Most cited papers from MRC Holland (Netherlands)

MRC Holland (Netherlands)

What are the most cited papers from MRC Holland (Netherlands)?

The most cited paper from MRC Holland (Netherlands) is "Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification" (Jan P. Schouten, 2002), with 2,709 citations. Next come "High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs" (961) and "Characterization of human disease phenotypes associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , ADAR , and IFIH1" (617).

Published TypeFieldAccessAuthorsCitations

Showing 50 of 60 papers. Every paper with more than 69 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Relative quantification of 40 nucleic acid sequences by multiplex ligation-dependent probe amplification Jan P. Schouten · Nucleic Acids Research Open access	15 Jun 2002	2,709
2	High sensitivity of BRCA1-deficient mammary tumors to the PARP inhibitor AZD2281 alone and in combination with platinum drugs Sven Rottenberg, Janneke E. Jaspers, Ariena J. Kersbergen et al. · Proceedings of the National Academy of Sciences Open access	29 Oct 2008	961
3	Characterization of human disease phenotypes associated with mutations in TREX1 , RNASEH2A , RNASEH2B , RNASEH2C , SAMHD1 , ADAR , and IFIH1 Yanick Joseph Crow et al. · American Journal of Medical Genetics Part A Open access136 authors	16 Jan 2015	617
4	Fanconi anemia is associated with a defect in the BRCA2 partner PALB2 Bing Xia, Josephine C. Dorsman, Najim Ameziane et al. · Nature Genetics	31 Dec 2006	470
5	Methylation-Specific MLPA (MS-MLPA): simultaneous detection of CpG methylation and copy number changes of up to 40 sequences Anders O.H. Nygren · Nucleic Acids Research Open access	2 Aug 2005	398
6	Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer Sven Rottenberg, Anders O.H. Nygren, Marina Pajic et al. · Proceedings of the National Academy of Sciences Open access	11 Jul 2007	305
7	High proportion of large genomic deletions and a genotype–phenotype update in 80 unrelated families with juvenile polyposis syndrome Stefan Aretz, Dietlinde Stienen, Siegfried Uhlhaas et al. · Journal of Medical Genetics Open access	14 Sep 2007	247
8	Prediction of outcome in newly diagnosed myeloma: a meta-analysis of the molecular profiles of 1905 trial patients on behalf of the NCRI Haemato-oncology CSG et al. · Leukemia ReviewOpen access	6 Jun 2017	240
9	The innovative organization Willem J. Vrakking · Long Range Planning	Apr 1990	237
10	Increasing the Yield in Targeted Next-Generation Sequencing by Implicating CNV Analysis, Non-Coding Exons and the Overall Variant Load: The Example of Retinal Dystrophies Tobias Eisenberger et al. · PLoS ONE Open access	12 Nov 2013	231
11	Germline CDH1 deletions in hereditary diffuse gastric cancer families Carla Oliveíra et al. · Human Molecular Genetics Open access	24 Jan 2009	224
12	Abnormal offspring following in vitro production of bovine preimplantation embryos: A field study A.M. van Wagtendonk-de Leeuw, B.J.G Aerts, J.H.G. den Daas · Theriogenology	Apr 1998	199
13	Deletion and duplication screening in the DMD gene using MLPA Tanja Lalic, Rolf H. A. M. Vossen, Jordy Coffa et al. · European Journal of Human Genetics	20 Jul 2005	193
14	MS-MLPA: an attractive alternative laboratory assay for robust, reliable, and semiquantitative detection of MGMT promoter hypermethylation in gliomas Judith W. M. Jeuken, Sandra J B Cornelissen, Martine Vriezen et al. · Laboratory Investigation Open access	14 Aug 2007	182
15	REEP1 mutation spectrum and genotype/phenotype correlation in hereditary spastic paraplegia type 31 Christian Beetz et al. · Brain Open access	5 Mar 2008	181
16	Genomic deletions of MSH2 and MLH1 in colorectal cancer families detected by a novel mutation detection approach J J P Gille, Frans B.L. Hogervorst, Gerard Pals et al. · British Journal of Cancer Open access	Oct 2002	169
17	Phenotype and genotype in 101 males with X-linked creatine transporter deficiency Jiddeke M. van de Kamp et al. · Journal of Medical Genetics Open access	3 May 2013	168
18	Genotype-Phenotype Analysis in Congenital Adrenal Hyperplasia due to P450 Oxidoreductase Deficiency Nils Peter Krone et al. · The Journal of Clinical Endocrinology & Metabolism Open access	8 Dec 2011	166
19	Large genomic deletions of SMAD4, BMPR1A and PTEN in juvenile polyposis W. Arnout van Hattem, Lodewijk A.A. Brosens, Wendy W.J. de Leng et al. · Gut	4 Jan 2008	163
20	Copy number variation at theFCGRlocus includesFCGR3A, FCGR2CandFCGR3Bbut notFCGR2AandFCGR2B Willemijn B. Breunis, Edwin van Mirre, Judy Geissler et al. · Human Mutation	23 Mar 2009	157
21	A/T mutagenesis in hypermutated immunoglobulin genes strongly depends on PCNAK164 modification Petra Langerak, Anders O.H. Nygren, Peter H.L. Krijger et al. · The Journal of Experimental Medicine Open access	30 Jul 2007	156
22	An intragenic ERG deletion is a marker of an oncogenic subtype of B-cell precursor acute lymphoblastic leukemia with a favorable outcome despite frequent IKZF1 deletions Emmanuelle Clappier et al. · Leukemia	25 Sep 2013	155
23	Two-color multiplex ligation-dependent probe amplification: Detecting genomic rearrangements in hereditary multiple exostoses Stefan J. White, Geraldine R. Vink, Marjolein Kriek et al. · Human Mutation Open access	2004	152
24	Multiplex Ligation-dependent Probe Amplification (MLPA) in Tumor Diagnostics and Prognostics Hömig-Hölzel Cornelia, Suvi P. Savola · Diagnostic Molecular Pathology	30 Oct 2012	145
25	Rapid, high throughput prenatal detection of aneuploidy using a novel quantitative method (MLPA) Howard Robert Slater, D L Bruno, H Ren et al. · Journal of Medical Genetics Open access	Dec 2003	132
26	Sequential gene promoter methylation during HPV-induced cervical carcinogenesis Florianne E Henken, Saskia M. Wilting, René Overmeer et al. · British Journal of Cancer Open access	30 Oct 2007	131
27	Methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) robustly detects and distinguishes 11p15 abnormalities associated with overgrowth and growth retardation Richard H. Scott, Jenny B. Douglas, Linda Baskcomb et al. · Journal of Medical Genetics	15 Oct 2007	127
28	An overview of L-2-hydroxyglutarate dehydrogenase gene (L2HGDH) variants: a genotype-phenotype study Marjan E. Steenweg et al. · Human Mutation Open access	5 Jan 2010	126
29	Perceptions of Mental Health and Help-Seeking Behavior in an Urban Community in Vietnam: An Explorative Study Lia van der Ham, Pamela Wright, Thang Van Vo et al. · Community Mental Health Journal Open access	16 Mar 2011	120
30	Evaluation of multiplex ligation‐dependent probe amplification as a method for the detection of copy number abnormalities in B‐cell precursor acute lymphoblastic leukemia Claire J. Schwab, Lisa R. Jones, Helen Morrison et al. · Genes Chromosomes and Cancer	2 Sep 2010	119
31	Gene amplification-associated overexpression of the RNA editing enzyme ADAR1 enhances human lung tumorigenesis Carmen M. Anadon, Sònia Guil, Laia Simó‐Riudalbas et al. · Oncogene Open access	7 Dec 2015	117
32	Detailed analysis of 22q11.2 with a high density MLPA probe set G R Jalali, Jacob A. S. Vorstman, Ab Errami et al. · Human Mutation Open access	21 Nov 2007	117
33	Myoclonus-dystonia: significance of largeSGCEdeletions Anne Grünewald et al. · Human Mutation Open access	18 Jan 2008	117
34	The sensitivity of linear regression coefficients’ confidence limits to the omission of a confounder Carrie Hosman, Ben B. Hansen, Paul W. Holland · The Annals of Applied Statistics Open access	Jun 2010	116
35	Intragenic deletions and a deep intronic mutation affecting pre-mRNA splicing in the dihydropyrimidine dehydrogenase gene as novel mechanisms causing 5-fluorouracil toxicity André B. P. Kuilenburg, Judith Meijer, Adri N. P. M. Mul et al. · Human Genetics Open access	28 Aug 2010	115
36	Poly(ADP-Ribose) Polymerase-1 Inhibitor Treatment Regresses Autochthonous Brca2/p53 -Mutant Mammary Tumors In vivo and Delays Tumor Relapse in Combination with Carboplatin Trevor Hay, James R. Matthews, Lucie Pietzka et al. · Cancer Research	21 Apr 2009	113
37	“Atypical” Pleomorphic Lipomatous Tumor David Creytens, Thomas Mentzel, Liesbeth Ferdinande et al. · The American Journal of Surgical Pathology	6 Sep 2017	109
38	Increased gene copy numbers at chromosome 20q are frequent in both squamous cell carcinomas and adenocarcinomas of the cervix Saskia M. Wilting, PJF Snijders, Gerrit A. Meijer et al. · The Journal of Pathology	14 Mar 2006	109
39	A new molecular mechanism for severe myoclonic epilepsy of infancy: Exonic deletions in SCN1A John C. Mulley, Paul V. Nelson, Sílvia Guerrero et al. · Neurology	25 Sep 2006	102
40	Molecular profiling of invasive breast cancer by multiplex ligation-dependent probe amplification-based copy number analysis of tumor suppressor and oncogenes Cathy Beatrice Moelans, Roel A. de Weger, Hanneke N. Monsuur et al. · Modern Pathology Open access	14 May 2010	95
41	KAT6B Is a Tumor Suppressor Histone H3 Lysine 23 Acetyltransferase Undergoing Genomic Loss in Small Cell Lung Cancer Laia Simó‐Riudalbas et al. · Cancer Research Open access	24 Jul 2015	95
42	Quantitative copy number analysis by Multiplex Ligation-dependent Probe Amplification (MLPA) of BRCA1-associated breast cancer regions identifies BRCAness Esther H. Lips, Nadja Laddach, Suvi P. Savola et al. · Breast Cancer Research Open access	27 Oct 2011	94
43	Moderate Increase in Mdr1a/1b Expression Causes In vivo Resistance to Doxorubicin in a Mouse Model for Hereditary Breast Cancer Marina Pajic, Jayasree Kaveri Iyer, Ariena J. Kersbergen et al. · Cancer Research	4 Aug 2009	94
44	Atypical spindle cell lipoma: a clinicopathologic, immunohistochemical, and molecular study emphasizing its relationship to classical spindle cell lipoma David Creytens, Joost van Gorp, Suvi P. Savola et al. · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin	22 Mar 2014	94
45	DNA profiling of primary serous ovarian and Fallopian tube carcinomas with array comparative genomic hybridization and multiplex ligation‐dependent probe amplification ME Nowee, AM Snijders, DAP Rockx et al. · The Journal of Pathology	31 Jul 2007	93
46	High-resolution mapping of molecular events associated with immortalization, transformation, and progression to breast cancer in the MCF10 model Maria J. Worsham, Gerard Pals, Jan P. Schouten et al. · Breast Cancer Research and Treatment	30 Nov 2005	90
47	The impact of SF3B1 mutations in CLL on the DNA-damage response G. Doreen te Raa, I. A. M. Derks, Veronika Navrkalová et al. · Leukemia Open access	5 Nov 2014	90
48	Coordinating marketing and manufacturing in ETO companies Paul A. Konijnendijk · International Journal of Production Economics	Nov 1994	88
49	Genetic subtyping of Fanconi anemia by comprehensive mutation screening Najim Ameziane, Abdellatif Errami, France Léveillé et al. · Human Mutation Open access	2007	87
50	Sensitivity and Acquired Resistance of BRCA1;p53-Deficient Mouse Mammary Tumors to the Topoisomerase I Inhibitor Topotecan Serge A.L. Zander, Ariena J. Kersbergen, Eline van der Burg et al. · Cancer Research	10 Feb 2010	85

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.