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Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in mice.
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NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel
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22 Mar 2005 |
563 |
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Cisplatin-incorporating polymeric micelles (NC-6004) can reduce nephrotoxicity and neurotoxicity of cisplatin in rats
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Sep 2005 |
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A Phase I clinical study of cisplatin-incorporated polymeric micelles (NC-6004) in patients with solid tumours
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Environment-Responsive Block Copolymer Micelles with a Disulfide Cross-Linked Core for Enhanced siRNA Delivery
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325 |
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Modeling the Onset of Symptoms of COVID-19
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13 Aug 2020 |
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Nanomedicines: From Bench to Bedside and Beyond
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NC ‐6300, an epirubicin‐incorporating micelle, extends the antitumor effect and reduces the cardiotoxicity of epirubicin
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17 Mar 2013 |
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Introduction of stearoyl moieties into a biocompatible cationic polyaspartamide derivative, PAsp(DET), with endosomal escaping function for enhanced siRNA-mediated gene knockdown
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31 Mar 2010 |
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Phase Ib/II Trial of NC-6004 (Nanoparticle Cisplatin) Plus Gemcitabine in Patients with Advanced Solid Tumors
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Tumor‐targeted chemotherapy with the nanopolymer‐based drug NC ‐6004 for oral squamous cell carcinoma
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6 Dec 2012 |
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Organic–inorganic hybrid-nanocarrier of siRNA constructing through the self-assembly of calcium phosphate and PEG-based block aniomer
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Improved anti‐tumor activity of stabilized anthracycline polymeric micelle formulation, NC‐6300
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Factors affecting toxicity and efficacy of polymeric nanomedicines
Eiki Igarashi · Toxicology and Applied Pharmacology
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General considerations regarding the in vitro and in vivo properties of block copolymer micelle products and their evaluation
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13 May 2015 |
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Assessment of antitumor activity and acute peripheral neuropathy of 1,2-diaminocyclohexane platinum (II)-incorporating micelles (NC-4016)
Takasyoshi Ueno, Kazuhira Endo, Kiyomi Hori et al. · International Journal of Nanomedicine
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Jun 2014 |
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Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment
Theofilus A. Tockary, Saed Abbasi, Miki Matsui-Masai et al. · Proceedings of the National Academy of Sciences
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10 Jul 2023 |
55 |
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Improvement of the skin penetration of hydrophobic drugs by polymeric micelles
Kensuke Yotsumoto, Kenta Ishii, Miho Kokubo et al. · International Journal of Pharmaceutics
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16 Oct 2018 |
52 |
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Effect of combined treatment with the epirubicin‐incorporating micelles (NC‐6300) and 1,2‐diaminocyclohexane platinum (II)‐incorporating micelles (NC‐4016) on a human gastric cancer model
Yoshiyuki Yamamoto, Ichinosuke Hyodo, Misato Takigahira et al. · International Journal of Cancer
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3 Dec 2013 |
40 |
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A Phase 1b Dose Escalation Trial of NC-6300 (Nanoparticle Epirubicin) in Patients with Advanced Solid Tumors or Advanced, Metastatic, or Unresectable Soft-tissue Sarcoma
Sant P. Chawla, Sanjay Goel, Warren Allen Chow et al. · Clinical Cancer Research
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7 May 2020 |
38 |
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Enhanced antitumor effect of anti‐tissue factor antibody‐conjugated epirubicin‐incorporating micelles in xenograft models
Yoshiyuki Yamamoto, Ichinosuke Hyodo, Yoshikatsu Koga et al. · Cancer Science
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25 Feb 2015 |
38 |
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Remodeling tumor microenvironment with nanomedicines
John Daniel Martin, Takuya Miyazaki, Horacio Cabral · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology
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14 Jun 2021 |
36 |
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OVA-bound nanoparticles induce OVA-specific IgG1, IgG2a, and IgG2b responses with low IgE synthesis
Noriko Yanase, Hiroko Toyota, Kikumi Hata et al. · Vaccine
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6 Sep 2014 |
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NC-6004 Phase I study in combination with gemcitabine for advanced solid tumors and population PK/PD analysis
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21 Feb 2017 |
32 |
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A multicenter, single-arm, basket design, phase II study of NC-6004 plus gemcitabine in patients with advanced unresectable lung, biliary tract, or bladder cancer
Simona Ruxandra Volovăț, Tudor–Eliade Ciuleanu, P. Koralewski et al. · Oncotarget
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18 Aug 2020 |
30 |
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Physico-chemical characterization of polymeric micelles loaded with platinum derivatives by capillary electrophoresis and related methods
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28 Sep 2014 |
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Combination therapy with dendritic cell vaccine and IL-2 encapsulating polymeric micelles enhances intra-tumoral accumulation of antigen-specific CTLs
Kenji Miki, Koji Nagaoka, Mitsunori Harada et al. · International Immunopharmacology
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4 Oct 2014 |
25 |
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Translational nanomedicine potentiates immunotherapy in sarcoma by normalizing the microenvironment
Fotios Mpekris, Myrofora Panagi, Christina Michael et al. · Journal of Controlled Release
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20 Dec 2022 |
24 |
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Anti-Inflammatory Therapy for Temporomandibular Joint Osteoarthritis Using mRNA Medicine Encoding Interleukin-1 Receptor Antagonist
Jia Deng, Yuta Fukushima, Kosuke Nozaki et al. · Pharmaceutics
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26 Aug 2022 |
23 |
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Prolonged circulation and in vivo efficacy of recombinant human granulocyte colony-stimulating factor encapsulated in polymeric micelles
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27 Jun 2011 |
23 |
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NC-6301, a polymeric micelle rationally optimized for effective release of docetaxel, is potent but is less toxic than native docetaxel in vivo
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May 2012 |
19 |
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Results of NC-6300 (Nanoparticle Epirubicin) in an Expansion Cohort of Patients with Angiosarcoma
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3 Aug 2022 |
18 |
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Reinforcement of antitumor effect of micelles containing anticancer drugs by binding of an anti-tissue factor antibody without direct cytocidal effects
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4 Apr 2020 |
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Utility of epirubicin‐incorporating micelles tagged with anti‐tissue factor antibody clone with no anticoagulant effect
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17 Dec 2015 |
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Vaccination with OVA-bound nanoparticles encapsulating IL-7 inhibits the growth of OVA-expressing E.G7 tumor cells in vivo
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12 Nov 2014 |
16 |
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Phase IIa/IIb clinical trial of NC-6004 (Nanoparticle Cisplatin) plus Pembrolizumab in patients with head and neck cancer (HNSCC) who have failed platinum or a platinum-containing regimen
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Oct 2020 |
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Core–Shell Type Polystyrene Latex Possessing Reactive Poly(ethylene glycol) Brushes on the Surface for High Performance Immunodiagnostics
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Dec 2002 |
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Catalytic Graphitization of Wood‐Based Carbons with Alumina by Pulse Current Heating
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Apr 2005 |
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Jet injection potentiates naked mRNA SARS-CoV-2 vaccine in mice and non-human primates by adding physical stress to the skin
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27 Feb 2023 |
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Histological tumor necrosis in pancreatic cancer after neoadjuvant therapy
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17 May 2022 |
7 |
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Non-clinical, quality and environmental impact assessments of cell and gene therapy products: Report on the 5th Asia Partnership Conference of Regenerative Medicine - April 7, 2022
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24 Apr 2023 |
6 |
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Preclinical Safety Evaluation of Intraperitoneally Administered Cu-Conjugated Anti-EGFR Antibody NCAB001 for the Early Diagnosis of Pancreatic Cancer Using PET
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12 Sep 2022 |
6 |
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Evaluation of 64Cu-Labeled New Anti-EGFR Antibody NCAB001 with Intraperitoneal Injection for Early PET Diagnosis of Pancreatic Cancer in Orthotopic Tumor-Xenografted Mice and Nonhuman Primates
Hiroki Matsumoto, Tadashi Watabe, Chika Igarashi et al. · Pharmaceuticals
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23 Sep 2021 |
5 |
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Normalizing the Tumor Microenvironment for Radiosensitization
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Book chapter |
2020 |
5 |
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Characterization and Stabilization of a New 64Cu-Labeled Anti-EGFR Antibody NCAB001 for the Early Detection of Pancreatic Cancer with Positron Emission Tomography
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28 Dec 2021 |
4 |
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Anti-VEGFR2 Antibody-modified Micelle for Triggered Drug Delivery and Effective Therapy of Choroidal Neovascularization
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Phase Ib/II trial of NC-6004 (nanoparticle cisplatin) plus gemcitabine (G) in pts with advanced solid tumors
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Oct 2016 |
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P1.03-044 Exploratory Analysis of Lung Cancer Patients in a Phase Ib/II Trial of NC-6004 (Nanoparticle Cisplatin) plus Gemcitabine
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Nov 2017 |
1 |
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Translational research of DDS based on polymeric micelles
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2011 |
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WS2 nanocarriers for cancer drug delivery: Structure, property, performance relationships and translational barriers
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9 Sep 2026 |
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