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Institution · Otsuka Pharmaceutical (Spain)

Most cited papers from Otsuka Pharmaceutical (Spain)

Otsuka Pharmaceutical (Spain)

What are the most cited papers from Otsuka Pharmaceutical (Spain)?

The most cited paper from Otsuka Pharmaceutical (Spain) is "Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure" (Biykem Bozkurt et al., 2021), with 1,644 citations. Next come "Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury" (887) and "Brain-derived Neurotrophic Factor Is Stored in Human Platelets and Released by Agonist Stimulation" (786).

Showing 50 of 60 papers. Every paper with more than 131 citations is listed.

Most cited papers, sortable by citations and release date
#Paper
1 Universal definition and classification of heart failure: a report of the Heart Failure Society of America, Heart Failure Association of the European Society of Cardiology, Japanese Heart Failure Society and Writing Committee of the Universal Definition of Heart Failure Biykem Bozkurt et al. · European Journal of Heart Failure Open access 19 Feb 2021 1,644
2 Inflammasome Activation of Cardiac Fibroblasts Is Essential for Myocardial Ischemia/Reperfusion Injury Masanori Kawaguchi, Masafumi Takahashi, Takeki Hata et al. · Circulation 31 Jan 2011 887
3 Brain-derived Neurotrophic Factor Is Stored in Human Platelets and Released by Agonist Stimulation Hironobu Fujimura, Ruoyan Chen, Takashi Nakamura et al. · Thrombosis and Haemostasis 2002 786
4 Evidence for the involvement of interleukin 6 in experimental cancer cachexia. Gideon Strassmann, M Fong, J S Kenney et al. · Journal of Clinical Investigation Open access May 1992 662
5 Neurotrophins and depression C. Anthony Altar · Trends in Pharmacological Sciences Review Feb 1999 537
6 IL-6 stimulates osteoclast-like multinucleated cell formation in long term human marrow cultures by inducing IL-1 release. Noriyoshi Kurihara, Donald R. Bertolini, Toshio Suda et al. · The Journal of Immunology Jun 1990 494
7 Cytoprotective Role of Ca 2+ - Activated K + Channels in the Cardiac Inner Mitochondrial Membrane Wenhong Xu, Yongge Liu, Sheng Wang et al. · Science 31 Oct 2002 478
8 Tissue-Specific mRNA Expression Profiles of Human Toll-Like Receptors and Related Genes Masuhiro Nishimura, Shinsaku Naito · Biological and Pharmaceutical Bulletin Open access 2005 448
9 Tissue-specific mRNA Expression Profiles of Human ATP-binding Cassette and Solute Carrier Transporter Superfamilies Masuhiro Nishimura, Shinsaku Naito · Drug Metabolism and Pharmacokinetics 2005 391
10 The loss of endothelium-dependent vascular relaxation in hypertension. Warren E. Lockette, Yuji Otsuka, Oscar A. Carretero · Hypertension Open access Jun 1986 371
11 Evidence for the involvement of interleukin 10 in the differential deactivation of murine peritoneal macrophages by prostaglandin E2. Gideon Strassmann, Vina Patil-koota, F D Finkelman et al. · The Journal of Experimental Medicine Open access Dec 1994 369
12 Genetic Polymorphism in the 5'-Flanking Region of HumanCYP1A2 Gene: Effect on the CYP1A2 Inducibility in Humans Mitsutoshi Nakajima, Tsuyoshi Yokoi, Mayumi Mizutani et al. · The Journal of Biochemistry Apr 1999 348
13 Delamanid improves outcomes and reduces mortality in multidrug-resistant tuberculosis Vija Skripconoka, Manfred Danilovitš, Lea Pehme et al. · European Respiratory Journal Open access 27 Sep 2012 344
14 Soluble E-selectin is found in supernatants of activated endothelial cells and is elevated in the serum of patients with septic shock Walter Newman, L. Dawson Beall, Craig W. Carson et al. · The Journal of Immunology 1993 343
15 A multicenter, randomized, double-blind, controlled phase 3 trial of fixed-dose brexpiprazole for the treatment of adults with acute schizophrenia John Michael Kane, Aleksandar Skuban, John Ouyang et al. · Schizophrenia Research 12 Feb 2015 327
16 Molecular Cloning and Expression of Rat Interleukin-1α cDNA Tsutomu Nishida, Naoki Nishino, Masaaki Takano et al. · The Journal of Biochemistry Mar 1989 327
17 Tissue Distribution of mRNA Expression of Human Cytochrome P450 Isoforms Assessedby High-Sensitivity Real-Time Reverse Transcription PCR Masuhiro Nishimura, Hiroshi YAGUTI, Hiroki YOSHITSUGU et al. · YAKUGAKU ZASSHI Open access 2003 316
18 Nocturnal Blood Pressure Fall on Ambulatory Monitoring in a Large International Database Jan A. Staessen, Leszek Bieniaszewski, Eoin O’Brien et al. · Hypertension 1997 315
19 Adhesion through the LFA-1 (CD11a/CD18)-ICAM-1 (CD54) and the VLA-4 (CD49d)-VCAM-1 (CD106) pathways prevents apoptosis of germinal center B cells. Gerrit Koopman, Robert M. J. Keehnen, Ernst Lindhout et al. · The Journal of Immunology Apr 1994 311
20 Hyponatremia in cirrhosis: From pathogenesis to treatment† Pere Ginès, Tomás Berl, Mauro Bernardi et al. · Hepatology Open access Sep 1998 300
21 Levels of the human hepatocyte growth factor in serum of patients with various liver diseases determined by an enzyme-linked immunosorbent assay Hirohito Tsubouchi, Yoshiyuki Niitani, Shuichi Hirono et al. · Hepatology Open access 1991 295
22 Disruption of Nuclear Vitamin D Receptor Gene Causes Enhanced Thrombogenicity in Mice Ken‐ichi Aihara, Hiroyuki Azuma, Masashi Akaike et al. · Journal of Biological Chemistry Open access 18 Jun 2004 268
23 Vasopressin-2-receptor antagonism augments water excretion without changes in renal hemodynamics or sodium and potassium excretion in human heart failure Lisa C. Costello‐Boerrigter, William Burton Smith, Guido Boerrigter et al. · American Journal of Physiology-Renal Physiology Open access 28 Sep 2005 264
24 Prevalence of autosomal dominant polycystic kidney disease in the European Union Cynthia J Willey, Jaime D. Blais, Anthony K Hall et al. · Nephrology Dialysis Transplantation Open access 20 Jun 2016 253
25 Switching patients to aripiprazole from other antipsychotic agents: a multicenter randomized study on behalf of the Aripiprazole Study Group, Daniel E. Casey, William H. Carson et al. · Psychopharmacology 28 Feb 2003 252
26 The Risk of Switch to Mania in Patients With Bipolar Disorder During Treatment With an Antidepressant Alone and in Combination With a Mood Stabilizer Alexander Viktorin, Paul Lichtenstein, Michael E. Thase et al. · American Journal of Psychiatry Open access 17 Jun 2014 250
27 Diagnosis and Management of Hyponatremia in Cancer Patients Jorge J. Castillo, Marc Vincent, Eric Justice · The Oncologist Open access 22 May 2012 241
28 Primary hyperparathyroidism caused by parathyroid-targeted overexpression of cyclin D1 in transgenic mice Yasuo Imanishi, Yoshitaka Hosokawa, Katsuhiko Yoshimoto et al. · Journal of Clinical Investigation Open access May 2001 238
29 The economic burden of bipolar I disorder in the United States in 2015 Martin Cloutier, Mallik Greene, Annie Guérin et al. · Journal of Affective Disorders Open access 14 Sep 2017 222
30 Effect of the Novel Antiplatelet Agent Cilostazol on Plasma Lipoproteins in Patients With Intermittent Claudication Marshall B. Elam, Jeffrey Heckman, John Robert Crouse et al. · Arteriosclerosis Thrombosis and Vascular Biology Open access Dec 1998 214
31 Regulation and function of the cyclic nucleotide phosphodiesterase (PDE3) gene family Yasmin Shakur, Lena Stenson Holst, Tova Rahn Landström et al. · Progress in nucleic acid research and molecular biology Book chapter 2000 214
32 Clinical Benefit of Islet Xenotransplantation for the Treatment of Type 1 Diabetes Shinichi Matsumoto, Adrián Abalovich, Carlos Wechsler et al. · EBioMedicine Open access 29 Aug 2016 208
33 T cells bind to cytokine-activated endothelial cells via a novel, inducible sialoglycoprotein and endothelial leukocyte adhesion molecule-1. Norma L. Graber, T. Venkat Gopal, Duncan Wilson et al. · The Journal of Immunology Aug 1990 198
34 Clinical Pattern of Tolvaptan-Associated Liver Injury in Subjects with Autosomal Dominant Polycystic Kidney Disease: Analysis of Clinical Trials Database Paul Brent Watkins, James H. Lewis, Neil Kaplowitz et al. · Drug Safety Open access 18 Jul 2015 197
35 Decreased food intake and body weight in pancreatic polypeptide-overexpressing mice Naohiko Ueno, Akio Inui, Masako Iwamoto et al. · Gastroenterology Open access Dec 1999 192
36 Targeted Mutagenesis in Mammalian Cells Mediated by Intracellular Triple Helix Formation Gan Wang, Dan D. Levy, Michael M. Seidman et al. · Molecular and Cellular Biology Open access Mar 1995 186
37 Digital health technology for use in patients with serious mental illness: a systematic review of the literature Sonal Batra, Ross A. Baker, Tao Wang et al. · Medical Devices Evidence and Research ReviewOpen access Oct 2017 185
38 Phase I and biomarker study of OPB-51602, a novel signal transducer and activator of transcription (STAT) 3 inhibitor, in patients with refractory solid malignancies Andrea L.A. Wong et al. · Annals of Oncology Open access 22 Jan 2015 175
39 Cilostazol as a Unique Antithrombotic Agent Junichi Kambayashi, Yongge Liu, Bing Sun et al. · Current Pharmaceutical Design Nov 2003 173
40 Tissue-specific mRNA Expression Profiles of Human Nuclear Receptor Subfamilies Masuhiro Nishimura, Shinsaku Naito, Tsuyoshi Yokoi · Drug Metabolism and Pharmacokinetics 2004 172
41 Efficacy and safety of delamanid in combination with an optimised background regimen for treatment of multidrug-resistant tuberculosis: a multicentre, randomised, double-blind, placebo-controlled, parallel group phase 3 trial Florian von Groote-Bidlingmaier et al. · The Lancet Respiratory Medicine Open access 8 Jan 2019 169
42 Mechanisms of resistance to delamanid, a drug for Mycobacterium tuberculosis Mamoru Fujiwara, Masanori Kawasaki, Norimitsu Hariguchi et al. · Tuberculosis 29 Dec 2017 166
43 Delamanid: From discovery to its use for pulmonary multidrug-resistant tuberculosis (MDR-TB) Yongge Liu, Makoto Matsumoto, Hidekaza Ishida et al. · Tuberculosis 3 May 2018 165
44 Upregulation of Prostacyclin Synthesis–Related Gene Expression by Shear Stress in Vascular Endothelial Cells Kazuhiro Okahara, Bing Sun, Junichi Kambayashi · Arteriosclerosis Thrombosis and Vascular Biology Open access Dec 1998 160
45 Cyclic nucleotide phosphodiesterase type IV participates in the regulation of IL-10 and in the subsequent inhibition of TNF-α and IL-6 release by endotoxin-stimulated macrophages Taku Kambayashi, Chaim O. Jacob, Dandan Zhou et al. · The Journal of Immunology Nov 1995 159
46 Hypoplasia of pancreatic islets in transgenic mice expressing activin receptor mutants. Takashi Yamaoka, Chiyoko Idehara, Masashi Yano et al. · Journal of Clinical Investigation Open access 15 Jul 1998 154
47 Aripiprazole once-monthly for treatment of schizophrenia: double-blind, randomised, non-inferiority study W. Wolfgang Fleischhacker, Raymond Sanchez, Pamela P. Perry et al. · The British Journal of Psychiatry Open access 13 Jun 2014 153
48 Use of supF, an Escherichia coli tyrosine suppressor tRNA gene, as a mutagenic target in shuttle-vector plasmids Kenneth H. Kraemer, Michael M. Seidman · Mutation Research/Reviews in Genetic Toxicology Mar 1989 153
49 Clinical Porcine Islet Xenotransplantation Under Comprehensive Regulation Shinichi Matsumoto, P. L. J. Tan, John Robert Baker et al. · Transplantation Proceedings Jul 2014 143
50 Mitochondrial ATP‐Dependent Potassium Channels: Viable Candidate Effectors of Ischemic Preconditioninga Yongge Liu, Toshiaki Sato, Jegatheesan Seharaseyon et al. · Annals of the New York Academy of Sciences Jun 1999 143

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.