| 1 |
Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): a phase 3, randomised-controlled, non-inferiority trial
Johan A. Maertens et al. · The Lancet
|
15 Dec 2015 |
1,006 |
| 2 |
Assessment of Myocardial Viability With Contrast-Enhanced Magnetic Resonance Imaging
Christoph A. Klein, Stephan G. Nekolla, Frank Michael Bengel et al. · Circulation
Open access |
15 Jan 2002 |
632 |
| 3 |
Selenium in Intensive Care (SIC): Results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock*
Matthias Angstwurm, Lothar Engelmann, Thomas Philipp Zimmermann et al. · Critical Care Medicine
|
9 Nov 2006 |
511 |
| 4 |
Transluminal endoscopic necrosectomy after acute pancreatitis: a multicentre study with long-term follow-up (the GEPARD Study)
Hans Helge Seifert, Michael Biermer, W Schmitt et al. · Gut
Open access |
11 Mar 2009 |
482 |
| 5 |
ISAR-SAFE: a randomized, double-blind, placebo-controlled trial of 6 vs. 12 months of clopidogrel therapy after drug-eluting stenting
Stefanie Schüpke et al. · European Heart Journal
Open access |
23 Jan 2015 |
431 |
| 6 |
Randomized Comparison of Percutaneous Coronary Intervention With Sirolimus-Eluting Stents Versus Coronary Artery Bypass Grafting in Unprotected Left Main Stem Stenosis
Enno Boudriot, Hölger Thiele, Thomas Walther et al. · Journal of the American College of Cardiology
Open access |
27 Jan 2011 |
416 |
| 7 |
Perioperative Results and Complications in 15,964 Transcatheter Aortic Valve Replacements
Thomas Walther, Christian W. Hamm, Gerhard C Schuler et al. · Journal of the American College of Cardiology
Open access |
15 Mar 2015 |
403 |
| 8 |
Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre FITT-STEMI trial
Karl Heinrich Scholz, Sebastian K.G. Maier, Lars Siegfried Maier et al. · European Heart Journal
Open access |
18 Jan 2018 |
377 |
| 9 |
The Munich Polypectomy Study (MUPS): Prospective Analysis of Complications and Risk Factors in 4000 Colonic Snare Polypectomies
Walter Heldwein, Markus Dollhopf, Thomas Rösch et al. · Endoscopy
|
Nov 2005 |
331 |
| 10 |
Early evidence of pronounced brain involvement in fatal COVID-19 outcomes
Claus Hann von Weyhern, Inès Kaufmann, Frauke Neff et al. · The Lancet
Open access |
Jun 2020 |
299 |
| 11 |
Posaconazole versus voriconazole for primary treatment of invasive aspergillosis: a phase 3, randomised, controlled, non-inferiority trial
Johan A. Maertens, Galia Rahav, Dong‐Gun Lee et al. · The Lancet
Open access |
Feb 2021 |
292 |
| 12 |
A Randomized Multicenter Trial to Compare Long-Term Functional Outcome, Quality of Life, and Complications of Surgical Procedures for Low Rectal Cancers
Victor W. Fazio, Massarat Zutshi, Feza H. Remzi et al. · Annals of Surgery
Open access |
20 Aug 2007 |
279 |
| 13 |
High-Protein Enteral Nutrition Enriched With Immune-Modulating Nutrients vs Standard High-Protein Enteral Nutrition and Nosocomial Infections in the ICU
Arthur R. H. van Zanten, F. Sztark, Udo X. Kaisers et al. · JAMA
|
5 Aug 2014 |
278 |
| 14 |
Pemetrexed Plus Cisplatin or Pemetrexed Plus Carboplatin for Chemonaïve Patients with Malignant Pleural Mesothelioma: Results of the International Expanded Access Program
Armando Santoro, Mary E.R. O'Brien, Rolf Arno Stahel et al. · Journal of Thoracic Oncology
Open access |
Jul 2008 |
255 |
| 15 |
S3-Leitlinie – Kolorektales Karzinom
Wolff Schmiegel, Barbara Buchberger, Markus Follmann et al. · Zeitschrift für Gastroenterologie
Open access |
Dec 2017 |
244 |
| 16 |
Carotid intimal-media thickness as a surrogate for cardiovascular disease events in trials of HMG-CoA reductase inhibitors
Mark Andrew Espeland, Daniel H. O’Leary, James Greg Terry et al. · Current Controlled Trials in Cardiovascular Medicine
Open access |
10 Mar 2005 |
225 |
| 17 |
Double-blind trial of omeprazole and amoxicillin to cure Helicobacter pylori infection in patients with duodenal ulcers
Ekkehard Bayerdörffer, Stephan Miehlke, Gerd Alexander Mannes et al. · Gastroenterology
Open access |
May 1995 |
213 |
| 18 |
EUS-guided drainage of pancreatic fluid collections using a novel lumen-apposing metal stent on an electrocautery-enhanced delivery system: a large retrospective study (with video)
Emanuele Rinninella, Rastislav Kunda, Markus Dollhopf et al. · Gastrointestinal Endoscopy
Open access |
23 May 2015 |
207 |
| 19 |
Multimodale Schmerztherapie
B. Arnold, Tamina Brinkschmidt, Hans‐Raimund Casser et al. · Der Schmerz
|
20 Jan 2009 |
188 |
| 20 |
EUS-guided choledochoduodenostomy for malignant distal biliary obstruction using a lumen-apposing fully covered metal stent after failed ERCP
Rastislav Kunda, Manuel Pérez‐Miranda, Uwe Will et al. · Surgical Endoscopy
|
11 Mar 2016 |
184 |
| 21 |
S3-Leitlinie Kolorektales Karzinom Version 1.0 - Juni 2013 AWMF-Registernummer: 021/007OL
Christian Peter Pox et al. · Zeitschrift für Gastroenterologie
Open access |
16 Aug 2013 |
183 |
| 22 |
EUS-guided gallbladder drainage in patients with acute cholecystitis and high surgical risk using an electrocautery-enhanced lumen-apposing metal stent device
Markus Dollhopf, Alberto Larghi, Uwe Will et al. · Gastrointestinal Endoscopy
|
Mar 2017 |
180 |
| 23 |
Primary prophylaxis of invasive fungal infections in patients with hematologic malignancies. Recommendations of the Infectious Diseases Working Party of the German Society for Haematology and Oncology
Oliver A. Cornely, Angelika Böhme, Dieter Buchheidt et al. · Haematologica
Open access |
9 Dec 2008 |
178 |
| 24 |
Central venous catheter–related infections in hematology and oncology: 2020 updated guidelines on diagnosis, management, and prevention by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO)
Boris Böll, Enrico Schalk, Dieter Buchheidt et al. · Annals of Hematology
Open access |
30 Sep 2020 |
166 |
| 25 |
Gastric Residual Volume in Critically Ill Patients
Gunnar Elke, Thomas W. Felbinger, Daren Keith Heyland · Nutrition in Clinical Practice
|
18 Dec 2014 |
166 |
| 26 |
Association between serum ferritin and the insulin resistance syndrome in a representative population
Christian E. Wrede, Roland Buettner, Leo Cornelius Bollheimer et al. · European Journal of Endocrinology
Open access |
Feb 2006 |
165 |
| 27 |
Carotid endarterectomy or stenting or best medical treatment alone for moderate-to-severe asymptomatic carotid artery stenosis: 5-year results of a multicentre, randomised controlled trial
Tilman Reiff et al. · The Lancet Neurology
162 authors |
14 Sep 2022 |
149 |
| 28 |
Clinical Nutrition in Critical Care Medicine – Guideline of the German Society for Nutritional Medicine (DGEM)
Gunnar Elke, Wolfgang H. Hartl, Karl Georg Kreymann et al. · Clinical Nutrition ESPEN
Open access |
9 Jul 2019 |
146 |
| 29 |
Final analysis of the randomised PEAK trial: overall survival and tumour responses during first-line treatment with mFOLFOX6 plus either panitumumab or bevacizumab in patients with metastatic colorectal carcinoma
Fernando Rivera, Meinolf Karthaus, Joel Randolph Hecht et al. · International Journal of Colorectal Disease
Open access |
19 Apr 2017 |
143 |
| 30 |
The Prognostic Value of Lymph Node Ratio in a Population-Based Collective of Colorectal Cancer Patients
ROBERT D. ROSENBERG, Jutta Engel, Christiane J. Bruns et al. · Annals of Surgery
|
19 May 2010 |
140 |
| 31 |
Acute sedation-associated complications in GI endoscopy (ProSed 2 Study): results from the prospective multicentre electronic registry of sedation-associated complications
Angelika Behrens et al. · Gut
|
3 Jan 2018 |
136 |
| 32 |
Interdisciplinary management of EGFR-inhibitor-induced skin reactions: a German expert opinion
Karin Potthoff, Ralf‐Dieter Hofheinz, Jessica Cecile Hassel et al. · Annals of Oncology
Open access |
14 Aug 2010 |
132 |
| 33 |
Diagnosis of invasive fungal infections in hematology and oncology—guidelines from the Infectious Diseases Working Party in Haematology and Oncology of the German Society for Haematology and Oncology (AGIHO)
Markus Ruhnke, Angelika Böhme, Dieter Buchheidt et al. · Annals of Oncology
Open access |
24 Sep 2011 |
129 |
| 34 |
German S3 guidelines: anal abscess and fistula (second revised version)
A. Ommer, Alexander Herold, E. Berg et al. · Langenbeck s Archives of Surgery
|
Mar 2017 |
126 |
| 35 |
Treatment of invasive fungal infections in cancer patients—Recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)
Angelika Böhme, Markus Ruhnke, Dieter Buchheidt et al. · Annals of Hematology
|
13 Oct 2008 |
122 |
| 36 |
Stress Related Shift Toward Inflammaging in Cosmonauts After Long-Duration Space Flight
Judith‐Irina Buchheim, Sandra Matzel, М. П. Рыкова et al. · Frontiers in Physiology
Open access |
18 Feb 2019 |
121 |
| 37 |
Pragmatic approach to nutrition in the ICU: Expert opinion regarding which calorie protein target
Pierre Singer, M. Hiesmayr, Gianni Biolo et al. · Clinical Nutrition
Open access |
21 Dec 2013 |
121 |
| 38 |
Cellular and extracellular mi RNA s are blood‐compartment‐specific diagnostic targets in sepsis
Marlene Reithmair, Dominik Buschmann, Melanie Märte et al. · Journal of Cellular and Molecular Medicine
Open access |
6 Apr 2017 |
120 |
| 39 |
A randomized trial of polytetrafluoroethylene-membrane-covered stents compared with conventional stents in aortocoronary saphenous vein grafts
Volker Schächinger, Christian W. Hamm, Thomas Münzel et al. · Journal of the American College of Cardiology
Open access |
Oct 2003 |
118 |
| 40 |
Angiodysplasia in the Colon and Rectum
W. Höchter, Josef Weingart, W. Kühner et al. · Endoscopy
|
Sep 1985 |
118 |
| 41 |
SPACE-2: A Missed Opportunity to Compare Carotid Endarterectomy, Carotid Stenting, and Best Medical Treatment in Patients with Asymptomatic Carotid Stenoses
Hans‐Henning Eckstein, Tilman Reiff, Peter Arthur Ringleb et al. · European Journal of Vascular and Endovascular Surgery
Open access |
13 Apr 2016 |
114 |
| 42 |
Endothelial‐like cells expanded from CD34 + blood cells improve left ventricular function after experimental myocardial infarction
Ilka Ott, Ulrich Bernd Keller, Martina Knoedler et al. · The FASEB Journal
|
6 Apr 2005 |
111 |
| 43 |
Proximal Endovascular Flow Blockage for Cerebral Protection During Carotid Artery Stenting: Results From a Prospective Multicenter Registry
Bernhard Reimers et al. · Journal of Endovascular Therapy
Open access |
Apr 2005 |
111 |
| 44 |
Graft patency and clinical outcome of femorodistal arterial reconstruction in diabetic and non-diabetic patients: Results of a multicentre comparative analysis
K. D. Wölfle, Hans-Kees Bruijnen, Henning Loeprecht et al. · European Journal of Vascular and Endovascular Surgery
Open access |
Mar 2003 |
108 |
| 45 |
Lumen apposing metal stents are superior to plastic stents in pancreatic walled-off necrosis: a large international multicenter study
Yen‐I Chen et al. · Endoscopy International Open
Open access |
28 Feb 2019 |
106 |
| 46 |
Stent-Protected Angioplasty in Asymptomatic Carotid Artery Stenosis vs. Endarterectomy: SPACE2 – a Three-Arm Randomised-Controlled Clinical Trial
Tilman Reiff, Robert Stingele, Hans‐Henning Eckstein et al. · International Journal of Stroke
|
Aug 2009 |
104 |
| 47 |
Carotid artery stenting in octogenarians: results from the ALKK Carotid Artery Stent (CAS) Registry
Ralf Zahn, Thomas A. Ischinger, Matthias Hochadel et al. · European Heart Journal
Open access |
12 Dec 2006 |
102 |
| 48 |
Comparative analysis of phase I and II enzyme activities in 5 hepatic cell lines identifies Huh-7 and HCC-T cells with the highest potential to study drug metabolism
Jie Lin, Lilianna Schyschka, Ruben Mühl‐Benninghaus et al. · Archives of Toxicology
|
6 Jul 2011 |
100 |
| 49 |
Dynamic molecular analysis and clinical correlates of tumor evolution within a phase II trial of panitumumab-based therapy in metastatic colorectal cancer
Salvatore Siena, Andrea Sartore Bianchi, Rocio García‐Carbonero et al. · Annals of Oncology
Open access |
Sep 2017 |
99 |
| 50 |
The German Experience
Peter Hermanek, Peter Hermanek, Ulrich Mansmann et al. · Surgical Oncology Clinics of North America
|
2000 |
99 |