| 1 |
Phase III Randomized Trial of Induction Chemotherapy in Patients With N2 or N3 Locally Advanced Head and Neck Cancer
Ezra E.W. Cohen et al. · Journal of Clinical Oncology
Open access |
22 Jul 2014 |
579 |
| 2 |
Solution Conformations Shed Light on PROTAC Cell Permeability
Yoseph Atilaw, Vasanthanathan Poongavanam, Caroline Svensson Nilsson et al. · ACS Medicinal Chemistry Letters
Open access |
25 Dec 2020 |
201 |
| 3 |
The Effect of Hematocrit on Bioanalysis of DBS: Results from The EBF DBS-Microsampling Consortium
Ronald de Vries, Matthew D. Barfield, Nico van de Merbel et al. · Bioanalysis
|
5 Jul 2013 |
134 |
| 4 |
Efficacy, Safety, and Mechanistic Insights of Cotadutide, a Dual Receptor Glucagon-Like Peptide-1 and Glucagon Agonist
Victoria E R Parker, Darren C. Robertson, Tao Wang et al. · The Journal of Clinical Endocrinology & Metabolism
Open access |
14 Oct 2019 |
122 |
| 5 |
JUMP Cell Painting dataset: morphological impact of 136,000 chemical and genetic perturbations
Srinivas Niranj Chandrasekaran et al. · bioRxiv (Cold Spring Harbor Laboratory)
PreprintOpen access |
24 Mar 2023 |
110 |
| 6 |
Minimized estradiol absorption with ultra-low-dose 10 μg 17β-estradiol vaginal tablets
M. Eugster-Hausmann, Josef Waitzinger, Dirk Lehnick · Climacteric
|
28 Apr 2010 |
107 |
| 7 |
Nickel‐Catalyzed N ‐Arylation of NH ‐Sulfoximines with Aryl Halides via Paired Electrolysis
Dong Liu, Zhao‐Ran Liu, Cong Ma et al. · Angewandte Chemie International Edition
|
12 Feb 2021 |
104 |
| 8 |
Degradation of CCNK/CDK12 is a druggable vulnerability of colorectal cancer
Sebastian M. Dieter et al. · Cell Reports
Open access |
Jul 2021 |
94 |
| 9 |
Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase
Colin W. Garvie et al. · Nature Communications
Open access |
16 Jul 2021 |
93 |
| 10 |
MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity
Arne Peirsman et al. · Nature Methods
Open access |
Nov 2021 |
87 |
| 11 |
Target 2035 – update on the quest for a probe for every protein
Susanne Müller et al. · RSC Medicinal Chemistry
Open access |
3 Dec 2021 |
83 |
| 12 |
Eliapixant is a selective P2X3 receptor antagonist for the treatment of disorders associated with hypersensitive nerve fibers
Adam J. Davenport, Ioana Berindan‐Neagoe, Nico Bräuer et al. · Scientific Reports
Open access |
6 Oct 2021 |
69 |
| 13 |
Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042)
Michael G. Hahn et al. · Journal of Medicinal Chemistry
Open access |
19 Apr 2021 |
67 |
| 14 |
First-in-human Phase I studies of PRS-080#22, a hepcidin antagonist, in healthy volunteers and patients with chronic kidney disease undergoing hemodialysis
Lutz Renders, Klemens Budde, Christian Rosenberger et al. · PLoS ONE
Open access |
27 Mar 2019 |
64 |
| 15 |
In-Depth Study of Homogeneity in DBS Using Two Different Techniques: Results from The EBF DBS-Microsampling Consortium
Zoe Cobb, Ronald de Vries, Neil Spooner et al. · Bioanalysis
|
5 Jul 2013 |
64 |
| 16 |
Phase 1 study in healthy participants of the safety, pharmacokinetics, and pharmacodynamics of enpatoran (M5049), a dual antagonist of toll‐like receptors 7 and 8
Andreas Port, Jamie V. Shaw, Lena Klopp‐Schulze et al. · Pharmacology Research & Perspectives
Open access |
19 Aug 2021 |
57 |
| 17 |
Pharmacodynamic and pharmacokinetic evaluation of coadministration of lacosamide and an oral contraceptive (levonorgestrel plus ethinylestradiol) in healthy female volunteers
Willi Cawello, Bernd Rosenkranz, Hans Bernhard Schmid et al. · Epilepsia
|
29 Jan 2013 |
57 |
| 18 |
Short-term variability of the human serum metabolome depending on nutritional and metabolic health status
Inoncent Agueusop, Petra B. Musholt, BEATE M. KLAUS et al. · Scientific Reports
Open access |
Oct 2020 |
51 |
| 19 |
Health-related quality of life in relapsing remitting multiple sclerosis patients during treatment with glatiramer acetate: a prospective, observational, international, multi-centre study
Peter Joseph Jongen, Dirk Lehnick, Evert A. C. M. Sanders et al. · Health and Quality of Life Outcomes
Open access |
2010 |
50 |
| 20 |
Pan-PI3K inhibition with copanlisib overcomes Treg- and M2-TAM-mediated immune suppression and promotes anti-tumor immune responses
Simon R. Heller, Sarah Glaeske, Katja Gluske et al. · Clinical and Experimental Medicine
Open access |
8 Nov 2023 |
45 |
| 21 |
The potent AMPK inhibitor BAY-3827 shows strong efficacy in androgen-dependent prostate cancer models
Clara Lemos, Volker Schulze, Simon J. Baumgart et al. · Cellular Oncology
Open access |
25 Jan 2021 |
45 |
| 22 |
Pharmacodynamics and safety of the novel selective progesterone receptor modulator vilaprisan: a double-blind, randomized, placebo-controlled phase 1 trial in healthy women
Barbara Schütt, Andreas Kaiser, Marcus‐Hillert Schultze‐Mosgau et al. · Human Reproduction
|
10 Jun 2016 |
45 |
| 23 |
Recommendations on The Interpretation of The New European Medicines Agency Guideline on Bioanalytical Method Validation By Global Cro Council For Bioanalysis (Gcc)
Mark Boterman et al. · Bioanalysis
|
Mar 2012 |
45 |
| 24 |
Arginase 1/2 Inhibitor OATD-02: From Discovery to First-in-man Setup in Cancer Immunotherapy
Bartlomiej Borek et al. · Molecular Cancer Therapeutics
Open access |
17 Mar 2023 |
38 |
| 25 |
Recommendations on Bioanalytical Method Stability Implications of Co-Administered And Co-Formulated Drugs By Global Cro Council For Bioanalysis (Gcc)
Steve Lowes et al. · Bioanalysis
|
Sep 2012 |
33 |
| 26 |
Toward understanding lipid reorganization in RNA lipid nanoparticles in acidic environments
Adiran Garaizar, Christian David Díaz‐Oviedo, Nina Zablowsky et al. · Proceedings of the National Academy of Sciences
Open access |
30 Oct 2024 |
32 |
| 27 |
Targeting RAS oncogenesis with SOS1 inhibitors
Roman Christian Hillig, Benjamin Bader · Advances in cancer research
Book chapter |
2022 |
32 |
| 28 |
Ocular metabolism and distribution of drugs in the rabbit eye: Quantitative assessment after intracameral and intravitreal administrations
Eva Maria del Amo, Anam Hammid, Melanie Tausch et al. · International Journal of Pharmaceutics
Open access |
9 Dec 2021 |
32 |
| 29 |
No Clinically Relevant Interactions of St. John's Wort Extract Ze 117 Low in Hyperforin With Cytochrome P450 Enzymes and P‐glycoprotein
Catherine Zahner, Esther Kruttschnitt, Julia Uricher et al. · Clinical Pharmacology & Therapeutics
Open access |
10 Feb 2019 |
30 |
| 30 |
CACHE Challenge #1: Targeting the WDR Domain of LRRK2, A Parkinson’s Disease Associated Protein
Fengling Li et al. · Journal of Chemical Information and Modeling
Open access |
5 Nov 2024 |
29 |
| 31 |
BRD-810 is a highly selective MCL1 inhibitor with optimized in vivo clearance and robust efficacy in solid and hematological tumor models
Ulrike Rauh et al. · Nature Cancer
Open access |
23 Aug 2024 |
29 |
| 32 |
Discovery and Characterization of BAY-805, a Potent and Selective Inhibitor of Ubiquitin-Specific Protease USP21
Fabian Göricke et al. · Journal of Medicinal Chemistry
Open access |
20 Feb 2023 |
28 |
| 33 |
Identification of a neural development gene expression signature in colon cancer stem cells reveals a role for EGR2 in tumorigenesis
Joseph L. Regan, Dirk Schumacher, Stephanie Staudte et al. · iScience
Open access |
31 May 2022 |
28 |
| 34 |
Artificial Intelligence in Toxicologic Pathology: Quantitative Evaluation of Compound-Induced Hepatocellular Hypertrophy in Rats
Hannah Pischon, David Y. Mason, Bettina Lawrenz et al. · Toxicologic Pathology
|
5 Jan 2021 |
26 |
| 35 |
Incurred Sample Reproducibility: 10 Years of Experiences: Views and Recommendations from the European Bioanalysis Forum
Morten Anders Kall, Marco Michi, Barry van der Strate et al. · Bioanalysis
Open access |
Nov 2018 |
25 |
| 36 |
Re-thinking the current paradigm for clinical immunogenicity assessment: an update from the discussion in the European Bioanalysis Forum
Joanne Goodman et al. · Bioanalysis
|
9 Aug 2024 |
24 |
| 37 |
Conference Report: 4Th Global Cro Council For Bioanalysis: Coadministered Drugs Stability, Ema/Us Fda Guidelines, 483S And Carryover
Steve Lowes et al. · Bioanalysis
|
Apr 2012 |
24 |
| 38 |
Fatigue and health-related quality of life in relapsing-remitting multiple sclerosis after 2 years glatiramer acetate treatment are predicted by changes at 6 months: an observational multi-center study
The FOCUS Extension Study Group, Peter Joseph Jongen, Dirk Lehnick et al. · Journal of Neurology
Open access |
2 May 2014 |
24 |
| 39 |
Dual targeting of the androgen receptor and PI3K / AKT / mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis
Tatsuo Sugawara, Ekaterina Nevedomskaya, Simon R. Heller et al. · Molecular Oncology
Open access |
15 Jan 2024 |
23 |
| 40 |
Targeting fatty acid oxidation via Acyl-CoA binding protein hinders glioblastoma invasion
Ceren Duman, Barbara Di Marco, Ekaterina Nevedomskaya et al. · Cell Death and Disease
Open access |
29 Apr 2023 |
23 |
| 41 |
A Small Molecule–Drug Conjugate (SMDC) Consisting of a Modified Camptothecin Payload Linked to an αVß3 Binder for the Treatment of Multiple Cancer Types
Hans‐Georg Lerchen, Beatrix Stelte‐Ludwig, Charlotte Kopitz et al. · Cancers
Open access |
13 Jan 2022 |
23 |
| 42 |
Update to the European Bioanalysis Forum Recommendation on Biomarkers Assays; Bringing Context of Use Into Practice
Joanne Goodman, Kyra J. Cowan, Michaela Golob et al. · Bioanalysis
|
Oct 2020 |
23 |
| 43 |
Comparison of the Pharmacokinetic and Pharmacodynamic Profiles of One US-Marketed and Two European-Marketed Epoetin Alfas
Michael Lissy, Marité Ode, Karsten Roth · Drugs in R&D
Open access |
Mar 2011 |
22 |
| 44 |
Development and validation of automated SPE‐HPLC‐MS/MS methods for the quantification of asenapine, a new antipsychotic agent, and its two major metabolites in human urine
Theo de Boer, Erik Meulman, Henri Meijering et al. · Biomedical Chromatography
|
16 Feb 2012 |
22 |
| 45 |
Target 2035 – an update on private sector contributions
Suzanne Z. Ackloo et al. · RSC Medicinal Chemistry
Open access |
2023 |
21 |
| 46 |
Sevabertinib, a Reversible HER2 Inhibitor with Activity in Lung Cancer
Franziska Siegel et al. · Cancer Discovery
Open access |
15 Oct 2025 |
20 |
| 47 |
Absolute Bioavailability and Effect of Food on the Disposition of Safinamide Immediate Release Tablets in Healthy Adult Subjects
Annick Seithel‐Keuth, Andreas Johne, Achim Freisleben et al. · Clinical Pharmacology in Drug Development
|
2013 |
20 |
| 48 |
Discovery and Structure-Based Design of Potent Covalent PPARγ Inverse-Agonists BAY-4931 and BAY-0069
Douglas L. Orsi, Elisabeth Pook, Nico Bräuer et al. · Journal of Medicinal Chemistry
Open access |
21 Oct 2022 |
19 |
| 49 |
DNA repair inhibitors sensitize cells differently to high and low LET radiation
Kristina Bannik, Balázs Gergely Madas, Sabrina Jarke et al. · Scientific Reports
Open access |
Dec 2021 |
19 |
| 50 |
New Generation of sGC Stimulators: Discovery of Imidazo[1,2-a]pyridine Carboxamide BAY 1165747 (BAY-747), a Long-Acting Soluble Guanylate Cyclase Stimulator for the Treatment of Resistant Hypertension
Alexandros Vakalopoulos et al. · Journal of Medicinal Chemistry
|
11 Apr 2023 |
18 |