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13 Dec 2018 |
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Vorapaxar in the Secondary Prevention of Atherothrombotic Events
David A. Morrow, Eugene Braunwald, Marc P. Bonaca et al. · New England Journal of Medicine
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24 Mar 2012 |
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Prasugrel versus Clopidogrel for Acute Coronary Syndromes without Revascularization
Matthew T. Roe et al. · New England Journal of Medicine
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26 Aug 2012 |
884 |
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Greater Clinical Benefit of More Intensive Oral Antiplatelet Therapy With Prasugrel in Patients With Diabetes Mellitus in the Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel–Thrombolysis in Myocardial Infarction 38
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The open abdomen in trauma and non-trauma patients: WSES guidelines
Federico Coccolini et al. · World Journal of Emergency Surgery
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2 Feb 2018 |
353 |
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Beneficial effects of weight loss associated with moderate calorie/carbohydrate restriction, and increased proportional intake of protein and unsaturated fat on serum urate and lipoprotein levels in gout: a pilot study
Patrick Hector Dessein, E A Shipton, A E Stanwix et al. · Annals of the Rheumatic Diseases
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Antimicrobial resistance in the next 30 years, humankind, bugs and drugs: a visionary approach
Matteo Bassetti, Garyphallia Poulakou, Étienne Ruppé et al. · Intensive Care Medicine
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14 Jul 2018 |
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A global call from five countries to collaborate in antibiotic stewardship: united we succeed, divided we might fail
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18 Nov 2016 |
244 |
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Biomarkers of endothelial dysfunction, cardiovascular risk factors and atherosclerosis in rheumatoid arthritis
Patrick Hector Dessein, Barry I. Joffe, Sham Singh · Arthritis Research & Therapy
Open access |
24 Mar 2005 |
241 |
| 11 |
Resistance to Colistin Associated with a Single Amino Acid Change in Protein PmrB among Klebsiella pneumoniae Isolates of Worldwide Origin
Aurélie Jayol, Laurent Poirel, Adrian John Brink et al. · Antimicrobial Agents and Chemotherapy
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10 Jun 2014 |
239 |
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Antimicrobial stewardship across 47 South African hospitals: an implementation study
Adrian John Brink, Angeliki P. Messina, Charles H. Feldman et al. · The Lancet Infectious Diseases
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17 Jun 2016 |
221 |
| 13 |
Insulin resistance and impaired beta cell function in rheumatoid arthritis
Patrick Hector Dessein, Barry I. Joffe · Arthritis & Rheumatism
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31 Aug 2006 |
216 |
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Global Unmet Needs in Cardiac Surgery
Peter Zilla et al. · Global Heart
Open access |
20 Sep 2018 |
213 |
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Heteroresistance to Colistin in Klebsiella pneumoniae Associated with Alterations in the PhoPQ Regulatory System
Aurélie Jayol, Patrice Nordmann, Adrian John Brink et al. · Antimicrobial Agents and Chemotherapy
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3 Mar 2015 |
209 |
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SeQuent Please World Wide Registry
Jochen Wöhrle, Mariusz Zadura, Sven Möbius‐Winkler et al. · Journal of the American College of Cardiology
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Oct 2012 |
203 |
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Antimicrobials: a global alliance for optimizing their rational use in intra-abdominal infections (AGORA)
Massimo Sartelli et al. · World Journal of Emergency Surgery
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14 Jul 2016 |
201 |
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Predictors of Bleeding and Time Dependence of Association of Bleeding With Mortality
Willibald Hochholzer, Stephen D. Wiviott, Elliott Marshall Antman et al. · Circulation
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24 May 2011 |
183 |
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Ischaemic risk and efficacy of ticagrelor in relation to time from P2Y 12 inhibitor withdrawal in patients with prior myocardial infarction: insights from PEGASUS-TIMI 54
Marc P. Bonaca et al. · European Heart Journal
Open access |
21 Oct 2015 |
167 |
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Effect of Alirocumab on Mortality After Acute Coronary Syndromes
Philippe Gabríel Steg et al. · Circulation
Open access |
23 May 2019 |
150 |
| 21 |
In Vivo Development of Ertapenem Resistance in a Patient with Pneumonia Caused by Klebsiella pneumoniae with an Extended-Spectrum -Lactamase
Eugenne Elliott, Adrian John Brink, Johan van Greune et al. · Clinical Infectious Diseases
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2 May 2006 |
147 |
| 22 |
Prevention of Stroke with the Addition of Ezetimibe to Statin Therapy in Patients With Acute Coronary Syndrome in IMPROVE-IT (Improved Reduction of Outcomes: Vytorin Efficacy International Trial)
Erin Ann Bohula, Stephen D. Wiviott, Robert Patrick Giugliano et al. · Circulation
Open access |
2 Oct 2017 |
142 |
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Genetic Features of MCR-1-Producing Colistin-Resistant Escherichia coli Isolates in South Africa
Laurent Poirel, Nicolas Kieffer, Adrian John Brink et al. · Antimicrobial Agents and Chemotherapy
Open access |
10 May 2016 |
140 |
| 24 |
EHRA expert consensus document on the management of arrhythmias in frailty syndrome, endorsed by the Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), Latin America Heart Rhythm Society (LAHRS), and Cardiac Arrhythmia Society of Southern Africa (CASSA)
Irina V. Savelieva et al. · EP Europace
Open access |
24 Aug 2022 |
127 |
| 25 |
Emergence of New Delhi Metallo-Beta-Lactamase (NDM-1) and Klebsiella pneumoniae Carbapenemase (KPC-2) in South Africa
Adrian John Brink, Jennifer Coetzee, Cornelis G. Clay et al. · Journal of Clinical Microbiology
Open access |
25 Nov 2011 |
123 |
| 26 |
Emergence of OXA-48 and OXA-181 Carbapenemases among Enterobacteriaceae in South Africa and Evidence of In Vivo Selection of Colistin Resistance as a Consequence of Selective Decontamination of the Gastrointestinal Tract
Adrian John Brink, Jennifer Coetzee, Craig Corcoran et al. · Journal of Clinical Microbiology
Open access |
15 Nov 2012 |
113 |
| 27 |
Prevalence and clinical outcomes of undiagnosed diabetes mellitus and prediabetes among patients with high-risk non–ST-segment elevation acute coronary syndrome
Roberto R. Giraldez, Robert M. Clare, Renato D. Lópes et al. · American Heart Journal
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13 Feb 2013 |
113 |
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Esomeprazole 20 mg and lansoprazole 15 mg in maintaining healed reflux oesophagitis: Metropole study results
K. Lauritsen, Jacques M.E. Deviere, Marc‐André Bigard et al. · Alimentary Pharmacology & Therapeutics
Open access |
Feb 2003 |
113 |
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Duration of Dual Antiplatelet Therapy After Coronary Stenting
Gilles Montalescot, David B. Brieger, Anthony J. Dalby et al. · Journal of the American College of Cardiology
Open access |
Aug 2015 |
112 |
| 30 |
Long-term Tolerability of Ticagrelor for the Secondary Prevention of Major Adverse Cardiovascular Events
Marc P. Bonaca et al. · JAMA Cardiology
Open access |
15 Jun 2016 |
100 |
| 31 |
From guidelines to practice: a pharmacist-driven prospective audit and feedback improvement model for peri-operative antibiotic prophylaxis in 34 South African hospitals
Adrian John Brink, Angeliki P. Messina, Charles H. Feldman et al. · Journal of Antimicrobial Chemotherapy
Open access |
9 Nov 2016 |
98 |
| 32 |
South African guideline for the management of community-acquired pneumonia in adults
South African Thoracic Society, Federation of Infectious Diseases Societies of S, Tom Hilary Boyles, Adrian John Brink et al. · Journal of Thoracic Disease
Open access |
Jun 2017 |
94 |
| 33 |
Subclinical Hypothyroidism is Associated with Insulin Resistance in Rheumatoid Arthritis
Patrick Hector Dessein, Barry I. Joffe, Anne E Stanwix · Thyroid
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Jun 2004 |
91 |
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The One Health stewardship of colistin as an antibiotic of last resort for human health in South Africa
Marc Mendelson et al. · The Lancet Infectious Diseases
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16 Apr 2018 |
87 |
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Clinical Efficacy and Safety of a Novel Antifungal, Fosmanogepix, in Patients with Candidemia Caused by Candida auris : Results from a Phase 2 Trial
José A. Vázquez, Peter G. Pappas, Kenneth David Boffard et al. · Antimicrobial Agents and Chemotherapy
Open access |
6 Apr 2023 |
85 |
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Emergence of plasmid-mediated colistin resistance (MCR-1) among Escherichia coli isolated from South African patients
Jennifer Coetzee, Craig Corcoran, Elizabeth Prentice et al. · South African Medical Journal
Open access |
19 Apr 2016 |
84 |
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Management of acute coronary syndrome in South Africa : insights from the ACCESS (Acute Coronary Events - a Multinational Survey of Current Management Strategies) registry : cardiovascular topics
Colin Schamroth · Cardiovascular journal of South Africa/Cardiovascular journal of Southern Africa
Open access |
12 Aug 2012 |
83 |
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Sudden Cardiac Death in Patients With Atrial Fibrillation: Insights From the ENGAGE AF‐TIMI 48 Trial
Alon Eisen, Christian Thomas Ruff, Eugene Braunwald et al. · Journal of the American Heart Association
Open access |
6 Jul 2016 |
82 |
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Vorapaxar in Patients With Diabetes Mellitus and Previous Myocardial Infarction
Matthew Aaron Cavender, Benjamin M. Scirica, Marc P. Bonaca et al. · Circulation
Open access |
14 Feb 2015 |
80 |
| 40 |
Pharmacokinetics of once-daily dosing of ertapenem in critically ill patients with severe sepsis
Adrian John Brink, GA Richards, V. Schillack et al. · International Journal of Antimicrobial Agents
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17 Dec 2008 |
80 |
| 41 |
Influence of nonclassical cardiovascular risk factors on the accuracy of predicting subclinical atherosclerosis in rheumatoid arthritis.
Patrick Hector Dessein, Gavin Robert Norton, Angela J Woodiwiss et al. · PubMed
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May 2007 |
79 |
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South African Dyslipidaemia Guideline Consensus Statement:
EQ Klug, Frederick Johan Raal, A.D. Marais et al. · Journal of Endocrinology Metabolism and Diabetes of South Africa
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Dec 2012 |
79 |
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Development and impact of a massive open online course (MOOC) for antimicrobial stewardship
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Open access |
4 Dec 2017 |
76 |
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Efficacy and Safety of Vorapaxar as Approved for Clinical Use in the United States
Giulia Magnani, Marc P. Bonaca, Eugene Braunwald et al. · Journal of the American Heart Association
Open access |
10 Mar 2015 |
75 |
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Hemoglobin glutamer‐250 (bovine) in South Africa: consensus usage guidelines from clinician experts who have treated patients
Mervyn Mer, Eric Hodgson, Lee Alan Wallis et al. · Transfusion
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23 Sep 2016 |
73 |
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Popliteal artery entrapment syndrome
Lewis J. Levien · Seminars in Vascular Surgery
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Sep 2003 |
73 |
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Hyposecretion of adrenal androgens and the relation of serum adrenal steroids, serotonin and insulin-like growth factor-1 to clinical features in women with fibromyalgia
H P. Dessein, A E. Shipton, I. Joffe et al. · Pain
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Nov 1999 |
69 |
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High-Level Resistance to Colistin Mediated by Various Mutations in the crrB Gene among Carbapenemase-Producing Klebsiella pneumoniae
Aurélie Jayol, Patrice Nordmann, Adrian John Brink et al. · Antimicrobial Agents and Chemotherapy
Open access |
6 Sep 2017 |
68 |
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Venous thromboembolism: Prophylactic and therapeutic practice guideline
Barry Frank Jacobson, Susan J. Louw, Harry Roger Buller et al. · South African Medical Journal
Open access |
15 Feb 2013 |
65 |
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A situational analysis of current antimicrobial governance, regulation, and utilization in South Africa
Natalie Schellack, Deon Benjamin, Adrian John Brink et al. · International Journal of Infectious Diseases
Open access |
8 Sep 2017 |
64 |