| 1 |
Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017
Christina Fitzmaurice et al. · JAMA Oncology
Open access628 authors |
27 Sep 2019 |
2,699 |
| 2 |
The PRIAMO study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson's disease
Paolo Barone et al. · Movement Disorders
|
9 Jun 2009 |
1,459 |
| 3 |
Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly
Annamaria Cattaneo et al. · Neurobiology of Aging
Open access |
9 Sep 2016 |
1,399 |
| 4 |
Radial versus femoral access in patients with acute coronary syndromes undergoing invasive management: a randomised multicentre trial
Marco Valgimigli et al. · The Lancet
Open access |
18 Mar 2015 |
1,311 |
| 5 |
Internal Mammary and Medial Supraclavicular Irradiation in Breast Cancer
Philip M. Poortmans et al. · New England Journal of Medicine
Open access |
22 Jul 2015 |
1,033 |
| 6 |
Burden of 375 diseases and injuries, risk-attributable burden of 88 risk factors, and healthy life expectancy in 204 countries and territories, including 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Simon I Hay et al. · The Lancet
Open access2,780 authors |
Oct 2025 |
762 |
| 7 |
SURVIVAL AND CAUSES OF DEATH IN THALASSAEMIA MAJOR
MariaGrazia Zurlo, Piero De Stefano, Caterina Borgna‐Pignatti et al. · The Lancet
|
Jul 1989 |
616 |
| 8 |
Sentinel Lymph Node Biopsy vs No Axillary Surgery in Patients With Small Breast Cancer and Negative Results on Ultrasonography of Axillary Lymph Nodes
Oreste Gentilini et al. · JAMA Oncology
Open access |
21 Sep 2023 |
566 |
| 9 |
Active Surveillance for Low-Risk Prostate Cancer Worldwide: The PRIAS Study
Meelan Bul, Xiaoye Zhu, R. Valdagni et al. · European Urology
|
12 Nov 2012 |
545 |
| 10 |
Global burden of 292 causes of death in 204 countries and territories and 660 subnational locations, 1990–2023: a systematic analysis for the Global Burden of Disease Study 2023
Mohsen Naghavi et al. · The Lancet
Open access2,463 authors |
Oct 2025 |
500 |
| 11 |
Outpatient Treatment of Recent-Onset Atrial Fibrillation with the “Pill-in-the-Pocket” Approach
Paoló Alboni, Giovanni Luca Botto, N Baldi et al. · New England Journal of Medicine
Open access |
Dec 2004 |
486 |
| 12 |
Predictive Value of the Short Physical Performance Battery Following Hospitalization in Older Patients
Stefano Volpato, Margherita Cavalieri, F. Sioulis et al. · The Journals of Gerontology Series A
Open access |
22 Sep 2010 |
468 |
| 13 |
Outcomes in Patients With Hyperglycemia Affected by COVID-19: Can We Do More on Glycemic Control?
Celestino Sardu, Nunzia D’Onofrio, Maria Luisa Balestrieri et al. · Diabetes Care
Open access |
19 May 2020 |
454 |
| 14 |
Clinical Presentation and Outcome in a Contemporary Cohort of Patients With Acute Myocarditis
Enrico Ammirati et al. · Circulation
Open access |
15 May 2018 |
449 |
| 15 |
Bacterial infection in patients with advanced cirrhosis: a multicentre prospective study
Mauro Borzio, Francesco Salerno, Lucas Piantoni et al. · Digestive and Liver Disease
|
Feb 2001 |
439 |
| 16 |
Diagnostic Performance of In‐Procedure Angiography‐Derived Quantitative Flow Reserve Compared to Pressure‐Derived Fractional Flow Reserve: The FAVOR II Europe‐Japan Study
Jelmer Sybren Westra et al. · Journal of the American Heart Association
Open access |
6 Jul 2018 |
425 |
| 17 |
Successful Validation of the Palliative Prognostic Score in Terminally Ill Cancer Patients
Marco Cesare Maltoni, Oriana Nanni, Marco Pirovano et al. · Journal of Pain and Symptom Management
Open access |
Apr 1999 |
419 |
| 18 |
A New Palliative Prognostic Score
Marco Pirovano, Marco Cesare Maltoni, Oriana Nanni et al. · Journal of Pain and Symptom Management
Open access |
Apr 1999 |
418 |
| 19 |
Presence and Duration of Atrial Fibrillation Detected by Continuous Monitoring: Crucial Implications for the Risk of Thromboembolic Events
Giovanni Luca Botto, Luigi Padeletti, Massimo Santini et al. · Journal of Cardiovascular Electrophysiology
Open access |
31 Oct 2008 |
381 |
| 20 |
Mechanism of Syncope in Patients With Isolated Syncope and in Patients With Tilt-Positive Syncope
Angel Moya, Michele Brignole, Carlo Menozzi et al. · Circulation
Open access |
11 Sep 2001 |
380 |
| 21 |
Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study
Roberto Cairoli · Blood
Open access |
30 Dec 2005 |
378 |
| 22 |
Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized controlled trial
Antonio Palumbo, Sara Bringhen, Anna Marina Liberati et al. · Blood
Open access |
27 May 2008 |
359 |
| 23 |
The current consensus on the clinical management of intracranial ependymoma and its distinct molecular variants
Kristian W. Pajtler et al. · Acta Neuropathologica
Open access |
17 Nov 2016 |
341 |
| 24 |
Occurrence of Pituitary Dysfunction following Traumatic Brain Injury
Marta Bondanelli, Laura De Marinis, Maria Rosaria Ambrosio et al. · Journal of Neurotrauma
|
Jun 2004 |
329 |
| 25 |
Clinical Presentation of COVID19 in Dementia Patients
Angelo Bianchetti, Renzo Rozzini, Fabio Guerini et al. · The journal of nutrition health & aging
Open access |
15 May 2020 |
327 |
| 26 |
Microsatellite Instability and High Content of Activated Cytotoxic Lymphocytes Identify Colon Cancer Patients with a Favorable Prognosis
Massimo Guidoboni, Roberta Gafà, Alessandra Viel et al. · American Journal Of Pathology
Open access |
Jul 2001 |
325 |
| 27 |
Management and Long-Term Prognosis of Spontaneous Coronary Artery Dissection
Corrado Lettieri et al. · The American Journal of Cardiology
|
10 Apr 2015 |
310 |
| 28 |
Radial versus femoral access and bivalirudin versus unfractionated heparin in invasively managed patients with acute coronary syndrome (MATRIX): final 1-year results of a multicentre, randomised controlled trial
Marco Valgimigli et al. · The Lancet
108 authors |
25 Aug 2018 |
309 |
| 29 |
Internal mammary and medial supraclavicular lymph node chain irradiation in stage I–III breast cancer (EORTC 22922/10925): 15-year results of a randomised, phase 3 trial
Philip M. Poortmans et al. · The Lancet Oncology
Open access |
2 Nov 2020 |
302 |
| 30 |
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders
Chris Q. Eijsbouts et al. · Nature Genetics
Open access127 authors |
Nov 2021 |
296 |
| 31 |
Phyllodes Tumor of the Breast
Yazid Belkacémi, Guilhem Bousquet, Hugo Raul Marsiglia et al. · International Journal of Radiation Oncology*Biology*Physics
|
14 Nov 2007 |
295 |
| 32 |
The tale of TILs in breast cancer: A report from The International Immuno-Oncology Biomarker Working Group
Khalid El Bairi et al. · npj Breast Cancer
Open access554 authors |
Dec 2021 |
288 |
| 33 |
Prospective Observational Study on acute Appendicitis Worldwide (POSAW)
Massimo Sartelli et al. · World Journal of Emergency Surgery
Open access149 authors |
16 Apr 2018 |
282 |
| 34 |
Outcomes and patterns of failure in solitary plasmacytoma: A multicenter Rare Cancer Network study of 258 patients
Mahmut Özsahin, Richard W. C. Tsang, Philip M. Poortmans et al. · International Journal of Radiation Oncology*Biology*Physics
|
18 Oct 2005 |
281 |
| 35 |
AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders
Vincenzo Salpietro et al. · Nature Communications
Open access239 authors |
12 Jul 2019 |
258 |
| 36 |
Glioblastoma‐derived tumorospheres identify a population of tumor stem‐like cells with angiogenic potential and enhanced multidrug resistance phenotype
Andrea Salmaggi, Amerigo Boiardi, Maurizio Gelati et al. · Glia
|
15 Sep 2006 |
255 |
| 37 |
Device-detected subclinical atrial tachyarrhythmias: definition, implications and management—an European Heart Rhythm Association (EHRA) consensus document, endorsed by Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS) and Sociedad Latinoamericana de Estimulación Cardíaca y Electrofisiología (SOLEACE)
Bülent Görenek et al. · EP Europace
Open access |
10 Jul 2017 |
246 |
| 38 |
Plasma cytokines profile in older subjects with late onset Alzheimer’s disease or vascular dementia
Giovanni Zuliani, Monica Ranzini, Gianluca Guerra et al. · Journal of Psychiatric Research
|
5 Apr 2006 |
243 |
| 39 |
The progression of non-motor symptoms in Parkinson’s disease and their contribution to motor disability and quality of life
Angelo Antonini et al. · Journal of Neurology
|
19 Jun 2012 |
240 |
| 40 |
Effectiveness of a cognitive rehabilitation program in mild dementia (MD) and mild cognitive impairment (MCI): A case control study
E Talassi, Massimo Guerreschi, Michela Feriani et al. · Archives of Gerontology and Geriatrics
|
2007 |
238 |
| 41 |
Infarct size, inflammatory burden, and admission hyperglycemia in diabetic patients with acute myocardial infarction treated with SGLT2-inhibitors: a multicenter international registry
Pasquale Paolisso, Luca Bergamaschi, Gaetano Santulli et al. · Cardiovascular Diabetology
Open access |
15 May 2022 |
221 |
| 42 |
Bolus tenecteplase for right ventricle dysfunction in hemodynamically stable patients with pulmonary embolism
Cecilia Becattini, Giancarlo Agnelli, Aldo Salvi et al. · Thrombosis Research
|
15 Oct 2009 |
220 |
| 43 |
Sporadic colorectal adenocarcinomas with high-frequency microsatellite instability
Roberta Gaf�, Iva Maestri, Maurizio Matteuzzi et al. · Cancer
|
15 Nov 2000 |
216 |
| 44 |
Gefitinib in patients with progressive high-grade gliomas: a multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)
Enrico Franceschi, Giovanni Patrick Cavallo, Sara Lonardi et al. · British Journal of Cancer
Open access |
13 Mar 2007 |
212 |
| 45 |
Impact of COVID-19 Pandemic on Mechanical Reperfusion for Patients With STEMI
Giuseppe De Luca et al. · Journal of the American College of Cardiology
Open access |
Nov 2020 |
210 |
| 46 |
Long-term oral branched-chain amino acid treatment in chronic hepatic encephalopathy
Giulio Marchesini, Francesco Saverio Dioguardi, Giampaolo P. Bianchi et al. · Journal of Hepatology
|
Jul 1990 |
210 |
| 47 |
Cardiorenal Syndrome: An Overview
Claudio Ronco, Antonio Bellasi, Luca Di Lullo · Advances in Chronic Kidney Disease
|
Sep 2018 |
209 |
| 48 |
Mechanism of Syncope in Patients With Heart Disease and Negative Electrophysiologic Test
Carlo Menozzi, Michele Brignole, Roberto García–Civera et al. · Circulation
Open access |
11 Jun 2002 |
205 |
| 49 |
Impact of delirium on the short term prognosis of advanced cancer patients
Augusto Tommaso Caraceni, Oriana Nanni, Marco Cesare Maltoni et al. · Cancer
|
Sep 2000 |
204 |
| 50 |
The diagnosis and clinical management of the neuropsychiatric manifestations of lupus
Marcello Govoni, Alessandra Bortoluzzi, Melissa Padovan et al. · Journal of Autoimmunity
Open access |
15 Jul 2016 |
203 |