| 1 |
Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes
Stephen D. Wiviott, Eugene Braunwald, Carolyn H. McCabe et al. · New England Journal of Medicine
Open access |
4 Nov 2007 |
6,822 |
| 2 |
A comprehensive 1000 Genomes–based genome-wide association meta-analysis of coronary artery disease
Majid Nikpay et al. · Nature Genetics
ReviewOpen access151 authors |
7 Sep 2015 |
2,733 |
| 3 |
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Cardiogenics et al. · Nature Genetics
Open access167 authors |
6 Mar 2011 |
1,959 |
| 4 |
Diagnosis and treatment of acute appendicitis: 2020 update of the WSES Jerusalem guidelines
Salomone Di Saverio et al. · World Journal of Emergency Surgery
Open access |
15 Apr 2020 |
1,456 |
| 5 |
Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT)
Gualtiero Palareti, Nicoletta Leali, SERGIO COCCHERI et al. · The Lancet
|
Aug 1996 |
1,342 |
| 6 |
Trial of Decompressive Craniectomy for Traumatic Intracranial Hypertension
Peter J. Hutchinson et al. · New England Journal of Medicine
Open access |
7 Sep 2016 |
1,295 |
| 7 |
Genome-wide meta-analyses identify multiple loci associated with smoking behavior
Helena Furberg et al. · Nature Genetics
Open access116 authors |
25 Apr 2010 |
1,169 |
| 8 |
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants
Sekar Kathiresan et al. · Nature Genetics
Open access123 authors |
8 Feb 2009 |
1,106 |
| 9 |
Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia
Amit V. Khera et al. · Journal of the American College of Cardiology
Open access |
3 Apr 2016 |
961 |
| 10 |
Characterization of Hepatitis B Virus (HBV)-Specific T-Cell Dysfunction in Chronic HBV Infection
Carolina Boni, Paola Fisicaro, Caterina Valdatta et al. · Journal of Virology
Open access |
7 Feb 2007 |
923 |
| 11 |
Prasugrel versus Clopidogrel for Acute Coronary Syndromes without Revascularization
Matthew T. Roe et al. · New England Journal of Medicine
Open access |
26 Aug 2012 |
884 |
| 12 |
Applications of Evolutionary Computing
David Hutchison et al. · Lecture notes in computer science
Conference paper |
2009 |
864 |
| 13 |
The hepatitis B virus persists for decades after patients' recovery from acute viral hepatitis despite active maintenance of a cytotoxic T–lymphocyte response
Barbara Rehermann, Carlo I. Ferrari, Claudio Pasquinelli et al. · Nature Medicine
|
Oct 1996 |
860 |
| 14 |
Biochemical markers of muscular damage
Paola Brancaccio, Giuseppe Lippi, Nicola Maffulli · Clinical Chemistry and Laboratory Medicine (CCLM)
|
Jun 2010 |
845 |
| 15 |
Statements from the Taormina expert meeting on occult hepatitis B virus infection
Giovanni Raimondo et al. · Journal of Hepatology
|
Aug 2008 |
834 |
| 16 |
The Role of Virus-Specific Cd8+ Cells in Liver Damage and Viral Control during Persistent Hepatitis B Virus Infection
Mala K. Maini, Carolina Boni, Chun Kyon Lee et al. · The Journal of Experimental Medicine
Open access |
10 Apr 2000 |
804 |
| 17 |
COVID-19 pneumonia: ARDS or not?
Luciano Gattinoni, Davide Chiumello, Sandra Rossi · Critical Care
Open access |
16 Apr 2020 |
707 |
| 18 |
Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study
Christopher Paul Cannon, Robert A. Harrington, Stefan Karl James et al. · The Lancet
|
2010 |
664 |
| 19 |
Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response.
Gabriele Missale, Roberto Bertoni, Vincenzo Lamonaca et al. · Journal of Clinical Investigation
Open access |
Aug 1996 |
663 |
| 20 |
Blood-pressure control for renoprotection in patients with non-diabetic chronic renal disease (REIN-2): multicentre, randomised controlled trial
Piero Luigi Ruggenenti, Annalisa Perna, Giacomina Loriga et al. · The Lancet
|
Mar 2005 |
648 |
| 21 |
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens
Krzysztof Kiryluk et al. · Nature Genetics
Open access |
12 Oct 2014 |
636 |
| 22 |
Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2017 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group
Richard P. G. ten Broek et al. · World Journal of Emergency Surgery
Open access |
18 Jun 2018 |
622 |
| 23 |
PD-1 Expression in Acute Hepatitis C Virus (HCV) Infection Is Associated with HCV-Specific CD8 Exhaustion
Simona Urbani, Barbara Amadei, Daniela Tola et al. · Journal of Virology
Open access |
28 Oct 2006 |
597 |
| 24 |
Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study
Armando Santoro et al. · The Lancet Oncology
|
19 Nov 2012 |
558 |
| 25 |
Cardiac computed tomography: indications, applications, limitations, and training requirements: Report of a Writing Group deployed by the Working Group Nuclear Cardiology and Cardiac CT of the European Society of Cardiology and the European Council of Nuclear Cardiology
Stephen R. Schroeder, Susanne Achenbach, F. Bengel et al. · European Heart Journal
Open access |
16 Dec 2007 |
557 |
| 26 |
Oxidative stress: role of physical exercise and antioxidant nutraceuticals in adulthood and aging
Carolina Simioni, Giorgio Zauli, Alberto Maria Martelli et al. · Oncotarget
Open access |
30 Mar 2018 |
527 |
| 27 |
Enoxaparin plus Compression Stockings Compared with Compression Stockings Alone in the Prevention of Venous Thromboembolism after Elective Neurosurgery
Giancarlo Agnelli, Franco Piovella, Pio Buoncristiani et al. · New England Journal of Medicine
|
9 Jul 1998 |
523 |
| 28 |
Adaptive immunity in HBV infection
Antonio Bertoletti, Carlo I. Ferrari · Journal of Hepatology
|
Apr 2016 |
507 |
| 29 |
RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg
Christine I. Wooddell, Man‐Fung Yuen, Henry Lik‐Yuen Chan et al. · Science Translational Medicine
Open access |
27 Sep 2017 |
499 |
| 30 |
Antiviral Intrahepatic T-Cell Responses Can Be Restored by Blocking Programmed Death-1 Pathway in Chronic Hepatitis B
Paola Fisicaro, Caterina Valdatta, Marco Massari et al. · Gastroenterology
Open access |
Oct 2009 |
497 |
| 31 |
New susceptibility locus for coronary artery disease on chromosome 3q22.3
Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group et al. · Nature Genetics
Open access |
8 Feb 2009 |
488 |
| 32 |
Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection
Antonio Bertoletti, Carlo I. Ferrari · Gut
|
9 Dec 2011 |
484 |
| 33 |
Lamivudine treatment can restore T cell responsiveness in chronic hepatitis B.
Carolina Boni, Antonio Bertoletti, Amalia Penna et al. · Journal of Clinical Investigation
Open access |
Sep 1998 |
462 |
| 34 |
WSES Jerusalem guidelines for diagnosis and treatment of acute appendicitis
Salomone Di Saverio et al. · World Journal of Emergency Surgery
Open access |
18 Jul 2016 |
450 |
| 35 |
Care of patients with chronic hepatitis C and HIV co-infection: recommendations from the HIV–HCV International Panel
Vincent Soriano, Mark Sulkowski, Colm J Bergin et al. · AIDS
|
Apr 2002 |
445 |
| 36 |
Natural history and risk factors for thrombosis in 360 patients with antiphospholipid antibodies: A four-year prospective study from the italian registry
Guido Finazzi, Vincenzo Brancaccio, Marco Moia et al. · The American Journal of Medicine
|
May 1996 |
435 |
| 37 |
AUGMENT: A Phase III Study of Lenalidomide Plus Rituximab Versus Placebo Plus Rituximab in Relapsed or Refractory Indolent Lymphoma
John Paul Leonard et al. · Journal of Clinical Oncology
Open access |
21 Mar 2019 |
433 |
| 38 |
Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population
Lim E.T. et al. · Digital Commons@Becker (Washington University School of Medicine)
Open access |
2014 |
428 |
| 39 |
Second-Generation Drug-Eluting Stent Implantation Followed by 6- Versus 12-Month Dual Antiplatelet Therapy
Antonio Hugo Bezerra Colombo, Alaide Chieffo, Arian Frasheri et al. · Journal of the American College of Cardiology
Open access |
15 Sep 2014 |
428 |
| 40 |
Adjuvant chemotherapy vs radiotherapy in high-risk endometrial carcinoma: results of a randomised trial
Renato Maggi, Andrea Alberto Lissoni, Francesco Spina et al. · British Journal of Cancer
Open access |
25 Jul 2006 |
425 |
| 41 |
Neuroprotective Effect of Reduced Glutathione on Oxaliplatin-Based Chemotherapy in Advanced Colorectal Cancer: A Randomized, Double-Blind, Placebo-Controlled Trial
Stefano Cascinu, Vincenzo Catalano, L. Cordella et al. · Journal of Clinical Oncology
|
15 Aug 2002 |
423 |
| 42 |
Gut Microbiota, Muscle Mass and Function in Aging: A Focus on Physical Frailty and Sarcopenia
Andrea Ticinesi, Antonio Nouvenne, Nicoletta Cerundolo et al. · Nutrients
Open access |
17 Jul 2019 |
411 |
| 43 |
Genome-wide meta-analyses identify three loci associated with primary biliary cirrhosis
Xiangdong Liu et al. · Nature Genetics
Open access |
18 Jul 2010 |
399 |
| 44 |
COVID-19 and kidney transplantation: Results from the TANGO International Transplant Consortium
Paolo Cravedi et al. · American Journal of Transplantation
Open access |
10 Jul 2020 |
397 |
| 45 |
Sentinel European Node Trial (SENT): 3-year results of sentinel node biopsy in oral cancer
Clare Schilling et al. · European Journal of Cancer
|
18 Nov 2015 |
396 |
| 46 |
Aging Gut Microbiota at the Cross-Road between Nutrition, Physical Frailty, and Sarcopenia: Is There a Gut–Muscle Axis?
Andrea Ticinesi, Fulvio Lauretani, Christian Milani et al. · Nutrients
Open access |
30 Nov 2017 |
393 |
| 47 |
Diagnostic accuracy of non-invasive 64-slice CT coronary angiography in patients with stable angina pectoris
Francesca Pugliese, Nico R. Mollet, Giuseppe Runza et al. · European Radiology
|
15 Nov 2005 |
381 |
| 48 |
Restored Function of HBV-Specific T Cells After Long-term Effective Therapy With Nucleos(t)ide Analogues
Carolina Boni, Diletta Laccabue, Pietro Lampertico et al. · Gastroenterology
|
14 Jul 2012 |
378 |
| 49 |
Direct ex vivo analysis of hepatitis B virus-specific CD8+ T cells associated with the control of infection
Mala K. Maini, Carolina Boni, Graham Stuart Ogg et al. · Gastroenterology
Open access |
Dec 1999 |
366 |
| 50 |
Efficacy of adjuvant chemotherapy after curative resection for gastric cancer: A meta-analysis of published randomised trials
Eleonora Mari, Irene Floriani, Angelo Tinazzi et al. · Annals of Oncology
ReviewOpen access |
Jul 2000 |
365 |