| 1 |
Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene
David Clement Whitcomb, Michael C. Gorry, Robert A. Preston et al. · Nature Genetics
|
Oct 1996 |
1,650 |
| 2 |
Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB–IIIA non-small-cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial
Jean‐Yves Douillard et al. · The Lancet Oncology
|
18 Aug 2006 |
1,600 |
| 3 |
Mapping the human genetic architecture of COVID-19
COVID-19 Host Genetics Initiative et al. · Nature
Open access3,896 authors |
8 Jul 2021 |
1,130 |
| 4 |
Inhaler mishandling remains common in real life and is associated with reduced disease control
Andrea S. Melani, Marco Bonavia, Vincenzo Cilenti et al. · Respiratory Medicine
Open access |
7 Mar 2011 |
951 |
| 5 |
Bartter's syndrome, hypokalaemic alkalosis with hypercalciuria, is caused by mutations in the Na–K–2CI cotransporter NKCC2
David B. Simon, Fiona E. Karet, Jahed M. Hamdan et al. · Nature Genetics
|
Jun 1996 |
911 |
| 6 |
Complications of Thyroid Surgery: Analysis of a Multicentric Study on 14,934 Patients Operated on in Italy over 5 Years
L Rosato, Nicola Avenia, Paolo Bernante et al. · World Journal of Surgery
|
17 Feb 2004 |
906 |
| 7 |
Genetic heterogeneity of Barter's syndrome revealed by mutations in the K+ channel, ROMK
David B. Simon, Fiona E. Karet, Juan Rodríguez‐Soriano et al. · Nature Genetics
|
Oct 1996 |
830 |
| 8 |
Tumor-selective action of HDAC inhibitors involves TRAIL induction in acute myeloid leukemia cells
Angela Nebbioso, Nicole Clarke, Emilie Voltz et al. · Nature Medicine
|
26 Dec 2004 |
620 |
| 9 |
Next-generation Allergic Rhinitis and Its Impact on Asthma (ARIA) guidelines for allergic rhinitis based on Grading of Recommendations Assessment, Development and Evaluation (GRADE) and real-world evidence
Jean Bousquet et al. · Journal of Allergy and Clinical Immunology
Open access102 authors |
15 Oct 2019 |
615 |
| 10 |
Sustained virological response to interferon-α is associated with improved outcome in HCV-related cirrhosis: A retrospective study
Savino Bruno, Tommaso Stroffolini, Massimo G. Colombo et al. · Hepatology
Open access |
26 Feb 2007 |
605 |
| 11 |
A randomized clinical trial of high‐intensity warfarin vs. conventional antithrombotic therapy for the prevention of recurrent thrombosis in patients with the antiphospholipid syndrome (WAPS)
Guido Finazzi, Roberto Marchioli, Vincenzo Brancaccio et al. · Journal of Thrombosis and Haemostasis
Open access |
29 Apr 2005 |
590 |
| 12 |
Clinical characteristics and risk factors associated with COVID-19 severity in patients with haematological malignancies in Italy: a retrospective, multicentre, cohort study
Francesco Passamonti et al. · The Lancet Haematology
Open access |
13 Aug 2020 |
555 |
| 13 |
Epidemiology and management of aortic disease: aortic aneurysms and acute aortic syndromes
Eduardo Bossone, Kim Allen Eagle · Nature Reviews Cardiology
Review |
22 Dec 2020 |
488 |
| 14 |
Prevalence of malnutrition in patients at first medical oncology visit: the PreMiO study
Maurizio Muscaritoli et al. · Oncotarget
Open access |
10 Aug 2017 |
442 |
| 15 |
Natural history and risk factors for thrombosis in 360 patients with antiphospholipid antibodies: A four-year prospective study from the italian registry
Guido Finazzi, Vincenzo Brancaccio, Marco Moia et al. · The American Journal of Medicine
|
May 1996 |
435 |
| 16 |
Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants
Veronica De Rosa, Mario Galgani, Antonio Porcellini et al. · Nature Immunology
Open access |
28 Sep 2015 |
419 |
| 17 |
Colistin and Rifampicin Compared With Colistin Alone for the Treatment of Serious Infections Due to Extensively Drug-Resistant Acinetobacter baumannii: A Multicenter, Randomized Clinical Trial
Emanuele Durante‐Mangoni, Giuseppe Signoriello, Roberto Andini et al. · Clinical Infectious Diseases
Open access |
24 Apr 2013 |
413 |
| 18 |
A phase 3, open-label, randomized study of asciminib, a STAMP inhibitor, vs bosutinib in CML after 2 or more prior TKIs
Delphine Réa et al. · Blood
Open access |
18 Aug 2021 |
345 |
| 19 |
Invasive aspergillosis in patients with acute myeloid leukemia: a SEIFEM-2008 registry study
Livio Pagano et al. · Haematologica
Open access |
22 Oct 2009 |
316 |
| 20 |
Bortezomib-thalidomide-dexamethasone is superior to thalidomide-dexamethasone as consolidation therapy after autologous hematopoietic stem cell transplantation in patients with newly diagnosed multiple myeloma
Michèle Cavo et al. · Blood
Open access |
13 Apr 2012 |
311 |
| 21 |
PML-RARα/RXR Alters the Epigenetic Landscape in Acute Promyelocytic Leukemia
Joost H.A. Martens, Arie B. Brinkman, Femke Simmer et al. · Cancer Cell
Open access |
Feb 2010 |
297 |
| 22 |
Prognostic Factors in Noncirrhotic Patients With Splanchnic Vein Thromboses
Lucio Amitrano, Maria Anna Guardascione, Mariano Scaglione et al. · The American Journal of Gastroenterology
|
10 Aug 2007 |
295 |
| 23 |
Effects of climate change on environmental factors in respiratory allergic diseases
Gennaro D’Amato, Lorenzo Cecchi · Clinical & Experimental Allergy
|
4 Jun 2008 |
291 |
| 24 |
Outdoor air pollution, climatic changes and allergic bronchial asthma
Gennaro D’Amato, Gennaro Liccardi, Maria D’Amato et al. · European Respiratory Journal
Open access |
Sep 2002 |
277 |
| 25 |
The laparoscopic mini-gastric bypass: the Italian experience: outcomes from 974 consecutive cases in a multicenter review
Mario Musella, Antonio Susa, Francesco Greco et al. · Surgical Endoscopy
|
27 Aug 2013 |
275 |
| 26 |
ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population
Elisa Benetti et al. · European Journal of Human Genetics
Open access138 authors |
17 Jul 2020 |
270 |
| 27 |
Dexamethasone plus rituximab yields higher sustained response rates than dexamethasone monotherapy in adults with primary immune thrombocytopenia
Francesco F. Zaja et al. · Blood
|
3 Feb 2010 |
262 |
| 28 |
Heterozygous Germline Mutations in the CBL Tumor-Suppressor Gene Cause a Noonan Syndrome-like Phenotype
Simone Martinelli et al. · The American Journal of Human Genetics
Open access |
9 Jul 2010 |
260 |
| 29 |
Clinical Diagnosis of Achilles Tendinopathy With Tendinosis
Nicola Maffulli, Michael G. Kenward, Vittorino Testa et al. · Clinical Journal of Sport Medicine
|
2003 |
251 |
| 30 |
Association of Systemic Inflammation Index and Body Mass Index with Survival in Patients with Renal Cell Cancer Treated with Nivolumab
Ugo De Giorgi et al. · Clinical Cancer Research
Open access |
9 Apr 2019 |
243 |
| 31 |
Increased Risk for Venous Thrombosis in Carriers of the Prothrombin G→A20210 Gene Variant
Maurizio Margaglione, Vincenzo Brancaccio, Nicola Giuliani et al. · Annals of Internal Medicine
|
15 Jul 1998 |
240 |
| 32 |
Biomechanics of the spine. Part I: Spinal stability
Roberto Izzo, Gianluigi Guarnieri, Giuseppe Guglielmi et al. · European Journal of Radiology
|
22 Oct 2012 |
238 |
| 33 |
Hypomethylation at multiple maternally methylated imprinted regions including PLAGL1 and GNAS loci in Beckwith–Wiedemann syndrome
Jet Bliek, Gaetano Verde, Jonathan L A Callaway et al. · European Journal of Human Genetics
Open access |
17 Dec 2008 |
236 |
| 34 |
Genetic Modulation of Oral Anticoagulation with Warfarin
Donatella Colaizzo, Giovanna D’Andrea, Vincenzo Brancaccio et al. · Thrombosis and Haemostasis
|
2000 |
235 |
| 35 |
Complications Following the Mini/One Anastomosis Gastric Bypass (MGB/OAGB): a Multi-institutional Survey on 2678 Patients with a Mid-term (5 Years) Follow-up
Mario Musella, Antonio Susa, Emilio Manno et al. · Obesity Surgery
|
31 May 2017 |
232 |
| 36 |
Haemoglobin switching in human embryos: asynchrony of ζ → α and ε → γ-globin switches in primitive and definitive erythropoietic lineage
C Peschle, Fulvio Mavilio, Alessandra Carè et al. · Nature
Open access |
1985 |
230 |
| 37 |
Endoscopic Management of Foreign Bodies in the Upper Gastrointestinal Tract: Report on a Series of 414 Adult Patients
S Mosca, Gianpiero Manes, Randall R. De Martino et al. · Endoscopy
|
Aug 2001 |
220 |
| 38 |
Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study
Chiara Fallerini et al. · eLife
Open access148 authors |
2 Mar 2021 |
218 |
| 39 |
Italian consensus on diagnosis and treatment of differentiated thyroid cancer: joint statements of six Italian societies
Furio Pacini et al. · Journal of Endocrinological Investigation
Open access |
4 May 2018 |
217 |
| 40 |
Preemptive‐TIPS Improves Outcome in High‐Risk Variceal Bleeding: An Observational Study
Virginia Hernández–Gea et al. · Hepatology
Open access |
17 Jul 2018 |
207 |
| 41 |
Cardiovascular toxicity following sunitinib therapy in metastatic renal cell carcinoma: a multicenter analysis
Giuseppe Di Lorenzo, Riccardo Autorino, Gianni Bruni et al. · Annals of Oncology
Open access |
28 May 2009 |
207 |
| 42 |
Thunderstorm‐asthma and pollen allergy
Gennaro D’Amato, Gennaro Liccardi, Giuseppe Frenguelli · Allergy
|
6 Dec 2006 |
207 |
| 43 |
Spectrum of diagnostic errors in radiology
Antônio Germane Alves Pinto · World Journal of Radiology
Open access |
2010 |
203 |
| 44 |
Peginterferon Alfa-2a Plus Ribavirin Is More Effective Than Peginterferon Alfa-2b Plus Ribavirin for Treating Chronic Hepatitis C Virus Infection
Antonio Ascione, M. De Luca, Maria Teresa Tartaglione et al. · Gastroenterology
|
21 Oct 2009 |
198 |
| 45 |
Immunophenotype of adult and childhood acute promyelocytic leukaemia: correlation with morphology, type of PML gene breakpoint and clinical outcome. A cooperative Italian study on 196 cases
Cesare Guglielmi, Maria Paola Martelli, Daniela Diverio et al. · British Journal of Haematology
Open access |
Sep 1998 |
197 |
| 46 |
Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS
Jonel Trebicka et al. · Journal of Hepatology
Open access |
24 Apr 2020 |
194 |
| 47 |
Final results from the large sunitinib global expanded-access trial in metastatic renal cell carcinoma
Martin Eric Gore et al. · British Journal of Cancer
Open access |
Jun 2015 |
194 |
| 48 |
Consensus statement AIGO/SICCR: Diagnosis and treatment of chronic constipation and obstructed defecation (part I: Diagnosis)
Antonio Bove · World Journal of Gastroenterology
Open access |
2012 |
188 |
| 49 |
Incidence of complications in bronchoscopy. Multicentre prospective study of 20,986 bronchoscopies
Nicola Cosimo Facciolongo, Marco Patelli, Stefano Gasparini et al. · Monaldi Archives for Chest Disease
Open access |
25 Jan 2016 |
186 |
| 50 |
Prognosis of Malignant Pheochromocytoma and Paraganglioma (MAPP-Prono Study): A European Network for the Study of Adrenal Tumors Retrospective Study
S. Hescot et al. · The Journal of Clinical Endocrinology & Metabolism
Open access |
Feb 2019 |
185 |