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Short-Chain Fatty Acids Stimulate Angiopoietin-Like 4 Synthesis in Human Colon Adenocarcinoma Cells by Activating Peroxisome Proliferator-Activated Receptor γ
Sheril Alex, Katja Lange, Tom Amolo et al. · Molecular and Cellular Biology
Open access |
23 Jan 2013 |
302 |
| 2 |
Triple‐negative breast cancer: Present challenges and new perspectives
Franca Podo, L.M.C. Buydens, Hadassa Degani et al. · Molecular Oncology
Open access |
24 Apr 2010 |
301 |
| 3 |
TRIM24 Is an Oncogenic Transcriptional Activator in Prostate Cancer
Anna C. Groner et al. · Cancer Cell
Open access |
27 May 2016 |
291 |
| 4 |
Selective Mineralocorticoid Receptor Cofactor Modulation as Molecular Basis for Finerenone’s Antifibrotic Activity
Jana Grune, Niklas Beyhoff, Elia Smeir et al. · Hypertension
Open access |
5 Feb 2018 |
289 |
| 5 |
Allele-Specific Chromatin Recruitment and Therapeutic Vulnerabilities of ESR1 Activating Mutations
Rinath M. Jeselsohn et al. · Cancer Cell
Open access |
Feb 2018 |
288 |
| 6 |
Therapeutic Ligands Antagonize Estrogen Receptor Function by Impairing Its Mobility
Jane Guan et al. · Cell
Open access |
25 Jul 2019 |
233 |
| 7 |
The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory
Bence Dániel, Gergely Gyorgy Nagy, Zsolt Czimmerer et al. · Immunity
Open access |
Oct 2018 |
192 |
| 8 |
ARv7 Represses Tumor-Suppressor Genes in Castration-Resistant Prostate Cancer
Laura Cato et al. · Cancer Cell
Open access |
14 Feb 2019 |
172 |
| 9 |
Loss of E-cadherin is not a necessity for epithelial to mesenchymal transition in human breast cancer
Antoinette Hollestelle, Justine K. Peeters, Marcel Smid et al. · Breast Cancer Research and Treatment
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20 Jan 2013 |
140 |
| 10 |
Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network
Jerome C. Nwachukwu, Sathish Srinivasan, Nelson E. Bruno et al. · eLife
Open access |
25 Apr 2014 |
139 |
| 11 |
Increased occurrence of protein kinase CK2 in astrocytes in Alzheimer’s disease pathology
Andrea F.N. Rosenberger, Tjado H. J. Morrema, Wouter H. Gerritsen et al. · Journal of Neuroinflammation
Open access |
5 Jan 2016 |
131 |
| 12 |
Kinome Profiling in Pediatric Brain Tumors as a New Approach for Target Discovery
Arend H. Sikkema, Sander H. Diks, Wilfred F.A. den Dunnen et al. · Cancer Research
Open access |
30 Jun 2009 |
120 |
| 13 |
The Effect of F877L and T878A Mutations on Androgen Receptor Response to Enzalutamide
Stefan Preković, Martin E. van Royen, Arnout R. D. Voet et al. · Molecular Cancer Therapeutics
Open access |
16 May 2016 |
118 |
| 14 |
TGF-β promotes microtube formation in glioblastoma through thrombospondin 1
Justin Vareecal Joseph et al. · Neuro-Oncology
Open access |
18 Sep 2021 |
112 |
| 15 |
Differential in Vitro Biological Action, Coregulator Interactions, and Molecular Dynamic Analysis of Bisphenol A (BPA), BPAF, and BPS Ligand–ERα Complexes
Yin Li, L. Perera, Laurel A. Coons et al. · Environmental Health Perspectives
Open access |
16 Jan 2018 |
100 |
| 16 |
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells
Sean William Fanning et al. · eLife
Open access |
29 Nov 2018 |
97 |
| 17 |
Multivalent Carbohydrate Recognition on a Glycodendrimer‐Functionalized Flow‐Through Chip
Hilbert M. Branderhorst, Rob Ruijtenbeek, Rob M. J. Liskamp et al. · ChemBioChem
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5 Jul 2008 |
90 |
| 18 |
Nuclear Receptor-Coregulator Interaction Profiling Identifies TRIP3 as a Novel Peroxisome Proliferator-activated Receptor γ Cofactor
Arjen Koppen, René Houtman, Dirk Pijnenburg et al. · Molecular & Cellular Proteomics
Open access |
11 Jul 2009 |
78 |
| 19 |
Peptide microarrays for detailed, high-throughput substrate identification, kinetic characterization, and inhibition studies on protein kinase A
Riet Hilhorst, Liesbeth Houkes, Adriënne van den Berg et al. · Analytical Biochemistry
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22 Jan 2009 |
75 |
| 20 |
Combined Inhibition of SHP2 and MEK Is Effective in Models of NF1-Deficient Malignant Peripheral Nerve Sheath Tumors
Jiawan Wang, Kai Pollard, Amy N. Allen et al. · Cancer Research
Open access |
8 Oct 2020 |
73 |
| 21 |
Rapid Screening of Lectins for Multivalency Effects with a Glycodendrimer Microarray
Núria Parera Pera, Hilbert M. Branderhorst, Raymond Kooij et al. · ChemBioChem
Open access |
29 Jul 2010 |
71 |
| 22 |
Profiling Activity of Cellular Kinases in Migrating T-Cells
Chandra Sekhar Chirumamilla, Mobashar Hussain Urf Turabe Fazil, Claudina Angela Perez-Novo et al. · Methods in molecular biology
Book chapter |
2019 |
64 |
| 23 |
The AF-1-deficient estrogen receptor ERα46 isoform is frequently expressed in human breast tumors
Élodie Chantalat, Frédéric Boudou, Henrik Laurell et al. · Breast Cancer Research
Open access |
Dec 2016 |
64 |
| 24 |
Focal Adhesion Kinase (FAK) Binds RET Kinase via Its FERM Domain, Priming a Direct and Reciprocal RET-FAK Transactivation Mechanism
Iván Plaza-Menacho, Andrea Morandi, Luca Mologni et al. · Journal of Biological Chemistry
Open access |
23 Mar 2011 |
64 |
| 25 |
Endogenous Phosphotyrosine Signaling in Zebrafish Embryos
Simone Lemeer, Rob Ruijtenbeek, Martijn W. H. Pinkse et al. · Molecular & Cellular Proteomics
Open access |
14 Aug 2007 |
64 |
| 26 |
Kinome and mRNA expression profiling of high-grade osteosarcoma cell lines implies Akt signaling as possible target for therapy
Marieke L. Kuijjer, Brendy E.W.M. van den Akker, Riet Hilhorst et al. · BMC Medical Genomics
Open access |
21 Jan 2014 |
62 |
| 27 |
Estrogenic Effects in the Immature Rat Uterus after Dietary Exposure to Ethinylestradiol and Zearalenone Using a Systems Biology Approach
Marjoke Heneweer, René Houtman, Jenneke Poortman et al. · Toxicological Sciences
Open access |
8 Jun 2007 |
61 |
| 28 |
Binding of bisphenol A, bisphenol AF, and bisphenol S on the androgen receptor: Coregulator recruitment and stimulation of potential interaction sites
L. Perera, Yin Li, Laurel A. Coons et al. · Toxicology in Vitro
Open access |
25 Jul 2017 |
60 |
| 29 |
Array-MLPA: comprehensive detection of deletions and duplications and its application to DMD patients
Fanyi Zeng, Zhaorui Ren, Shangzhi Huang et al. · Human Mutation
Open access |
13 Sep 2007 |
60 |
| 30 |
Corticosteroid Action in the Brain: The Potential of Selective Receptor Modulation
Eva M. G. Viho, Jacobus C. Buurstede, Ahmed Essam Mahfouz et al. · Neuroendocrinology
Open access |
2019 |
59 |
| 31 |
Prediction of Response to Preoperative Chemoradiotherapy in Rectal Cancer by Multiplex Kinase Activity Profiling
Sigurd Folkvord, Kjersti Flatmark, Svein Dueland et al. · International Journal of Radiation Oncology*Biology*Physics
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3 Aug 2010 |
58 |
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Protein-Tyrosine Kinase Activity Profiling in Knock Down Zebrafish Embryos
Simone Lemeer, Chris Jopling, Faris Naji et al. · PLoS ONE
Open access |
3 Jul 2007 |
55 |
| 33 |
A Mixed Glucocorticoid/Mineralocorticoid Selective Modulator With Dominant Antagonism in the Male Rat Brain
Erika Atucha, Ioannis Zalachoras, José K. van den Heuvel et al. · Endocrinology
Open access |
25 Aug 2015 |
54 |
| 34 |
Predictive features of ligand‐specific signaling through the estrogen receptor
Jerome C. Nwachukwu, Sathish Srinivasan, Yangfan Zheng et al. · Molecular Systems Biology
Open access |
Apr 2016 |
53 |
| 35 |
Omega-3 Fatty Acids DHA and EPA Reduce Bortezomib Resistance in Multiple Myeloma Cells by Promoting Glutathione Degradation
Jing Chen, Esther A. Zaal, Celia R. Berkers et al. · Cells
Open access |
2 Sep 2021 |
51 |
| 36 |
Quantitative assessment of a novel flow-through porous microarray for the rapid analysis of gene expression profiles
Ying Wu · Nucleic Acids Research
Open access |
18 Aug 2004 |
51 |
| 37 |
Biochemical characterization of the major sorghum grain peroxidase
Mamoudou Hama Dicko, Harry Gruppen, Riet Hilhorst et al. · FEBS Journal
Open access |
25 Apr 2006 |
46 |
| 38 |
Fast and Specific Hybridization Using Flow-Through Microarrays on Porous Metal Oxide
Rinie van Beuningen, Henk van Damme, Piet J. Boender et al. · Clinical Chemistry
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Oct 2001 |
45 |
| 39 |
Peptide Microarrays for Profiling of Serine/Threonine Kinase Activity of Recombinant Kinases and Lysates of Cells and Tissue Samples
Riet Hilhorst, Liesbeth Houkes, Monique Mommersteeg et al. · Methods in molecular biology
Book chapter |
2013 |
42 |
| 40 |
Protein Kinase Activity Decreases with Higher Braak Stages of Alzheimer’s Disease Pathology
Andrea F.N. Rosenberger, Riet Hilhorst, Elisabeth Coart et al. · Journal of Alzheimer s Disease
Open access |
27 Oct 2015 |
42 |
| 41 |
ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models
Shanchun Guo, Changde Zhang, Melyssa R. Bratton et al. · Oncotarget
Open access |
8 Jan 2018 |
41 |
| 42 |
Understanding stress-effects in the brain via transcriptional signal transduction pathways
Ioannis Zalachoras, René Houtman, Onno Cornelis Meijer · Neuroscience
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29 Mar 2013 |
41 |
| 43 |
Kinome Array Profiling of Patient-Derived Pancreatic Ductal Adenocarcinoma Identifies Differentially Active Protein Tyrosine Kinases
Justin F. Creeden, Khaled Alganem, Ali Sajid Imami et al. · International Journal of Molecular Sciences
Open access |
17 Nov 2020 |
40 |
| 44 |
Intracellular and extracellular domains of protein tyrosine phosphatase PTPRZ-B differentially regulate glioma cell growth and motility
Annika M. Bourgonje, Anna C. Navis, Jan T. G. Schepens et al. · Oncotarget
Open access |
19 Aug 2014 |
40 |
| 45 |
Growth and Multiplexed Analysis of Microorganisms on a Subdivided, Highly Porous, Inorganic Chip Manufactured from Anopore
Colin J. Ingham, Maaike van den Ende, Dirk Pijnenburg et al. · Applied and Environmental Microbiology
Open access |
Dec 2005 |
39 |
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Profiling of 3696 Nuclear Receptor–Coregulator Interactions: A Resource for Biological and Clinical Discovery
Marjoleine F. Broekema, Danielle A.A. Hollman, Arjen Koppen et al. · Endocrinology
Open access |
30 Apr 2018 |
38 |
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Analysis of Jak2 Catalytic Function by Peptide Microarrays: The Role of the JH2 Domain and V617F Mutation
Arturo Sanz Sanz, Daniela Ungureanu, Tuija Pekkala et al. · PLoS ONE
Open access |
18 Apr 2011 |
38 |
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Drug-induced aneuploidy and polyploidy is a mechanism of disease relapse in MYC/BCL2-addicted diffuse large B-cell lymphoma
Shariful Islam, Andrew L. Paek, Michael F. Hammer et al. · Oncotarget
Open access |
13 Nov 2018 |
37 |
| 49 |
Cetuximab Prevents Methotrexate-Induced Cytotoxicity in Vitro through Epidermal Growth Factor Dependent Regulation of Renal Drug Transporters
Pedro Caetano-Pinto, Amer Jamalpoor, Janneke C. Ham et al. · Molecular Pharmaceutics
Open access |
11 May 2017 |
37 |
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Extending an In Vitro Panel for Estrogenicity Testing: The Added Value of Bioassays for Measuring Antiandrogenic Activities and Effects on Steroidogenesis
Si Wang, Jeroen C.W. Rijk, Harrie T. Besselink et al. · Toxicological Sciences
Open access |
16 Jun 2014 |
34 |