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Most cited papers from Model Animal Research Center

Model Animal Research Center

What are the most cited papers from Model Animal Research Center?

The most cited paper from Model Animal Research Center is "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1" (Daniel J. Klionsky et al., 2021), with 2,743 citations. Next come "High-throughput discovery of novel developmental phenotypes" (1,321) and "Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation" (1,052).

Showing 50 of 60 papers. Every paper with more than 192 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 Daniel J. Klionsky et al. · Autophagy Open access2,930 authors 2 Jan 2021 2,743
2 High-throughput discovery of novel developmental phenotypes Mary E. Dickinson et al. · Nature Open access 13 Sep 2016 1,321
3 Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation Weiwei Yang, Yan Xia, Haitao Ji et al. · Nature Open access 4 Nov 2011 1,052
4 Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos Yuyu Niu et al. · Cell Open access 31 Jan 2014 1,048
5 Efficient genome modification by CRISPR-Cas9 nickase with minimal off-target effects Bin Shen, Wensheng Zhang, Jun Zhang et al. · Nature Methods 2 Mar 2014 849
6 p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase Peng Jiang, Wenjing Du, Xingwu Wang et al. · Nature Cell Biology Open access 20 Feb 2011 823
7 Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling Chuwen Lin, Xuan Jiang, Zhongquan Dai et al. · Journal of Bone and Mineral Research Open access 6 May 2009 631
8 Generation of gene-modified mice via Cas9/RNA-mediated gene targeting Bin Shen, Jun Zhang, Hongya Wu et al. · Cell Research Open access 2 Apr 2013 572
9 Programming and Inheritance of Parental DNA Methylomes in Mammals Lu Wang, Jun Zhang, Jialei Duan et al. · Cell Open access May 2014 558
10 Liver-resident NK cells confer adaptive immunity in skin-contact inflammation Hui Chin Peng, Xiaojun Jiang, Yonglin Chen et al. · Journal of Clinical Investigation Open access 25 Mar 2013 547
11 Sperm, but Not Oocyte, DNA Methylome Is Inherited by Zebrafish Early Embryos Lan Jiang, Jing Zhang, Jingjing Wang et al. · Cell Open access May 2013 516
12 Longitudinal Association Between Markers of Liver Injury and Mortality in COVID‐19 in China Fang Lei et al. · Hepatology Open access 2 May 2020 451
13 sgRNAcas9: A Software Package for Designing CRISPR sgRNA and Evaluating Potential Off-Target Cleavage Sites Shengsong Xie, Bin Shen, Chaobao Zhang et al. · PLoS ONE Open access 23 Jun 2014 434
14 CD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis Jianwei Hao, Juan Wang, Huiling Guo et al. · Nature Communications Open access 21 Sep 2020 432
15 Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation Yufang Wang, Peiliang Shi, Qin Chen et al. · Journal of Molecular Cell Biology Open access 11 Mar 2019 373
16 Opposing Roles for the lncRNA Haunt and Its Genomic Locus in Regulating HOXA Gene Activation during Embryonic Stem Cell Differentiation Yafei Yin, Pixi Yan, Jinlong Y. Lu et al. · Cell stem cell Open access 17 Apr 2015 340
17 DNA Methylation, Its Mediators and Genome Integrity Huan Meng, Ying Cao, Jinzhong Qin et al. · International Journal of Biological Sciences Open access 2015 334
18 Mutations in Myosin Light Chain Kinase Cause Familial Aortic Dissections Li Wang, Dongchuan Guo, Jiumei Cao et al. · The American Journal of Human Genetics Open access Nov 2010 325
19 CRISPR-Cas9 mediated efficient PD-1 disruption on human primary T cells from cancer patients Shu Su, Bian Hu, Jie Shao et al. · Scientific Reports Open access 28 Jan 2016 305
20 Chimeric antigen receptor macrophage therapy for breast tumours mediated by targeting the tumour extracellular matrix Wenlong Zhang, Ling Liu, Huifang Su et al. · British Journal of Cancer Open access 30 Sep 2019 294
21 Skeletal muscle mitochondrial remodeling in exercise and diseases Zhenji Gan, Tingting Fu, Daniel P. Kelly et al. · Cell Research Open access 14 Aug 2018 292
22 TSC1 controls macrophage polarization to prevent inflammatory disease Linnan Zhu, Tao Yang, Longjie Li et al. · Nature Communications Open access Sep 2014 291
23 Antibiotics-induced depletion of mice microbiota induces changes in host serotonin biosynthesis and intestinal motility Xiaolong Ge, Chao Ding, Wei Han Zhao et al. · Journal of Translational Medicine Open access 13 Jan 2017 290
24 Leucine Deprivation Increases Hepatic Insulin Sensitivity via GCN2/mTOR/S6K1 and AMPK Pathways Fei Xiao, Zhiying Huang, Houkai Li et al. · Diabetes Open access Feb 2011 285
25 Prevalence of sexual dimorphism in mammalian phenotypic traits Natasha A. Karp et al. · Nature Communications Open access202 authors 26 Jun 2017 277
26 Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium Terrence F. Meehan et al. · Nature Genetics Open access 26 Jun 2017 274
27 Graphene Oxide Induces Toll-like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages Guangbo Qu, Sijin Liu, Shuping Zhang et al. · ACS Nano 4 Jun 2013 274
28 Preclinical development of a microRNA-based therapy for intervertebral disc degeneration Ming-liang Ji, Hua Jiang, Xuejun Zhang et al. · Nature Communications Open access 22 Nov 2018 270
29 Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration Dongquan Shi, Xingquan Xu, Yanqi Ye et al. · ACS Nano 12 Jan 2016 270
30 Genome modification by CRISPR /Cas9 Yuanwu Ma, Lianfeng Zhang, Xingxu Huang · FEBS Journal Open access 15 Oct 2014 263
31 TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway Zhongyang Lv, Xingquan Xu, Ziying Sun et al. · Cell Death and Disease Open access 18 May 2021 256
32 TGFβ1 secreted by cancer-associated fibroblasts induces epithelial-mesenchymal transition of bladder cancer cells through lncRNA-ZEB2NAT Junlong Zhuang, Qun Lu, Bing Shen et al. · Scientific Reports Open access 8 Jul 2015 254
33 Bacterial colonization dampens influenza-mediated acute lung injury via induction of M2 alveolar macrophages Jian Wang, Fengqi Li, Rui Sun et al. · Nature Communications Open access 3 Jul 2013 254
34 Nonalcoholic Fatty Liver Disease Yan-Ci Zhao, Guojun Zhao, Ze Chen et al. · Hypertension Open access 23 Dec 2019 251
35 Potential role of fecal microbiota from patients with slow transit constipation in the regulation of gastrointestinal motility Xiaolong Ge, Wei Han Zhao, Chao Ding et al. · Scientific Reports Open access 21 Mar 2017 245
36 STING-mediated intestinal barrier dysfunction contributes to lethal sepsis Qiongyuan Hu, Huajian Ren, Guanwei Li et al. · EBioMedicine Open access Mar 2019 238
37 Therapeutic targeting of ependymoma as informed by oncogenic enhancer profiling Stephen C. Mack et al. · Nature Open access 18 Dec 2017 232
38 Apigenin, a modulator of PPARγ, attenuates HFD-induced NAFLD by regulating hepatocyte lipid metabolism and oxidative stress via Nrf2 activation Xiujing Feng, Wen Yu, Xinda Li et al. · Biochemical Pharmacology 13 Apr 2017 231
39 Understanding the Multifaceted Role of Neutrophils in Cancer and Autoimmune Diseases Xu Wang, Lin Qiu, Ziyi Li et al. · Frontiers in Immunology Open access 9 Nov 2018 230
40 Cannabidiol inhibits human glioma by induction of lethal mitophagy through activating TRPV4 Tengfei Huang, Tianqi Xu, Yangfan Wang et al. · Autophagy Open access 25 Feb 2021 228
41 Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans Luang Xu, Xinyu Liu, Na Sheng et al. · Journal of Biological Chemistry Open access 28 Jun 2017 227
42 Fibroblast Growth Factor 13 Is a Microtubule-Stabilizing Protein Regulating Neuronal Polarization and Migration Qingfeng Wu, Yang Liu, Shuai Li et al. · Cell Open access Jun 2012 225
43 Generation of gene-modified goats targeting MSTN and FGF5 via zygote injection of CRISPR/Cas9 system Xiaolong Wang et al. · Scientific Reports Open access 10 Sep 2015 222
44 Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development Yan Geng, Yingying Dong, Mingyan Yu et al. · Proceedings of the National Academy of Sciences Open access 11 Apr 2011 222
45 Apple-Derived Pectin Modulates Gut Microbiota, Improves Gut Barrier Function, and Attenuates Metabolic Endotoxemia in Rats with Diet-Induced Obesity Tingting Jiang, Xuejin Gao, Chao Wu et al. · Nutrients Open access 29 Feb 2016 220
46 Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice # Qiong A Wang, Lei Jiang, Jue Wang et al. · Hepatology Open access 9 Dec 2008 217
47 Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries Xueying Tian et al. · Cell Research Open access 25 Jun 2013 214
48 JAK1–STAT1–STAT3, a key pathway promoting proliferation and preventing premature differentiation of myoblasts Luguo Sun, Kewei Ma, Haixia Wang et al. · The Journal of Cell Biology Open access Oct 2007 213
49 Generation of Genetically Modified Mice by Oocyte Injection of Androgenetic Haploid Embryonic Stem Cells Hui Xiang Yang, Linyu Shi, Bang-An Wang et al. · Cell Open access Apr 2012 213
50 De Novo Reconstruction of Adipose Tissue Transcriptomes Reveals Long Non-coding RNA Regulators of Brown Adipocyte Development Juan R. Alvarez‐Dominguez, Zhiqiang Bai, Dan Xu et al. · Cell Metabolism Open access 25 Apr 2015 210

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.