| 1 |
Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients
Michael J. Mack et al. · New England Journal of Medicine
Open access |
16 Mar 2019 |
4,895 |
| 2 |
Biological, clinical and population relevance of 95 loci for blood lipids
Tanya M. Teslovich et al. · Nature
Open access209 authors |
Aug 2010 |
3,706 |
| 3 |
Recommendations for Noninvasive Evaluation of Native Valvular Regurgitation
William A. Zoghbi, David H Adams, Robert O. Bonow et al. · Journal of the American Society of Echocardiography
|
14 Mar 2017 |
3,570 |
| 4 |
Discovery and refinement of loci associated with lipid levels
Cristen J. Willer et al. · Nature Genetics
Open access259 authors |
6 Oct 2013 |
3,319 |
| 5 |
Effects of Torcetrapib in Patients at High Risk for Coronary Events
Philip J. Barter, Mark J. Caulfield, Mats A. L. Eriksson et al. · New England Journal of Medicine
Open access |
5 Nov 2007 |
3,168 |
| 6 |
Transcatheter Mitral-Valve Repair in Patients with Heart Failure
Gregg W. Stone, JoAnn M. Lindenfeld, William T. Abraham et al. · New England Journal of Medicine
Open access |
23 Sep 2018 |
2,986 |
| 7 |
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
Majid Nikpay et al. · Nature Genetics
ReviewOpen access151 authors |
7 Sep 2015 |
2,733 |
| 8 |
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Josée Dupuis et al. · Nature Genetics
Open access263 authors |
17 Jan 2010 |
2,239 |
| 9 |
Effects of Exenatide (Exendin-4) on Glycemic Control and Weight Over 30 Weeks in Metformin-Treated Patients With Type 2 Diabetes
Ralph Anthony DeFronzo, Robert E. Ratner, Jenny Han et al. · Diabetes Care
|
May 2005 |
1,565 |
| 10 |
Standardization of bronchial inhalation challenge procedures
Hyman Chai, Richard S. Farr, Luz A. Froehlich et al. · Journal of Allergy and Clinical Immunology
Open access |
Oct 1975 |
1,464 |
| 11 |
Safety of Transcranial Direct Current Stimulation: Evidence Based Update 2016
Marom Bikson et al. · Brain stimulation
Open access |
17 Jun 2016 |
1,438 |
| 12 |
Diabetes and cardiovascular disease
Barbara V. Howard, Michelle Fischmann Magee · Current Atherosclerosis Reports
|
Nov 2000 |
1,386 |
| 13 |
Genome-wide association study identifies eight loci associated with blood pressure
Christopher Newton‐Cheh et al. · Nature Genetics
Open access158 authors |
10 May 2009 |
1,232 |
| 14 |
Central Pressure More Strongly Relates to Vascular Disease and Outcome Than Does Brachial Pressure
Mary J. Roman, Richard B. Devereux, Jorge R. Kizer et al. · Hypertension
Open access |
8 May 2007 |
1,230 |
| 15 |
Non-traumatic avascular necrosis of the femoral head.
Michael A. Mont, David S. Hungerford · Journal of Bone and Joint Surgery
|
Mar 1995 |
1,222 |
| 16 |
World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions
Stephen Kaptoge et al. · The Lancet Global Health
Open access101 authors |
2 Sep 2019 |
1,208 |
| 17 |
Association of Cardiometabolic Multimorbidity With Mortality
Emanuele Di Angelantonio et al. · JAMA
Open access |
7 Jul 2015 |
1,189 |
| 18 |
Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores
Marshall Plaut, Jacalyn H. Pierce, Cynthia J. Watson et al. · Nature
|
May 1989 |
1,179 |
| 19 |
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
Mary Furlan Feitosa et al. · PLoS ONE
Open access273 authors |
18 Jun 2018 |
1,174 |
| 20 |
Targeting HER2-positive breast cancer: advances and future directions
Sandra M. Swain, Mythili Shastry, Erika Paige Hamilton · Nature Reviews Drug Discovery
ReviewOpen access |
7 Nov 2022 |
1,156 |
| 21 |
Low-Fat Dietary Pattern and Risk of Cardiovascular Disease
Barbara V. Howard et al. · JAMA
|
7 Feb 2006 |
1,097 |
| 22 |
Possible Subclinical Leaflet Thrombosis in Bioprosthetic Aortic Valves
Raj Makkar et al. · New England Journal of Medicine
Open access |
5 Oct 2015 |
1,054 |
| 23 |
Predictors of Assistive Technology Abandonment
Betsy Phillips, Hongxin John Zhao · Assistive Technology
|
30 Jun 1993 |
1,006 |
| 24 |
Early breast cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up
Sibylle Loibl et al. · Annals of Oncology
Open access |
13 Dec 2023 |
991 |
| 25 |
Association of Usual Sleep Duration With Hypertension: The Sleep Heart Health Study
Daniel J. Gottlieb, Susan S Redline, Francisco Javier Nieto et al. · SLEEP
Open access |
Aug 2006 |
948 |
| 26 |
Impact of Diabetes on Cardiac Structure and Function
Richard B. Devereux, Mary J. Roman, Mary Paranicas et al. · Circulation
Open access |
16 May 2000 |
947 |
| 27 |
Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA): end-of-study results from a double-blind, randomised, placebo-controlled, phase 3 study
Sandra M. Swain et al. · The Lancet Oncology
222 authors |
12 Mar 2020 |
934 |
| 28 |
Modulation of Inflammation and Immunity by Cyclic AMP
Henry R. Bourne, Yacob Weinstein, Kenneth L. Melmon et al. · Science
|
5 Apr 1974 |
919 |
| 29 |
Common variants associated with plasma triglycerides and risk for coronary artery disease
Ron Do et al. · Nature Genetics
Open access263 authors |
6 Oct 2013 |
912 |
| 30 |
Multicenter, Placebo-Controlled Trial of Lorcaserin for Weight Management
Steven R. Smith, Neil J. Weissman, Christen M. Anderson et al. · New England Journal of Medicine
Open access |
14 Jul 2010 |
912 |
| 31 |
Intensive Glycemic Control and the Prevention of Cardiovascular Events: Implications of the ACCORD, ADVANCE, and VA Diabetes Trials
Jay S. Skyler, Richard M. Bergenstal, Robert O. Bonow et al. · Diabetes Care
Open access |
17 Dec 2008 |
887 |
| 32 |
Prevention of Diabetes in Women with a History of Gestational Diabetes: Effects of Metformin and Lifestyle Interventions
Robert E. Ratner, Costas A. Christophi, Boyd E. Metzger et al. · The Journal of Clinical Endocrinology & Metabolism
Open access |
Oct 2008 |
883 |
| 33 |
Ten simple rules for neuroimaging meta-analysis
Veronika I. Müller, Edna C. Cieslik, Angela R. Laird et al. · Neuroscience & Biobehavioral Reviews
Open access |
24 Nov 2017 |
864 |
| 34 |
Baseline Cardiovascular Risk Assessment in Cancer Patients Scheduled to Receive Cardiotoxic Cancer Therapies: A Position Statement and New Risk Assessment Tools from the Cardio-Oncology Study Group of the Heart Failure Association of the European Society of Cardiology in Collaboration with the International Cardio-Oncology Society
Alexander Richard Lyon et al. · European Journal of Heart Failure
Open access |
28 May 2020 |
823 |
| 35 |
New loci associated with kidney function and chronic kidney disease
Anna Köttgen et al. · Nature Genetics
Open access132 authors |
11 Apr 2010 |
818 |
| 36 |
Contemporary Patterns of Spontaneous Labor With Normal Neonatal Outcomes
Jun Zhang, Helain J. Landy, David Ware Branch et al. · Obstetrics and Gynecology
Open access |
23 Nov 2010 |
801 |
| 37 |
Posttraumatic Stress Disorder in Critical Illness Survivors
Ann Marie Parker, Thiti Sricharoenchai, Sandeep Raparla et al. · Critical Care Medicine
|
5 Feb 2015 |
793 |
| 38 |
Detection of Silent Myocardial Ischemia in Asymptomatic Diabetic Subjects
Frans J.Th. Wackers, Lawrence H. Young, Silvio E. Inzucchi et al. · Diabetes Care
Open access |
Aug 2004 |
791 |
| 39 |
Semaglutide versus dulaglutide once weekly in patients with type 2 diabetes (SUSTAIN 7): a randomised, open-label, phase 3b trial
Richard E. Pratley, Vanita R. Aroda, Ildiko Lingvay et al. · The Lancet Diabetes & Endocrinology
|
Feb 2018 |
789 |
| 40 |
Biochemicals Associated With Pain and Inflammation are Elevated in Sites Near to and Remote From Active Myofascial Trigger Points
Jay P. Shah, JEROME V. DANOFF, Mehul J. Desai et al. · Archives of Physical Medicine and Rehabilitation
|
2008 |
765 |
| 41 |
Intrapericardial Left Ventricular Assist Device for Advanced Heart Failure
Joseph G. Rogers, Francis D. Pagani, Antone J. Tatooles et al. · New England Journal of Medicine
Open access |
Feb 2017 |
763 |
| 42 |
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Simon I Hay et al. · The Lancet
Open access2,780 authors |
Oct 2025 |
762 |
| 43 |
Pioglitazone for Diabetes Prevention in Impaired Glucose Tolerance
Ralph A. DeFronzo, Devjit Tripathy, Dawn C. Schwenke et al. · New England Journal of Medicine
Open access |
23 Mar 2011 |
752 |
| 44 |
The retinoblastoma tumour suppressor in development and cancer
Marie Classon, Ed Harlow · Nature reviews. Cancer
Review |
Dec 2002 |
747 |
| 45 |
Lipoprotein Management in Patients With Cardiometabolic Risk
John D. Brunzell, Michael H. Davidson, Curt Daniel Furberg et al. · Diabetes Care
Open access |
28 Mar 2008 |
709 |
| 46 |
Effect of adding mFOLFOX6 after neoadjuvant chemoradiation in locally advanced rectal cancer: a multicentre, phase 2 trial
Julio García‐Aguilar, Oliver S. Chow, David D. Smith et al. · The Lancet Oncology
Open access |
14 Jul 2015 |
708 |
| 47 |
The Cost-Effectiveness of Lifestyle Modification or Metformin in Preventing Type 2 Diabetes in Adults with Impaired Glucose Tolerance
William H. Herman, Thomas J. Hoerger, Michael Brändle et al. · Annals of Internal Medicine
Open access |
Mar 2005 |
704 |
| 48 |
Burden of Undiagnosed Hypertension in Sub-Saharan Africa
Feven Ataklte, Sebhat A. Erqou, Stephen Kaptoge et al. · Hypertension
|
10 Nov 2014 |
688 |
| 49 |
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
Ron Do et al. · Nature
Open access |
8 Dec 2014 |
685 |
| 50 |
Vitamin D Supplementation and Prevention of Type 2 Diabetes
Anastassios G. Pittas et al. · New England Journal of Medicine
Open access |
7 Jun 2019 |
680 |