| 1 |
Survey of chronic pain in Europe: Prevalence, impact on daily life, and treatment
Harald Breivik, Beverly Collett, Vittorio Ventafridda et al. · European Journal of Pain
Open access |
11 Aug 2005 |
5,568 |
| 2 |
How many drug targets are there?
John P. Overington, Bissan Al‐Lazikani, Andrew L. Hopkins · Nature Reviews Drug Discovery
Review |
Dec 2006 |
3,554 |
| 3 |
The Human Plasma Proteome
N. Leigh Anderson, Malu Polanski, Rembert Pieper et al. · Molecular & Cellular Proteomics
Open access |
12 Jan 2004 |
1,013 |
| 4 |
Cancer-related pain: a pan-European survey of prevalence, treatment, and patient attitudes
Harald Breivik, Nathan I. Cherny, Brent R. Collett et al. · Annals of Oncology
Open access |
24 Feb 2009 |
805 |
| 5 |
Can we rationally design promiscuous drugs?
Andrew L. Hopkins, John O. Mason, John P. Overington · Current Opinion in Structural Biology
|
27 Jan 2006 |
472 |
| 6 |
2012 Provisional classification criteria for polymyalgia rheumatica: A European League Against Rheumatism/American College of Rheumatology collaborative initiative
Bhaskar Dasgupta et al. · Arthritis & Rheumatism
Open access |
2 Mar 2012 |
415 |
| 7 |
Critical inhaler errors in asthma and COPD: a systematic review of impact on health outcomes
Omar Sharif Usmani, Federico Lavorini, Jonathan Marshall et al. · Respiratory Research
ReviewOpen access |
16 Jan 2018 |
409 |
| 8 |
Defective acute inflammation in Crohn's disease: a clinical investigation
Daniel JB Marks, Marcus Harbord, Raymond J. MacAllister et al. · The Lancet
|
Feb 2006 |
383 |
| 9 |
Diversity of conformational states and changes within the EF-hand protein superfamily
Kyoko L. Yap, James B. Ames, Mark Basil Swindells et al. · Proteins Structure Function and Bioinformatics
Open access |
15 Nov 1999 |
276 |
| 10 |
A systematic approach to modeling, capturing, and disseminating proteomics experimental data
Chris F. Taylor et al. · Nature Biotechnology
|
28 Feb 2003 |
248 |
| 11 |
Prolonged‐release oxycodone enhances the effects of existing gabapentin therapy in painful diabetic neuropathy patients
Magdi Hanna, Cathy O’Brien, Margaret C. Wilson · European Journal of Pain
|
11 Feb 2008 |
223 |
| 12 |
Povidone-Iodine Demonstrates Rapid In Vitro Virucidal Activity Against SARS-CoV-2, The Virus Causing COVID-19 Disease
Danielle E. Anderson, Velraj Sivalingam, Adrian Eng Zheng Kang et al. · Infectious Diseases and Therapy
Open access |
8 Jul 2020 |
179 |
| 13 |
Fixed-ratio combination oxycodone/naloxone compared with oxycodone alone for the relief of opioid-induced constipation in moderate-to-severe noncancer pain
Karen H Simpson, Petra Leyendecker, Michael Hopp et al. · Current Medical Research and Opinion
|
12 Nov 2008 |
179 |
| 14 |
Combined prolonged-release oxycodone and naloxone improves bowel function in patients receiving opioids for moderate-to-severe non-malignant chronic pain: a randomised controlled trial
Oliver Löwenstein, Petra Leyendecker, Michael Hopp et al. · Expert Opinion on Pharmacotherapy
|
26 Feb 2009 |
159 |
| 15 |
The role of matrix metalloproteinases (MMPs) in the pathophysiology of chronic obstructive pulmonary disease (COPD): a therapeutic role for inhibitors of MMPs?
Maria Gabriela Belvisi, K M K Bottomley · Inflammation Research
|
Mar 2003 |
159 |
| 16 |
Identification of human and mouse CatSper3 and CatSper4 genes: Characterisation of a common interaction domain and evidence for expression in testis
Anna Lobley, Valerie Pierron, Lindsey Reynolds et al. · Reproductive Biology and Endocrinology
Open access |
Aug 2003 |
155 |
| 17 |
Inferring Function Using Patterns of Native Disorder in Proteins
Anna Lobley, Mark Basil Swindells, Christine Anne Orengo et al. · PLoS Computational Biology
Open access |
22 Aug 2007 |
153 |
| 18 |
Molecular Effects of Povidone-Iodine on Relevant Microorganisms: An Electron-Microscopic and Biochemical Study
Harold J. Schreier, Gregory W. Erdos, Karen M. Reimer et al. · Dermatology
|
6 Oct 2009 |
150 |
| 19 |
The Budget Impact of Biosimilar Infliximab (Remsima®) for the Treatment of Autoimmune Diseases in Five European Countries
Ashok Kumar Jha, Alex Upton, W. Dunlop et al. · Advances in Therapy
Open access |
Aug 2015 |
147 |
| 20 |
Prolonged-release oxycodone–naloxone for treatment of severe pain in patients with Parkinson's disease (PANDA): a double-blind, randomised, placebo-controlled trial
Claudia Trenkwalder, К. Ray Chaudhuri, Pablo Martínez‐Martín et al. · The Lancet Neurology
Open access |
23 Oct 2015 |
125 |
| 21 |
Predicting postoperative analgesia outcomes: NNT league tables or procedure-specific evidence? † †Declaration of interest. The authors are members of the Procedure Specific Postoperative Pain Management (PROSPECT) Group, which conducts procedure-specific systematic reviews of the literature using the Cochrane Protocol, supplements these with evidence from other procedures and from clinical practic
Anthony W. Gray, Henrik Kehlet, Francis J. Bonnet et al. · British Journal of Anaesthesia
ReviewOpen access |
16 Apr 2005 |
123 |
| 22 |
Clinical use of thrombin generation assays
Nikolaus B. Binder, François Depasse, Julia Müeller et al. · Journal of Thrombosis and Haemostasis
Open access |
30 Sep 2021 |
111 |
| 23 |
Altersetin, a New Antibiotic from Cultures of Endophytic Alternaria spp. Taxonomy, Fermentation, Isolation, Structure Elucidation and Biological Activities.
Veronika Hellwig, Torsten Grothe, Anke Mayer‐Bartschmid et al. · The Journal of Antibiotics
Open access |
2002 |
111 |
| 24 |
Target-induced conformational adaptation of calmodulin revealed by the crystal structure of a complex with nematode Ca2+/calmodulin-dependent kinase kinase peptide
Hirofumi Kurokawa, Masanori Osawa, Hiroyuki Kurihara et al. · Journal of Molecular Biology
|
Sep 2001 |
111 |
| 25 |
Pharmacokinetics of concentrated naloxone nasal spray for opioid overdose reversal: Phase I healthy volunteer study
Rebecca S. McDonald, Ulrike Lorch, Jo Woodward et al. · Addiction
Open access |
16 Nov 2017 |
103 |
| 26 |
Validation of the Short Form of the Brief Pain Inventory ( BPI ‐ SF ) in Spanish Patients with Non‐Cancer‐Related Pain
Javier De Andrés Ares, Luis Miguel Cruces Prado, María Angeles Canos Verdecho et al. · Pain Practice
|
28 Apr 2014 |
102 |
| 27 |
Low absolute bioavailability of oral naloxone in healthy subjects
Kevin J. Smith, Michael Hopp, Gill Mundin et al. · International Journal of Clinical Pharmacology and Therapeutics
|
5 Mar 2012 |
100 |
| 28 |
Pediatric-Like Acute Lymphoblastic Leukemia Therapy in Adults With Lymphoblastic Lymphoma: The GRAALL-LYSA LL03 Study
Stéphane Leprêtre et al. · Journal of Clinical Oncology
|
8 Dec 2015 |
100 |
| 29 |
High-throughput protein arrays: prospects for molecular diagnostics
Gerald Walter, Konrad Büssow, Angelika Lueking et al. · Trends in Molecular Medicine
Review |
Jun 2002 |
95 |
| 30 |
An Innovative Topical Drug Formulation for Wound Healing and Infection Treatment: In vitro and in vivo Investigations of a Povidone-Iodine Liposome Hydrogel
Karen M. Reimer, P.M. Vogt, Bianca Broegmann et al. · Dermatology
|
2000 |
91 |
| 31 |
Gene profiling and bioinformatic analysis of Schwann cell embryonic development and myelination
Maurizio D’Antonio, David Michalovich, Morris Paterson et al. · Glia
|
20 Dec 2005 |
89 |
| 32 |
Optimal Use of Bendamustine in Chronic Lymphocytic Leukemia, Non-Hodgkin Lymphomas, and Multiple Myeloma: Treatment Recommendations From an International Consensus Panel
Bruce D. Cheson, Clemens‐Martin Wendtner, Angelika Pieper et al. · Clinical Lymphoma Myeloma & Leukemia
|
Feb 2010 |
89 |
| 33 |
Meeting the Challenges of Opioid-Induced Constipation in Chronic Pain Management – A Novel Approach
Karen M. Reimer, Michael Hopp, Michael W. Zenz et al. · Pharmacology
|
27 Oct 2008 |
80 |
| 34 |
Current practices in cancer pain management in Asia: a survey of patients and physicians across 10 countries
The ACHEON Working Group, Yong‐Chul Kim, Jin Seok Ahn et al. · Cancer Medicine
Open access |
27 Apr 2015 |
80 |
| 35 |
Detection and outcome of occult leptomeningeal disease in diffuse large B-cell lymphoma and Burkitt lymphoma
W. H. Wilson, Jacoline E. C. Bromberg, Maryalice Stetler‐Stevenson et al. · Haematologica
Open access |
11 Apr 2014 |
79 |
| 36 |
ADMET Property Prediction: The State of the Art and Current Challenges
Joelle M. R. Gola, Olga Obrezanova, Ed Champness et al. · QSAR & Combinatorial Science
Open access |
18 Oct 2006 |
75 |
| 37 |
Fluticasone/formoterol combination therapy is as effective as fluticasone/salmeterol in the treatment of asthma, but has a more rapid onset of action: an open-label, randomized study
Anna Bodzenta‐Łukaszyk, Andrzej Dymek, Kirsten McAulay et al. · BMC Pulmonary Medicine
Open access |
23 May 2011 |
73 |
| 38 |
Cost-Effectiveness of Take-Home Naloxone for the Prevention of Overdose Fatalities among Heroin Users in the United Kingdom
Sue Langham, Antony Wright, James Kenworthy et al. · Value in Health
Open access |
4 Feb 2018 |
72 |
| 39 |
Laxatives Do Not Improve Symptoms of Opioid-Induced Constipation: Results of a Patient Survey
Anton V Emmanuel, Martin E. Johnson, Paula McSkimming et al. · Pain Medicine
Open access |
8 Oct 2016 |
72 |
| 40 |
Focus on success: using a probabilistic approach to achieve an optimal balance of compound properties in drug discovery
Matt D Segall, Alan P. Beresford, Joelle M. R. Gola et al. · Expert Opinion on Drug Metabolism & Toxicology
|
24 Mar 2006 |
71 |
| 41 |
Fungi and animals may share a common ancestor to nuclear receptors
Chris B. Phelps, Valentina Gburcik, Elena Suslova et al. · Proceedings of the National Academy of Sciences
Open access |
24 Apr 2006 |
70 |
| 42 |
Bactericidal and Virucidal Activity of Povidone-Iodine and Chlorhexidine Gluconate Cleansers in an In Vivo Hand Hygiene Clinical Simulation Study
Maren Eggers, Torsten Koburger‐Janssen, Lois Ward et al. · Infectious Diseases and Therapy
Open access |
14 May 2018 |
69 |
| 43 |
The Finnish Allergy Program 2008-2018: Society-wide proactive program for change of management to mitigate allergy burden
Tari Haahtela et al. · Journal of Allergy and Clinical Immunology
Open access |
5 May 2021 |
68 |
| 44 |
Fine Particle Profile of Fluticasone Propionate/Formoterol Fumarate Versus Other Combination Products: the DIFFUSE Study
Baljinder Johal, Markus Howald, Manfréd M. Fischer et al. · Combination Products in Therapy
Open access |
29 Aug 2013 |
68 |
| 45 |
Long-term safety and efficacy of oxycodone/naloxone prolonged-release tablets in patients with moderate-to-severe chronic cancer pain
Sam Hjelmeland Ahmedzai, Wojciech Leppert, Marcin Janecki et al. · Supportive Care in Cancer
Open access |
13 Sep 2014 |
67 |
| 46 |
The role of inhaled methoxyflurane in acute pain management
Keith M. Porter, Anthony D. Dayan, Sara Dickerson et al. · Open Access Emergency Medicine
Open access |
Oct 2018 |
66 |
| 47 |
Benefits, Challenges and Potential Strategies of Open Source Health Economic Models
W. Dunlop, Nicola Mason, James Kenworthy et al. · PharmacoEconomics
Open access |
7 Dec 2016 |
65 |
| 48 |
Efficacy and safety of fluticasone and formoterol in a single pressurized metered dose inhaler
Anna Bodzenta‐Łukaszyk, Grażyna Pulka, Andrzej Dymek et al. · Respiratory Medicine
Open access |
4 Jan 2011 |
64 |
| 49 |
37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3)
Daniel Rob et al. · Critical Care
Open access928 authors |
Mar 2017 |
61 |
| 50 |
The Effect of Ethanol on the Release of Opioids from Oral Prolonged-Release Preparations
Malcolm Walden, Fiona A. Nicholls, Kevin J. Smith et al. · Drug Development and Industrial Pharmacy
Open access |
2007 |
61 |