| 1 |
Analysis of shared heritability in common disorders of the brain
Verneri Anttila et al. · Science
Open access577 authors |
21 Jun 2018 |
2,056 |
| 2 |
The Bronchiectasis Severity Index. An International Derivation and Validation Study
James Duncan Chalmers, Pieter Goeminne, Stefano Aliberti et al. · American Journal of Respiratory and Critical Care Medicine
Open access |
Mar 2014 |
1,129 |
| 3 |
Systematic review of the long-term effects and economic consequences of treatments for obesity and implications for health improvement
Alison Avenell, John I Broom, Tamara J. Brown et al. · Health Technology Assessment
ReviewOpen access |
May 2004 |
1,040 |
| 4 |
Oral versus Intravenous Antibiotics for Bone and Joint Infection
Ho Kwong Li et al. · New England Journal of Medicine
Open access |
30 Jan 2019 |
945 |
| 5 |
The rising tide of polypharmacy and drug-drug interactions: population database analysis 1995–2010
Bruce Guthrie, Boikanyo Makubate, Virginia Hernandez Santiago et al. · BMC Medicine
Open access |
7 Apr 2015 |
870 |
| 6 |
Hospital mortality in relation to staff workload: a 4-year study in an adult intensive-care unit
W. Tarnow-Mordi, Cynthia Hau, A. Warden et al. · The Lancet
|
Jul 2000 |
741 |
| 7 |
Evidence for 28 genetic disorders discovered by combining healthcare and research data
Joanna Kaplanis et al. · Nature
Open access282 authors |
14 Oct 2020 |
698 |
| 8 |
ESPEN endorsed recommendations. Definition and classification of intestinal failure in adults
Loris Pironi et al. · Clinical Nutrition
Open access |
21 Sep 2014 |
684 |
| 9 |
Gait Analysis — An Introduction
David Condie · International Journal of Rehabilitation Research
|
Jun 1992 |
658 |
| 10 |
Process evaluations for cluster-randomised trials of complex interventions: a proposed framework for design and reporting
Aileen M Grant, Shaun P. Treweek, Tobias Dreischulte et al. · Trials
Open access |
2013 |
597 |
| 11 |
Subcallosal cingulate deep brain stimulation for treatment-resistant depression: a multisite, randomised, sham-controlled trial
Paul E. Holtzheimer et al. · The Lancet Psychiatry
Open access |
10 Oct 2017 |
576 |
| 12 |
Frequency of Severe Hypoglycemia Requiring Emergency Treatment in Type 1 and Type 2 Diabetes
Graham Leese, Jixian Wang, Janice Broomhall et al. · Diabetes Care
|
Apr 2003 |
566 |
| 13 |
Risk factors for delayed presentation and referral of symptomatic cancer: evidence for common cancers
Una Macleod, Elizabeth Mitchell, Caroline C. Burgess et al. · British Journal of Cancer
Open access |
Dec 2009 |
540 |
| 14 |
What Is eHealth (4): A Scoping Exercise to Map the Field
Claudia Pagliari, DAVID A. SLOAN, Peter Gregor et al. · Journal of Medical Internet Research
Open access |
31 Mar 2005 |
490 |
| 15 |
Postsplenectomy sepsis and its mortality rate: Actual versus perceived risks
R J Holdsworth, Andy Irving, A. Cuschieri · British journal of surgery
|
Sep 1991 |
481 |
| 16 |
Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort
Joseph D. Symonds et al. · Brain
Open access |
12 Jun 2019 |
470 |
| 17 |
The partitioning of nitrate assimilation between root and shoot of higher plants
M. Andrews · Plant Cell & Environment
|
Sep 1986 |
462 |
| 18 |
Adherence to prescribed oral hypoglycaemic medication in a population of patients with Type 2 diabetes: a retrospective cohort study
Peter T. Donnan, Thomas MacLennan MacDonald, Andrew D. Morris · Diabetic Medicine
|
Apr 2002 |
440 |
| 19 |
Strategies to improve recruitment to randomised controlled trials
Shaun P. Treweek, Elizabeth Mitchell, Marie Pitkethly et al. · Cochrane Database of Systematic Reviews
Open access |
13 Apr 2010 |
381 |
| 20 |
ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells
Aparajitha Vaidyanathan, Lynne Sawers, Anne‐Louise Gannon et al. · British Journal of Cancer
Open access |
14 Jul 2016 |
379 |
| 21 |
18F-Fluorodeoxyglucose Positron Emission Tomography to Evaluate Cervical Node Metastases in Patients With Head and Neck Squamous Cell Carcinoma: A Meta-analysis
P. Kyzas, Evangelos Evangelou, Despina Denaxa-Kyza et al. · JNCI Journal of the National Cancer Institute
Review |
13 May 2008 |
364 |
| 22 |
Trial Forge Guidance 1: what is a Study Within A Trial (SWAT)?
Shaun P. Treweek et al. · Trials
Open access |
23 Feb 2018 |
354 |
| 23 |
Severity assessment tools for predicting mortality in hospitalised patients with community-acquired pneumonia. Systematic review and meta-analysis
James Duncan Chalmers, Aran Singanayagam, Ahsan R. Akram et al. · Thorax
ReviewOpen access |
20 Aug 2010 |
347 |
| 24 |
Living and dying with severe chronic obstructive pulmonary disease: multi-perspective longitudinal qualitative study
Hilary Pinnock, Marilyn Kendall, Scott A Murray et al. · BMJ
Open access |
24 Jan 2011 |
341 |
| 25 |
European Maxillofacial Trauma (EURMAT) project: A multicentre and prospective study
Paolo Boffano et al. · Journal of Cranio-Maxillofacial Surgery
|
22 Oct 2014 |
335 |
| 26 |
Antibody to Saccharomyces cerevisiae (bakers' yeast) in Crohn's disease.
Janice Main, Harold C. McKenzie, Grant R. Yeaman et al. · BMJ
Open access |
29 Oct 1988 |
335 |
| 27 |
Etiology of Non–Cystic Fibrosis Bronchiectasis in Adults and Its Correlation to Disease Severity
Sara Lonni, James Duncan Chalmers, Pieter Goeminne et al. · Annals of the American Thoracic Society
Open access |
2 Oct 2015 |
328 |
| 28 |
International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways
Heather Jane Cordell et al. · Nature Communications
Open access462 authors |
22 Sep 2015 |
313 |
| 29 |
Depth Penetration of Light into Skin as a Function of Wavelength from 200 to 1000 nm
Louise Finlayson, Isla R. M. Barnard, Lewis McMillan et al. · Photochemistry and Photobiology
Open access |
26 Oct 2021 |
307 |
| 30 |
A randomised controlled trial evaluating the use of enteral nutritional supplements postoperatively in malnourished surgical patients
A Beattie, A T Prach, J P Baxter et al. · Gut
Open access |
Jun 2000 |
300 |
| 31 |
Increased Hospital-Based Physical Rehabilitation and Information Provision After Intensive Care Unit Discharge
Timothy Simon Walsh, Lisa Salisbury, Judith L. Merriweather et al. · JAMA Internal Medicine
Open access |
13 Apr 2015 |
299 |
| 32 |
Parafoveal-on-foveal effects in normal reading
Alan Kennedy, Joël Pynte · Vision Research
Open access |
10 Dec 2004 |
296 |
| 33 |
Longitudinal Serological Analysis and Neutralizing Antibody Levels in Coronavirus Disease 2019 Convalescent Patients
Frauke Muecksch, Helen M. Wise, Becky Batchelor et al. · The Journal of Infectious Diseases
Open access |
15 Oct 2020 |
295 |
| 34 |
Management of bronchiectasis in adults
James Duncan Chalmers, Stefano Aliberti, Francesco Blasi · European Respiratory Journal
|
18 Mar 2015 |
290 |
| 35 |
The phenotypic spectrum of SCN8A encephalopathy
Jan Larsen et al. · Neurology
Open access |
8 Jan 2015 |
289 |
| 36 |
Continuity of care matters
Bruce Guthrie, John W. Saultz, George K Freeman et al. · BMJ
|
7 Aug 2008 |
285 |
| 37 |
Clinical phenotypes in adult patients with bronchiectasis
Stefano Aliberti, Sara Lonni, Simone Dore et al. · European Respiratory Journal
Open access |
4 Feb 2016 |
278 |
| 38 |
ALA and Photofrin® Fluorescence-guided resection and repetitive PDT in glioblastoma multiforme: a single centre Phase III randomised controlled trial
Sam Eljamel, Carol Goodman, Harry H. Moseley · Lasers in Medical Science
|
9 Oct 2007 |
275 |
| 39 |
Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis
Toshifumi Nomura, Aileen Sandilands, Masashi Akiyama et al. · Journal of Allergy and Clinical Immunology
Open access |
Feb 2007 |
273 |
| 40 |
Reduced protection against exercise induced bronchoconstriction after chronic dosing with salmeterol
Lynn Ramage, Brian Jonathon Lipworth, Cambell Ingram et al. · Respiratory Medicine
Open access |
May 1994 |
272 |
| 41 |
Burnout in psychiatric nursing
Catherine Kilfedder, Kevin G. Power, Tony J. Wells · Journal of Advanced Nursing
|
9 May 2001 |
271 |
| 42 |
Early childhood epilepsies: epidemiology, classification, aetiology, and socio-economic determinants
Joseph D. Symonds et al. · Brain
Open access |
21 Apr 2021 |
266 |
| 43 |
Echocardiography in chronic heart failure in the community
N.M. WHEELDON, Thomas MacLennan MacDonald, C.J. FLUCKER et al. · QJM
|
1993 |
265 |
| 44 |
The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults
Fiona McGill, Robert S. Heyderman, Benedict Daniel Michael et al. · Journal of Infection
Open access |
2 Feb 2016 |
257 |
| 45 |
“Seeing is believing, and believing is seeing”: An exploration of the meaning and impact of women's mental images of their breast cancer and their potential origins
Alison Harrow, Mary Ellen Wells, Gerry M. Humphris et al. · Patient Education and Counseling
|
23 Aug 2008 |
253 |
| 46 |
A comprehensive assessment of memory, delay aversion, timing, inhibition, decision making and variability in attention deficit hyperactivity disorder: advancing beyond the three-pathway models
David Coghill, Sarah Seth, Keith Matthews · Psychological Medicine
|
31 Oct 2013 |
249 |
| 47 |
Whole-genome sequencing of a sporadic primary immunodeficiency cohort
James E. D. Thaventhiran et al. · Nature
Open access635 authors |
6 May 2020 |
245 |
| 48 |
Effects of Weight Loss in Overweight/Obese Individuals and Long-Term Hypertension Outcomes
Lorna S. Aucott, Amudha S. Poobalan, William Cairns Smith et al. · Hypertension
|
17 May 2005 |
242 |
| 49 |
GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19
Erola Pairo‐Castineira et al. · Nature
Open access2,642 authors |
17 May 2023 |
233 |
| 50 |
A Randomized Trial Directly Comparing Ventral Capsule and Anteromedial Subthalamic Nucleus Stimulation in Obsessive-Compulsive Disorder: Clinical and Imaging Evidence for Dissociable Effects
Himanshu Ravindra Tyagi, Annemieke M. Apergis-Schoute, Harith Akram et al. · Biological Psychiatry
Open access |
30 Jan 2019 |
233 |