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NOV03 for Dry Eye Disease Associated with Meibomian Gland Dysfunction
Joseph Tauber et al. · Ophthalmology
Open access |
24 Dec 2022 |
100 |
| 2 |
A Clinical Phase II Study to Assess Efficacy, Safety, and Tolerability of Waterfree Cyclosporine Formulation for Treatment of Dry Eye Disease
David Wirta, Gail L. Torkildsen, Helen R. Moreira et al. · Ophthalmology
Open access |
28 Jan 2019 |
86 |
| 3 |
Efficacy and Safety of a Water-Free Topical Cyclosporine, 0.1%, Solution for the Treatment of Moderate to Severe Dry Eye Disease
Esen K. Akpek, David Wirta, Johnathon Downing et al. · JAMA Ophthalmology
Open access |
6 Apr 2023 |
76 |
| 4 |
Semifluorinated Alkane Eye Drops for Treatment of Dry Eye Disease—A Prospective, Multicenter Noninterventional Study
Philipp Steven, Dieter Scherer, Sonja Krösser et al. · PubMed Central
Open access |
Oct 2015 |
72 |
| 5 |
Semifluorinated alkane based systems for enhanced corneal penetration of poorly soluble drugs
Priyanka Agarwal, Dieter Scherer, Bernhard Günther et al. · International Journal of Pharmaceutics
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12 Jan 2018 |
71 |
| 6 |
NOV03 for Signs and Symptoms of Dry Eye Disease Associated With Meibomian Gland Dysfunction: The Randomized Phase 3 MOJAVE Study
John D. Sheppard, Fred Kurata, Alice Epitropoulos et al. · American Journal of Ophthalmology
Open access |
21 Mar 2023 |
68 |
| 7 |
Semifluorinated Alkane Eye Drops for Treatment of Dry Eye Disease Due to Meibomian Gland Disease
Philipp Steven, Albert J. Augustin, Gerd Geerling et al. · Journal of Ocular Pharmacology and Therapeutics
Open access |
18 Oct 2017 |
65 |
| 8 |
A Randomized Clinical Study (SEECASE) to Assess Efficacy, Safety, and Tolerability of NOV03 for Treatment of Dry Eye Disease
Joseph Tauber, David Wirta, Kenneth N. Sall et al. · Cornea
Open access |
22 Dec 2020 |
64 |
| 9 |
A Water-free 0.1% Cyclosporine A Solution for Treatment of Dry Eye Disease: Results of the Randomized Phase 2B/3 ESSENCE Study
John D. Sheppard, David Wirta, Eugene B. McLaurin et al. · Cornea
Open access |
11 Jan 2021 |
59 |
| 10 |
Influence of Perfluorohexyloctane Eye Drops on Tear Film Thickness in Patients with Mild to Moderate Dry Eye Disease: A Randomized Controlled Clinical Trial
Doreen Schmidl, Ahmed M. Bata, Stephan Szegedi et al. · Journal of Ocular Pharmacology and Therapeutics
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2 Jan 2020 |
52 |
| 11 |
Perfluorohexyloctane Eye Drops for Dry Eye Disease Associated With Meibomian Gland Dysfunction in Chinese Patients
Lei Tian, Zuojun Gao, Lei Zhu et al. · JAMA Ophthalmology
Open access |
16 Mar 2023 |
46 |
| 12 |
Preclinical studies evaluating the effect of semifluorinated alkanes on ocular surface and tear fluid dynamics
Priyanka Agarwal, Darina Khun, Sonja Krösser et al. · The Ocular Surface
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2 Mar 2019 |
44 |
| 13 |
A New Oxygen Carrier for Improved Long-Term Storage of Human Pancreata Before Islet Isolation
Heide Brandhorst, Sana Asif, Karin Andersson et al. · Transplantation
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16 Jan 2010 |
43 |
| 14 |
N-octanoyl-Dopamine Is an Agonist at the Capsaicin Receptor TRPV1 and Mitigates Is Chemia-Induced Acute Kidney Injury in Rat
Charalambos Tsagogiorgas, Johannes Wedel, Maximilia C. Hottenrott et al. · PLoS ONE
Open access |
20 Aug 2012 |
42 |
| 15 |
Powder suspensions in non-aqueous vehicles for delivery of therapeutic proteins
Christoph Marschall, Madlen Witt, Bernhard Hauptmeier et al. · European Journal of Pharmaceutics and Biopharmaceutics
Open access |
5 Feb 2021 |
34 |
| 16 |
Topical semifluorinated alkane-based azithromycin suspension for the management of ocular infections
Priyanka Agarwal, Jennifer P. Craig, Sonja Krösser et al. · European Journal of Pharmaceutics and Biopharmaceutics
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10 Jun 2019 |
30 |
| 17 |
Donor Preconditioning After the Onset of Brain Death With Dopamine Derivate n-Octanoyl Dopamine Improves Early Posttransplant Graft Function in the Rat
Shenghua Li, Sevil Korkmaz‐Icöz, Tamás Radovits et al. · American Journal of Transplantation
Open access |
24 Jan 2017 |
30 |
| 18 |
Long-Term Safety and Efficacy of Perfluorohexyloctane Ophthalmic Solution for the Treatment of Patients With Dry Eye Disease: The KALAHARI Study
Eugene E. Protzko, Bruce Segal, Michael S. Korenfeld et al. · Cornea
Open access |
3 Nov 2023 |
29 |
| 19 |
A semifluorinated alkane (F4H5) as novel carrier for cyclosporine A: a promising therapeutic and prophylactic option for topical treatment of dry eye
Uta Gehlsen, Tobias Braun, Maria Notara et al. · Graefe s Archive for Clinical and Experimental Ophthalmology
Open access |
14 Jan 2017 |
29 |
| 20 |
Water-Free Cyclosporine Ophthalmic Solution vs Vehicle for Dry Eye Disease
Rongmei Peng, Ying Jie, Qin Long et al. · JAMA Ophthalmology
Open access |
7 Mar 2024 |
26 |
| 21 |
A Water-Free Omega-3 Fatty Acid Eye Drop Formulation for the Treatment of Evaporative Dry Eye Disease: A Prospective, Multicenter Noninterventional Study
Christina Jacobi, Simone Angstmann-Mehr, Anja Erika Lange et al. · Journal of Ocular Pharmacology and Therapeutics
Open access |
4 May 2022 |
25 |
| 22 |
Semifluorinated alkanes – A new class of excipients suitable for pulmonary drug delivery
Charalambos Tsagogiorgas, Joerg Krebs, M. Pukelsheim et al. · European Journal of Pharmaceutics and Biopharmaceutics
Open access |
3 Jun 2010 |
25 |
| 23 |
N-Octanoyl Dopamine for Donor Treatment in a Brain-death Model of Kidney and Heart Transplantation
R Spindler, Peter Schnuelle, Lukas Nickels et al. · Transplantation
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12 Feb 2015 |
25 |
| 24 |
Quality of Isolated Pig Islets is Improved Using Perfluorohexyloctane for Pancreas Storage in a Split Lobe Model
Heide Brandhorst, Marcus Iken, William Earl Dodge Scott et al. · Cell Transplantation
Open access |
9 Apr 2013 |
23 |
| 25 |
UW is Superior Compared with HTK After Prolonged Preservation of Renal Grafts
Simone Hoeger, Georgia Lueg, Charalambos Tsagogiorgas et al. · Journal of Surgical Research
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26 Jun 2011 |
23 |
| 26 |
Drug Product Characterization of High Concentration Non-Aqueous Protein Powder Suspensions
Christoph Marschall, Madlen Witt, Bernhard Hauptmeier et al. · Journal of Pharmaceutical Sciences
Open access |
29 Jun 2022 |
22 |
| 27 |
CRF1 Receptor Signaling via the ERK1/2-MAP and Akt Kinase Cascades: Roles of Src, EGF Receptor, and PI3-Kinase Mechanisms
G. Karina Parra-Mercado, Alma Mariana Fuentes-González, Judith Hernández-Aranda et al. · Frontiers in Endocrinology
Open access |
12 Dec 2019 |
22 |
| 28 |
Self-assembly of different single-chain bolaphospholipids and their miscibility with phospholipids or classical amphiphiles
Alfred Blume, Simon Drescher, Gesche Graf et al. · Advances in Colloid and Interface Science
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13 Jan 2014 |
21 |
| 29 |
Pancreatic L-Glutamine Administration Protects Pig Islets from Cold Ischemic Injury and Increases Resistance toward Inflammatory Mediators
Heide Brandhorst, Bastian Theisinger, Bernhard Guenther et al. · Cell Transplantation
Open access |
5 Feb 2016 |
19 |
| 30 |
Improvement of oxygen supply by an artificial carrier in combination with normobaric oxygenation decreases the volume of tissue hypoxia and tissue damage from transient focal cerebral ischemia
David Julian Seiffge, Natalia Lapina, Charalambos Tsagogiorgas et al. · Experimental Neurology
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21 Jun 2012 |
17 |
| 31 |
A Low Concentration of Tacrolimus/Semifluorinated Alkane (SFA) Eyedrop Suppresses Intraocular Inflammation in Experimental Models of Uveitis
Sunipa Majumdar, M. Subinya, Johannes Korward et al. · Current Molecular Medicine
Open access |
7 Aug 2017 |
16 |
| 32 |
Aerosolized semifluorinated alkanes as excipients are suitable for inhalative drug delivery—A pilot study
Charalambos Tsagogiorgas, Taehyun Jung, Joerg Krebs et al. · International Journal of Pharmaceutics
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8 Nov 2011 |
16 |
| 33 |
Long-Term Safety and Efficacy of a Water-Free Cyclosporine 0.1% Ophthalmic Solution for Treatment of Dry Eye Disease: ESSENCE-2 OLE
David Wirta, Anat Galor, Carol Aune et al. · Cornea
Open access |
21 May 2024 |
14 |
| 34 |
Evaluation of pharmacokinetic properties and anaesthetic effects of propofol in a new perfluorohexyloctane (F6H8) emulsion in rats – A comparative study
Charalambos Tsagogiorgas, Sonja Theisinger, E.J.M. van Heesch et al. · International Journal of Pharmaceutics
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29 Mar 2015 |
13 |
| 35 |
Semifluorinated Alkane Eye Drops in Chronic Ocular Graft-versus-Host Disease: A Prospective, Multicenter, Noninterventional Study
Philipp Eberwein, Sonja Krösser, Philipp Steven · Ophthalmic Research
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22 May 2019 |
12 |
| 36 |
Perfluorohexyloctane improves long-term storage of rat pancreata for subsequent islet isolation
Heide Brandhorst, Bastian Theisinger, Hideyuki Yamaya et al. · Transplant International
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10 Jul 2009 |
12 |
| 37 |
Intensified Early Postoperative Topical Steroids Do Not Influence Endothelial Cell Density After Descemet Membrane Endothelial Keratoplasty Combined With Cataract Surgery (Triple-DMEK)
Robert Hoerster, Tisha Prabriputaloong Stanzel, Bjoern O. Bachmann et al. · Cornea
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18 Aug 2016 |
11 |
| 38 |
Buccal absorption of propofol when dosed in 1-perfluorobutylpentane to anaesthetised and conscious Wistar rats and Göttingen mini-pigs
Charalambos Tsagogiorgas, Sonja Theisinger, Per Holm et al. · European Journal of Pharmaceutics and Biopharmaceutics
Open access |
10 Jul 2013 |
11 |
| 39 |
The impact of food components on the intrinsic dissolution rate of ketoconazole
Heba S. Ghazal, A. M. Dyas, James L. C. Ford et al. · Drug Development and Industrial Pharmacy
Open access |
19 Nov 2014 |
10 |
| 40 |
New Class of Oxygen Carriers Improves Islet Isolation From Long-Term Stored Rat Pancreata
Heide Brandhorst, H. Brandhorst, Bernd M. Muehling et al. · Transplantation Proceedings
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Mar 2008 |
10 |
| 41 |
VEGF TrapR1R2 Suspended in the Semifluorinated Alkane F6H8 Inhibits Inflammatory Corneal Hem- and Lymphangiogenesis
Viet Nhat Hung Le, Deniz Hos, Yanhong Hou et al. · Translational Vision Science & Technology
Open access |
14 Oct 2020 |
9 |
| 42 |
Einfluss von Alterung auf Schweregrad und antientzündliche Therapie des experimentellen Trockenen Auges
Philipp Steven, Tobias Braun, Sonja Krösser et al. · Klinische Monatsblätter für Augenheilkunde
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15 May 2017 |
9 |
| 43 |
Perfluorohexyloctane ophthalmic solution for dry eye disease: pooled analysis of two phase 3 clinical trials
Ahmad M. Fahmy, Jennifer Harthan, David G. Evans et al. · Frontiers in Ophthalmology
Open access |
5 Nov 2024 |
8 |
| 44 |
Efficacy of a new water-free topical cyclosporine 0.1% solution for optimizing the ocular surface in patients with dry eye and cataract
Esen K. Akpek, John D. Sheppard, Adam Hamm et al. · Journal of Cataract & Refractive Surgery
Open access |
9 Feb 2024 |
8 |
| 45 |
Preclinical characterization of water-free cyclosporine eye drops – Factors impacting ocular penetration ex vivo and in vivo
Priyanka Agarwal, Johannes Korward, Sonja Krösser et al. · European Journal of Pharmaceutics and Biopharmaceutics
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11 May 2023 |
8 |
| 46 |
Ocular and Systemic Distribution of 14C- Perfluorohexyloctane following Topical Ocular Administration to Rabbits
Sonja Kroesser, Elizabeth A. Spencer, Ralf Grillenberger et al. · Investigative Ophthalmology & Visual Science
Open access |
13 Jul 2018 |
8 |
| 47 |
19F Oximetry with semifluorinated alkanes
Stefan Kegel, Jorge Chacon‐Caldera, Charalambos Tsagogiorgas et al. · Artificial Cells Nanomedicine and Biotechnology
Open access |
2 Dec 2015 |
8 |
| 48 |
N-octanoyl-dopamine is a potent inhibitor of platelet function
Lamia Ait-Hsiko, Tineke Kraaij, Johannes Wedel et al. · Platelets
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23 Aug 2012 |
8 |
| 49 |
Evaluation of Perfluorohexyloctane/Polydimethylsiloxane for Pancreas Preservation for Clinical Islet Isolation and Transplantation
Magnus Ståhle, Aksel Espen Foss, Bengt Gustafsson et al. · Cell Transplantation
Open access |
15 Jun 2016 |
6 |
| 50 |
Corneal Staining Responder Analysis
Esen K. Akpek, John D. Sheppard, Sonja Krösser · Ophthalmology
Open access |
24 Jul 2025 |
4 |