Most cited papers from Noxxon Pharma (Germany)

Noxxon Pharma (Germany)

What are the most cited papers from Noxxon Pharma (Germany)?

The most cited paper from Noxxon Pharma (Germany) is "Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury" (Christer Baeck, Alexander Wehr, Karlin Raja Karlmark et al., 2011), with 618 citations. Next come "Immune and Inflammatory Cell Involvement in the Pathology of Idiopathic Pulmonary Arterial Hypertension" (413) and "Chemokine (C‐C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen‐induced acute liver injury" (327).

Published TypeFieldAccessCitations

Showing 50 of 60 papers. Every paper with more than 45 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury Christer Baeck, Alexander Wehr, Karlin Raja Karlmark et al. · Gut	3 Aug 2011	618
2	Immune and Inflammatory Cell Involvement in the Pathology of Idiopathic Pulmonary Arterial Hypertension Rajkumar Savai, Soni Savai Pullamsetti, Julia Kolbe et al. · American Journal of Respiratory and Critical Care Medicine	7 Sep 2012	413
3	Chemokine (C‐C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen‐induced acute liver injury Jana C. Mossanen, Oliver Krenkel, Can Ergen et al. · Hepatology Open access	15 Jun 2016	327
4	Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+ macrophage infiltration in mice Christer Baeck, Xiao Wei, Matthias Bartneck et al. · Hepatology Open access	30 Jan 2014	276
5	CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis Josef Ehling, Matthias Bartneck, Xiao Wei et al. · Gut Open access	21 Feb 2014	275
6	Turning mirror-image oligonucleotides into drugs: the evolution of Spiegelmer® therapeutics Axel Vater, Sven Klußmann · Drug Discovery Today Open access	16 Sep 2014	251
7	The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization Julia Hoellenriegel, Dirk Zboralski, Christian Maasch et al. · Blood Open access	26 Nov 2013	243
8	C-C motif-ligand 2 inhibition with emapticap pegol (NOX-E36) in type 2 diabetic patients with albuminuria Jan Menne, Dirk Eulberg, Diana Beyer et al. · Nephrology Dialysis Transplantation Open access	27 Apr 2016	204
9	Spiegelmer Inhibition of CCL2/MCP-1 Ameliorates Lupus Nephritis in MRL-(Fas)lpr Mice Onkar P. Kulkarni, Rahul D. Pawar, Werner G. Purschke et al. · Journal of the American Society of Nephrology	11 Jul 2007	190
10	Spiegelmers: Biostable Aptamers Dirk Eulberg, Sven Klußmann · ChemBioChem	26 Sep 2003	183
11	In vivo properties of an anti-GnRH Spiegelmer: An example of an oligonucleotide-based therapeutic substance class Britta Wlotzka, Susanne Leva, Bernd Eschgfäller et al. · Proceedings of the National Academy of Sciences Open access	17 Jun 2002	183
12	Increasing Tumor-Infiltrating T Cells through Inhibition of CXCL12 with NOX-A12 Synergizes with PD-1 Blockade Dirk Zboralski, Kai Hoehlig, Dirk Eulberg et al. · Cancer Immunology Research	30 Sep 2017	171
13	Podocytes produce homeostatic chemokine stromal cell-derived factor-1/CXCL12, which contributes to glomerulosclerosis, podocyte loss and albuminuria in a mouse model of type 2 diabetes Sufyan G. Sayyed, Holger Hägele, Onkar P. Kulkarni et al. · Diabetologia Open access	25 Aug 2009	167
14	Neonatal ghrelin programs development of hypothalamic feeding circuits Sophie Marie Steculorum, Gustav Colldén, Bérengère Coupé et al. · Journal of Clinical Investigation Open access	19 Jan 2015	157
15	The effects of the anti-hepcidin Spiegelmer NOX-H94 on inflammation-induced anemia in cynomolgus monkeys Frank Schwoebel, Lucas Theodorus van Eijk, Dirk Zboralski et al. · Blood Open access	25 Jan 2013	155
16	Ghrelin Neutralization by a Ribonucleic Acid-SPM Ameliorates Obesity in Diet-Induced Obese Mice Lauren P. Shearman, Sheng-Ping Wang, Steffen Helmling et al. · Endocrinology	9 Dec 2005	141
17	Development of an automated in vitro selection protocol to obtain RNA-based aptamers: identification of a biostable substance P antagonist Dirk Eulberg · Nucleic Acids Research Open access	23 Feb 2005	140
18	SDF-1 Inhibition Targets the Bone Marrow Niche for Cancer Therapy Aldo Maria Roccaro et al. · Cell Reports Open access	25 Sep 2014	139
19	Short bioactive Spiegelmers to migraine-associated calcitonin gene-related peptide rapidly identified by a novel approach: Tailored-SELEX Axel Vater · Nucleic Acids Research Open access	24 Oct 2003	136
20	Late Onset of Ccl2 Blockade with the Spiegelmer mNOX-E36–3′PEG Prevents Glomerulosclerosis and Improves Glomerular Filtration Rate in db/db Mice Volha Ninichuk, Sebastian Clauß, Onkar P. Kulkarni et al. · American Journal Of Pathology Open access	8 Feb 2008	135
21	Dual Blockade of the Homeostatic Chemokine CXCL12 and the Proinflammatory Chemokine CCL2 Has Additive Protective Effects on Diabetic Kidney Disease Murthy N. Darisipudi, Onkar P. Kulkarni, Sufyan G. Sayyed et al. · American Journal Of Pathology Open access	3 May 2011	117
22	Identification of Ghrelin in Human Saliva: Production by the Salivary Glands and Potential Role in Proliferation of Oral Keratinocytes Michael Gröschl, Hans G Topf, Jörg Edgar Bohlender et al. · Clinical Chemistry	25 Mar 2005	114
23	Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans Lucas Theodorus van Eijk, Aaron S. E. John, Frank Schwoebel et al. · Blood Open access	28 Aug 2014	109
24	The CCR2+ Macrophage Subset Promotes Pathogenic Angiogenesis for Tumor Vascularization in Fibrotic Livers Matthias Bartneck, Peter L. Schrammen, Diana Möckel et al. · Cellular and Molecular Gastroenterology and Hepatology Open access	18 Oct 2018	107
25	Progressive glomerulosclerosis in type 2 diabetes is associated with renal histone H3K9 and H3K23 acetylation, H3K4 dimethylation and phosphorylation at serine 10 Sufyan G. Sayyed, Anil Bhanudas Gaikwad, Julia Lichtnekert et al. · Nephrology Dialysis Transplantation Open access	12 Jan 2010	105
26	CXCL12 blockade preferentially regenerates lost podocytes in cortical nephrons by targeting an intrinsic podocyte-progenitor feedback mechanism Simone Romoli, Maria Lucia Angelotti, Giulia Antonelli et al. · Kidney International Open access	29 Oct 2018	101
27	Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2 Dominik Oberthür, John Achenbach, Azat G. Gabdulkhakov et al. · Nature Communications Open access	22 Apr 2015	101
28	Pharmacokinetics and systemic endocrine effects of the phyto‐oestrogen 8‐prenylnaringenin after single oral doses to postmenopausal women Mohammad Navid Soltani Rad, Michael Humpel, Olaf Schaefer et al. · British Journal of Clinical Pharmacology Open access	21 Apr 2006	100
29	Blockade of SDF-1 after irradiation inhibits tumor recurrences of autochthonous brain tumors in rats Shie-Chau Liu, Reem Alomran, Sophia B. Chernikova et al. · Neuro-Oncology Open access	10 Dec 2013	96
30	Olaptesed pegol (NOX-A12) with bendamustine and rituximab: a phase IIa study in patients with relapsed/refractory chronic lymphocytic leukemia Michael Steurer, Marco Montillo, Lydia Scarfò et al. · Haematologica Open access	16 May 2019	93
31	GnRH Binding RNA and DNA Spiegelmers Susanne Leva, Andrea Lichte, Jens Burmeister et al. · Chemistry & Biology Open access	Mar 2002	93
32	A Novel C5a-neutralizing Mirror-image (l-)Aptamer Prevents Organ Failure and Improves Survival in Experimental Sepsis Kai Hoehlig, Christian Maasch, Nelli Shushakova et al. · Molecular Therapy Open access	26 Jul 2013	91
33	Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer Laure Yatime, Christian Maasch, Kai Hoehlig et al. · Nature Communications Open access	22 Apr 2015	91
34	Systemic Monocyte Chemotactic Protein-1 Inhibition Modifies Renal Macrophages and Restores Glomerular Endothelial Glycocalyx and Barrier Function in Diabetic Nephropathy Margien G. S. Boels, Angela Koudijs, M. Cristina Avramut et al. · American Journal Of Pathology Open access	22 Aug 2017	90
35	Toward third-generation aptamers: Spiegelmers and their therapeutic prospects. Axel Vater, Sven Klußmann · PubMed	Mar 2003	90
36	A thermostable d-polymerase for mirror-image PCR Andreas Pech, John Achenbach, Michael Jahnz et al. · Nucleic Acids Research Open access	30 Jan 2017	88
37	Hematopoietic Stem and Progenitor Cell Mobilization in Mice and Humans by a First-in-Class Mirror-Image Oligonucleotide Inhibitor of CXCL12 Axel Vater, Jörg Sahlmann, Nicolaus Kröger et al. · Clinical Pharmacology & Therapeutics Open access	19 Mar 2013	88
38	Site-Specific Cleavage of RNA by a Metal-Free Artificial Nuclease Attached to Antisense Oligonucleotides Claudio Gnaccarini, Sascha Peter, Ute Scheffer et al. · Journal of the American Chemical Society	25 May 2006	85
39	Safety, pharmacokinetics and pharmacodynamics of the anti‐hepcidin Spiegelmer lexaptepid pegol in healthy subjects Malcolm J. Boyce, Steve Warrington, B Cortezi et al. · British Journal of Pharmacology Open access	16 Jan 2016	83
40	Olaptesed pegol, an anti-CXCL12/SDF-1 Spiegelmer, alone and with bortezomib–dexamethasone in relapsed/refractory multiple myeloma: a Phase IIa Study Heinz Ludwig, Katja Christina Weisel, Maria Teresa Petrucci et al. · Leukemia Open access	11 Jan 2017	82
41	DNA vs. Mirror‐Image DNA: A Universal Approach to Tune the Absolute Configuration in DNA‐Based Asymmetric Catalysis Jocelyn Wang, Erica Benedetti, Lucas Bethge et al. · Angewandte Chemie International Edition	12 Sep 2013	82
42	Combined inhibition of CXCL12 and PD-1 in MSS colorectal and pancreatic cancer: modulation of the microenvironment and clinical effects Meggy Suarez‐Carmona, Anja Williams, Jutta Schreiber et al. · Journal for ImmunoTherapy of Cancer Open access	Oct 2021	79
43	A DNA Spiegelmer to staphylococcal enterotoxin B Werner G. Purschke · Nucleic Acids Research Open access	11 Jun 2003	76
44	Targeting complement component 5a promotes vascular integrity and limits airway remodeling Mohammad Afzal Khan, Christian Maasch, Axel Vater et al. · Proceedings of the National Academy of Sciences Open access	25 Mar 2013	71
45	Liquid Crystal Ordering and Isotropic Gelation in Solutions of Four-Base-Long DNA Oligomers Tommaso P. Fraccia, Gregory P. Smith, Lucas Bethge et al. · ACS Nano Open access	29 Aug 2016	69
46	EF-G and EF4: translocation and back-translocation on the bacterial ribosome Hiroshi Yamamoto, Yan Qin, John Achenbach et al. · Nature Reviews Microbiology Review	23 Dec 2013	69
47	Identification of epitope‐like consensus motifs using mRNA display Rick Baggio, Petra Burgstaller, Stephen P. Hale et al. · Journal of Molecular Recognition	May 2002	68
48	Tissue specificity of 8-prenylnaringenin: Protection from ovariectomy induced bone loss with minimal trophic effects on the uterus Michael Humpel, Päivi Isaksson, Olaf Schaefer et al. · The Journal of Steroid Biochemistry and Molecular Biology	9 Sep 2005	68
49	Bioactive Lipids S1P and C1P Are Prometastatic Factors in Human Rhabdomyosarcoma, and Their Tissue Levels Increase in Response to Radio/Chemotherapy Gabriela Schneider, Ewa Bryndza, Ahmed K. Abdel-Latif et al. · Molecular Cancer Research Open access	24 Apr 2013	67
50	Outwitting EF-Tu and the ribosome: translation with d-amino acids John Achenbach, Michael Jahnz, Lucas Bethge et al. · Nucleic Acids Research Open access	30 May 2015	62

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.