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Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis
Kateřina Rohlenová et al. · Cell Metabolism
Open access |
Apr 2020 |
332 |
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Therapeutic depletion of CCR8 + tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy
Helena Van Damme et al. · Journal for ImmunoTherapy of Cancer
Open access |
Feb 2021 |
213 |
| 3 |
Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop
Yichao Hua et al. · Cancer Cell
Open access |
23 Nov 2022 |
167 |
| 4 |
Common pathways in dementia and diabetic retinopathy: understanding the mechanisms of diabetes-related cognitive decline
Karis Little et al. · Trends in Endocrinology and Metabolism
ReviewOpen access |
15 Nov 2021 |
133 |
| 5 |
The role of placental growth factor (PlGF) and its receptor system in retinal vascular diseases
Tine Van Bergen, Isabelle Étienne, Fiona M Cunningham et al. · Progress in Retinal and Eye Research
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29 Oct 2018 |
116 |
| 6 |
Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathy
Inge Van Hove, Lies De Groef, Bram Boeckx et al. · Diabetologia
Open access |
30 Jul 2020 |
113 |
| 7 |
Longitudinal In Vivo Characterization of the Streptozotocin-Induced Diabetic Mouse Model: Focus on Early Inner Retinal Responses
Jurgen Sergeys, Isabelle Étienne, Inge Van Hove et al. · Investigative Ophthalmology & Visual Science
Open access |
27 Feb 2019 |
107 |
| 8 |
Targeting RGD-binding integrins as an integrative therapy for diabetic retinopathy and neovascular age-related macular degeneration
Inge Van Hove, Tjing‐Tjing Hu, Karen Beets et al. · Progress in Retinal and Eye Research
Open access |
26 Mar 2021 |
75 |
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The killifish visual system as an in vivo model to study brain aging and rejuvenation
Sophie Vanhunsel, Steven Bergmans, An Beckers et al. · npj Aging and Mechanisms of Disease
Open access |
17 Aug 2021 |
56 |
| 10 |
The potent small molecule integrin antagonist THR-687 is a promising next-generation therapy for retinal vascular disorders
Tjing‐Tjing Hu, Marc Vanhove, Michaël Porcu et al. · Experimental Eye Research
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22 Nov 2018 |
35 |
| 11 |
The age factor in optic nerve regeneration: Intrinsic and extrinsic barriers hinder successful recovery in the short‐living killifish
Sophie Vanhunsel, Steven Bergmans, An Beckers et al. · Aging Cell
Open access |
19 Dec 2021 |
33 |
| 12 |
Dysregulation of the kallikrein-kinin system in bronchoalveolar lavage fluid of patients with severe COVID-19
Caroline P. Martens et al. · EBioMedicine
Open access |
5 Aug 2022 |
32 |
| 13 |
Phase I trial on robot assisted retinal vein cannulation with ocriplasmin infusion for central retinal vein occlusion
Koen Willekens, Andy Gijbels, J. M. M. Smits et al. · Acta Ophthalmologica
Open access |
23 Jul 2020 |
26 |
| 14 |
Tightening the retinal glia limitans attenuates neuroinflammation after optic nerve injury
Evy Lefevere, Manuel Salinas‐Navarro, Lien Andries et al. · Glia
Open access |
9 Jul 2020 |
25 |
| 15 |
Phase 1 Study of THR-687, a Novel, Highly Potent Integrin Antagonist for the Treatment of Diabetic Macular Edema
Arshad M. Khanani, Sunil S. Patel, Víctor H. González et al. · Ophthalmology Science
Open access |
14 Jul 2021 |
23 |
| 16 |
Phase 1 Dose-Escalation Study of Plasma Kallikrein Inhibitor THR-149 for the Treatment of Diabetic Macular Edema
Pravin U. Dugel, Arshad M. Khanani, Brian B. Berger et al. · Translational Vision Science & Technology
Open access |
23 Dec 2021 |
18 |
| 17 |
The Placental Growth Factor Pathway and Its Potential Role in Macular Degenerative Disease
Fiona M Cunningham, Tine Van Bergen, Paul E. Canning et al. · Current Eye Research
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6 May 2019 |
17 |
| 18 |
OCRIPLASMIN FOR VITREOMACULAR TRACTION IN CLINICAL PRACTICE
DAVID H. STEEL, Niall Patton, Theodor Stappler et al. · Retina
Open access |
2 Jun 2020 |
15 |
| 19 |
KD determination from time-resolved experiments on live cells with LigandTracer and reconciliation with end-point flow cytometry measurements
Diana Spiegelberg, Jonas Stenberg, Pascale Richalet et al. · European Biophysics Journal
Open access |
24 Jul 2021 |
12 |
| 20 |
The retinal tyrosine kinome of diabetic Akimba mice highlights potential for specific Src family kinase inhibition in retinal vascular disease
Jurgen Sergeys, Inge Van Hove, Tjing‐Tjing Hu et al. · Experimental Eye Research
Open access |
23 Jun 2020 |
12 |
| 21 |
Heparanase Deficiency Is Associated with Disruption, Detachment, and Folding of the Retinal Pigment Epithelium
Tine Van Bergen, Isabelle Étienne, Juan Jia et al. · Current Eye Research
Open access |
29 Dec 2020 |
11 |
| 22 |
PATIENT-REPORTED VISUAL FUNCTION FROM THE OCRIPLASMIN FOR TREATMENT FOR SYMPTOMATIC VITREOMACULAR ADHESION, INCLUDING MACULAR HOLE (OASIS) STUDY
Calvin E. Mein, Pravin U. Dugel, Leonard Feiner et al. · Retina
Open access |
25 Jun 2019 |
10 |
| 23 |
Targeting Plasma Kallikrein With a Novel Bicyclic Peptide Inhibitor (THR-149) Reduces Retinal Thickening in a Diabetic Rat Model
Tine Van Bergen, Tjing‐Tjing Hu, Karis Little et al. · Investigative Ophthalmology & Visual Science
Open access |
22 Oct 2021 |
9 |
| 24 |
Calculating the individual probability of successful ocriplasmin treatment in eyes with vitreomacular traction–Validation and refinement of a multivariable prediction model
Christoph C. Paul, Hans‐Helge Müller, Thomas Raber et al. · PLoS ONE
Open access |
25 Jul 2022 |
6 |
| 25 |
Systemic exposure following intravitreal administration of therapeutic agents: an integrated pharmacokinetic approach. 2. THR-687
Marc Vanhove, Jean-Marc Wagner, Bernard Noppen et al. · Journal of Pharmacokinetics and Pharmacodynamics
Open access |
23 Jul 2021 |
6 |
| 26 |
A novel assay based on pre-equilibrium titration curves for the determination of enzyme inhibitor binding kinetics
Bernard Noppen, Anouk Vanbelle, Alan W. Stitt et al. · European Biophysics Journal
Open access |
22 Jun 2021 |
6 |
| 27 |
Prognostic Factors Associated with Ocriplasmin Efficacy for the Treatment of Symptomatic Vitreomacular Adhesion and Full-thickness Macular Hole: Analysis from Four Studies
Brian C. Joondeph, Paul C. P. H. Willems, Thomas Raber et al. · Journal of Ophthalmic and Vision Research
Open access |
20 Jan 2021 |
5 |
| 28 |
Predicting the individual probability of macular hole closure following intravitreal ocriplasmin injections for vitreomacular traction release using baseline characteristics
Thomas Bertelmann, Lars Berndzen, Thomas Raber et al. · Scientific Reports
Open access |
16 Dec 2021 |
3 |
| 29 |
A method to assess the robustness of complex mathematical models used for quantitative interpretation of experimental data by nonlinear regression analysis: application to high-affinity binding models
Marc Vanhove · European Biophysics Journal
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17 Jun 2021 |
3 |
| 30 |
Resolution of outer retinal abnormalities in eyes with vitreomacular traction without macular hole in the OASIS trial
Akshay S. Thomas, Luc Duchateau, Petra Kozma-Wiebe et al. · British Journal of Ophthalmology
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14 Mar 2022 |
2 |
| 31 |
Anticancer immunotherapies transition postcapillary venules into high-endothelial venules that generate TCF1+ T lymphocyte niches through a feed-forward loop
Yichao Hua, Gerlanda Vella, Florian Rambow et al. · bioRxiv (Cold Spring Harbor Laboratory)
PreprintOpen access |
24 Dec 2021 |
2 |
| 32 |
Systemic exposure following intravitreal administration of therapeutic agents: an integrated pharmacokinetic approach. 1. THR-149
Marc Vanhove, Bernard Noppen, Jean-Marc Wagner et al. · Journal of Pharmacokinetics and Pharmacodynamics
Open access |
23 Jul 2021 |
2 |
| 33 |
IL-33trap-mediated IL-33 neutralization does not exacerbate choroidal neovascularization, but fails to protect against retinal degeneration in a dry age-related macular degeneration model
Inge Van Hove, Tine Van Bergen, Isabelle Étienne et al. · Experimental Eye Research
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27 Apr 2021 |
1 |
| 34 |
Placental growth factor (PlGF) induced signalling regulates barrier properties of the retinal pigment epithelium (RPE)
Fiona M Cunningham, Paul E. Canning, Tine Van Bergen et al. · Research Portal (Queen's University Belfast)
Conference paperOpen access |
22 Jul 2019 |
1 |
| 35 |
Cell‐type specific insights into the pathobiology of advanced diabetic retinopathy using single‐cell transcriptome analysis of the Akimba retina
Inge Van Hove, Michaël Porcu, Lies De Groef et al. · Acta Ophthalmologica
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Dec 2019 |
1 |
| 36 |
The effect of combined PlGF and VEGF inhibition on vascular leakage and inflammation in experimental murine models
Tine Van Bergen, Tjing‐Tjing Hu, Isabelle Étienne et al. · Investigative Ophthalmology & Visual Science
Open access |
22 Jul 2019 |
0 |
| 37 |
A potential role for Src during early experimental diabetic retinopathy?
Jurgen Sergeys, Isabelle Étienne, Evy Lefevere et al. · Lirias
Open access |
30 Apr 2019 |
0 |
| 38 |
The Mouse Sodium Iodate Model Exhibits Acute Retinal Inflammation
Karen Beets, Michaël Porcu, Tjing‐Tjing Hu et al. · Investigative Ophthalmology & Visual Science
Open access |
21 Jun 2021 |
0 |
| 39 |
Retrospective Study of Ellipsoid Zone Integrity Following Treatment with Intravitreal Ocriplasmin (OZONE Study)
Kimberly A. Drenser, Dante J Pieramici, Joseph M Gunn et al. · Clinical ophthalmology
Open access |
Jul 2021 |
0 |
| 40 |
The role of placental growth factor (PlGF) in retinal pigment epithelial (RPE) barrier integrity and outer retinal integrity in geographic atrophy
Fiona M Cunningham, Tine Van Bergen, Jean H.M. Feyen et al. · Investigative Ophthalmology & Visual Science
Open access |
21 Jun 2021 |
0 |
| 41 |
The potent integrin antagonist THR‐687 is a promising next‐generation drug candidate for the treatment of multifactorial retinal diseases
Tjing‐Tjing Hu, Tine Van Bergen, Isabelle Étienne et al. · Acta Ophthalmologica
|
Dec 2019 |
0 |