| 1 |
Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success
Frank Lovering, Jack Andrew Bikker, Christine C. Humblet · Journal of Medicinal Chemistry
|
14 Oct 2009 |
4,568 |
| 2 |
Extended-Spectrum β-Lactamases in the 21st Century: Characterization, Epidemiology, and Detection of This Important Resistance Threat
Patricia A. Bradford · Clinical Microbiology Reviews
Open access |
Oct 2001 |
2,640 |
| 3 |
The evolving role of natural products in drug discovery
Frank E. Koehn, Guy T. Carter · Nature Reviews Drug Discovery
Review |
24 Feb 2005 |
2,586 |
| 4 |
The Human Cytomegalovirus US11 Gene Product Dislocates MHC Class I Heavy Chains from the Endoplasmic Reticulum to the Cytosol
Emmanuel J. H. J. Wiertz, Thomas R. Jones, Lei Sun et al. · Cell
Open access |
Mar 1996 |
1,090 |
| 5 |
A Trial of a 9-Valent Pneumococcal Conjugate Vaccine in Children with and Those without HIV Infection
Keith P. Klugman, Shabir Ahmed Madhi, Robin E. Huebner et al. · New England Journal of Medicine
Open access |
Oct 2003 |
1,018 |
| 6 |
Which Pneumococcal Serogroups Cause the Most Invasive Disease: Implications for Conjugate Vaccine Formulation and Use, Part I
William P. Hausdorff, John Bryant, Peter R. Paradiso et al. · Clinical Infectious Diseases
|
2000 |
872 |
| 7 |
Society for Healthcare Epidemiology of America and Infectious Diseases Society of America Joint Committee on the Prevention of Antimicrobial Resistance: Guidelines for the Prevention of Antimicrobial Resistance in Hospitals
David M. Shlaes, Dale N. Gerding, Joseph F. John et al. · Clinical Infectious Diseases
Open access |
Sep 1997 |
787 |
| 8 |
Evaluation of fluorescence-based thermal shift assays for hit identification in drug discovery
Mei-Chu Lo, ANN E. AULABAUGH, Guixian Jin et al. · Analytical Biochemistry
|
2 Jun 2004 |
701 |
| 9 |
Transcription Profiling-Based Identification of Staphylococcus aureus Genes Regulated by the agr and/or sarA Loci
Paul M. Dunman, Ellen Murphy, Staci L. Haney et al. · Journal of Bacteriology
|
15 Dec 2001 |
647 |
| 10 |
Aluminum compounds as vaccine adjuvants
Gupta Rk · Advanced Drug Delivery Reviews
|
6 Jul 1998 |
629 |
| 11 |
Recommendations for the validation of immunoassays used for detection of host antibodies against biotechnology products
Gopi Shankar, Viswanath Devanarayan, Lakshmi S. Amaravadi et al. · Journal of Pharmaceutical and Biomedical Analysis
|
20 Sep 2008 |
609 |
| 12 |
Global Gene Expression in Staphylococcus aureus Biofilms
Karen E. Beenken, Paul M. Dunman, Fionnuala McAleese et al. · Journal of Bacteriology
Open access |
Jul 2004 |
587 |
| 13 |
A 13-amino-acid motif in the cytoplasmic domain of FcγRIIB modulates B-cell receptor signalling
Tatsushi Muta, Tomohiro Kurosaki, Ziva Misulovin et al. · Nature
|
3 Mar 1994 |
586 |
| 14 |
A Comparative Efficacy Trial in Germany in Infants Who Received Either the Lederle/Takeda Acellular Pertussis Component DTP (DTaP) Vaccine, the Lederle Whole-Cell Component DTP Vaccine, or DT Vaccine
KLEMENS STEHR, James D. Cherry, Ulrich Heininger et al. · PEDIATRICS
|
1998 |
513 |
| 15 |
Why is big Pharma getting out of antibacterial drug discovery?
Steven J. Projan · Current Opinion in Microbiology
|
16 Sep 2003 |
503 |
| 16 |
Combinatorial chemoprevention of intestinal neoplasia
Christopher J. Torrance, Peta E. Jackson, Elizabeth Anne Montgomery et al. · Nature Medicine
|
Sep 2000 |
496 |
| 17 |
Emergence of Carbapenem-Resistant Klebsiella Species Possessing the Class A Carbapenem-Hydrolyzing KPC-2 and Inhibitor-Resistant TEM-30 -Lactamases in New York City
Patricia A. Bradford, Simona Bratu, Carl M. Urban et al. · Clinical Infectious Diseases
|
21 Jun 2004 |
488 |
| 18 |
The ER-Luminal Domain of the HCMV Glycoprotein US6 Inhibits Peptide Translocation by TAP
Kwangseog Ahn, Albrecht Gruhler, Begoña Galocha et al. · Immunity
Open access |
May 1997 |
484 |
| 19 |
Imipenem resistance in Klebsiella pneumoniae is associated with the combination of ACT-1, a plasmid-mediated AmpC beta-lactamase, and the foss of an outer membrane protein
Patricia A. Bradford, Carl M. Urban, N Mariano et al. · Antimicrobial Agents and Chemotherapy
Open access |
Mar 1997 |
453 |
| 20 |
mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer.
Ker Yu, Lourdes Toral‐Barza, Carolyn M. Discafani et al. · Endocrine Related Cancer
Open access |
Sep 2001 |
421 |
| 21 |
Human cytomegalovirus US3 impairs transport and maturation of major histocompatibility complex class I heavy chains.
Thomas R. Jones, Emmanuel J. H. J. Wiertz, Lei Sun et al. · Proceedings of the National Academy of Sciences
Open access |
15 Oct 1996 |
416 |
| 22 |
SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice.
Jennifer M. Golas, Kim T. Arndt, Carlo Etienne et al. · PubMed
|
15 Jan 2003 |
415 |
| 23 |
In Vitro and In Vivo Antibacterial Activities of a Novel Glycylcycline, the 9- t -Butylglycylamido Derivative of Minocycline (GAR-936)
Peter J. Petersen, Nilda V. Jacobus, Jason Weiss et al. · Antimicrobial Agents and Chemotherapy
Open access |
Apr 1999 |
413 |
| 24 |
Some properties of brain specific benzodiazepine receptors: New evidence for multiple receptors
Richard F. Squires, Donald I. Benson, Claus Bræstrup et al. · Pharmacology Biochemistry and Behavior
|
May 1979 |
411 |
| 25 |
Serological criteria for evaluation and licensure of new pneumococcal conjugate vaccine formulations for use in infants
Luis Jódar, Jay C. Butler, George M. Carlone et al. · Vaccine
|
7 Apr 2003 |
389 |
| 26 |
Channeling of Substrates and Intermediates in Enzyme-Catalyzed Reactions
Xinyi Huang, Hazel M. Holden, Frank M. Raushel · Annual Review of Biochemistry
Review |
Jun 2001 |
380 |
| 27 |
Estimating the protective concentration of anti-pneumococcal capsular polysaccharide antibodies
George R. Siber, Ih Chang, Sherryl A. Baker et al. · Vaccine
|
22 Feb 2007 |
373 |
| 28 |
Carbapenem-hydrolyzing beta-lactamases
B A Rasmussen, Karen Bush · Antimicrobial Agents and Chemotherapy
Open access |
Feb 1997 |
360 |
| 29 |
Atypical Multidrug Resistance: Breast Cancer Resistance Protein Messenger RNA Expression in Mitoxantrone-Selected Cell Lines
D D Ross, Weidong Yang, Lynne V. Abruzzo et al. · JNCI Journal of the National Cancer Institute
Open access |
3 Mar 1999 |
353 |
| 30 |
Prognostic relevance of the mTOR pathway in renal cell carcinoma
Allan J. Pantuck, David B. Seligson, Tobias Klatte et al. · Cancer
|
17 Apr 2007 |
351 |
| 31 |
Vaccine Potential of theNeisseria meningitidis2086 Lipoprotein
Leah D. Fletcher, Liesel Bernfield, Vicki L. Barniak et al. · Infection and Immunity
Open access |
23 Mar 2004 |
336 |
| 32 |
Targeting the mTOR signaling network in cancer
Gary Gene Chiang, Robert T. Abraham · Trends in Molecular Medicine
Review |
Oct 2007 |
335 |
| 33 |
The Contribution of Specific Pneumococcal Serogroups to Different Disease Manifestations: Implications for Conjugate Vaccine Formulation and Use, Part II
William P. Hausdorff, John Bryant, C. Kloek et al. · Clinical Infectious Diseases
Open access |
2000 |
334 |
| 34 |
Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cell-wall-active antibiotics reveals a cell-wall-stress stimulon
Sugunya Utaida, Paul M. Dunman, Daphne Macapagal et al. · Microbiology
|
Oct 2003 |
331 |
| 35 |
Recommendations on risk-based strategies for detection and characterization of antibodies against biotechnology products
Eugen Koren, Holly W. Smith, Elizabeth W. Shores et al. · Journal of Immunological Methods
|
30 Jan 2008 |
328 |
| 36 |
Mechanisms of protein stabilization in the solid state
Liuquan Chang, Michael Jon Pikal · Journal of Pharmaceutical Sciences
Open access |
30 Jun 2009 |
326 |
| 37 |
Automated analysis of protein NMR assignments using methods from artificial intelligence
Diane E. Zimmerman, Casimir A. Kulikowski, Yuanpeng Janet Huang et al. · Journal of Molecular Biology
|
Jun 1997 |
313 |
| 38 |
Evaluation of a Live, Cold‐Passaged, Temperature‐Sensitive, Respiratory Syncytial Virus Vaccine Candidate in Infancy
Peter F. Wright, Ruth A. Karron, Robert B. Belshe et al. · The Journal of Infectious Diseases
|
Nov 2000 |
308 |
| 39 |
Optimization of 6,7-Disubstituted-4-(arylamino)quinoline-3-carbonitriles as Orally Active, Irreversible Inhibitors of Human Epidermal Growth Factor Receptor-2 Kinase Activity
Hwei‐Ru Tsou, Elsebe G. Overbeek-Klumpers, William Andrew Hallett et al. · Journal of Medicinal Chemistry
Open access |
27 Jan 2005 |
302 |
| 40 |
Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling.
Tomohiro Kurosaki, Minoru Takata, Yuji Yamanashi et al. · The Journal of Experimental Medicine
Open access |
May 1994 |
294 |
| 41 |
Human neutrophil chemotactic and degranulating activities of leukotriene B5 (LTB5) derived from eicosapentaenoic acid
Dodi Goldman, W C Pickett, Edward J. Goetzl · Biochemical and Biophysical Research Communications
|
Nov 1983 |
293 |
| 42 |
Identification of a Recombinant Live Attenuated Respiratory Syncytial Virus Vaccine Candidate That Is Highly Attenuated in Infants
Ruth A. Karron, Peter F. Wright, Robert B. Belshe et al. · The Journal of Infectious Diseases
|
12 Mar 2005 |
287 |
| 43 |
Evidence for two apoptotic pathways in light-induced retinal degeneration
Wenshan Hao, Andreas Wenzel, Martin S. Obin et al. · Nature Genetics
|
3 Sep 2002 |
287 |
| 44 |
Multidrug Resistance in Staphylococcus aureus Due to Overexpression of a Novel Multidrug and Toxin Extrusion (MATE) Transport Protein
Glenn William Kaatz, Fionnuala McAleese, Susan M. Seo · Antimicrobial Agents and Chemotherapy
Open access |
26 Apr 2005 |
285 |
| 45 |
Efflux-Mediated Resistance to Tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1
Charles R. Dean, Melissa A. Visalli, Steven J. Projan et al. · Antimicrobial Agents and Chemotherapy
Open access |
25 Feb 2003 |
284 |
| 46 |
Cytomegalovirus US2 destroys two components of the MHC class II pathway, preventing recognition by CD4+ T cells
Roman Tomazin, Jessica M. Boname, Nagendra R. Hegde et al. · Nature Medicine
|
Sep 1999 |
279 |
| 47 |
Isolation and Characterization of Novel Marine-Derived Actinomycete Taxa Rich in Bioactive Metabolites
Nathan A. Magarvey, Jessica M. Keller, Valerie S. Bernan et al. · Applied and Environmental Microbiology
Open access |
Dec 2004 |
277 |
| 48 |
Synthesis and Structure−Activity Relationships of 6,7-Disubstituted 4-Anilinoquinoline-3-carbonitriles. The Design of an Orally Active, Irreversible Inhibitor of the Tyrosine Kinase Activity of the Epidermal Growth Factor Receptor (EGFR) and the Human Epidermal Growth Factor Receptor-2 (HER-2)
Allan Wissner, Elsebe Overbeek, Marvin F. Reich et al. · Journal of Medicinal Chemistry
Open access |
2 Dec 2002 |
267 |
| 49 |
Correlation of Cellular Immune Responses with Protection against Culture-Confirmed Influenza Virus in Young Children
Bruce D. Forrest, Michael W. Pride, Andrew J. Dunning et al. · Clinical and Vaccine Immunology
Open access |
May 2008 |
256 |
| 50 |
SarA, a Global Regulator of Virulence Determinants inStaphylococcus aureus, Binds to a Conserved Motif Essential for sar-dependent Gene Regulation
Yueh‐tyng Chien, Adhar C. Manna, Steven J. Projan et al. · Journal of Biological Chemistry
Open access |
Dec 1999 |
253 |