| 1 |
An integrated map of genetic variation from 1,092 human genomes
Gil A. McVean et al. · Nature
Open access363 authors |
31 Oct 2012 |
8,281 |
| 2 |
Genetic studies of body mass index yield new insights for obesity biology
The LifeLines Cohort Study et al. · Nature
Open access487 authors |
10 Feb 2015 |
4,954 |
| 3 |
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
MAGIC et al. · Nature Genetics
Open access376 authors |
10 Oct 2010 |
2,999 |
| 4 |
Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research
Andrew I.R. Maas et al. · The Lancet Neurology
Open access335 authors |
6 Nov 2017 |
2,659 |
| 5 |
Genomic atlas of the human plasma proteome
Benjamin B. Sun et al. · Nature
Open access |
29 May 2018 |
2,496 |
| 6 |
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
Urmo Võsa et al. · Nature Genetics
Open access114 authors |
Sep 2021 |
2,339 |
| 7 |
Defining the role of common variation in the genomic and biological architecture of adult human height
Andrew R. Wood et al. · Nature Genetics
446 authors |
5 Oct 2014 |
2,114 |
| 8 |
Hundreds of variants clustered in genomic loci and biological pathways affect human height
Hana Lango Allen et al. · Nature
Open access293 authors |
29 Sep 2010 |
2,063 |
| 9 |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Cardiogenics et al. · Nature Genetics
Open access167 authors |
6 Mar 2011 |
1,959 |
| 10 |
Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B
Amit C. Nathwani et al. · New England Journal of Medicine
Open access |
10 Dec 2011 |
1,875 |
| 11 |
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
Sadia Saeed et al. · Science
Open access |
25 Sep 2014 |
1,805 |
| 12 |
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Cristen J. Willer et al. · Nature Genetics
Open access145 authors |
14 Dec 2008 |
1,733 |
| 13 |
Large-scale association analysis identifies new risk loci for coronary artery disease
Panos Deloukas et al. · Nature Genetics
Open access183 authors |
2 Dec 2012 |
1,681 |
| 14 |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease
William John Astle et al. · Cell
Open access |
Nov 2016 |
1,429 |
| 15 |
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
Paul Robert Burton et al. · Nature Genetics
Open access215 authors |
21 Oct 2007 |
1,386 |
| 16 |
A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes
Daniel G. MacArthur et al. · Science
Open access |
16 Feb 2012 |
1,353 |
| 17 |
Common variants near MC4R are associated with fat mass, weight and risk of obesity
The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial et al. · Nature Genetics
Open access107 authors |
4 May 2008 |
1,349 |
| 18 |
Long-Term Safety and Efficacy of Factor IX Gene Therapy in Hemophilia B
Amit Chunilal Nathwani et al. · New England Journal of Medicine
Open access |
20 Nov 2014 |
1,276 |
| 19 |
Drug-Resistant E. coli Bacteremia Transmitted by Fecal Microbiota Transplant
Zachariah Michael DeFilipp, Patricia Pringle Bloom, Mariam Torres Soto et al. · New England Journal of Medicine
Open access |
30 Oct 2019 |
1,250 |
| 20 |
Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion
Jeffrey L. Carson, Simon J. Stanworth, Nareg H. Roubinian et al. · Cochrane Database of Systematic Reviews
Open access |
12 Oct 2016 |
1,227 |
| 21 |
Altered TMPRSS2 usage by SARS-CoV-2 Omicron impacts infectivity and fusogenicity
Bo Meng et al. · Nature
Open access222 authors |
Feb 2022 |
1,189 |
| 22 |
A COMPARISON OF TACROLIMUS (FK506) AND CYCLOSPORINE FOR IMMUNOSUPPRESSION AFTER CADAVERIC RENAL TRANSPLANTATION1
John D. Pirsch, Joshua Miller, Mark H. Deierhoi et al. · Transplantation
|
Apr 1997 |
1,141 |
| 23 |
Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion
C. A. Llewelyn, P. B Hewitt, RSG Knight et al. · The Lancet
|
Feb 2004 |
1,130 |
| 24 |
SARS-CoV-2 evolution during treatment of chronic infection
Steven A. Kemp et al. · Nature
Open access1,134 authors |
5 Feb 2021 |
1,091 |
| 25 |
Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts
Karani Santhanakrishnan Vimaleswaran et al. · PLoS Medicine
Open access |
5 Feb 2013 |
1,069 |
| 26 |
RISK FACTORS FOR PRIMARY DYSFUNCTION AFTER LIVER TRANSPLANTATION—A MULTIVARIATE ANALYSIS
Rutger J. Ploeg, Anthony M. D’Alessandro, Stuart J. Knechtle et al. · Transplantation
|
Apr 1993 |
1,049 |
| 27 |
Multipotent adult progenitor cells from bone marrow differentiate into functional hepatocyte-like cells
Robert E. Schwartz, Morayma Reyes, Lisa Koodie et al. · Journal of Clinical Investigation
Open access |
15 May 2002 |
1,034 |
| 28 |
Impact of Healthy Lifestyle Factors on Life Expectancies in the US Population
Yanping Li, An Pan, Dong D. Wang et al. · Circulation
Open access |
30 Apr 2018 |
985 |
| 29 |
A catalog of genetic loci associated with kidney function from analyses of a million individuals
Lifelines Cohort Study et al. · Nature Genetics
Open access329 authors |
31 May 2019 |
946 |
| 30 |
Effect of Hydrocortisone on Mortality and Organ Support in Patients With Severe COVID-19
Derek C. Angus et al. · JAMA
Open access |
2 Sep 2020 |
895 |
| 31 |
Graft-Versus-Host Disease in Children Who Have Received a Cord-Blood or Bone Marrow Transplant from an HLA-Identical Sibling
Vanderson Rocha, John E. Wagner, Kathleen A. Sobocinski et al. · New England Journal of Medicine
Open access |
22 Jun 2000 |
872 |
| 32 |
Genome-wide association analysis identifies 20 loci that influence adult height
Diabetes Genetics Initiative et al. · Nature Genetics
Open access |
6 Apr 2008 |
859 |
| 33 |
A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia
Konstantinos Tzelepis et al. · Cell Reports
Open access |
Oct 2016 |
858 |
| 34 |
Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls
Nick Craddock et al. · Nature
Open access217 authors |
30 Mar 2010 |
824 |
| 35 |
Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.
Lisa M. Colletti, Daniel George Remick, GORDON D. BURTCH et al. · Journal of Clinical Investigation
Open access |
Jun 1990 |
821 |
| 36 |
The Human Phenotype Ontology in 2017
Sebastian Köhler et al. · Nucleic Acids Research
Open access |
28 Nov 2016 |
819 |
| 37 |
Classification of low quality cells from single-cell RNA-seq data
Tomislav Ilicic, Jong Kyoung Kim, Aleksandra A. Kolodziejczyk et al. · Genome biology
Open access |
17 Feb 2016 |
810 |
| 38 |
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells
Lu Chen et al. · Cell
Open access |
Nov 2016 |
793 |
| 39 |
Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets
Jing Hua Zhao et al. · Nature Immunology
Open access |
10 Aug 2023 |
774 |
| 40 |
The Polygenic and Monogenic Basis of Blood Traits and Diseases
Dragana Vuckovic et al. · Cell
Open access112 authors |
Sep 2020 |
758 |
| 41 |
Trans-ethnic and Ancestry-Specific Blood-Cell Genetics in 746,667 Individuals from 5 Global Populations
Ming‐Huei Chen et al. · Cell
Open access110 authors |
Sep 2020 |
752 |
| 42 |
Mendelian randomization for cardiovascular diseases: principles and applications
Susanna C. Larsson, Adam S. Butterworth, Stephen Burgess · European Heart Journal
Open access |
18 Oct 2023 |
736 |
| 43 |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Sonja I. Berndt et al. · Nature Genetics
Open access322 authors |
7 Apr 2013 |
688 |
| 44 |
Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases
Jorge A. Marrero, Laura Kulik, Claude B. Sirlin et al. · Clinical Liver Disease
Open access |
2019 |
664 |
| 45 |
Common genetic variation drives molecular heterogeneity in human iPSCs
Helena Kilpinen et al. · Nature
Open access |
8 May 2017 |
659 |
| 46 |
Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis
Rajiv Chowdhury, Anna Ramond, Linda M. O’Keeffe et al. · BMJ
ReviewOpen access |
29 Aug 2018 |
644 |
| 47 |
Guidelines for the use of platelet transfusions
Lise J Estcourt, Janet E. Birchall, Shubha Allard et al. · British Journal of Haematology
Open access |
23 Dec 2016 |
644 |
| 48 |
A Validation Study of a Retrospective Venous Thromboembolism Risk Scoring Method
Vinita Bahl, Hsou Mei Hu, Peter K. Henke et al. · Annals of Surgery
|
21 Jan 2010 |
625 |
| 49 |
UK guidelines on the management of iron deficiency in pregnancy
Sue R. Pavord, Bethan Myers, Susan E. Robinson et al. · British Journal of Haematology
Open access |
16 Jan 2012 |
609 |
| 50 |
Post-Transplantation Cyclophosphamide-Based Graft-versus-Host Disease Prophylaxis
Javier Bolaños‐Meade et al. · New England Journal of Medicine
Open access |
21 Jun 2023 |
599 |