| 1 |
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)
Mervyn Singer, Clifford Scott Deutschman, Christopher W. Seymour et al. · JAMA
Open access |
22 Feb 2016 |
29,012 |
| 2 |
The European Organization for Research and Treatment of Cancer QLQ-C30: A Quality-of-Life Instrument for Use in International Clinical Trials in Oncology
N.K. Aaronson, Sam Hjelmeland Ahmedzai, Bengt Bergman et al. · JNCI Journal of the National Cancer Institute
|
3 Mar 1993 |
16,252 |
| 3 |
Adverse Renal Effects of Immune Checkpoint Inhibitors: A Narrative Review
Rimda Wanchoo, Sabine Karam, Nupur N. Uppal et al. · American Journal of Nephrology
ReviewOpen access |
2017 |
15,286 |
| 4 |
Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area
Safiya I. Richardson et al. · JAMA
Open access |
22 Apr 2020 |
9,915 |
| 5 |
Biological insights from 108 schizophrenia-associated genetic loci
Stephan Ripke et al. · Nature
Open access297 authors |
Jul 2014 |
8,181 |
| 6 |
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
Daniel R. Rosen et al. · Nature
|
Mar 1993 |
7,116 |
| 7 |
Development of criteria for the classification and reporting of osteoarthritis: Classification of osteoarthritis of the knee
Roy Davis Altman et al. · Arthritis & Rheumatism
|
Aug 1986 |
6,848 |
| 8 |
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky et al. · Autophagy
Open access2,467 authors |
2 Jan 2016 |
6,023 |
| 9 |
The SCARE 2020 Guideline: Updating Consensus Surgical CAse REport (SCARE) Guidelines
Riaz Agha et al. · International Journal of Surgery
Open access |
9 Nov 2020 |
5,605 |
| 10 |
Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus
Michelle Petri et al. · Arthritis & Rheumatism
Open access |
2 May 2012 |
5,385 |
| 11 |
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
George Adrian Calin, Calin Dan Dumitru, Masayoshi Shimizu et al. · Proceedings of the National Academy of Sciences
Open access |
14 Nov 2002 |
5,063 |
| 12 |
Guidelines for the Prevention of Intravascular Catheter-related Infections
Naomi P. O’Grady, Mary Alexander, Lillian A. Burns et al. · Clinical Infectious Diseases
Open access |
2 Apr 2011 |
4,713 |
| 13 |
Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
Lyudmila V. Borovikova, Svetlana Ivanova, Minghuang Zhang et al. · Nature
|
May 2000 |
4,235 |
| 14 |
Clozapine for the Treatment-Resistant Schizophrenic
John Michael Kane · Archives of General Psychiatry
|
Sep 1988 |
4,159 |
| 15 |
A framework for advancing our understanding of cancer-associated fibroblasts
Erik A. Sahai et al. · Nature reviews. Cancer
ReviewOpen access |
24 Jan 2020 |
3,962 |
| 16 |
Assessment of Clinical Criteria for Sepsis
Christopher W. Seymour, Vincent X. Liu, Theodore John Iwashyna et al. · JAMA
Open access |
22 Feb 2016 |
3,936 |
| 17 |
Age at onset of mental disorders worldwide: large-scale meta-analysis of 192 epidemiological studies
Marco Solmi, Joaquim Raduà, Miriam Olivola et al. · Molecular Psychiatry
ReviewOpen access |
2 Jun 2021 |
3,868 |
| 18 |
Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute–Working Group 1996 guidelines
Michael J. Hallek, Bruce D. Cheson, Daniel Catovsky et al. · Blood
Open access |
23 Jan 2008 |
3,806 |
| 19 |
Frequent Detection and Isolation of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and at Risk for AIDS
Robert C. Gallo, Syed Zaki Salahuddin, Mikuláš Popovič et al. · Science
|
4 May 1984 |
3,658 |
| 20 |
HMG-1 as a Late Mediator of Endotoxin Lethality in Mice
Haichao Wang, Ona Bloom, Minghuang Zhang et al. · Science
|
9 Jul 1999 |
3,422 |
| 21 |
The Treatment-Naive Microbiome in New-Onset Crohn’s Disease
Dirk Gevers et al. · Cell Host & Microbe
Open access |
Mar 2014 |
3,362 |
| 22 |
Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy
Lionel Apétoh et al. · Nature Medicine
|
19 Aug 2007 |
3,040 |
| 23 |
COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up
Behnood Bikdeli et al. · Journal of the American College of Cardiology
Open access |
17 Apr 2020 |
2,956 |
| 24 |
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
James J. Lee et al. · Nature Genetics
Open access |
20 Jul 2018 |
2,896 |
| 25 |
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Vassily Vladimirovich Trubetskoy et al. · Nature
Open access613 authors |
8 Apr 2022 |
2,894 |
| 26 |
Strong Association of De Novo Copy Number Mutations with Autism
Jonathan L. Sebat et al. · Science
Open access |
15 Mar 2007 |
2,862 |
| 27 |
Peginterferon-α2a and Ribavirin Combination Therapy in Chronic Hepatitis C
Stephanos J. Hadziyannis, Hoel Sette, Timothy R. Morgan et al. · Annals of Internal Medicine
|
2 Mar 2004 |
2,842 |
| 28 |
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Daniel J. Klionsky et al. · Autophagy
Open access2,930 authors |
2 Jan 2021 |
2,743 |
| 29 |
The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hip
Roy Davis Altman et al. · Arthritis & Rheumatism
|
May 1991 |
2,667 |
| 30 |
2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus
Martin Aringer et al. · Arthritis & Rheumatology
Open access |
6 Aug 2019 |
2,644 |
| 31 |
Ig V Gene Mutation Status and CD38 Expression As Novel Prognostic Indicators in Chronic Lymphocytic Leukemia
Rajendra N. Damle, Tarun Wasil, Franco Fais et al. · Blood
|
15 Sep 1999 |
2,607 |
| 32 |
The gut microbiota influences blood-brain barrier permeability in mice
Viorica Braniste, Maha Al‐Asmakh, Czeslawa Kowal et al. · Science Translational Medicine
Open access |
19 Nov 2014 |
2,520 |
| 33 |
Genetics of rheumatoid arthritis contributes to biology and drug discovery
Yukinori Okada et al. · Nature
Open access |
24 Dec 2013 |
2,501 |
| 34 |
Developing a New Definition and Assessing New Clinical Criteria for Septic Shock
Manu Shankar‐Hari, Gary S. Phillips, Mitchell L. Levy et al. · JAMA
Open access |
22 Feb 2016 |
2,439 |
| 35 |
Incorporation of Bevacizumab in the Primary Treatment of Ovarian Cancer
Robert Allen Burger, Mark F. Brady, Michael A. Bookman et al. · New England Journal of Medicine
Open access |
28 Dec 2011 |
2,422 |
| 36 |
Transplantation of Embryonic Dopamine Neurons for Severe Parkinson's Disease
Curt R. Freed, Paul E. Greene, Robert E. Breeze et al. · New England Journal of Medicine
Open access |
8 Mar 2001 |
2,381 |
| 37 |
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
S Hong Lee et al. · Nature Genetics
Open access370 authors |
11 Aug 2013 |
2,374 |
| 38 |
Epidemiology of Pancreatic Cancer: Global Trends, Etiology and Risk Factors
Prashanth Rawla, Tagore Sunkara, Vinaya V. Gaduputi · World Journal of Oncology
Open access |
2019 |
2,345 |
| 39 |
The SCARE 2018 statement: Updating consensus Surgical CAse REport (SCARE) guidelines
Riaz Agha et al. · International Journal of Surgery
Open access |
18 Oct 2018 |
2,340 |
| 40 |
Thyroid Hormone and the Cardiovascular System
Irwin L. Klein, Kaie Ojamaa · New England Journal of Medicine
|
15 Feb 2001 |
2,315 |
| 41 |
The Nature of the Principal Type 1 Interferon-Producing Cells in Human Blood
Frederick P. Siegal, Norimitsu Kadowaki, Michael Shodell et al. · Science
|
11 Jun 1999 |
2,286 |
| 42 |
STROCSS 2021: Strengthening the reporting of cohort, cross-sectional and case-control studies in surgery
Ginimol Mathew et al. · International Journal of Surgery
Open access |
10 Nov 2021 |
2,166 |
| 43 |
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Peter T. Nelson et al. · Journal of Neuropathology & Experimental Neurology
Open access |
6 Apr 2012 |
2,144 |
| 44 |
Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases
Salvatore L. Ruggiero, Bhoomi Mehrotra, Tracey J. Rosenberg et al. · Journal of Oral and Maxillofacial Surgery
|
23 Apr 2004 |
2,066 |
| 45 |
Screening for Colorectal Cancer
US Preventive Services Task Force, Karina W. Davidson, Michael J. Barry et al. · JAMA
Open access |
18 May 2021 |
2,051 |
| 46 |
Genome-wide association study identifies five new schizophrenia loci
Stephan Ripke et al. · Nature Genetics
Open access196 authors |
18 Sep 2011 |
1,966 |
| 47 |
How mental health care should change as a consequence of the COVID-19 pandemic
Carmen Moreno et al. · The Lancet Psychiatry
Open access |
16 Jul 2020 |
1,919 |
| 48 |
Entrainment of Neuronal Oscillations as a Mechanism of Attentional Selection
Peter Laszlo Lakatos, George Karmos, Ashesh D. Mehta et al. · Science
|
3 Apr 2008 |
1,837 |
| 49 |
Screening for Lung Cancer
US Preventive Services Task Force, Alex H. Krist, Karina W. Davidson et al. · JAMA
Open access |
9 Mar 2021 |
1,824 |
| 50 |
The Role of Mononuclear Phagocytes in HTLV-III/LAV Infection
Suzanne Gartner, Paul Markovits, David M. Markovitz et al. · Science
|
11 Jul 1986 |
1,822 |