Most cited papers from Merz (Germany)

Merz (Germany)

What are the most cited papers from Merz (Germany)?

The most cited paper from Merz (Germany) is "Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data" (Chris G. Parsons, Wojciech Danysz, G. Quack, 1999), with 883 citations. Next come "Glycine and N-Methyl-d-Aspartate Receptors: Physiological Significance and Possible Therapeutic Applications" (656) and "Glutamate in CNS disorders as a target for drug development: an update" (452).

Published TypeFieldAccessCitations

Showing 50 of 60 papers. Every paper with more than 54 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data Chris G. Parsons, Wojciech Danysz, G. Quack · Neuropharmacology	Jun 1999	883
2	Glycine and N-Methyl-d-Aspartate Receptors: Physiological Significance and Possible Therapeutic Applications Wojciech Danysz, Chris G. Parsons · Pharmacological Reviews	Dec 1998	656
3	Glutamate in CNS disorders as a target for drug development: an update Chris G. Parsons, Wojciech Danysz, G. Quack · Drug News & Perspectives	1998	452
4	The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence Wojciech Danysz, Chris G. Parsons · International Journal of Geriatric Psychiatry	2003	403
5	Memantine is a potent blocker of N-methyl-D-aspartate (NMDA) receptor channels Joachim Bormann · European Journal of Pharmacology	Aug 1989	354
6	Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents — preclinical studies Wojciech Danysz, Chris G. Parsons, Johannes Kornhuber et al. · Neuroscience & Biobehavioral Reviews	1997	322
7	Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo Chris G. Parsons, G. Quack, I. Bresink et al. · Neuropharmacology	Oct 1995	314
8	Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study Johannes Kornhuber, Joachim Bormann, Marianne Hübers et al. · European Journal of Pharmacology Molecular Pharmacology	Apr 1991	308
9	Patch clamp studies on the kinetics and selectivity of N-methyl-d-aspartate receptor antagonism by memantine (1-amino-3,5-dimethyladamantan) Chris G. Parsons, René Gruner, Jouri Rozental et al. · Neuropharmacology	Dec 1993	282
10	Neuroprotective and symptomatological action of memantine relevant for alzheimer’s disease — a unified glutamatergic hypothesis on the mechanism of action Wojciech Danysz, Chris G. Parsons, Hans Jörg Möbius et al. · Neurotoxicity Research	Jun 2000	268
11	NMDA receptors as targets for drug action in neuropathic pain Chris G. Parsons · European Journal of Pharmacology	Oct 2001	227
12	The N-methyl-d-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT3 receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner Gerhard Rammes, Rainer Rupprecht, Uta Ferrari et al. · Neuroscience Letters	Jun 2001	200
13	Novel systemically active antagonists of the glycine site of the N-methyl-D-aspartate receptor: electrophysiological, biochemical and behavioral characterization. Chris G. Parsons, Wojciech Danysz, G. Quack et al. · PubMed	Dec 1997	193
14	Glutamate antagonists have different effects on spontaneous locomotor activity in rats Wojciech Danysz, Ursula Essmann, I. Bresink et al. · Pharmacology Biochemistry and Behavior	May 1994	192
15	Modulation of learning processes by ionotropic glutamate receptor ligands Wojciech Danysz, Wojciech M. Zajączkowski, Chris G. Parsons · Behavioural Pharmacology	Aug 1995	186
16	Oral L-ornithine-L-aspartate therapy of chronic hepatic encephalopathy: results of a placebo-controlled double-blind study S Stauch, GERALD KIRCHEIS, Guideo Adler et al. · Journal of Hepatology	May 1998	169
17	Desensitization of the P2X2 receptor controlled by alternative splicing U. Brändle, Peter Spielmanns, Ralph Osteroth et al. · FEBS Letters Open access	10 Mar 1997	165
18	L -Ornithine- L -aspartate lowers plasma and cerebrospinal fluid ammonia and prevents brain edema in rats with acute liver failure Christopher F. Rose, Adrianna Michalak, Kakulavarapu V. Rama Rao et al. · Hepatology	Sep 1999	158
19	Potential Antidepressive Properties of Amantadine, Memantine and Bifemelane Elżbieta Moryl, Wojciech Danysz, G. Quack · Pharmacology & Toxicology	Jun 1993	157
20	Cerebrospinal fluid and serum concentrations of the N-methyl-d-aspartate (NMDA) receptor antagonist memantine in man Johannes Kornhuber, G. Quack · Neuroscience Letters	Aug 1995	157
21	The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801 Gerhard Rammes, Beatrice Mahal, Jörg Putzke et al. · Neuropharmacology	May 2001	152
22	Effects of the Uncompetitive NMDA Receptor Antagonist Memantine on Hippocampal Long‐term Potentiation, Short‐term Exploratory Modulation and Spatial Memory in Awake, Freely Moving Rats Carol A. Barnes, Wojciech Danysz, Chris G. Parsons · European Journal of Neuroscience	Mar 1996	148
23	Increase of the duration of the anticonvulsive activity of a novel NMDA receptor antagonist using poly(butylcyanoacrylate) nanoparticles as a parenteral controlled release system Anika Friese · European Journal of Pharmaceutics and Biopharmaceutics	Mar 2000	140
24	Effects of memantine and MK‐801 on NMDA‐induced currents in cultured neurones and on synaptic transmission and LTP in area CA1 of rat hippocampal slices Tadeusz Frankiewicz, Brigitte Potier, Zafar Iqbal Bashir et al. · British Journal of Pharmacology Open access	Feb 1996	135
25	Amino-alkyl-cyclohexanes are novel uncompetitive NMDA receptor antagonists with strong voltage-dependency and fast blocking kinetics: in vitro and in vivo characterization Chris G. Parsons, Wojciech Danysz, Annette Bartmann et al. · Neuropharmacology	1999	132
26	Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine Gary L. Wenk, Chris G. Parsons, Wojciech Danysz · Behavioural Pharmacology	29 Aug 2006	129
27	How to overcome resistance of influenza A viruses against adamantane derivatives Christoph Scholtissek, G. Quack, Hans‐Dieter Klenk et al. · Antiviral Research	Feb 1998	128
28	The cytotoxicity of chronic neuroinflammation upon basal forebrain cholinergic neurons of rats can be attenuated by glutamatergic antagonism or cyclooxygenase-2 inhibition Lauren B. Willard, Beatrice Hauss‐Wegrzyniak, Wojciech Danysz et al. · Experimental Brain Research	23 Aug 2000	125
29	Antidepressants are functional antagonists at the serotonin type 3 (5-HT3) receptor B Eisensamer, Gerhard Rammes, Gerald Gimpl et al. · Molecular Psychiatry	26 Nov 2003	124
30	Different binding affinities of NMDA receptor channel blockers in various brain regions—Indication of NMDA receptor heterogeneity I. Bresink, Wojciech Danysz, Chris G. Parsons et al. · Neuropharmacology Open access	May 1995	116
31	Comparative Patch‐clamp Studies with Freshly Dissociated Rat Hippocampal and Striatal Neurons on the NMDA Receptor Antagonistic Effects of Amantadine and Memantine Chris G. Parsons, V. A. Panchenko, V. Pinchenko et al. · European Journal of Neuroscience	Mar 1996	114
32	Infusion of (+)-MK-801 and memantine — contrasting effects on radial maze learning in rats with entorhinal cortex lesion Wojciech M. Zajączkowski, G. Quack, Wojciech Danysz · European Journal of Pharmacology	Feb 1996	112
33	Therapeutic brain concentration of the NMDA receptor antagonist amantadine Johannes Kornhuber, G. Quack, Wojciech Danysz et al. · Neuropharmacology	Jul 1995	112
34	Memantine restores long term potentiation impaired by tonic N-methyl-d-aspartate (NMDA) receptor activation following reduction of Mg2+ In hippocampal slices Tadeusz Frankiewicz, Chris G. Parsons · Neuropharmacology	Sep 1999	111
35	Uncompetitive NMDA receptor antagonists attenuate NMDA-induced impairment of passive avoidance learning and LTP Wojciech M. Zajączkowski, Tadeusz Frankiewicz, Chris G. Parsons et al. · Neuropharmacology	Jul 1997	110
36	Evidence for alcohol anti-craving properties of memantine Sabine M. Hölter, Wojciech Danysz, Rainer Spanagel · European Journal of Pharmacology	Oct 1996	106
37	Learning deficits induced by chronic intraventricular infusion of quinolinic acid — protection by MK-801 and memantine Marcin Misztal, Tadeusz Frankiewicz, Chris G. Parsons et al. · European Journal of Pharmacology	1996	104
38	Effects of memantine on recombinant rat NMDA receptors expressed in HEK 293 cells I. Bresink, Tim A. Benke, Valerie J. Collett et al. · British Journal of Pharmacology Open access	Sep 1996	102
39	MK-801, memantine and amantadine show neuroprotective activity in the nucleus basalis magnocellularis Gary L. Wenk, Wojciech Danysz, Sherri L. Mobley · European Journal of Pharmacology Environmental Toxicology and Pharmacology	Oct 1995	98
40	L-Ornithine-L-Aspartate in Experimental Portal-Systemic Encephalopathy: Therapeutic Efficacy and Mechanism of Action Christopher F. Rose, Adrianna Michalak, Pierre Pannunzio et al. · Metabolic Brain Disease	Jun 1998	96
41	Expression of Polyglutamine-expanded Huntingtin Induces Tyrosine Phosphorylation of N-Methyl-D-aspartate Receptors Cheng Song, Yuntian Zhang, Chris G. Parsons et al. · Journal of Biological Chemistry Open access	Aug 2003	95
42	D-Cycloserine reverses the working memory impairment of hippocampal-lesioned rats in a spatial learning task Gertrud M. Schuster, Werner J. Schmidt · European Journal of Pharmacology	Nov 1992	95
43	Memantine-induced dopamine release in the prefrontal cortex and striatum of the rat — a pharmacokinetic microdialysis study Rainer Spanagel, Bernd Eilbacher, Rolf Wilke · European Journal of Pharmacology	Sep 1994	92
44	Randomized, double-blind, placebo-controlled trial of interferon Alfa2a with and without amantadine as initial treatment for chronic hepatitis C Stefan Zeuzem, G Teuber, Uta Naumann et al. · Hepatology Open access	Oct 2000	91
45	Calcium hydroxylapatite microspheres activate fibroblasts through direct contact to stimulate neocollagenesis Bartosch Nowag, Gabriela Casabona, Stefan Kippenberger et al. · Journal of Cosmetic Dermatology Open access	27 Dec 2022	90
46	Ethanol and N -methyl- D -aspartate receptor complex interactions: a detailed drug discrimination study in the rat W. Hundt, Wojciech Danysz, Sabine M. Hölter et al. · Psychopharmacology	8 Jan 1998	89
47	Degradation of radiation grafted hydroxide anion exchange membrane immersed in neutral pH: removal of vinylbenzyl trimethylammonium hydroxide due to oxidation Richard Espiritu, Bernard T. Golding, Keith Scott et al. · Journal of Materials Chemistry A Open access	12 Dec 2016	88
48	Antioxidant treatment of experimental diabetic retinopathy in rats with nicanartine Hans‐Peter Hammes, A. Bartmann, Lewis L. Engel et al. · Diabetologia Open access	30 May 1997	87
49	No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use Gary L. Wenk, Guenter Quack, Hans-Joerg Moebius et al. · Life Sciences	Feb 2000	83
50	Neuroprotection of acetylcholinergic basal forebrain neurons by memantine and neurokinin B Gary L. Wenk, Wojciech M. Zajączkowski, Wojciech Danysz · Behavioural Brain Research	Feb 1997	81

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.