Most cited papers from OncoMed (United States)

OncoMed (United States)

What are the most cited papers from OncoMed (United States)?

The most cited paper from OncoMed (United States) is "Phenotypic characterization of human colorectal cancer stem cells" (Piero D. Dalerba, Scott J. Dylla, In-Kyung Park et al., 2007), with 2,223 citations. Next come "The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis(x) oligosaccharide" (693) and "Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors" (634).

Published TypeFieldAccessCitations

Showing 50 of 61 papers. Every paper with more than 82 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Phenotypic characterization of human colorectal cancer stem cells Piero D. Dalerba, Scott J. Dylla, In-Kyung Park et al. · Proceedings of the National Academy of Sciences Open access	4 Jun 2007	2,223
2	The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis(x) oligosaccharide Carrol Foxall, SR Watson, Donald J. Dowbenko et al. · The Journal of Cell Biology Open access	15 May 1992	693
3	Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors Austin L. Gurney et al. · Proceedings of the National Academy of Sciences Open access	2 Jul 2012	634
4	Colorectal Cancer Stem Cells Are Enriched in Xenogeneic Tumors Following Chemotherapy Scott J. Dylla, Lucia Beviglia, In‐Kyung Park et al. · PLoS ONE Open access	17 Jun 2008	583
5	Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer Jing Shan Lim, Alvaro Ibaseta, Marcus M. Fischer et al. · Nature Open access	9 May 2017	513
6	T cell gelatinases mediate basement membrane transmigration in vitro. David Leppert, Emmanuelle L. Waubant, Richard E. Galardy et al. · The Journal of Immunology	May 1995	503
7	Safety and Efficacy of Nivolumab Monotherapy in Recurrent or Metastatic Cervical, Vaginal, or Vulvar Carcinoma: Results From the Phase I/II CheckMate 358 Trial Robert Wendel Naumann, Antoine Hollebecque, Tim Meyer et al. · Journal of Clinical Oncology Open access	5 Sep 2019	443
8	DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency Timothy Hoey, Wan-Ching Yen, Fumiko T. Axelrod et al. · Cell stem cell Open access	Aug 2009	399
9	Detection of tumor messenger RNA in the serum of patients with malignant melanoma. MICHAEL S. KOPRESKI, Floyd A. Benko, Larry W. Kwak et al. · PubMed	Aug 1999	365
10	Design Parameters to Control Synthetic Gene Expression in Escherichia coli Mark Welch, Sridhar Govindarajan, Jon E. Ness et al. · PLoS ONE Open access	11 Sep 2009	361
11	Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases. Koenraad Gijbels, Richard E. Galardy, Lawrence Steinman · Journal of Clinical Investigation Open access	Dec 1994	341
12	Carbohydrate ligands of the LEC cell adhesion molecules Brian K. Brandley, Stuart J. Swiedler, Phillips W. Robbins · Cell	Nov 1990	337
13	Isolation and Molecular Characterization of Cancer Stem Cells in MMTV-Wnt-1 Murine Breast Tumors Robert W. Cho, Xinhao Wang, Maximilian Diehn et al. · Stem Cells	Nov 2007	291
14	Hormonal Maintenance Therapy for Women With Low-Grade Serous Cancer of the Ovary or Peritoneum David Marc Gershenson, Diane C. Bodurka, Robert Louis Coleman et al. · Journal of Clinical Oncology Open access	21 Feb 2017	279
15	Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency Wan-Ching Yen, Marcus M. Fischer, Fumiko T. Axelrod et al. · Clinical Cancer Research	30 Apr 2015	245
16	Heparin in Inflammation: Potential Therapeutic Applications beyond Anticoagulation David J. Tyrrell, Angela P. Horne, Kevin R. Holme et al. · Advances in pharmacology Book chapter	1999	245
17	Structural requirements for the carbohydrate ligand of E-selectin. David J. Tyrrell, Paul G. James, Narasinga B. N. Rao et al. · Proceedings of the National Academy of Sciences Open access	15 Nov 1991	243
18	Carbohydrate ligands for endothelial-leukocyte adhesion molecule 1. Michael Tiemeyer, Stuart J. Swiedler, Mayumi Ishihara et al. · Proceedings of the National Academy of Sciences Open access	15 Feb 1991	235
19	A First-in-Human Phase I Study of the Anticancer Stem Cell Agent Ipafricept (OMP-54F28), a Decoy Receptor for Wnt Ligands, in Patients with Advanced Solid Tumors Antonio Jimeno, Michael A. Gordon, Rashmi K Chugh et al. · Clinical Cancer Research	28 Sep 2017	208
20	Canonical Wnt Signaling Is Required for Pancreatic Carcinogenesis Yaqing Zhang, John P. Morris, Wei Yan et al. · Cancer Research Open access	12 Jun 2013	207
21	Dose Escalation Trial of the Wee1 Inhibitor Adavosertib (AZD1775) in Combination With Gemcitabine and Radiation for Patients With Locally Advanced Pancreatic Cancer Kyle Clifford Cuneo, Meredith Ann Morgan, Vaibhav Sahai et al. · Journal of Clinical Oncology Open access	9 Aug 2019	203
22	Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study of Sulfasalazine for the treatment of progressing malignant gliomas in adults Pierre A. J. T. Robe, Didier Martin, Minh Nguyen-Khac et al. · BMC Cancer Open access	19 Oct 2009	188
23	Soluble lactose-binding lectin from rat intestine with two different carbohydrate-binding domains in the same peptide chain. Yuko Oda, Joerg Herrmann, Michael A. Gitt et al. · Journal of Biological Chemistry Open access	Mar 1993	183
24	Development of Idarubicin and Doxorubicin Solid Lipid Nanoparticles to Overcome Pgp-Mediated Multiple Drug Resistance in Leukemia Ping Ma, Xiaowei Dong, Courtney L. Swadley et al. · Journal of Biomedical Nanotechnology Open access	26 Mar 2009	174
25	Structure--function studies on selectin carbohydrate ligands. Modifications to fucose, sialic acid and sulphate as a sialic acid replacement Brian K. Brandley, Makato Kiso, S. Abbas et al. · Glycobiology	Dec 1993	171
26	In Vivo Collagen Turnover Following Experimental Balloon Angioplasty Injury and the Role of Matrix Metalloproteinases Bradley H. Strauss, Ranga Robinson, Wayne Batchelor et al. · Circulation Research	Sep 1996	163
27	A Phase I Dose Escalation and Expansion Study of the Anticancer Stem Cell Agent Demcizumab (Anti-DLL4) in Patients with Previously Treated Solid Tumors David C. Smith, Peter D. Eisenberg, Georgy Moiseevich Manikhas et al. · Clinical Cancer Research	17 Oct 2014	161
28	The Safety, Tolerability, and Efficacy of Once-Daily Memantine (28 mg): A Multinational, Randomized, Double-Blind, Placebo-Controlled Trial in Patients with Moderate-to-Severe Alzheimer’s Disease Taking Cholinesterase Inhibitors George Thomas Grossberg, Facundo Francisco Manes, Ricardo Allegri et al. · CNS Drugs Open access	Jun 2013	159
29	Low Molecular Weight Inhibitors in Corneal Ulcerationa Richard E. Galardy et al. · Annals of the New York Academy of Sciences	Sep 1994	159
30	Phase Ib clinical trial of the anti-frizzled antibody vantictumab (OMP-18R5) plus paclitaxel in patients with locally advanced or metastatic HER2-negative breast cancer Jennifer Robinson Diamond, Carlos Becerra, Donald Richards et al. · Breast Cancer Research and Treatment Open access	14 Aug 2020	158
31	WNT antagonists exhibit unique combinatorial antitumor activity with taxanes by potentiating mitotic cell death Marcus M. Fischer, Belinda Cancilla, Vincent Yeung et al. · Science Advances Open access	2 Jun 2017	157
32	Characterization of renal ischemia-reperfusion injury in rats Patricia D. Williams, Henry Lopez, Deborah E. Britt et al. · Journal of Pharmacological and Toxicological Methods	Feb 1997	154
33	Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling Rachel Eyre, Denis Alférez, Angélica Santiago-Gómez et al. · Nature Communications Open access	Nov 2019	150
34	Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations Dustin James Flanagan, Nick Barker, Natasha S. Di Costanzo et al. · Cancer Research Open access	8 Jan 2019	150
35	Serologic Response to Messenger RNA Coronavirus Disease 2019 Vaccines in Inflammatory Bowel Disease Patients Receiving Biologic Therapies Serre-Yu Wong et al. · Gastroenterology Open access	20 Apr 2021	141
36	A phase I dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors Renata Ferrarotto, Gail Eckhardt, Akash Patnaik et al. · Annals of Oncology Open access	2 May 2018	140
37	Inhibition of angiogenesis by the matrix metalloprotease inhibitor N-[2R-2-(hydroxamidocarbonymethyl)-4-methylpentanoyl)]-L-tryptophan methylamide. Richard E. Galardy, Damian W. Grobelny, Harald G. Foellmer et al. · PubMed	Sep 1994	140
38	Preparation of affinity-fractionated, heparin-derived oligosaccharides and their effects on selected biological activities mediated by basic fibroblast growth factor. Masayuki Ishihara, David J. Tyrrell, G.B. Stauber et al. · Journal of Biological Chemistry Open access	Mar 1993	139
39	Chemical modifications of heparin that diminish its anticoagulant but preserve its heparanase-inhibitory, angiostatic, anti-tumor and anti-metastatic properties France Lapierre, Kevin R. Holme, Lun H. Lam et al. · Glycobiology	1996	137
40	A Juxtacrine Mechanism for Neutrophil Adhesion on Platelets Involves Platelet-Activating Factor and a Selectin-Dependent Activation Process Lena L Ostrovsky, Alison J. King, Samantha Bond et al. · Blood	15 Apr 1998	135
41	Cabozantinib As Salvage Therapy for Patients With Tyrosine Kinase Inhibitor–Refractory Differentiated Thyroid Cancer: Results of a Multicenter Phase II International Thyroid Oncology Group Trial Maria E. Cabanillas, Jonas A. de Souza, Susan Michelle Geyer et al. · Journal of Clinical Oncology Open access	17 Aug 2017	132
42	Somatic Mutation Screening: Identification of Individuals Harboring K-ras Mutations With the Use of Plasma DNA MICHAEL S. KOPRESKI · JNCI Journal of the National Cancer Institute	7 Jun 2000	131
43	Therapeutic antibody targeting of Notch1 in T-acute lymphoblastic leukemia xenografts Valentina Agnusdei, Sonia Anna Minuzzo, Chiara Frasson et al. · Leukemia	18 Jun 2013	128
44	Targeting RSPO3-LGR4 Signaling for Leukemia Stem Cell Eradication in Acute Myeloid Leukemia Basit Salik et al. · Cancer Cell Open access	18 Jun 2020	121
45	Anti-DLL4 Inhibits Growth and Reduces Tumor-Initiating Cell Frequency in Colorectal Tumors with Oncogenic KRAS Mutations Marcus M. Fischer, Wan-Ching Yen, Ann M. Kapoun et al. · Cancer Research	30 Dec 2010	121
46	Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia Zhifu Xiang, Hui Luo, Jacqueline E. Payton et al. · Journal of Clinical Investigation Open access	20 May 2010	118
47	A four‐gene methylation marker panel as triage test in high‐risk human papillomavirus positive patients Jasper J.H. Eijsink, Ágnes Lendvai, Valérie Deregowski et al. · International Journal of Cancer Open access	27 Jul 2011	117
48	Therapeutic Targeting of Tumor-Derived R-Spondin Attenuates β-Catenin Signaling and Tumorigenesis in Multiple Cancer Types Cécile Chartier et al. · Cancer Research	11 Jan 2016	115
49	Ca2+/calmodulin-dependent kinase II triggers cell membrane injury by inducing complement factor B gene expression in the mouse heart Madhu V. Singh, Ann M. Kapoun, Linda Slanec Higgins et al. · Journal of Clinical Investigation Open access	9 Mar 2009	114
50	A phase 1b dose escalation study of Wnt pathway inhibitor vantictumab in combination with nab-paclitaxel and gemcitabine in patients with previously untreated metastatic pancreatic cancer Sarah Lindsey Davis, Dana Backlund Cardin, Safi Shahda et al. · Investigational New Drugs Open access	23 Jul 2019	110

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.