Most cited papers from Metabolic Solutions

Metabolic Solutions

What are the most cited papers from Metabolic Solutions?

The most cited paper from Metabolic Solutions is "An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans" (Caroline B. Kurtz, Yves A. Millet, Marja Kaarina Puurunen et al., 2019), with 403 citations. Next come "Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors" (242) and "Role of Gut Microbiota and Short Chain Fatty Acids in Modulating Energy Harvest and Fat Partitioning in Youth" (183).

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Showing 50 of 73 papers. Every paper is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans Caroline B. Kurtz, Yves A. Millet, Marja Kaarina Puurunen et al. · Science Translational Medicine	16 Jan 2019	403
2	Phase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors Erin M Dunbar, Bonnie S. Coats, Albert L. Shroads et al. · Investigational New Drugs Open access	2 Dec 2013	242
3	Role of Gut Microbiota and Short Chain Fatty Acids in Modulating Energy Harvest and Fat Partitioning in Youth Martina Goffredo, Kendra Mass, Elizabeth Jane Parks et al. · The Journal of Clinical Endocrinology & Metabolism Open access	20 Sep 2016	183
4	Safety and pharmacodynamics of an engineered E. coli Nissle for the treatment of phenylketonuria: a first-in-human phase 1/2a study Marja Kaarina Puurunen, Jerry E. Vockley, Shawn L. Searle et al. · Nature Metabolism	22 Jul 2021	170
5	Engineering microbial hosts for production of bacterial natural products Mingzi M. Zhang, Yajie Wang, Ee Lui Ang et al. · Natural Product Reports Open access	2016	170
6	Palmitoleic acid is elevated in fatty liver disease and reflects hepatic lipogenesis Joseph Jonathan Lee, Jennifer E. Lambert, Yelena Hovhannisyan et al. · American Journal of Clinical Nutrition Open access	20 Nov 2014	166
7	Lactate Metabolism R. D. Cohen, Roy L. Simpson · Anesthesiology Open access	Dec 1975	95
8	Screening and Characterization of a Novel Cellulase Gene from the Gut Microflora of Hermetia illucens Using Metagenomic Library Chang‐Muk Lee, Youngseok Lee, Sohyeon Seo et al. · Journal of Microbiology and Biotechnology Open access	28 Sep 2014	95
9	Simultaneous Measurement of Gastric Emptying with a Simple Muffin Meal Using [13C]Octanoate Breath Test and Scintigraphy in Normal Subjects and Patients with Dyspeptic Symptoms Matthew Q. Bromer, Steve B. Kantor, David A. Wagner et al. · Digestive Diseases and Sciences	Jul 2002	94
10	Investigation of triterpene synthesis and regulation in oats reveals a role for β-amyrin in determining root epidermal cell patterning Ariane C. Kemen, Suvi Honkanen, Rachel E. Melton et al. · Proceedings of the National Academy of Sciences Open access	27 May 2014	85
11	Quantitative liver function tests improve the prediction of clinical outcomes in chronic hepatitis C: Results from the hepatitis C antiviral long-term treatment against cirrhosis trial Gregory T. Everson, Mitchell L. Shiffman, John Carl Hoefs et al. · Hepatology Open access	26 Oct 2011	78
12	Preserving Mafa Expression in Diabetic Islet β-Cells Improves Glycemic Control in Vivo Taka‐aki Matsuoka, Hideaki Kaneto, Satoshi Kawashima et al. · Journal of Biological Chemistry Open access	3 Feb 2015	65
13	A perspective on the isolation and characterization of extracellular vesicles from different biofluids Reshma Bano, Farhan Jalees Ahmad, Mohd. Mohsin · RSC Advances Open access	2021	59
14	L-[1-13C] phenylalanine oxidation as a measure of hepatocyte functional capacity in end-stage liver disease Peter Burke, Jennifer A. Stack, David A. Wagner et al. · The American Journal of Surgery	Apr 1997	58
15	Increased Dynamics of Tricarboxylic Acid Cycle and Glutamate Synthesis in Obese Adipose Tissue Hirofumi Nagao, Hitoshi Nishizawa, Takeshi Bamba et al. · Journal of Biological Chemistry Open access	25 Jan 2017	55
16	The FBXL10/KDM2B Scaffolding Protein Associates with Novel Polycomb Repressive Complex-1 to Regulate Adipogenesis Takeshi Inagaki, Satoshi Iwasaki, Yoshihiro Matsumura et al. · Journal of Biological Chemistry Open access	23 Dec 2014	51
17	Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate Albert L. Shroads, Taimour Yousef Langaee, Bonnie S. Coats et al. · The Journal of Clinical Pharmacology Open access	4 Jun 2011	50
18	Cytochrome P450 3A4 and P‐glycoprotein mediate the interaction between an oral erythromycin breath test and rifampin Mary F. Paine, David A. Wagner, Keith A. Hoffmaster et al. · Clinical Pharmacology & Therapeutics Open access	Nov 2002	49
19	Nutrient intakes in an urbanized Micronesian population with a high diabetes prevalence Helen Ringrose, Paul Zimmet · American Journal of Clinical Nutrition	Jun 1979	49
20	First-in-Human Side-to-Side Magnetic Compression Duodeno-ileostomy with the Magnet Anastomosis System Michel Gagner, David Abuladze, Levan Koiava et al. · Obesity Surgery Open access	2 Jul 2023	46
21	Use of an oral stable isotope label to confirm variation in red blood cell mean age that influences HbA1c interpretation Paramjit K. Khera, Eric P. Smith, Christopher John Lindsell et al. · American Journal of Hematology Open access	8 Oct 2014	45
22	Zinc Deficiency Is associated With Depressive Symptoms—Results From the Berlin Aging Study II Alissa Jung, Dominik Spira, Elisabeth Steinhagen‐Thiessen et al. · The Journals of Gerontology Series A	27 Oct 2016	39
23	Gastrointestinal Absorption of Pravastatin in Healthy Subjects Joseph M. Triscari, Denis O’Donnell, Miguel A. Zinny et al. · The Journal of Clinical Pharmacology	Feb 1995	39
24	Impaired hepatic mitochondrial oxidation using the 13C-methionine breath test in patients with macrovesicular steatosis and patients with cirrhosis. Laurent Spahr, Francesco Negro, Gioacchino Leandro et al. · PubMed	2003	37
25	Quantitative tests of liver function measure hepatic improvement after sustained virological response: results from the HALT‐C trial Gregory T. Everson, Mitchell L. Shiffman, John Carl Hoefs et al. · Alimentary Pharmacology & Therapeutics Open access	Dec 2008	37
26	The spectrum of hepatic functional impairment in compensated chronic hepatitis C: results from the Hepatitis C Anti‐viral Long‐term Treatment against Cirrhosis Trial1 Gregory T. Everson, Mitchell L. Shiffman, Timothy R.M. Morgan et al. · Alimentary Pharmacology & Therapeutics Open access	8 Feb 2008	37
27	Carbohydrate-induced manipulation of insulin sensitivity independently of intramyocellular lipids Louise M. Goff, Gary Steven Frost, Gavin Hamilton et al. · British Journal Of Nutrition Open access	Mar 2003	34
28	Gastric Emptying Characteristics of a Novel 13C-Octanoate-labeled Muffin Meal WD Chey, Brahm Shapiro, A Zawadski et al. · Journal of Clinical Gastroenterology	May 2001	33
29	Effect of Meal Size and Test Duration on Gastric Emptying and Gastric Myoelectrical Activity as Determined with Simultaneous [13C]Octanoate Breath Test and Electrogastrography in Normal Subjects Using a Muffin Meal Sutep Gonlachanvit, William D. Chey, Keith J. Goodman et al. · Digestive Diseases and Sciences Open access	Dec 2001	31
30	Side-to-side magnet anastomosis system duodeno-ileostomy with sleeve gastrectomy: early multi-center results Michel Gagner, Guy-Bernard Cadière, Andrés Sánchez-Pernaute et al. · Surgical Endoscopy Book chapterOpen access	22 May 2023	30
31	CYP3A4 and the erythromycin breath test David A. Wagner · Clinical Pharmacology & Therapeutics	Jul 1998	29
32	Roles of Dietary Protein upon Serum Cholesterol Level in Malnourished Subjects Kshetrabasi Tripathy, Hernán Lotero, Óscar Bolaños · American Journal of Clinical Nutrition	Sep 1970	29
33	A super-agonist of growth hormone–releasing hormone causes rapid improvement of nutritional status in patients with chronic kidney disease Stanisław Niemczyk, Hanna M. Sikorska, Andrzej Więcek et al. · Kidney International Open access	16 Dec 2009	28
34	Side-to-side duodeno-ileal magnetic compression anastomosis: design and feasibility of a novel device in a porcine model Michel Gagner, Todd Krinke, Maxime Lapointe-Gagner et al. · Surgical Endoscopy	11 May 2023	24
35	Sensory acceptable equivalent doses of β-phenylethyl isothiocyanate (PEITC) induce cell cycle arrest and retard the growth of p53 mutated oral cancer in vitro and in vivo Aroonwan Lam‐ubol, Alison L. Fitzgerald, Arnat Ritdej et al. · Food & Function	2018	23
36	Performance of Human Mass Balance/Metabolite Identification Studies Using Stable Isotope (13C, 15N) Labeling and Continuous‐Flow Isotope‐Ratio Mass Spectrometry as an Alternative to Radioactive Labeling Methods Thomas R. Browne, George K. Szabo, Alfred Ajami et al. · The Journal of Clinical Pharmacology	Mar 1993	23
37	CASE REPORT: Acute Valproate-Associated Microvesicular Steatosis: Could the [13C]Methionine Breath Test Be Useful to Assess Liver Mitochondrial Function? Laurent Spahr, Francesco Negro, Laura Rubbia‐Brandt et al. · Digestive Diseases and Sciences	Dec 2001	21
38	Endothelin-1-induced mini-stroke in the dorsal hippocampus or lateral amygdala results in deficits in learning and memory Tao Sheng, Zhang Xueting, Wang Shaoli et al. · Journal of Biomedical Research Open access	2015	20
39	A Comparison of Two Regimens for the Management of Diabetes during Open-heart Surgery Martin J. Elliott, GEOFFREY V. GILL, PHILIP D. HOME et al. · Anesthesiology Open access	Apr 1984	20
40	Phenylalanine kinetics in healthy volunteers and liver cirrhotics: implications for the phenylalanine breath test I. Tugtekin, Ulrich A. Wachter, E. Barth et al. · American Journal of Physiology-Endocrinology and Metabolism	Dec 2002	17
41	Quantifying Gastric Helicobacter pylori Infection: A Comparison of Quantitative Culture, Urease Breath Testing, and Histology Sanjeev Tummala, Sunil G. Sheth, Jeffrey D. Goldsmith et al. · Digestive Diseases and Sciences	11 Jan 2007	15
42	Whole Body Protein Turnover and Net Protein Balance After Pediatric Thoracic Surgery: A Noninvasive Single‐Dose 15N Glycine Stable Isotope Protocol With End‐Product Enrichment Brenna S. Fullerton, Eric A. Sparks, Faraz Ali Khan et al. · Journal of Parenteral and Enteral Nutrition	16 Nov 2016	14
43	Evaluation of the Ez‐HBT Helicobacter blood test to establish Helicobacter pylori eradication Farzana Ahmed, Uma K. Murthy, William D. Chey et al. · Alimentary Pharmacology & Therapeutics Open access	14 Oct 2005	14
44	A new 13 C breath test to detect vitamin B12 deficiency: a prevalent and poorly diagnosed health problem David A. Wagner, Richard A. Schatz, Richard J. Coston et al. · Journal of Breath Research Open access	23 Jun 2011	14
45	Gastric Emptying in Trauma Patients C.B. Carlin, P.H. Scanlon, David A. Wagner et al. · Digestive Surgery	1999	14
46	Extracorporeal liver cross-circulation using transgenic xenogeneic pig livers with brain-dead human decedents Abraham Shaked et al. · Nature Medicine	9 Feb 2026	13
47	Fat/Vessel-derived Secretory Protein (Favine)/CCDC3 Is Involved in Lipid Accumulation Sachiko Kobayashi, Atsunori Fukuhara, Michio Otsuki et al. · Journal of Biological Chemistry Open access	21 Jan 2015	13
48	Colonic Fermentation and Acetate Production in Youth with and without Obesity Brittany Galuppo, Gary W. Cline, MICHELLE A. VAN NAME et al. · Journal of Nutrition Open access	30 Jul 2021	11
49	Magnetic compression anastomosis gastrojejunostomy: feasibility and efficacy of a novel device in a swine model Michel Gagner, Todd Krinke, Maxime Lapointe-Gagner et al. · Surgery for Obesity and Related Diseases	20 May 2024	9
50	Dysprosium Chloride as a Nonabsorbable Gastrointestinal Marker for Studies of Stable Isotope-Labeled Triglyceride Excretion in Man Sally A. Schuette, Morteza Janghorbani, Mitchell B. Cohen et al. · Journal of the American College of Nutrition	Oct 2003	9

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.