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Genetic studies of body mass index yield new insights for obesity biology
The LifeLines Cohort Study et al. · Nature
Open access487 authors |
10 Feb 2015 |
4,954 |
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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
European Alzheimer's Disease Initiative (EADI) et al. · Nature Genetics
ReviewOpen access184 authors |
27 Oct 2013 |
4,711 |
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Biological, clinical and population relevance of 95 loci for blood lipids
Tanya M. Teslovich et al. · Nature
Open access209 authors |
Aug 2010 |
3,706 |
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Discovery and refinement of loci associated with lipid levels
Cristen J. Willer et al. · Nature Genetics
Open access259 authors |
6 Oct 2013 |
3,319 |
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Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Brian W. Kunkle et al. · Nature Genetics
ReviewOpen access469 authors |
28 Feb 2019 |
3,277 |
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Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
MAGIC et al. · Nature Genetics
Open access376 authors |
10 Oct 2010 |
2,999 |
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New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC☆
Hans F. A. Vasen, Peter Hamilton Watson, Jukka‐Pekka Mecklin et al. · Gastroenterology
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Jun 1999 |
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Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials
Naveed A. Sattar et al. · The Lancet
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Feb 2010 |
2,471 |
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Defining the role of common variation in the genomic and biological architecture of adult human height
Andrew R. Wood et al. · Nature Genetics
446 authors |
5 Oct 2014 |
2,114 |
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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease
the Alzheimer's Disease Neuroimaging Initiative et al. · Nature Genetics
Open access173 authors |
3 Apr 2011 |
2,100 |
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Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Georg Ehret et al. · Nature
Open access346 authors |
9 Sep 2011 |
2,085 |
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Hundreds of variants clustered in genomic loci and biological pathways affect human height
Hana Lango Allen et al. · Nature
Open access293 authors |
29 Sep 2010 |
2,063 |
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Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Andrew Paul Morris et al. · Nature Genetics
Open access204 authors |
12 Aug 2012 |
2,021 |
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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Cardiogenics et al. · Nature Genetics
Open access167 authors |
6 Mar 2011 |
1,959 |
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Systematic identification of trans eQTLs as putative drivers of known disease associations
Harm-Jan Westra et al. · Nature Genetics
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8 Sep 2013 |
1,800 |
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New genetic loci link adipose and insulin biology to body fat distribution
Dmitry Shungin et al. · Nature
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10 Feb 2015 |
1,726 |
| 17 |
Common genetic determinants of vitamin D insufficiency: a genome-wide association study
Thomas J. Wang et al. · The Lancet
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11 Jun 2010 |
1,552 |
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Projections on the number of individuals with atrial fibrillation in the European Union, from 2000 to 2060
B. P. Krijthe, Anton Eduard Kunst, Emelia J. Benjamin et al. · European Heart Journal
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30 Jul 2013 |
1,452 |
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Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
Valentina Escott‐Price et al. · PLoS ONE
Open access188 authors |
12 Jun 2014 |
1,408 |
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Genome-wide association study of blood pressure and hypertension
Daniel Levy et al. · Nature Genetics
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10 May 2009 |
1,397 |
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Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans
Jennifer E. Huffman et al. · PLoS ONE
Open access120 authors |
26 Mar 2015 |
1,233 |
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Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Karol Estrada et al. · Nature Genetics
Open access180 authors |
15 Apr 2012 |
1,223 |
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Subclinical Hypothyroidism and the Risk of Coronary Heart Disease and Mortality
Nicolas Rodondi et al. · JAMA
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21 Sep 2010 |
1,222 |
| 24 |
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Helena Furberg et al. · Nature Genetics
Open access116 authors |
25 Apr 2010 |
1,169 |
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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Rebecca C. Sims et al. · Nature Genetics
Open access450 authors |
17 Jul 2017 |
1,122 |
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Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Anubha Mahajan et al. · Nature Genetics
Open access332 authors |
9 Feb 2014 |
1,085 |
| 27 |
Identification of seven loci affecting mean telomere length and their association with disease
Veryan Codd et al. · Nature Genetics
Open access |
27 Mar 2013 |
973 |
| 28 |
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
MAGIC et al. · Nature Genetics
301 authors |
10 Oct 2010 |
965 |
| 29 |
Common variants associated with plasma triglycerides and risk for coronary artery disease
Ron Do et al. · Nature Genetics
Open access263 authors |
6 Oct 2013 |
912 |
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Simple Risk Model Predicts Incidence of Atrial Fibrillation in a Racially and Geographically Diverse Population: the CHARGE‐AF Consortium
Álvaro Alonso et al. · Journal of the American Heart Association
Open access |
12 Mar 2013 |
902 |
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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Alisa K Manning et al. · Nature Genetics
Open access216 authors |
13 May 2012 |
894 |
| 32 |
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
LifeLines Cohort Study et al. · Nature Genetics
Open access226 authors |
21 Dec 2012 |
893 |
| 33 |
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Robert A. Scott et al. · Nature Genetics
Open access214 authors |
12 Aug 2012 |
859 |
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An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
Robert A. Scott et al. · Diabetes
Open access175 authors |
31 May 2017 |
830 |
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Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis
Hans F. A. Vasen, JT Wijnen, FH Menko et al. · Gastroenterology
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Apr 1996 |
824 |
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New loci associated with kidney function and chronic kidney disease
Anna Köttgen et al. · Nature Genetics
Open access132 authors |
11 Apr 2010 |
818 |
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Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies
Fernando Rivadeneira et al. · Nature Genetics
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4 Oct 2009 |
710 |
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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Thomas W. Winkler et al. · PLoS Genetics
Open access439 authors |
Oct 2015 |
699 |
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Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Sonja I. Berndt et al. · Nature Genetics
Open access322 authors |
7 Apr 2013 |
688 |
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Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
Australian Ovarian Cancer Study et al. · Nature
Open access202 authors |
23 Jul 2014 |
667 |
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Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population
Carolina H. Y. Ling, Anton J.M. de Craen, Pieternella E. Slagboom et al. · Clinical Nutrition
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10 May 2011 |
666 |
| 42 |
Multiple loci associated with indices of renal function and chronic kidney disease
Anna Köttgen et al. · Nature Genetics
Open access |
10 May 2009 |
666 |
| 43 |
Identification of common variants associated with human hippocampal and intracranial volumes
the Alzheimer's Disease Neuroimaging Initiative (ADNI) et al. · Nature Genetics
Open access204 authors |
15 Apr 2012 |
662 |
| 44 |
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
Dana B. Hancock et al. · Nature Genetics
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13 Dec 2009 |
645 |
| 45 |
Whole‐genome sequencing identifies EN1 as a determinant of bone density and fracture
Hou‐Feng Zheng et al. · Nature
Open access155 authors |
14 Sep 2015 |
639 |
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Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old
Diana G. Taekema, Jacobijn Gussekloo, Andrea Britta Maier et al. · Age and Ageing
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10 Mar 2010 |
638 |
| 47 |
Meta-analysis identifies six new susceptibility loci for atrial fibrillation
Patrick T. Ellinor et al. · Nature Genetics
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29 Apr 2012 |
612 |
| 48 |
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
John Campbell Chambers et al. · Nature Genetics
Open access137 authors |
16 Oct 2011 |
601 |
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The risk of extra‐colonic, extra‐endometrial cancer in the Lynch syndrome
Patrice A. Watson, Hans F. A. Vasen, Jukka‐Pekka Mecklin et al. · International Journal of Cancer
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8 Apr 2008 |
597 |
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Physical Activity Attenuates the Influence of FTO Variants on Obesity Risk: A Meta-Analysis of 218,166 Adults and 19,268 Children
Tuomas O. Kilpeläinen et al. · PLoS Medicine
ReviewOpen access116 authors |
Nov 2011 |
571 |