Institution · Napp Pharmaceuticals (United Kingdom)

Most cited papers from Napp Pharmaceuticals (United Kingdom)

Napp Pharmaceuticals (United Kingdom)

What are the most cited papers from Napp Pharmaceuticals (United Kingdom)?

The most cited paper from Napp Pharmaceuticals (United Kingdom) is "Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM" (Ian Hickson, Yan Zhao, Caroline J. Richardson et al., 2004), with 1,227 citations. Next come "Chemistry challenges in lead optimization: silicon isosteres in drug discovery" (429) and "The 'rule of three' for fragment-based drug discovery: where are we now?" (337).

Published TypeFieldAccessCitations

Showing 50 of 60 papers. Every paper with more than 20 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM Ian Hickson, Yan Zhao, Caroline J. Richardson et al. · Cancer Research	15 Dec 2004	1,227
2	Chemistry challenges in lead optimization: silicon isosteres in drug discovery Graham A. Showell, JOHN S. MILLS · Drug Discovery Today	Jun 2003	429
3	The 'rule of three' for fragment-based drug discovery: where are we now? Harren Jhoti, Glyn Williams, David C. Rees et al. · Nature Reviews Drug Discovery	12 Jul 2013	337
4	Formulation aspects of biodegradable polymeric microspheres for antigen delivery Harjit Tamber, Pål Johansen, Hans Peter Merkle et al. · Advanced Drug Delivery Reviews	4 Oct 2004	316
5	Assessment of Dose Proportionality: Report from the Statisticians in the Pharmaceutical Industry/Pharmacokinetics UK Joint Working Party Kevin A Gough, Michael G. Hutchison, Oliver N. Keene et al. · Drug Information Journal	Jul 1995	269
6	Mutational analysis of the “slippery-sequence” component of a coronavirus ribosomal frameshifting signal Ian Brierley, Alison J. Jenner, Stephen C. Inglis · Journal of Molecular Biology Open access	Sep 1992	256
7	Minor Capsid Protein of Human Genital Papillomaviruses Contains Subdominant, Cross-Neutralizing Epitopes Richard B. S. Roden, William H. Yutzy, Rosemary Fallon et al. · Virology Open access	May 2000	245
8	IL-12: a key cytokine in immune regulation Alan G. Lamont, Luciano Adorini · Immunology Today	May 1996	232
9	Discovery of 4-{4-[(3 R )-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1 H -indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity Kevin M. Foote, Kevin Blades, Anna S. Cronin et al. · Journal of Medicinal Chemistry Open access	11 Feb 2013	217
10	CD4+ T-cell memory, CD45R subsets and the persistence of antigen—a unifying concept Eric B. Bell, Sheila M. Sparshott, Campbell Bunce · Immunology Today	Feb 1998	206
11	From fragment to clinical candidate—a historical perspective Gianni Chessari, Andrew Woodhead · Drug Discovery Today	8 May 2009	201
12	Human therapeutic cocaine vaccine: safety and immunogenicity Thomas R. Kosten, Marc I. Rosen, Julian F. Bond et al. · Vaccine	2002	194
13	Construction and characterisation of a recombinant vaccinia virus expressing human papillomavirus proteins for immunotherapy of cervical cancer M. E. G. Boursnell · Vaccine Open access	Nov 1996	117
14	Population preference values for treatment outcomes in chronic lymphocytic leukaemia: a cross-sectional utility study Kathleen Marie Beusterien, John Maelor Davies, M.J. Leach et al. · Health and Quality of Life Outcomes Open access	2010	112
15	Higher throughput calorimetry: opportunities, approaches and challenges Francisco Eduardo Torres, Michael I. Recht, Joseph E. Coyle et al. · Current Opinion in Structural Biology ReviewOpen access	Oct 2010	97
16	Age and the Pharmacokinetics of Morphine S. P. BAILLIE, David Nicholas Bateman, Peter E. Coates et al. · Age and Ageing	1989	96
17	Silicon chemistry as a novel source of chemical diversity in drug design. William Bains, Reinhold Tacke · PubMed	Jul 2003	91
18	A Structural Comparison of Inhibitor Binding to PKB, PKA and PKA-PKB Chimera Thomas G. Davies, Marcel L. Verdonk, Brent L. Graham et al. · Journal of Molecular Biology Open access	10 Jan 2007	90
19	Solving molecular crystal structures from laboratory X-ray powder diffraction data withDASH: the state of the art and challenges Alastair J. Florence, Norman Shankland, Kenneth Shankland et al. · Journal of Applied Crystallography Open access	11 Mar 2005	86
20	Group Efficiency: A Guideline for Hits‐to‐Leads Chemistry Marcel L. Verdonk, David C. Rees · ChemMedChem	23 Jul 2008	86
21	A comparison of five heat and moisture exchangers Maire P Shelly, D.W. Bethune, R.D. Latimer · Anaesthesia Open access	May 1986	82
22	Low-dose theophylline modulates T-lymphocyte activation in allergen-challenged asthmatics ZH Jaffar, Patrick S. Sullivan, Clive Peter Page et al. · European Respiratory Journal Open access	Mar 1996	77
23	Suppression of Collagen Induced Arthritis by Oral Administration of Type II Collagen: Changes in Immune and Arthritic Responses Mediated by Active Peripheral Suppression H. S. G. Thompson, Nicole Harper, D. J. Bevan et al. · Autoimmunity	1993	71
24	A Randomized, Double-Blind, Double-Dummy Comparison of the Efficacy and Tolerability of Low-Dose Transdermal Buprenorphine (BuTrans Seven-Day Patches) With Buprenorphine Sublingual Tablets (Temgesic ) in Patients With Osteoarthritis Pain Ian G.V. James, Catherine O’Brien, Chris J. McDonald · Journal of Pain and Symptom Management Open access	14 Jun 2010	68
25	Phase I safety and antigenicity of TA-GW: a recombinant HPV6 L2E7 vaccine for the treatment of genital warts H. Thompson, Matt Davies, F.P Holding et al. · Vaccine	1999	66
26	Induction of a protective immune response by mucosal vaccination with a DISC HSV-1 vaccine Cornelia S. McLean, D. NíChallanáin, Imogen A. Duncan et al. · Vaccine	Jul 1996	61
27	The Impact of Helicobacter pylori Eradication on Peptic Ulcer Healing Gerhard G. Treiber, John Lambert · The American Journal of Gastroenterology	Jul 1998	57
28	Ketamine infusion G R Park, Alex R. Manara, L. Mendel et al. · Anaesthesia	Sep 1987	55
29	Gene Expression Profiling of Transcription Factors of Helicobacter pylori under Different Environmental Conditions Miguel Ángel De la Cruz, Miguel Ángel Ares, Kristine von Bargen et al. · Frontiers in Microbiology Open access	10 Apr 2017	51
30	Quality of life benefits and cost impact of prolonged release oxycodone/naloxone versus prolonged release oxycodone in patients with moderate-to-severe non-malignant pain and opioid-induced constipation: a UK cost-utility analysis W. Dunlop, Reiner Uhl, Iftekhar Khan et al. · Journal of Medical Economics Open access	2012	46
31	The effect of wetting agents on the dissolution of indomethacin solid dispersion systems Jane E. Hilton, M P Summers · International Journal of Pharmaceutics	Jul 1986	46
32	Transdermal buprenorphine plus oral paracetamol vs an oral codeine-paracetamol combination for osteoarthritis of hip and/or knee: a randomised trial Philip G. Conaghan, C.M. O’Brien, Mark C. Wilson et al. · Osteoarthritis and Cartilage Open access	15 Apr 2011	45
33	The Contin delivery system: Dosing considerations Stewart Leslie · Journal of Allergy and Clinical Immunology	Oct 1986	42
34	The efficacy and tolerability of controlled-release dihydrocodeine tablets and combination dextro-propoxyphene/paracetamol tablets in patients with severe osteoarthritis of the hips R. Stephen Lloyd, Fiona Costello, M. J. Eves et al. · Current Medical Research and Opinion	1992	42
35	The affinity adsorptive recovery of an infectious Herpes Simplex Virus vaccine Roderic S. O'Keeffe, M. D. Johnston, Nigel K.H. Slater · Biotechnology and Bioengineering	5 Mar 1999	41
36	A Comparison of the Pharmacokinetics, Clinical Efficacy, and Tolerability of Once-Daily Tramadol Tablets with Normal Release Tramadol Capsules Bhavesh Bodalia, Chris J. McDonald, Kevin J. Smith et al. · Journal of Pain and Symptom Management Open access	Feb 2003	41
37	PHARMACOKINETICS OF MORPHINE IN TWO CHILDREN BEFORE AND AFTER LIVER TRANSPLANTATION Maire P Shelly, E.P. CORY, G.R. Park · British Journal of Anaesthesia Open access	Nov 1986	39
38	African swine fever virus encodes two genes which share significant homology with the two largest subunits of DNA-dependent RNA polymerases Rafael J. Yáñez‐Muñoz, M. E. G. Boursnell, Marfa L. Nogal et al. · Nucleic Acids Research Open access	1993	38
39	Cost-Effectiveness of Canagliflozin Added to Standard of Care for Treating Diabetic Kidney Disease (DKD) in Patients with Type 2 Diabetes Mellitus (T2DM) in England: Estimates Using the CREDEM-DKD Model Michael S. Willis, Andreas Nilsson, Klas Kellerborg et al. · Diabetes Therapy Open access	2 Dec 2020	36
40	Mechanistic Modeling of Antigen Sink Effect for Mavrilimumab Following Intravenous Administration in Patients With Rheumatoid Arthritis Bing Wang, Yvonne Y. Lau, Meina Liang et al. · The Journal of Clinical Pharmacology	24 Sep 2011	36
41	Enhanced immunogenicity of a recombinant genital warts vaccine adjuvanted with monophosphoryl lipid A H. Thompson, Matt Davies, Matt Watts et al. · Vaccine	Dec 1998	35
42	Fifty-year old samples of progesterone demonstrate the complex role of synthetic impurities in stabilizing a metastable polymorph Robert W. Lancaster, Lisa D. Harris, David Pearson · CrystEngComm	2011	34
43	A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia Britta Julia Vormoor et al. · Pediatric Blood & Cancer Open access	Dec 2016	33
44	Ionic co-crystals of racetams: solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg2+ and Ca2+ chlorides Fabrizia Grepioni, Johan Wouters, Dario Braga et al. · CrystEngComm	2014	33
45	Two putative African swine fever virus helicases similar to yeast ‘DEAH’ pre-mRNA processing proteins and vaccinia virus ATPases D11L and D6R Rafael J. Yáñez‐Muñoz, Javier María Rodríguez, M. E. G. Boursnell et al. · Gene	Dec 1993	32
46	Influence of different spacer arms on Mimetic Ligand™ A2P and B14 membranes for human IgG purification Cristiana Boi, Simone Dimartino, Stefan Hofer et al. · Journal of Chromatography B	15 Apr 2011	31
47	Controlled-release indomethacin and sustained-release diclofenac sodium in the treatment of osteoarthritis: A comparative controlled clinical trial in general practice N. K. Gostick, I. G. V. James, Teck K Khong et al. · Current Medical Research and Opinion	1990	30
48	Application of reversible amide-bond protection to suppress peptide segment epimerisation John Offer, Tony Johnson, Martin Quibell · Tetrahedron Letters	Dec 1997	29
49	Controlled-release indomethacin and sustained-release diclofenac sodium in the treatment of rheumatoid arthritis: A comparative controlled clinical trial B. Crowley, Joseph Hamill, Stuart Lyndon et al. · Current Medical Research and Opinion	1990	28
50	The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study J G Johnson, Miller Aj · Palliative Medicine	Apr 1994	27

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.