| 1 |
Apixaban versus Warfarin in Patients with Atrial Fibrillation
Christopher B. Granger et al. · New England Journal of Medicine
Open access |
28 Aug 2011 |
9,001 |
| 2 |
A Comparison of Balloon-Expandable-Stent Implantation with Balloon Angioplasty in Patients with Coronary Artery Disease
Patrick W. Serruys, Peter de Jaegere, Ferdinand Kiemeneij et al. · New England Journal of Medicine
Open access |
25 Aug 1994 |
4,563 |
| 3 |
STARD 2015: an updated list of essential items for reporting diagnostic accuracy studies
Patrick M. Bossuyt, Johannes B. Reitsma, David E. Bruns et al. · BMJ
Open access |
28 Oct 2015 |
3,605 |
| 4 |
Post-Traumatic Growth After a Myocardial Infarction: A Matter of Personality, Psychological Health, or Cognitive Coping?
Nadia Garnefski, V. Kraaij, Maya J. Schroevers et al. · Journal of Clinical Psychology in Medical Settings
Open access |
Dec 2008 |
2,496 |
| 5 |
Autonomic Dysregulation, Cognitive Impairment, and Symptoms of Psychosis as an Unusual Presentation in an Anti-Aquaporin 4-Positive Patient.
Annabel M. Ruiter, Jan F Meilof, Rosemarijn R. J. Somanje-Bolweg et al. · PubMed
Open access |
6 Feb 2017 |
1,761 |
| 6 |
Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: an open-label, randomised, controlled trial
Willem J.M. Dewilde, Tom Oirbans, Freek W.A. Verheugt et al. · The Lancet
|
12 Feb 2013 |
1,725 |
| 7 |
European Hernia Society guidelines on the treatment of inguinal hernia in adult patients
Maarten P. Simons, Theo J. Aufenacker, Morten Bay‐Nielsen et al. · Hernia
Open access |
27 Jul 2009 |
1,621 |
| 8 |
Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers
Myriam Chalabi et al. · Nature Medicine
Open access |
Apr 2020 |
1,437 |
| 9 |
Outcomes associated with drug-eluting and bare-metal stents: a collaborative network meta-analysis
Christoph David Stettler et al. · The Lancet
|
Sep 2007 |
1,432 |
| 10 |
Classification of primary and incisional abdominal wall hernias
Filip E. Muysoms et al. · Hernia
Open access |
2 Jun 2009 |
1,423 |
| 11 |
Preoperative Chemoradiotherapy Versus Immediate Surgery for Resectable and Borderline Resectable Pancreatic Cancer: Results of the Dutch Randomized Phase III PREOPANC Trial
Eva Versteijne et al. · Journal of Clinical Oncology
Open access |
27 Feb 2020 |
1,101 |
| 12 |
Preoperative Biliary Drainage for Cancer of the Head of the Pancreas
Niels Anthony Van Der Gaag, Erik A. Rauws, Casper H.J. van Eijck et al. · New England Journal of Medicine
Open access |
13 Jan 2010 |
1,049 |
| 13 |
Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study
Alison J. Rodger et al. · The Lancet
Open access189 authors |
2 May 2019 |
1,029 |
| 14 |
Increased Mortality Associated with Growth Hormone Treatment in Critically Ill Adults
Jukka Takala, Esko Ruokonen, Nigel R. Webster et al. · New England Journal of Medicine
Open access |
9 Sep 1999 |
1,012 |
| 15 |
Effect of a Comprehensive Surgical Safety System on Patient Outcomes
Eefje N. de Vries, Hubert A. Prins, Rogier M. P. H. Crolla et al. · New England Journal of Medicine
Open access |
10 Nov 2010 |
1,008 |
| 16 |
Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction
Sanjiv Jayendra Shah, Dalane W. Kitzman, Barry A. Borlaug et al. · Circulation
Open access |
29 Jun 2016 |
1,007 |
| 17 |
Apixaban with Antiplatelet Therapy after Acute Coronary Syndrome
John Hunter Alexander et al. · New England Journal of Medicine
Open access |
24 Jul 2011 |
1,002 |
| 18 |
A Randomized Comparison of Percutaneous Transluminal Coronary Angioplasty by the Radial, Brachial and Femoral Approaches: The Access Study
Ferdinand Kiemeneij, Gert Jan Laarman, Diego A. M. Odekerken et al. · Journal of the American College of Cardiology
Open access |
May 1997 |
956 |
| 19 |
Future challenges for clinical care of an ageing population infected with HIV: a modelling study
Mikaëla Smit, Kees Brinkman, Suzanne E. Geerlings et al. · The Lancet Infectious Diseases
Open access |
12 Jun 2015 |
947 |
| 20 |
Detection of Deep-Vein Thrombosis by Real-Time B-Mode Ultrasonography
Anthonie W.A. Lensing, Paolo Prandoni, Dees P. M. Brandjes et al. · New England Journal of Medicine
|
9 Feb 1989 |
884 |
| 21 |
Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy
Kees Brinkman, Jan A.M. Smeitink, Johannes Anthonius Romijn et al. · The Lancet
|
Sep 1999 |
881 |
| 22 |
Effectiveness of positron emission tomography in the preoperative assessment of patients with suspected non-small-cell lung cancer: the PLUS multicentre randomised trial
Harm van Tinteren, Otto S. Hoekstra, Egbert Frederik Smit et al. · The Lancet
|
Apr 2002 |
865 |
| 23 |
Induction of labour versus expectant monitoring for gestational hypertension or mild pre-eclampsia after 36 weeks' gestation (HYPITAT): a multicentre, open-label randomised controlled trial
Corine M. Koopmans et al. · The Lancet
|
4 Aug 2009 |
802 |
| 24 |
Ticagrelor plus aspirin for 1 month, followed by ticagrelor monotherapy for 23 months vs aspirin plus clopidogrel or ticagrelor for 12 months, followed by aspirin monotherapy for 12 months after implantation of a drug-eluting stent: a multicentre, open-label, randomised superiority trial
Pascal Vranckx et al. · The Lancet
Open access203 authors |
27 Aug 2018 |
797 |
| 25 |
In Vitro Fertilization with Preimplantation Genetic Screening
Sebastiaan Mastenbroek, Moniek Twisk, Jannie van Echten‐Arends et al. · New England Journal of Medicine
Open access |
4 Jul 2007 |
782 |
| 26 |
Laparoscopy in Combination with Fast Track Multimodal Management is the Best Perioperative Strategy in Patients Undergoing Colonic Surgery
Malaika Sanne Vlug, Jan Wind, Markus W. Hollmann et al. · Annals of Surgery
|
19 May 2011 |
761 |
| 27 |
Neoadjuvant Chemoradiotherapy Versus Upfront Surgery for Resectable and Borderline Resectable Pancreatic Cancer: Long-Term Results of the Dutch Randomized PREOPANC Trial
Eva Versteijne et al. · Journal of Clinical Oncology
Open access |
27 Jan 2022 |
755 |
| 28 |
Endoscopic or Surgical Step-Up Approach for Infected Necrotising Pancreatitis: A Multicentre Randomised Trial
Sandra van Brunschot et al. · The Lancet
Open access |
3 Nov 2017 |
743 |
| 29 |
Diastolic Stiffness of the Failing Diabetic Heart
Loek van Heerebeek, Nazha Hamdani, M. Louis Handoko et al. · Circulation
Open access |
10 Dec 2007 |
735 |
| 30 |
Preoperative Intensive Inspiratory Muscle Training to Prevent Postoperative Pulmonary Complications in High-Risk Patients Undergoing CABG Surgery
Erik H.J. Hulzebos, Paul J.M. Helders, Nine J. Favié et al. · JAMA
|
17 Oct 2006 |
700 |
| 31 |
Burden of adhesions in abdominal and pelvic surgery: systematic review and met-analysis
Richard P. G. ten Broek, Yama Issa, Evert J. P. van Santbrink et al. · BMJ
ReviewOpen access |
3 Oct 2013 |
691 |
| 32 |
Effects of early high-volume continuous venovenous hemofiltration on survival and recovery of renal function in intensive care patients with acute renal failure: A prospective, randomized trial
Catherine S. C. Bouman, Heleen M. Oudemans–van Straaten, Jan G.P. Tijssen et al. · Critical Care Medicine
|
Oct 2002 |
660 |
| 33 |
EORTC Nomograms and Risk Groups for Predicting Recurrence, Progression, and Disease-specific and Overall Survival in Non–Muscle-invasive Stage Ta–T1 Urothelial Bladder Cancer Patients Treated with 1–3 Years of Maintenance Bacillus Calmette-Guérin
Samantha Cambier, Richard J Sylvester, Laurence Collette et al. · European Urology
Open access |
23 Jul 2015 |
660 |
| 34 |
Randomised comparison of implantation of heparin-coated stents with balloon angioplasty in selected patients with coronary artery disease (Benestent II)
Patrick W Serruys, Ben van Hout, Hans Bonnier et al. · The Lancet
|
Aug 1998 |
656 |
| 35 |
European Hernia Society guidelines on the closure of abdominal wall incisions
Filip E. Muysoms et al. · Hernia
Open access |
24 Jan 2015 |
654 |
| 36 |
A Genotype-Guided Strategy for Oral P2Y 12 Inhibitors in Primary PCI
Daniel M.F. Claassens, Gerrit J.A. Vos, Thomas O. Bergmeijer et al. · New England Journal of Medicine
Open access |
3 Sep 2019 |
649 |
| 37 |
Minimally Invasive Versus Open Distal Pancreatectomy (LEOPARD)
Thijs de Rooij et al. · Annals of Surgery
Open access |
3 Aug 2018 |
625 |
| 38 |
Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours (LEOPARD-2): a multicentre, patient-blinded, randomised controlled phase 2/3 trial
Jony van Hilst et al. · The Lancet. Gastroenterology & hepatology
Open access115 authors |
27 Jan 2019 |
611 |
| 39 |
Effect on Survival of Androgen Deprivation Therapy Alone Compared to Androgen Deprivation Therapy Combined with Concurrent Radiation Therapy to the Prostate in Patients with Primary Bone Metastatic Prostate Cancer in a Prospective Randomised Clinical Trial: Data from the HORRAD Trial
Liselotte M.S. Boevé, Maarten C.C.M. Hulshof, André N. Vis et al. · European Urology
|
25 Sep 2018 |
581 |
| 40 |
Continuous renal replacement therapy: A worldwide practice survey
Shigehiko Uchino, Rinaldo Bellomo, Hiroshi Morimatsu et al. · Intensive Care Medicine
|
26 Jun 2007 |
578 |
| 41 |
A bioresorbable everolimus-eluting scaffold versus a metallic everolimus-eluting stent for ischaemic heart disease caused by de-novo native coronary artery lesions (ABSORB II): an interim 1-year analysis of clinical and procedural secondary outcomes from a randomised controlled trial
Patrick W.J.C. Serruys, Bernard Chevalier, Dariusz Dudek et al. · The Lancet
Open access |
15 Sep 2014 |
565 |
| 42 |
Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest
Martje M. Suverein et al. · New England Journal of Medicine
Open access |
25 Jan 2023 |
558 |
| 43 |
Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study
Tom van der Hulle et al. · The Lancet
|
23 May 2017 |
552 |
| 44 |
Coronary Angiography after Cardiac Arrest without ST-Segment Elevation
Jorrit S. Lemkes et al. · New England Journal of Medicine
Open access |
18 Mar 2019 |
548 |
| 45 |
Standardization of terminology of pelvic floor muscle function and dysfunction: Report from the pelvic floor clinical assessment group of the International Continence Society
Bert Messelink, Thomas Benson, Bary C. M. Berghmans et al. · Neurourology and Urodynamics
|
2005 |
548 |
| 46 |
Nitroglycerin in septic shock after intravascular volume resuscitation
Peter E. Spronk, Can İnce, Martin Gardien et al. · The Lancet
|
Nov 2002 |
543 |
| 47 |
Induction versus expectant monitoring for intrauterine growth restriction at term: randomised equivalence trial (DIGITAT)
Kim E. Boers et al. · BMJ
Open access |
21 Dec 2010 |
538 |
| 48 |
Significance of (sub)clinical thyroid dysfunction and thyroid autoimmunity before conception and in early pregnancy: a systematic review
E. van den Boogaard, Rosa Vissenberg, Jolande A. Land et al. · Human Reproduction Update
Review |
28 May 2011 |
533 |
| 49 |
Diagnosis, treatment and prevention of ankle sprains: update of an evidence-based clinical guideline
Gwendolyn Vuurberg, Alexander Hoorntje, Lauren M. Wink et al. · British Journal of Sports Medicine
Open access |
7 Mar 2018 |
527 |
| 50 |
Final Results of an EORTC-GU Cancers Group Randomized Study of Maintenance Bacillus Calmette-Guérin in Intermediate- and High-risk Ta, T1 Papillary Carcinoma of the Urinary Bladder: One-third Dose Versus Full Dose and 1 Year Versus 3 Years of Maintenance
Jorg Reinier Oddens, Maurizio A. Brausi, Richard J Sylvester et al. · European Urology
|
2 Nov 2012 |
523 |