Institution · Millennium Engineering and Integration (United States)
Most cited papers from Millennium Engineering and Integration (United States)
What are the most cited papers from Millennium Engineering and Integration (United States)?
The most cited paper from Millennium Engineering and Integration (United States) is "Imaging Intracellular Fluorescent Proteins at Nanometer Resolution" (Eric Betzig, George H. Patterson, Rachid Sougrat et al., 2006), with 9,061 citations. Next come "Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance" (5,834) and "Identification and expression cloning of a leptin receptor, OB-R" (3,513).
Showing 50 of 59 papers. Every paper with more than 704 citations is listed.
| # | Paper | ||
|---|---|---|---|
| 1 | Imaging Intracellular Fluorescent Proteins at Nanometer Resolution Eric Betzig, George H. Patterson, Rachid Sougrat et al. · Science | 10 Aug 2006 | 9,061 |
| 2 | Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance Haiyan Xu, Glenn T. Barnes, Qing Yang et al. · Journal of Clinical Investigation | 15 Dec 2003 | 5,834 |
| 3 | Identification and expression cloning of a leptin receptor, OB-R Louis A. Tartaglia, Marlene Dembski, Xun Weng et al. · Cell | Dec 1995 | 3,513 |
| 4 | Targeted Disruption of the Melanocortin-4 Receptor Results in Obesity in Mice Dennis Huszar, Catherine A. Lynch, Victoria Fairchild-Huntress et al. · Cell | 1997 | 3,071 |
| 5 | Vedolizumab as Induction and Maintenance Therapy for Ulcerative Colitis Brian G. Feagan, Paul J. Rutgeerts, Bruce E. Sands et al. · New England Journal of Medicine | 21 Aug 2013 | 2,910 |
| 6 | Vedolizumab as Induction and Maintenance Therapy for Crohn's Disease William J. Sandborn, Brian G. Feagan, Paul J. Rutgeerts et al. · New England Journal of Medicine | 21 Aug 2013 | 2,734 |
| 7 | IKKε and TBK1 are essential components of the IRF3 signaling pathway Katherine A. Fitzgerald, Sarah M. McWhirter, Kerrie L. Faia et al. · Nature Immunology | 14 Apr 2003 | 2,723 |
| 8 | A Phase 2 Study of Bortezomib in Relapsed, Refractory Myeloma Paul Gerard Guy Richardson et al. · New England Journal of Medicine | 25 Jun 2003 | 2,656 |
| 9 | Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein Dora Games et al. · Nature | Feb 1995 | 2,521 |
| 10 | Bortezomib or High-Dose Dexamethasone for Relapsed Multiple Myeloma Paul Gerard Guy Richardson et al. · New England Journal of Medicine | 15 Jun 2005 | 2,514 |
| 11 | Direct analysis of protein complexes using mass spectrometry Andrew J. Link, Jimmy K. Eng, David M. Schieltz et al. · Nature Biotechnology | Jul 1999 | 2,245 |
| 12 | Evidence That the Diabetes Gene Encodes the Leptin Receptor: Identification of a Mutation in the Leptin Receptor Gene in db/db Mice Hong Chen, Olga Charlat, Louis A. Tartaglia et al. · Cell | Feb 1996 | 2,242 |
| 13 | An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer Teresa A. Soucy et al. · Nature | Apr 2009 | 2,048 |
| 14 | Bortezomib plus Melphalan and Prednisone for Initial Treatment of Multiple Myeloma Jesús F. San Miguel et al. · New England Journal of Medicine | 27 Aug 2008 | 1,913 |
| 15 | Breast Cancer Molecular Subtypes Respond Differently to Preoperative Chemotherapy Roman Rouzier, Charles M. Perou, W. Fraser Symmans et al. · Clinical Cancer Research | 15 Aug 2005 | 1,908 |
| 16 | Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease Laurent Monney, Catherine A. Sabatos, Jason L. Gaglia et al. · Nature | 2002 | 1,647 |
| 17 | Nod1 Detects a Unique Muropeptide from Gram-Negative Bacterial Peptidoglycan Stephen E. Girardin, Ivo Gomperts Boneca, Letícia A. M. Carneiro et al. · Science | 6 Jun 2003 | 1,593 |
| 18 | Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes Federica Sallusto, Danielle Lenig, Charles Reay Mackay et al. · The Journal of Experimental Medicine | 16 Mar 1998 | 1,568 |
| 19 | Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 ( Tlr4 ) Salman T. Qureshi, Line Larivière, Gary Leveque et al. · The Journal of Experimental Medicine | 15 Feb 1999 | 1,541 |
| 20 | Efficacy of an Adjuvanted Herpes Zoster Subunit Vaccine in Older Adults Himal Lal, Anthony Lawrence Cunningham, Olivier Godeaux et al. · New England Journal of Medicine | 28 Apr 2015 | 1,456 |
| 21 | Hydrolysis of Biological Peptides by Human Angiotensin-converting Enzyme-related Carboxypeptidase Chad Vickers, Paul Hales, Virendar K. Kaushik et al. · Journal of Biological Chemistry | Apr 2002 | 1,434 |
| 22 | The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood Alessandro Aiuti, Iain James Webb, Conrad C. Bleul et al. · The Journal of Experimental Medicine | 1997 | 1,401 |
| 23 | Fast Plasma Investigation for Magnetospheric Multiscale C. J. Pollock et al. · Space Science Reviews | Mar 2016 | 1,349 |
| 24 | The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling Hidetoshi Hayashi, Shirin Abdollah, Yubin Qiu et al. · Cell | Jun 1997 | 1,343 |
| 25 | Increased Energy Expenditure, Decreased Adiposity, and Tissue-Specific Insulin Sensitivity in Protein-Tyrosine Phosphatase 1B-Deficient Mice Lori D. Klaman, Olivier Boss, Odile D. Peroni et al. · Molecular and Cellular Biology | Aug 2000 | 1,243 |
| 26 | A major role for VCAM-1, but not ICAM-1, in early atherosclerosis Myron I. Cybulsky, Kaeko Iiyama, Hongmei Li et al. · Journal of Clinical Investigation | 15 May 2001 | 1,216 |
| 27 | Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation Federica Sallusto, Patrick Schaerli, Pius Loetscher et al. · European Journal of Immunology | Sep 1998 | 1,181 |
| 28 | Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3 Thirumala‐Devi Kanneganti, Nesrin Özören, Mathilde Body–Malapel et al. · Nature | 11 Jan 2006 | 1,150 |
| 29 | Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages Luigi Franchi, Amal O. Amer, Mathilde Body–Malapel et al. · Nature Immunology | 30 Apr 2006 | 1,141 |
| 30 | Oral Ixazomib, Lenalidomide, and Dexamethasone for Multiple Myeloma Philippe Moreau et al. · New England Journal of Medicine | 27 Apr 2016 | 1,067 |
| 31 | Brigatinib versus Crizotinib in ALK -Positive Non–Small-Cell Lung Cancer D. Ross Camidge et al. · New England Journal of Medicine | 25 Sep 2018 | 997 |
| 32 | Promiscuous Mutations Activate the Noncanonical NF-κB Pathway in Multiple Myeloma Jonathan J. Keats et al. · Cancer Cell | Aug 2007 | 991 |
| 33 | Critical Role for NALP3/CIAS1/Cryopyrin in Innate and Adaptive Immunity through Its Regulation of Caspase-1 Fayyaz Shiraz Sutterwala, Yasunori Ogura, Marian Szczepanik et al. · Immunity | Mar 2006 | 976 |
| 34 | Modulation of A-type potassium channels by a family of calcium sensors Wei An, Mark R. Bowlby, Maria Betty et al. · Nature | Feb 2000 | 974 |
| 35 | Fibrinogen Stimulates Macrophage Chemokine Secretion Through Toll-Like Receptor 4 Stephen T. Smiley, Jennifer A. King, Wayne W. Hancock · The Journal of Immunology | Sep 2001 | 955 |
| 36 | TRPV3 is a calcium-permeable temperature-sensitive cation channel Haoxing Xu, Ian Scott Ramsey, Suhas A. Kotecha et al. · Nature | 23 Jun 2002 | 955 |
| 37 | Frequent Engagement of the Classical and Alternative NF-κB Pathways by Diverse Genetic Abnormalities in Multiple Myeloma Christina M. Annunziata et al. · Cancer Cell | Aug 2007 | 955 |
| 38 | Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study Michael J. Keating, Ian W. Flinn, Vinay Kumar Jain et al. · Blood | 15 May 2002 | 951 |
| 39 | Principles and Applications of Methods for DNA-Based Typing of Microbial Organisms Daniel Olive, Pamela Bean · Journal of Clinical Microbiology | Jun 1999 | 932 |
| 40 | Ecological Forecasts: An Emerging Imperative James S. Clark, Steven R. Carpenter, M. Craig Barber et al. · Science | 27 Jul 2001 | 926 |
| 41 | Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study Philippe Moreau, Halyna Pylypenko, Sebastian Grosicki et al. · The Lancet Oncology | 21 Apr 2011 | 925 |
| 42 | The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models Leming M. Shi et al. · Nature Biotechnology | 30 Jul 2010 | 922 |
| 43 | Increased Expression of Interleukin 23 p19 and p40 in Lesional Skin of Patients with Psoriasis Vulgaris Edmund Lee, William L. Trepicchio, Judith L. Oestreicher et al. · The Journal of Experimental Medicine | 5 Jan 2004 | 900 |
| 44 | High-Density Miniaturized Thermal Shift Assays as a General Strategy for Drug Discovery Michael W. Pantoliano, Eugene C. Petrella, Joseph D. Kwasnoski et al. · SLAS DISCOVERY | Dec 2001 | 900 |
| 45 | NF-κB as a Therapeutic Target in Multiple Myeloma Teru Hideshima, Dharminder Chauhan, Paul Gerard Guy Richardson et al. · Journal of Biological Chemistry | May 2002 | 894 |
| 46 | DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein Hien G Tran, Anne Sophie Brunet, Jill M. Grenier et al. · Science | 19 Apr 2002 | 870 |
| 47 | Lenalidomide, bortezomib, and dexamethasone combination therapy in patients with newly diagnosed multiple myeloma Paul Gerard Guy Richardson et al. · Blood | 12 Apr 2010 | 869 |
| 48 | PTP1B Regulates Leptin Signal Transduction In Vivo Janice M. Zabolotny, Kendra K. Bence, Alain Stricker‐Krongrad et al. · Developmental Cell | Apr 2002 | 824 |
| 49 | Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells Robert Shigeo Ohgami, Dean R. Campagna, Eric Lieberman Greer et al. · Nature Genetics | 16 Oct 2005 | 801 |
| 50 | The BioPAX community standard for pathway data sharing Emek Demir et al. · Nature Biotechnology | Sep 2010 | 782 |
Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.