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Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore
Fraser F. Fleming, Lihua Yao, Ponneri Chandrababu Ravikumar et al. · Journal of Medicinal Chemistry
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30 Aug 2010 |
1,756 |
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Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia
Xiaoming Hu, Peiying Li, Yanling Guo et al. · Stroke
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29 Aug 2012 |
1,604 |
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Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection
Meijuan Zhang, Chengrui An, Yanqin Gao et al. · Progress in Neurobiology
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29 Sep 2012 |
618 |
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Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury
Guohua Wang, Jia Zhang, Xiaoming Hu et al. · Journal of Cerebral Blood Flow & Metabolism
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14 Aug 2013 |
492 |
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Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injury
Yejie Shi, Lili Zhang, Hongjian Pu et al. · Nature Communications
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27 Jan 2016 |
438 |
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Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release
Yalikun Suofu et al. · Proceedings of the National Academy of Sciences
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5 Sep 2017 |
418 |
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HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis
Guohua Wang, Yejie Shi, Xiaoyan Jiang et al. · Proceedings of the National Academy of Sciences
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17 Feb 2015 |
399 |
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The impact of cerebrovascular aging on vascular cognitive impairment and dementia
Tuo Yang, Yang Sun, Zhengyu Lu et al. · Ageing Research Reviews
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30 Sep 2016 |
211 |
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Preconditioning provides neuroprotection in models of CNS disease: Paradigms and clinical significance
Ruth Anne Stetler, Rehana Khan Leak, Yu Gan et al. · Progress in Neurobiology
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3 Jan 2014 |
193 |
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Omega-3 Fatty Acids Protect the Brain against Ischemic Injury by Activating Nrf2 and Upregulating Heme Oxygenase 1
Meijuan Zhang, Suping Wang, Leilei Mao et al. · Journal of Neuroscience
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29 Jan 2014 |
181 |
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A systematic review of quality of life instruments in long-term breast cancer survivors
Ishveen Chopra, Khalid M. Kamal · Health and Quality of Life Outcomes
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2012 |
161 |
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Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood–brain barrier disruption after ischemic brain injury
Yejie Shi, Xiaoyan Jiang, Lili Zhang et al. · Proceedings of the National Academy of Sciences
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30 Jan 2017 |
160 |
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Effect of a Proposed Trastuzumab Biosimilar Compared With Trastuzumab on Overall Response Rate in Patients With ERBB2 (HER2)–Positive Metastatic Breast Cancer
Hope S. Rugo et al. · JAMA
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5 Dec 2016 |
147 |
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Catalytic Isonitrile Insertions and Condensations Initiated by RNC–X Complexation
Suravi Chakrabarty, Shruti Choudhary, Arpit Doshi et al. · Advanced Synthesis & Catalysis
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20 Jun 2014 |
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Omega-3 Polyunsaturated Fatty Acid Supplementation Improves Neurologic Recovery and Attenuates White Matter Injury after Experimental Traumatic Brain Injury
Hongjian Pu, Yanling Guo, Wenting Zhang et al. · Journal of Cerebral Blood Flow & Metabolism
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26 Jun 2013 |
133 |
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Randomized, Double-Blind, Placebo-Controlled Trial Demonstrates the Efficacy and Safety of Oral Aripiprazole for the Treatment of Tourette's Disorder in Children and Adolescents
Floyd R. Sallee, Eva Kohegyi, Joan Liu Zhao et al. · Journal of Child and Adolescent Psychopharmacology
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7 Jul 2017 |
130 |
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Polymorphism in generic drug product development
Dixie Snider · Advanced Drug Delivery Reviews
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7 Feb 2004 |
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Loperamide
Claud Regnard, Robert Twycross, Mary Mihalyo et al. · Journal of Pain and Symptom Management
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27 Jun 2011 |
118 |
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19 F MRI detection of acute allograft rejection with in vivo perfluorocarbon labeling of immune cells
T. Kevin Hitchens, Qing Ye, Danielle F. Eytan et al. · Magnetic Resonance in Medicine
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8 Feb 2011 |
118 |
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Co-proccessed excipients with enhanced direct compression functionality for improved tableting performance
John Rojas, Ira S. Buckner, Vijay Kumar · Drug Development and Industrial Pharmacy
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12 Sep 2012 |
118 |
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Ketamine*
Rachel Quibell, Eric Prommer, Mary Mihalyo et al. · Journal of Pain and Symptom Management
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Mar 2011 |
114 |
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Continued efficacy and safety of subcutaneous apomorphine in patients with advanced Parkinson's disease
Ronald F. Pfeiffer, Ludwig Gutmann, Keith L. Hull et al. · Parkinsonism & Related Disorders
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19 Oct 2006 |
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The Dynamics of the Mitochondrial Organelle as a Potential Therapeutic Target
Ruth Anne Stetler, Rehana Khan Leak, Yanqin Gao et al. · Journal of Cerebral Blood Flow & Metabolism
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24 Oct 2012 |
110 |
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Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry
David J. Lapinsky · Bioorganic & Medicinal Chemistry
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13 Sep 2012 |
106 |
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Scriptaid, a Novel Histone Deacetylase Inhibitor, Protects Against Traumatic Brain Injury via Modulation of PTEN and AKT Pathway
Guohua Wang, Xiaoyan Jiang, Hongjian Pu et al. · Neurotherapeutics
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6 Nov 2012 |
105 |
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Oncogenic signaling of MEK5-ERK5
Van T. Hoang, Thomas J. Yan, Jane E. Cavanaugh et al. · Cancer Letters
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30 Jan 2017 |
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Adoptive Regulatory T-Cell Therapy Preserves Systemic Immune Homeostasis After Cerebral Ischemia
Peiying Li, Leilei Mao, Guoqing Zhou et al. · Stroke
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4 Oct 2013 |
101 |
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Application of the Biopharmaceutical Classification System in Clinical Drug Development—An Industrial View
Jack Cook, William J. Addicks, Yunhui Wu · The AAPS Journal
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23 May 2008 |
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Onset of Action of the Fixed Combination Intranasal Azelastine-Fluticasone Propionate in an Allergen Exposure Chamber
Jean Bousquet, Eli O. Meltzer, Peter R. Couroux et al. · The Journal of Allergy and Clinical Immunology In Practice
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6 Feb 2018 |
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Selective lesion of cholinergic neurons in the medial septum by 192 IgG-saporin impairs learning in a delayed matching to position T-maze paradigm
David A. Johnson, Natalie J Zambon, Robert B. Gibbs · Brain Research
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Effects of raloxifene and estradiol on hippocampal acetylcholine release and spatial learning in the rat
Robert B. Gibbs, Rachel Gabor, Teresa Bruner Cox et al. · Psychoneuroendocrinology
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The 2nd Calibration and Validation Group Workshop on Recent Issues in Good Laboratory Practice Bioanalysis
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27 Mar 2009 |
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Pharmacological Induction of Heme Oxygenase-1 by a Triterpenoid Protects Neurons Against Ischemic Injury
Feng Zhang, Suping Wang, Meijuan Zhang et al. · Stroke
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30 Mar 2012 |
92 |
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Subcutaneous apomorphine in patients with advanced Parkinson's disease: A dose-escalation study with randomized, double-blind, placebo-controlled crossover evaluation of a single dose
Rajesh Pahwa, William C. Koller, Richard M. Trosch et al. · Journal of the Neurological Sciences
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30 Apr 2007 |
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Propofol
Staffan Lundström, Robert Twycross, Mary Mihalyo et al. · Journal of Pain and Symptom Management
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Sep 2010 |
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Preventive and Protective Roles of Dietary Nrf2 Activators Against Central Nervous System Diseases
Yang Sun, Tuo Yang, Rehana Khan Leak et al. · CNS & Neurological Disorders - Drug Targets
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12 Apr 2017 |
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2009 White Paper on Recent Issues in Regulated Bioanalysis from The 3rd Calibration and Validation Group Workshop
Natasha Savoie, Fabio Garofolo, Peter van Amsterdam et al. · Bioanalysis
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22 Dec 2009 |
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Estrogen enhances potassium-stimulated acetylcholine release in the rat hippocampus
Rachel Gabor, Rajesh Nagle, David A. Johnson et al. · Brain Research
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30 Jan 2003 |
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Omega-3 polyunsaturated fatty acids mitigate blood–brain barrier disruption after hypoxic–ischemic brain injury
Wenting Zhang, Hui Zhang, Hongfeng Mu et al. · Neurobiology of Disease
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25 Feb 2016 |
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Implementation of a pharmacogenomics service in a community pharmacy
Stefanie P. Ferreri, Angelo J. Greco, Natasha M. Michaels et al. · Journal of the American Pharmacists Association
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Current Challenges in Bioequivalence, Quality, and Novel Assessment Technologies for Topical Products
Avraham Yacobi et al. · Pharmaceutical Research
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6 Jan 2014 |
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Towards an Understanding of the Structurally Based Potential for Mechanically Activated Disordering of Small Molecule Organic Crystals
Peter L. D. Wildfong, Bruno C. Hancock, Michael D. Moore et al. · Journal of Pharmaceutical Sciences
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22 Aug 2006 |
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Gastroretentive Floating Drug-Delivery Systems: A Critical Review
Udaya K. Kotreka, Moji Christianah Adeyeye · Critical Reviews in Therapeutic Drug Carrier Systems
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Considerations for managing chronic obstructive pulmonary disease in the elderly
George E. Taffet, James F. Donohue, Pablo Altman · Clinical Interventions in Aging
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Dec 2013 |
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Implantation of Brain-Derived Extracellular Matrix Enhances Neurological Recovery after Traumatic Brain Injury
Yun Wu, Jiayin Wang, Yejie Shi et al. · Cell Transplantation
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30 Jun 2017 |
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Benzodiazepines
Paul D. Howard, Robert Twycross, John L. Shuster et al. · Journal of Pain and Symptom Management
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27 Mar 2014 |
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Resveratrol attenuates cisplatin renal cortical cytotoxicity by modifying oxidative stress
Monica A. Valentovic, John G. Ball, Janet M. Brown et al. · Toxicology in Vitro
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12 Nov 2013 |
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Generation of antigen-specific Foxp3+ regulatory T-cells in vivo following administration of diabetes-reversing tolerogenic microspheres does not require provision of antigen in the formulation
Carl Engman, Yi Wen, Wilson S. Meng et al. · Clinical Immunology
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FMRP interacts with G-quadruplex structures in the 3’-UTR of its dendritic target Shank1 mRNA
Yang Zhang, Christian M. Gaetano, Kathryn R. Williams et al. · RNA Biology
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2 Nov 2014 |
66 |
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Translational Stroke Research on Blood-Brain Barrier Damage: Challenges, Perspectives, and Goals
Yejie Shi, Rehana Khan Leak, Richard F. Keep et al. · Translational Stroke Research
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13 Jan 2016 |
65 |