Institution · Medicines Discovery Catapult
Most cited papers from Medicines Discovery Catapult
What are the most cited papers from Medicines Discovery Catapult?
The most cited paper from Medicines Discovery Catapult is "Unexplored therapeutic opportunities in the human genome" (Tudor Ionel Oprea et al., 2018), with 398 citations. Next come "Evaluating Robustness and Sensitivity of the NanoString Technologies nCounter Platform to Enable Multiplexed Gene Expression Analysis of Clinical Samples" (339) and "Improving the odds of drug development success through human genomics: modelling study" (280).
Showing 50 of 60 papers. Every paper with more than 13 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Unexplored therapeutic opportunities in the human genome Tudor Ionel Oprea et al. · Nature Reviews Drug Discovery | 23 Feb 2018 | 398 |
| 2 | Evaluating Robustness and Sensitivity of the NanoString Technologies nCounter Platform to Enable Multiplexed Gene Expression Analysis of Clinical Samples Margaret H. Veldman-Jones, Roz Brant, Claire M. Rooney et al. · Cancer Research | 11 Jun 2015 | 339 |
| 3 | Improving the odds of drug development success through human genomics: modelling study Aroon Dinesh Hingorani, Valerie Kuan, Chris Finan et al. · Scientific Reports | 11 Dec 2019 | 280 |
| 4 | PCSK9 monoclonal antibodies for the primary and secondary prevention of cardiovascular disease Amand Floriaan Schmidt, Lucy S Pearce, John T. Wilkins et al. · Cochrane Database of Systematic Reviews | 28 Apr 2017 | 213 |
| 5 | Drug Target Commons: A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions Jing Ping Tang et al. · Cell chemical biology | 21 Dec 2017 | 172 |
| 6 | Inhibitors of 3-Hydroxy-3-Methylglutaryl–CoA Reductase Reduce Receptor-Mediated Endocytosis in Opossum Kidney Cells James E. Sidaway, Robert G. Davidson, Fergus McTaggart et al. · Journal of the American Society of Nephrology | Sep 2004 | 157 |
| 7 | Osimertinib Western and Asian clinical pharmacokinetics in patients and healthy volunteers: implications for formulation, dose, and dosing frequency in pivotal clinical studies David Planchard, Kathryn H. Brown, Dong‐Wan Kim et al. · Cancer Chemotherapy and Pharmacology | 22 Feb 2016 | 148 |
| 8 | Optimisation of robust singleplex and multiplex droplet digital PCR assays for high confidence mutation detection in circulating tumour DNA Vicky Rowlands, Andrzej Rutkowski, Elena Meuser et al. · Scientific Reports | 2 Sep 2019 | 114 |
| 9 | Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption Vanessa Allwardt, Alexander J. Ainscough, Priyalakshmi Viswanathan et al. · Bioengineering | 16 Sep 2020 | 90 |
| 10 | A combined in vitro approach to improve the prediction of mitochondrial toxicants Julie A. Eakins, Caroline Bauch, Heather Woodhouse et al. · Toxicology in Vitro | 12 Apr 2016 | 81 |
| 11 | Medication overuse and drug addiction: a narrative review from addiction perspective Tatiane T. Takahashi, Raffaele Ornello, Giuseppe Quatrosi et al. · The Journal of Headache and Pain | 28 Apr 2021 | 79 |
| 12 | Artificial intelligence, drug repurposing and peer review Jeremy M. Levin, Tudor Ionel Oprea, Sagie Davidovich et al. · Nature Biotechnology | 14 Sep 2020 | 78 |
| 13 | Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues Nicola Ingram et al. · Theranostics | 2020 | 69 |
| 14 | Nuisance compounds in cellular assays Jayme L. Dahlin, Douglas S. Auld, Ina Rothenaigner et al. · Cell chemical biology | 16 Feb 2021 | 64 |
| 15 | A practical guide to secondary pharmacology in drug discovery Stephen G. Jenkinson, Friedemann Schmidt, Lyn Rosenbrier Ribeiro et al. · Journal of Pharmacological and Toxicological Methods | 14 Apr 2020 | 60 |
| 16 | Organ-on-a-chip technology: turning its potential for clinical benefit into reality Malcolm Haddrick, Peter B. Simpson · Drug Discovery Today | 14 Mar 2019 | 57 |
| 17 | Acute pharmacodynamic and antivascular effects of the vascular endothelial growth factor signaling inhibitor AZD2171 in Calu-6 human lung tumor xenografts Neil R. Smith, Neil H. James, I Oakley et al. · Molecular Cancer Therapeutics | Aug 2007 | 57 |
| 18 | Potent Fibrinolysis Inhibitor Discovered by Shape and Electrostatic Complementarity to the Drug Tranexamic Acid Jonas Boström, Jennifer Grant, Ola Fjellström et al. · Journal of Medicinal Chemistry | 25 Mar 2013 | 56 |
| 19 | Discovery of 1-Methyl-1 H -imidazole Derivatives as Potent Jak2 Inhibitors Qibin Su, Stephanos Ioannidis, Claudio E. Chuaqui et al. · Journal of Medicinal Chemistry | 10 Dec 2013 | 56 |
| 20 | Screening for molecular glues – Challenges and opportunities Geoffrey A. Holdgate, Catherine Bardelle, Sophia K. Berry et al. · SLAS DISCOVERY | 15 Dec 2023 | 54 |
| 21 | Spatially resolved deconvolution of the fibrotic niche in lung fibrosis Michael Eyres, Joseph A. Bell, Elizabeth R. Davies et al. · Cell Reports | Aug 2022 | 53 |
| 22 | Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1 -Mutant Diffuse Intrinsic Pontine Glioma Diana M. Carvalho et al. · Cancer Discovery | 22 Sep 2021 | 51 |
| 23 | Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1 Joseph Shaw, Ian L. Dale, PAUL E. HEMSLEY et al. · SLAS DISCOVERY | 13 Dec 2018 | 49 |
| 24 | Prolonged Scar-in-a-Jar: an in vitro screening tool for anti-fibrotic therapies using biomarkers of extracellular matrix synthesis Sarah Rank Rønnow, Rand Qais Dabbagh, Federica Genovese et al. · Respiratory Research | 7 May 2020 | 48 |
| 25 | Structural and Functional View of Polypharmacology Aurelio A. Moya‐García, Tolulope Tosin Adeyelu, Felix Alexander Krüger et al. · Scientific Reports | 24 Aug 2017 | 46 |
| 26 | Small-Molecule Degraders beyond PROTACs—Challenges and Opportunities Johanna Kastl, Gareth M. Davies, Eleanor Godsman et al. · SLAS DISCOVERY | 26 Feb 2021 | 42 |
| 27 | Assessment of neurovascular coupling and cortical spreading depression in mixed mouse models of atherosclerosis and Alzheimer’s disease Osman Shabir, Ben Pendry, Llywelyn Lee et al. · eLife | 20 Dec 2021 | 41 |
| 28 | Biophysical methods in early drug discovery Geoffrey A. Holdgate, Kevin J. Embrey, Alexander G. Milbradt et al. · ADMET & DMPK | 10 Dec 2019 | 40 |
| 29 | Vascularised cardiac spheroids-on-a-chip for testing the toxicity of therapeutics Stefania Di Ciò, Emilie Marhuenda, Malcolm Haddrick et al. · Scientific Reports | 9 Feb 2024 | 38 |
| 30 | The global hearing therapeutic pipeline: 2021 Beverley J. Isherwood, Ana Cláudia Gonçalves, Rick P. C. Cousins et al. · Drug Discovery Today | 11 Nov 2021 | 38 |
| 31 | Modulation of striatal functional connectivity differences in adults with and without autism spectrum disorder in a single-dose randomized trial of cannabidivarin Charlotte M. Pretzsch, Dorothea L. Floris, Bogdan Voinescu et al. · Molecular Autism | Jul 2021 | 35 |
| 32 | CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells Ashley J. Clark, Niamh Mullooly, Dewi Safitri et al. · Communications Biology | 23 Jun 2021 | 35 |
| 33 | Prediction of Chameleonic Efficiency Laurent David, Mark C. Wenlock, Patrick Barton et al. · ChemMedChem | 9 Jul 2021 | 35 |
| 34 | Target Identification of Mycobacterium tuberculosis Phenotypic Hits Using a Concerted Chemogenomic, Biophysical, and Structural Approach Grace Mugumbate, V. Mendes, Michał Błaszczyk et al. · Frontiers in Pharmacology | 26 Sep 2017 | 35 |
| 35 | Modeling the mechanical stiffness of pancreatic ductal adenocarcinoma Delanyo Kpeglo, Matt D. G. Hughes, Lorna Dougan et al. · Matrix Biology Plus | 21 Mar 2022 | 31 |
| 36 | Meeting the discovery challenge of drug-resistant infections: progress and focusing resources Gordon Dougan, Christopher Gerard Dowson, John P. Overington · Drug Discovery Today | 23 Nov 2018 | 28 |
| 37 | Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase Sara R. Henderson, C.E.M. Stevenson, Brandon F. Malone et al. · Journal of Antimicrobial Chemotherapy | 13 Jun 2020 | 27 |
| 38 | Investigating sex determination through MALDI MS analysis of peptides and proteins in natural fingermarks through comprehensive statistical modelling Cameron Heaton, Charles S. Bury, Ekta D. Patel et al. · Forensic Chemistry | Aug 2020 | 25 |
| 39 | A Scalable Approach Reveals Functional Responses of iPSC Cardiomyocyte 3D Spheroids Matthew P. Burnham, Rachel Harvey, Rebecca Sargeant et al. · SLAS DISCOVERY | 10 Dec 2020 | 24 |
| 40 | Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation Elena Ortiz Zapater, Dustin Bagley, Virginia Llopis-Hernández et al. · Nature Communications | 27 Oct 2022 | 21 |
| 41 | The genotoxicological assessment of a tobacco heating product relative to cigarette smoke using the in vitro micronucleus assay David Thorne, James Whitwell, Julie M. Clements et al. · Toxicology Reports | 2020 | 21 |
| 42 | Fragment-based screening: A new paradigm for ligand and target discovery Sinéad Knight, Davide Gianni, Adam G. Hendricks · SLAS DISCOVERY | 2022 | 20 |
| 43 | High throughput diagnostics and dynamic risk assessment of SARS-CoV-2 variants of concern Alfredo Maria Gravagnuolo, Layla Faqih, Cara Cronshaw et al. · EBioMedicine | Aug 2021 | 20 |
| 44 | TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors Benedetta Arnò, Francesco Galli, Urmas Roostalu et al. · Journal of Cell Science | 9 Jul 2019 | 19 |
| 45 | A perspective on the changing landscape of HTS Alice Lanne, Laura E J Usselmann, Poppy Llowarch et al. · Drug Discovery Today | 15 Jun 2023 | 18 |
| 46 | The effects of locomotion on sensory-evoked haemodynamic responses in the cortex of awake mice Beth Eyre, Kira Shaw, Paul S. Sharp et al. · Scientific Reports | 14 Apr 2022 | 18 |
| 47 | Regenerable Biosensors for Small-Molecule Kinetic Characterization Using SPR Anders Gunnarsson, Christopher J. Stubbs, Philip B. Rawlins et al. · SLAS DISCOVERY | 10 Dec 2020 | 18 |
| 48 | Modelling and breaking down the biophysical barriers to drug delivery in pancreatic cancer Delanyo Kpeglo, Malcolm Haddrick, Margaret A. Knowles et al. · Lab on a Chip | 2024 | 17 |
| 49 | Infrared emitting and absorbing conjugated polymer nanoparticles as biological imaging probes Daniel Honeybone, Hannah Peace, Mark A Green · Journal of Materials Chemistry C | 7 Sep 2022 | 17 |
| 50 | Rational design of non-resistant targeted cancer therapies Francisco Martínez-Jiménez, John P. Overington, Bissan Al‐Lazikani et al. · Scientific Reports | 24 Apr 2017 | 17 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.