Most cited papers from National Epilepsy Center

National Epilepsy Center

What are the most cited papers from National Epilepsy Center?

The most cited paper from National Epilepsy Center is "Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study" (Jacqueline A. French, John A. Lawson, Zühal Yapıcı et al., 2016), with 770 citations. Next come "Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains" (522) and "Mutations in EFHC1 cause juvenile myoclonic epilepsy" (376).

Published TypeFieldAccessAuthorsCitations

Showing 50 of 61 papers. Every paper with more than 79 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study Jacqueline A. French, John A. Lawson, Zühal Yapıcı et al. · The Lancet Open access	7 Sep 2016	770
2	Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains Takashi Nonaka, Masami Masuda‐Suzukake, Tetsuaki Arai et al. · Cell Reports Open access	Jul 2013	522
3	Mutations in EFHC1 cause juvenile myoclonic epilepsy Toshimitsu Suzuki et al. · Nature Genetics	18 Jul 2004	376
4	Mutations of sodium channel alpha subunit type 1 (SCN1A) in intractable childhood epilepsies with frequent generalized tonic-clonic seizures Tateki Fujiwara · Brain	3 Feb 2003	348
5	Clinical heterogeneity of α‐synuclein gene duplication in Parkinson's disease Kenya Nishioka, Shin Hayashi, Matthew James Farrer et al. · Annals of Neurology	15 Dec 2005	316
6	Multi‐institutional Study on the Teratogenicity and Fetal Toxicity of Antiepileptic Drugs: A Report of a Collaborative Study Group in Japan Yoshibumi Nakane et al. · Epilepsia	Dec 1980	305
7	Genetic Variants Associated With Phenytoin-Related Severe Cutaneous Adverse Reactions Wen‐Hung Chung et al. · JAMA	5 Aug 2014	297
8	TuberOus SClerosis registry to increase disease Awareness (TOSCA) – baseline data on 2093 patients John Christopher Kingswood et al. · Orphanet Journal of Rare Diseases Open access	5 Jan 2017	290
9	Zonisamide blocks T-type calcium channel in cultured neurons of rat cerebral cortex Setsuo Suzuki, Kaori Kawakami, Shigeko Nishimura et al. · Epilepsy Research	Jun 1992	269
10	Comparative Analyses of Copy-Number Variation in Autism Spectrum Disorder and Schizophrenia Reveal Etiological Overlap and Biological Insights Itaru Kushima et al. · Cell Reports Open access	Sep 2018	265
11	Epilepsy in tuberous sclerosis complex: Findings from the TOSCA Study Rima Nabbout et al. · Epilepsia Open Open access	15 Nov 2018	247
12	HLA‐B1511 is a risk factor for carbamazepine‐induced Stevens‐Johnson syndrome and toxic epidermal necrolysis in Japanese patients Nahoko Kaniwa, Yoshiro Saito, Michiko Aihara et al. · Epilepsia* Open access	3 Nov 2010	229
13	GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture Remi Stevelink et al. · Nature Genetics ReviewOpen access319 authors	31 Aug 2023	226
14	Ambroxol chaperone therapy for neuronopathic Gaucher disease: A pilot study Aya Narita et al. · Annals of Clinical and Translational Neurology Open access	2 Feb 2016	215
15	A Nonsense Mutation of the Sodium Channel GeneSCN2Ain a Patient with Intractable Epilepsy and Mental Decline Kazusaku Kamiya, Makoto Kaneda, Takashi Sugawara et al. · Journal of Neuroscience Open access	17 Mar 2004	196
16	TSC-associated neuropsychiatric disorders (TAND): findings from the TOSCA natural history study Petrus J. de Vries et al. · Orphanet Journal of Rare Diseases Open access	10 Sep 2018	194
17	A whole-genome association study of major determinants for allopurinol-related Stevens–Johnson syndrome and toxic epidermal necrolysis in Japanese patients Masahiro Tohkin, Nahoko Kaniwa, Yoshiro Saito et al. · The Pharmacogenomics Journal	13 Sep 2011	186
18	Mass spectrometric analysis of accumulated TDP-43 in amyotrophic lateral sclerosis brains Fuyuki Kametani, Tomokazu Obi, Takeo Shishido et al. · Scientific Reports Open access	16 Mar 2016	179
19	How to record high‐frequency oscillations in epilepsy: A practical guideline Maeike Zijlmans, Gregory A. Worrell, Matthias Dümpelmann et al. · Epilepsia Open access	16 Jun 2017	173
20	Increased Synchronization of Cortical Oscillatory Activities between Human Supplementary Motor and Primary Sensorimotor Areas during Voluntary Movements Shinji Ohara, Tatsuya Mima, Koichi Baba et al. · Journal of Neuroscience Open access	Dec 2001	168
21	PNES around the world: Where we are now and how we can close the diagnosis and treatment gaps—an ILAE PNES Task Force report Kousuke Kanemoto, William Curt LaFrance Jr, Roderick D. Duncan et al. · Epilepsia Open Open access	9 May 2017	166
22	Efficacy, safety, and tolerability of lacosamide monotherapy versus controlled-release carbamazepine in patients with newly diagnosed epilepsy: a phase 3, randomised, double-blind, non-inferiority trial Michel Baulac, Felix Rosenow, Manuel Toledo et al. · The Lancet Neurology	23 Nov 2016	165
23	Ring chromosome 20 and nonconvulsive status epilepticus. A new epileptic syndrome Yushi Inoue · Brain	Jun 1997	162
24	Intrathecal overproduction of proinflammatory cytokines and chemokines in febrile infection-related refractory status epilepticus Hiroshi Sakuma, Naoyuki Tanuma, Ichiro Kuki et al. · Journal of Neurology Neurosurgery & Psychiatry	14 Nov 2014	161
25	HLA Class I markers in Japanese patients with carbamazepine‐induced cutaneous adverse reactions Hiroko Ikeda, Yukitoshi Takahashi, Etsuko Yamazaki et al. · Epilepsia	19 Aug 2009	145
26	Standardized computer-based organized reporting of EEG: SCORE – Second version Sándor Beniczky et al. · Clinical Neurophysiology Open access	9 Aug 2017	139
27	A Kv4.2 truncation mutation in a patient with temporal lobe epilepsy B. P. Singh, Ikuo Ogiwara, Makoto Kaneda et al. · Neurobiology of Disease Open access	25 Aug 2006	136
28	Expanding the clinical phenotype of SNCA duplication carriers Kenya Nishioka, Owen A. Ross, Kenji Ishii et al. · Movement Disorders	26 Jun 2009	134
29	Acute encephalitis with refractory, repetitive partial seizures (AERRPS): a peculiar form of childhood encephalitis Hiroshi Sakuma, Yutaka Awaya, Masashi Shiomi et al. · Acta Neurologica Scandinavica	17 Dec 2009	126
30	Outcome of vagus nerve stimulation for drug‐resistant epilepsy: the first three years of a prospective Japanese registry Kensuke Kawai, Tatsuya Tanaka, Hiroshi Baba et al. · Epileptic Disorders	Sep 2017	123
31	Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice Ikuo Ogiwara, Hiroyuki Miyamoto, Tetsuya Tatsukawa et al. · Communications Biology Open access	13 Jul 2018	122
32	Adjunctive everolimus for children and adolescents with treatment-refractory seizures associated with tuberous sclerosis complex: post-hoc analysis of the phase 3 EXIST-3 trial Paolo Curatolo, David Neal Franz, John A. Lawson et al. · The Lancet Child & Adolescent Health	24 May 2018	119
33	Comprehensive multi-omic profiling of somatic mutations in malformations of cortical development Changuk Chung et al. · Nature Genetics Open access205 authors	12 Jan 2023	118
34	Elfn1 recruits presynaptic mGluR7 in trans and its loss results in seizures Naoko Hara Tomioka, Hiroki Yasuda, Hiroyuki Miyamoto et al. · Nature Communications Open access	22 Jul 2014	118
35	STXBP1 mutations cause not only Ohtahara syndrome but also West syndrome—Result of Japanese cohort study Motoko Otsuka, Hirokazu Oguni, Jao‐Shwann Liang et al. · Epilepsia Open access	3 Nov 2010	117
36	Renal angiomyolipoma in patients with tuberous sclerosis complex: findings from the TuberOus SClerosis registry to increase disease Awareness John Christopher Kingswood et al. · Nephrology Dialysis Transplantation Open access	8 Mar 2018	115
37	Stiripentol open study in Japanese patients with Dravet syndrome Yushi Inoue, Yoko Ohtsuka, Hirokazu Oguni et al. · Epilepsia Open access	22 Jun 2009	114
38	Rapid amygdala gamma oscillations in response to fearful facial expressions Wataru Sato, Takanori Kochiyama, Shota Uono et al. · Neuropsychologia Open access	22 Dec 2010	114
39	Clinicogenetic study of mutations in LRRK2 exon 41 in Parkinson's disease patients from 18 countries Hiroyuki Tomiyama et al. · Movement Disorders Open access	18 Apr 2006	112
40	In vivo mitochondrial and glycolytic impairments in patients with Alzheimer disease Tatsuhiro Terada, Tomokazu Obi, Tomoyasu Bunai et al. · Neurology	6 Mar 2020	111
41	Everolimus for treatment-refractory seizures in TSC David Neal Franz et al. · Neurology Clinical Practice Open access118 authors	Oct 2018	111
42	Independent strong association of HLA-A02:06 and HLA-B44:03 with cold medicine-related Stevens-Johnson syndrome with severe mucosal involvement Mayumi Ueta, Nahoko Kaniwa, Chie Sotozono et al. · Scientific Reports Open access	30 Apr 2014	100
43	Vitamin B 6 –responsive epilepsy due to inherited GPI deficiency Ichiro Kuki, Yukitoshi Takahashi, Shin Okazaki et al. · Neurology	19 Sep 2013	99
44	Surgical Versus Medical Treatment for Epilepsy. I. Outcome Related to Survival, Seizures, and Neurologic Deficit B Guldvog, Yngve Løyning, Eivinn Hauglie-Hanssen et al. · Epilepsia	Jun 1991	97
45	Long-term developmental outcome after early hemispherotomy for hemimegalencephaly in infants with epileptic encephalopathy Ryoko Honda, Takanobu Kaido, Kenji Sugai et al. · Epilepsy & Behavior	7 Aug 2013	93
46	A homozygous mutation of voltage‐gated sodium channel β I gene SCN1B in a patient with Dravet syndrome Ikuo Ogiwara, Tojo Nakayama, Tetsushi Yamagata et al. · Epilepsia	13 Nov 2012	93
47	Mutational analysis ofCACNA1Gin idiopathic generalized epilepsy B. P. Singh, Arnaud Monteil, Isabelle Bidaud et al. · Human Mutation Open access	30 Mar 2007	92
48	Bilateral periventricular nodular heterotopia due to filamin 1 gene mutation: widespread glomeruloid microvascular anomaly and dysplastic cytoarchitecture in the cerebral cortex Akiyoshi Kakita, Shintaro Hayashi, Francesca Moro et al. · Acta Neuropathologica	Dec 2002	90
49	Autoantibodies and Cell‐mediated Autoimmunity to NMDA‐type GluRɛ2 in Patients with Rasmussen's Encephalitis and Chronic Progressive Epilepsia Partialis Continua Yukitoshi Takahashi, Hisashi Mori, Masayoshi Mishina et al. · Epilepsia	29 Jun 2005	90
50	Epilepsy in the Elderly Toshio Hiyoshi, Kazuichi Yagi · Epilepsia Open access	Sep 2000	89

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.