| 1 |
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1
Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews
Review |
Mar 2001 |
18,154 |
| 2 |
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
Rahul S. Desikan, Florent Ségonne, Bruce R. Fischl et al. · NeuroImage
|
14 Mar 2006 |
14,405 |
| 3 |
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
Christopher A. Lipinski, Franco Lombardo, Beryl W. Dominy et al. · Advanced Drug Delivery Reviews
Review |
1997 |
11,492 |
| 4 |
2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative
Daniel Aletaha et al. · Arthritis & Rheumatism
Open access |
10 Aug 2010 |
9,731 |
| 5 |
Biological insights from 108 schizophrenia-associated genetic loci
Stephan Ripke et al. · Nature
Open access297 authors |
Jul 2014 |
8,181 |
| 6 |
Lead- and drug-like compounds: the rule-of-five revolution
Christopher A. Lipinski · Drug Discovery Today Technologies
|
Dec 2004 |
6,290 |
| 7 |
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky et al. · Autophagy
Open access2,467 authors |
2 Jan 2016 |
6,023 |
| 8 |
Cardiac-Resynchronization Therapy with or without an Implantable Defibrillator in Advanced Chronic Heart Failure
Michael R. Bristow, Leslie Ann Saxon, JOHN P. BOEHMER et al. · New England Journal of Medicine
|
19 May 2004 |
5,848 |
| 9 |
Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale
John T. Farrar, James P. Young, Linda LaMoreaux et al. · Pain
|
Nov 2001 |
5,825 |
| 10 |
Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma
Robert John Motzer, Thomas E. Hutson, Piotr Tomczak et al. · New England Journal of Medicine
Open access |
10 Jan 2007 |
5,801 |
| 11 |
Principles of Good Practice for the Translation and Cultural Adaptation Process for Patient-Reported Outcomes (PRO) Measures: Report of the ISPOR Task Force for Translation and Cultural Adaptation
Diane J. Wild, Alyson Grove, Mona L. Martin et al. · Value in Health
Open access |
Mar 2005 |
5,609 |
| 12 |
Proposed minimum reporting standards for chemical analysis
Lloyd W. Sumner et al. · Metabolomics
Open access |
11 Sep 2007 |
5,359 |
| 13 |
The biology and management of non-small cell lung cancer
Roy S. Herbst, Daniel Morgensztern, CHRIS H. BOSHOFF · Nature
|
2018 |
5,116 |
| 14 |
Genetic effects on gene expression across human tissues
François Aguet et al. · Nature
Open access250 authors |
10 Oct 2017 |
4,762 |
| 15 |
Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer
Eunice Lee Kwak et al. · New England Journal of Medicine
Open access |
27 Oct 2010 |
4,517 |
| 16 |
MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling
Jeffrey A. Engelman, Kreshnik Zejnullahu, Tetsuya Mitsudomi et al. · Science
|
26 Apr 2007 |
4,504 |
| 17 |
FinnGen provides genetic insights from a well-phenotyped isolated population
Mitja Kurki et al. · Nature
Open access169 authors |
18 Jan 2023 |
4,362 |
| 18 |
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
Takeshi Nishikawa, Diane Edelstein, Xue Liang Du et al. · Nature
|
Apr 2000 |
4,302 |
| 19 |
Core outcome measures for chronic pain clinical trials: IMMPACT recommendations
Robert H. Dworkin et al. · Pain
|
6 Nov 2004 |
3,789 |
| 20 |
Macromodel—an integrated software system for modeling organic and bioorganic molecules using molecular mechanics
Fariborz Mohamadi, Nigel G. J. Richards, Wayne C. Guida et al. · Journal of Computational Chemistry
|
May 1990 |
3,774 |
| 21 |
Drug-like properties and the causes of poor solubility and poor permeability
Christopher A. Lipinski · Journal of Pharmacological and Toxicological Methods
|
Jul 2000 |
3,766 |
| 22 |
Genotypic and Histological Evolution of Lung Cancers Acquiring Resistance to EGFR Inhibitors
Lecia Van Dam Sequist et al. · Science Translational Medicine
Open access |
23 Mar 2011 |
3,603 |
| 23 |
How many drug targets are there?
John P. Overington, Bissan Al‐Lazikani, Andrew L. Hopkins · Nature Reviews Drug Discovery
Review |
Dec 2006 |
3,554 |
| 24 |
Core outcome domains for chronic pain clinical trials: IMMPACT recommendations
Dennis C. Turk et al. · Pain
|
22 Sep 2003 |
3,518 |
| 25 |
Intensive Lipid Lowering with Atorvastatin in Patients with Stable Coronary Disease
John C. LaRosa, Scott M. Grundy, David D. Waters et al. · New England Journal of Medicine
Open access |
9 Mar 2005 |
3,517 |
| 26 |
Interpreting the Clinical Importance of Treatment Outcomes in Chronic Pain Clinical Trials: IMMPACT Recommendations
Robert H. Dworkin et al. · Journal of Pain
Open access |
13 Dec 2007 |
3,496 |
| 27 |
Crizotinib versus Chemotherapy in Advanced ALK -Positive Lung Cancer
Alice Tsang Shaw et al. · New England Journal of Medicine
Open access |
Jun 2013 |
3,429 |
| 28 |
Membrane transporters in drug development
Kathleen M. Giacomini et al. · Nature Reviews Drug Discovery
ReviewOpen access |
Mar 2010 |
3,373 |
| 29 |
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
eQTLGen et al. · Nature Genetics
Open access218 authors |
26 Apr 2018 |
3,347 |
| 30 |
The druggable genome
Andrew L. Hopkins, Colin R. Groom · Nature Reviews Drug Discovery
|
Sep 2002 |
3,335 |
| 31 |
Voriconazole versus Amphotericin B for Primary Therapy of Invasive Aspergillosis
Raoul Herbrecht et al. · New England Journal of Medicine
Open access |
8 Aug 2002 |
3,326 |
| 32 |
Applications of machine learning in drug discovery and development
Jessica J. Vamathevan, Dominic A. Clark, Paul Czodrowski et al. · Nature Reviews Drug Discovery
ReviewOpen access |
11 Apr 2019 |
3,274 |
| 33 |
A Novel Serum Protein Similar to C1q, Produced Exclusively in Adipocytes
Philipp E. Scherer, Suzanne P. Williams, Michael Fogliano et al. · Journal of Biological Chemistry
Open access |
Nov 1995 |
3,253 |
| 34 |
First-Line Crizotinib versus Chemotherapy in ALK -Positive Lung Cancer
Benjamin J. Solomon, Tony S.K. Mok, Dong‐Wan Kim et al. · New England Journal of Medicine
Open access |
3 Dec 2014 |
3,251 |
| 35 |
Effects of Torcetrapib in Patients at High Risk for Coronary Events
Philip J. Barter, Mark J. Caulfield, Mats A. L. Eriksson et al. · New England Journal of Medicine
Open access |
5 Nov 2007 |
3,168 |
| 36 |
Eplerenone in Patients with Systolic Heart Failure and Mild Symptoms
Faiez M. Zannad, John J.V. McMurray, Henry Krum et al. · New England Journal of Medicine
Open access |
14 Nov 2010 |
3,112 |
| 37 |
Development and evaluation of an abridged, 5-item version of the International Index of Erectile Function (IIEF-5) as a diagnostic tool for erectile dysfunction
RC Rosen, JC Cappelleri, MD Smith et al. · International Journal of Impotence Research
|
Dec 1999 |
3,073 |
| 38 |
Palbociclib and Letrozole in Advanced Breast Cancer
Richard S. Finn, Miguel Martín, Hope S. Rugo et al. · New England Journal of Medicine
|
16 Nov 2016 |
3,059 |
| 39 |
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
Vassily Vladimirovich Trubetskoy et al. · Nature
Open access613 authors |
8 Apr 2022 |
2,894 |
| 40 |
Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy
Matthew J. Maurer et al. · New England Journal of Medicine
Open access |
27 Aug 2018 |
2,841 |
| 41 |
The PI3K Pathway in Human Disease
David A. Fruman, Honyin Chiu, Benjamin David Hopkins et al. · Cell
Open access |
Aug 2017 |
2,806 |
| 42 |
Comparison of pain syndromes associated with nervous or somatic lesions and development of a new neuropathic pain diagnostic questionnaire (DN4)
Didier Bouhassira, Nadine Attal, H. Alchaar et al. · Pain
|
29 Jan 2005 |
2,755 |
| 43 |
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Daniel J. Klionsky et al. · Autophagy
Open access2,930 authors |
2 Jan 2021 |
2,743 |
| 44 |
A synthetic inhibitor of the mitogen-activated protein kinase cascade.
David T. Dudley, Long Pang, Stuart J. Decker et al. · Proceedings of the National Academy of Sciences
Open access |
15 Aug 1995 |
2,717 |
| 45 |
From Vulnerable Plaque to Vulnerable Patient
Morteza Naghavi et al. · Circulation
|
13 Oct 2003 |
2,670 |
| 46 |
Population-Based Survey of Urinary Incontinence, Overactive Bladder, and Other Lower Urinary Tract Symptoms in Five Countries: Results of the EPIC Study
Debra E. Irwin, Ian Milsom, Steinar Hunskaar et al. · European Urology
|
3 Oct 2006 |
2,647 |
| 47 |
Atorvastatin in Patients with Type 2 Diabetes Mellitus Undergoing Hemodialysis
Christoph Wanner, Vera Krane, Winfried März et al. · New England Journal of Medicine
Open access |
20 Jul 2005 |
2,634 |
| 48 |
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Veit Hornung, Andrea Ablasser, Marie Charrel-Dennis et al. · Nature
Open access |
21 Jan 2009 |
2,632 |
| 49 |
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial
George D. Demetri, Allan T. van Oosterom, Christopher R. Garrett et al. · The Lancet
|
Oct 2006 |
2,626 |
| 50 |
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Céline Bellenguez et al. · Nature Genetics
Open access1,266 authors |
Apr 2022 |
2,608 |