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Bisphosphonate conjugation for bone specific drug targeting
Kristen B. Farrell, Alexander M. Karpeisky, Douglas H. Thamm et al. · Bone Reports
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2 Jul 2018 |
183 |
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The promise of Immuno-oncology: implications for defining the value of cancer treatment
Howard L. Kaufman, Michael B. Atkins, Prasun Subedi et al. · Journal for ImmunoTherapy of Cancer
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17 May 2019 |
115 |
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Colorado Medical Students’ Attitudes and Beliefs About Marijuana
Michael Chan, Christopher E. Knoepke, Madeline L. Cole et al. · Journal of General Internal Medicine
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17 Jan 2017 |
81 |
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Phase 1 Single‐ and Multiple‐Ascending‐Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG‐348, a First‐in‐Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers
Hua Qiang Yang, Elizabeth Merica, Yue Chen et al. · Clinical Pharmacology in Drug Development
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9 Aug 2018 |
57 |
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A promising approach for treatment of tumor-induced bone diseases: Utilizing bisphosphonate derivatives of nucleoside antimetabolites
Monica Madden Reinholz et al. · Bone
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16 Mar 2010 |
40 |
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Brain Mitochondrial Drug Delivery: Influence of Drug Physicochemical Properties
Shelley A. Durazo, Rajendra S. Kadam, Derek A. Drechsel et al. · Pharmaceutical Research
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27 Jul 2011 |
35 |
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First-in-Human Phase I Study of MBC-11, a Novel Bone-Targeted Cytarabine-Etidronate Conjugate in Patients with Cancer-Induced Bone Disease
Shawn Patrick Zinnen, Alexander M. Karpeisky, Daniel D. Von Hoff et al. · The Oncologist
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9 Nov 2018 |
17 |
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3D electron tomographic and biochemical analysis of ER, Golgi and trans Golgi network membrane systems in stimulated Venus flytrap (Dionaea muscipula) glandular cells
Zachary R. Gergely, Dana E. Martínez, Bryon S. Donohoe et al. · Journal of Biological Research - Thessaloniki
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8 Aug 2018 |
15 |
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Bisphosphonate Derivatives of Nucleoside Antimetabolites: Hydrolytic Stability and Hydroxyapatite Adsorption of 5′-β,γ-Methylene and 5′-β,γ-(1-Hydroxyethylidene) Triphosphates of 5-Fluorouridine and ara-Cytidine
Mikko Ora, Tuomas Lönnberg, Diana Florea‐Wang et al. · The Journal of Organic Chemistry
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13 May 2008 |
15 |
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Application of adaptive design and decision making to a phase II trial of a phosphodiesterase inhibitor for the treatment of intermittent claudication
Roger Lewis, Jason T. Connor, John R. Teerlink et al. · Trials
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25 May 2011 |
9 |
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Effects of AG-348, a Pyruvate Kinase Activator, on Anemia and Hemolysis in Patients with Pyruvate Kinase Deficiency: Data from the DRIVE PK Study
Rachael F. Grace et al. · Blood
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2 Dec 2016 |
6 |
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Gemcitabine–Ibandronate Conjugate Enables the Bone-Targeted Combination Therapy in Bone Cancer: Synthesis and Efficacy in Combination with Docetaxel
Kristen B. Farrell, Shawn Patrick Zinnen, Douglas H. Thamm et al. · Bioconjugate Chemistry
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15 Nov 2021 |
5 |
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Effect of Mild and Moderate Hepatic Impairment on the Pharmacokinetics, Safety, and Tolerability of a Single Dose of Oral Ivosidenib in Otherwise Healthy Participants
Bin Fan, David L. Dai, Marvin B. Cohen et al. · Clinical Pharmacology in Drug Development
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9 Jul 2020 |
4 |
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StrandAdvantage test for early‐line and advanced‐stage treatment decisions in solid tumors
Manimala Sen et al. · Cancer Medicine
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3 Apr 2017 |
4 |
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Evaluation of a novel bone targeted aracytidine therapy in dogs with spontaneous osteosarcoma
Shawn Patrick Zinnen, Doug Thamm, David M. Vail et al. · Bone
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22 Dec 2010 |
4 |
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Population Pharmacokinetics and Pharmacodynamics of AG-348 in Healthy Human Volunteers Guide Dose Selection for the Treatment of Pyruvate Kinase Deficiency
Kha N. Le, Marvin B. Cohen, Yue Chen et al. · Blood
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3 Dec 2015 |
3 |
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Results Update from the DRIVE PK Study: Effects of AG-348, a Pyruvate Kinase Activator, in Patients with Pyruvate Kinase Deficiency
Rachael F. Grace, David Mark Layton, F. Galactéros et al. · Blood
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7 Dec 2017 |
2 |
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Phase I Single (SAD) and Multiple Ascending Dose (MAD) Studies of the Safety, Tolerability, Pharmacokinetics (PK) and Pharmacodynamics (PD) of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase-R, in Healthy Subjects
Hua Qiang Yang, Elizabeth Merica, Yue Chen et al. · Blood
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6 Dec 2014 |
2 |
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Effect of helix length on the stability of the lac repressor antiparallel coiled coil
Wheaton Little, James P. Robblee, Caroline L. Dahlberg et al. · Biopolymers
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13 May 2015 |
2 |
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Novel Approaches to Monitor Pharmacokinetics and Metabolism of Gemcitabine-Ibandronate Conjugate in Mice and Dogs
Jost Klawitter, Mckay Easton, Alexander M. Karpeisky et al. · Molecules
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16 Jan 2025 |
1 |
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Cannabidiol for treatment of Irritability and Aggressive Behavior in Children and Adolescents with ASD: Background and Methods of the CAnnabidiol Study in Children with Autism Spectrum DisordEr (CASCADE) Study
Elise M. Sannar, Joan R. Winter, Ronda K. Franke et al. · medRxiv
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13 Aug 2024 |
1 |
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DRIVE PK: A Phase 2 Trial of AG-348 in Patients with Pyruvate Kinase Deficiency
Ann Barbier, Bruce A. Silver, Elizabeth Merica et al. · Blood
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3 Dec 2015 |
1 |
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Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Doses of AG-519, an Allosteric Activator of Pyruvate Kinase-R, in Healthy Subjects
Ann Barbier, Susan Bodie, Gary Connor et al. · Blood
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2 Dec 2016 |
0 |
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Population Pharmacokinetics and Pharmacodynamics of AG-519, a Pyruvate Kinase Activator for the Treatment of Pyruvate Kinase Deficiency, in Human Healthy Volunteers
Kha N. Le, Marvin B. Cohen, Ann Barbier et al. · Blood
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2 Dec 2016 |
0 |
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The Effect of Spices and Herbs on Acceptance of Reduced-Fat/Reduced-Calorie Food
James O. Hill · Nutrition Today
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Sep 2014 |
0 |
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Novel vitamin B6 derivative of alendronate rapidly absorbed following oral administration
Shawn Patrick Zinnen, David P. Sebesta, Alexander M. Karpeisky et al. · Bone
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14 Feb 2006 |
0 |