novel contactin‐associated transmembrane receptor with multiple domains implicated in protein–protein interactions Elior Peles, Moshe Nativ, Marc Lustig et al. · The EMBO Journal Open access	Mar 1997	410
20	The carbonic anhydrase domain of receptor tyrosine phosphatase β is a functional ligand for the axonal cell recognition molecule contactin Elior Peles, Moshe Nativ, Phillip L. Campbell et al. · Cell Open access	Jul 1995	398
21	Early Detection of Apoptosis Using a Fluorescent Conjugate of Annexin V Guohong Zhang, Vanessa Gurtu, Steven R. Kain et al. · BioTechniques Open access	Sep 1997	391
22	Genome shuffling of Lactobacillus for improved acid tolerance Ranjan Patnaik, Susan Louie, Vesna Gavrilovic et al. · Nature Biotechnology	Jul 2002	383
23	Diaphanous-Related Formins Bridge Rho GTPase and Src Tyrosine Kinase Signaling Tomoko Tominaga, Erik A. Sahai, Pierre Teilhard de Chardin et al. · Molecular Cell Open access	2000	378
24	The Axonal Membrane Protein Caspr, a Homologue of Neurexin IV, Is a Component of the Septate-like Paranodal Junctions That Assemble during Myelination Steven Einheber, George J. Zanazzi, William Ching et al. · The Journal of Cell Biology Open access	15 Dec 1997	372
25	Loss of Nuclear Receptor SHP Impairs but Does Not Eliminate Negative Feedback Regulation of Bile Acid Synthesis Thomas A. Kerr, Shigeru Saeki, Manfred P Schneider et al. · Developmental Cell Open access	Jun 2002	353
26	The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis James Robert Bischoff, Gregory D. Plowman · Trends in Cell Biology Review	Nov 1999	333
27	Wnt-1 Regulates Free Pools of Catenins and Stabilizes APC-Catenin Complexes Jackie Papkoff, Bonnee Rubinfeld, Brian B. Schryver et al. · Molecular and Cellular Biology Open access	May 1996	330
28	Discovery and Directed Evolution of a Glyphosate Tolerance Gene Linda A. Castle, Daniel L. Siehl, Rebecca J. Gorton et al. · Science	20 May 2004	329
29	A Genome-wide Drosophila Screen for Heat Nociception Identifies α2δ3 as an Evolutionarily Conserved Pain Gene G. Gregory Neely et al. · Cell Open access	Nov 2010	327
30	The phytochrome-interacting transcription factor, PIF3, acts early, selectively, and positively in light-induced chloroplast development Elena Monte, James M. Tepperman, Bassem Al‐Sady et al. · Proceedings of the National Academy of Sciences Open access	25 Oct 2004	326
31	Flk-1 as a target for tumor growth inhibition. L M Strawn, Gerald McMahon, Harald App et al. · PubMed	Aug 1996	319
32	Myc but not Fos rescue of PDGF signalling block caused by kinase-inactive Src Maria Vittoria Barone, Sara A. Courtneidge · Nature	Nov 1995	311
33	Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway George Y. Tokiwa, I. Dikic, Sima Lev et al. · Science	9 Aug 1996	310
34	Src family protein tyrosine kinases and cellular signal transduction pathways Thorsten Erpel, Sara A. Courtneidge · Current Opinion in Cell Biology Review	1995	296
35	Directed evolution of proteins by exon shuffling Joost A. Kolkman, Willem P.C. Stemmer · Nature Biotechnology	May 2001	280
36	Synergy between LRH-1 and β-Catenin Induces G1 Cyclin-Mediated Cell Proliferation Oronza Antonietta Botrugno, Elisabeth Fayard, Jean‐Sébastien Annicotte et al. · Molecular Cell Open access	Aug 2004	277
37	Directed evolution of a fucosidase from a galactosidase by DNA shuffling and screening Ji-Hu Zhang, Glenn N. Dawes, Willem P.C. Stemmer · Proceedings of the National Academy of Sciences Open access	29 Apr 1997	276
38	The 2.35 å crystal structure of the inactivated form of chicken src: a dynamic molecule with multiple regulatory interactions John C Williams, Albert Weijland, Stefania Gonfloni et al. · Journal of Molecular Biology	Dec 1997	248
39	Predicting the emergence of antibiotic resistance by directed evolution and structural analysis. M. Cecilia Orencia, Jun Sik Yoon, Jon E. Ness et al. · Nature Structural Biology	Mar 2001	245
40	DNA Synthesis Induced by Some but Not All Growth Factors Requires Src Family Protein Tyrosine Kinases Serge Roche, Manfred Koegl, Maria Vittoria Barone et al. · Molecular and Cellular Biology Open access	Feb 1995	243
41	A fast neutron deletion mutagenesis‐based reverse genetics system for plants Xin Li, Yujuan Song, Karen S. Century et al. · The Plant Journal Open access	Aug 2001	236
42	Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent. Dirk B. Mendel, Alexander Laird, Beverly D. Smolich et al. · PubMed	Feb 2000	234
43	Transgenic expression of the human amphiregulin gene induces a psoriasis-like phenotype. Paul W. Cook, Michael W. Piepkorn, Christopher H. Clegg et al. · Journal of Clinical Investigation Open access	Nov 1997	230
44	Directed Evolution and Biocatalysis Keith A. Powell, Sandra W. Ramer, Stephen B. del Cardayré et al. · Angewandte Chemie International Edition	5 Nov 2001	226
45	DNA shuffling of subgenomic sequences of subtilisin Jon E. Ness, Mark Welch, Lori Giver et al. · Nature Biotechnology	Sep 1999	225
46	Isolation and Characterization of phyC Mutants in Arabidopsis Reveals Complex Crosstalk between Phytochrome Signaling Pathways Elena Monte, José M. Alonso, Joseph R. Ecker et al. · The Plant Cell Open access	8 Aug 2003	222
47	A Novel Juxtamembrane Domain Isoform of HER4/ErbB4 Klaus Elenius, Gabriel Corfas, Subroto Paul et al. · Journal of Biological Chemistry Open access	Oct 1997	215
48	Daughter of Sevenless Is a Substrate of the Phosphotyrosine Phosphatase Corkscrew and Functions during Sevenless Signaling Ronald Herbst, Pamela M. Carroll, John D. Allard et al. · Cell Open access	Jun 1996	212
49	An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3. D O Clary, Louis French Reichardt · Proceedings of the National Academy of Sciences Open access	8 Nov 1994	210
50	A simple nomenclature for a complex proton pump: VHA genes encode the vacuolar H+-ATPase Heven Sze, Karin Schumacher, Mathias L. Müller et al. · Trends in Plant Science Review	Apr 2002	206

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.