Institution · Phenex Pharmaceuticals (Germany)

Most cited papers from Phenex Pharmaceuticals (Germany)

Phenex Pharmaceuticals (Germany)

What are the most cited papers from Phenex Pharmaceuticals (Germany)?

The most cited paper from Phenex Pharmaceuticals (Germany) is "Genome-wide, large-scale production of mutant mice by ENU mutagenesis" (Martin Hrabě de Angelis et al., 2000), with 677 citations. Next come "Protein Kinase G from Pathogenic Mycobacteria Promotes Survival Within Macrophages" (594) and "Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β" (437).

Published TypeFieldAccessCitations

Showing 50 of 59 papers. Every paper with more than 38 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Genome-wide, large-scale production of mutant mice by ENU mutagenesis Martin Hrabě de Angelis et al. · Nature Genetics Open access	Aug 2000	677
2	Protein Kinase G from Pathogenic Mycobacteria Promotes Survival Within Macrophages Anne Walburger, Anil Koul, Giorgio Ferrari et al. · Science	24 May 2004	594
3	Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β Justin M. Nussbaum, Stephan Schilling, Holger Cynis et al. · Nature Open access	May 2012	437
4	Interplay between mycobacteria and host signalling pathways Anil Koul, Thomas Herget, Bert Klebl et al. · Nature Reviews Microbiology Review	20 Feb 2004	370
5	An efficient proteomics method to identify the cellular targets of protein kinase inhibitors Klaus Godl, Josef B. Wissing, Alexander Kurtenbach et al. · Proceedings of the National Academy of Sciences Open access	10 Dec 2003	337
6	Strategies to overcome resistance to targeted protein kinase inhibitors Henrik Daub, Katja Specht, Axel Ullrich · Nature Reviews Drug Discovery Review	Dec 2004	336
7	Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis Anna Worthmann, Clara John, Malte Christoph Rühlemann et al. · Nature Medicine	12 Jun 2017	334
8	Isolation and biochemical characterization of LEAP‐2, a novel blood peptide expressed in the liver Alexander Krause, Rannar Sillard, Burkhard Kleemeier et al. · Protein Science Open access	2003	235
9	Medicinal chemistry of target family-directed masterkeys Gerhard Müller · Drug Discovery Today	Aug 2003	207
10	Cloning and Characterization of Secretory Tyrosine Phosphatases of Mycobacterium tuberculosis Anil Koul, Axel Choidas, Martin Treder et al. · Journal of Bacteriology Open access	Oct 2000	182
11	The FXR agonist PX20606 ameliorates portal hypertension by targeting vascular remodelling and sinusoidal dysfunction Philipp Schwabl, Eva Hambruch, Berit Seeland et al. · Journal of Hepatology Open access	18 Dec 2016	176
12	An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice Johannes Grosse, Attila Braun, Dávid Varga-Szabó et al. · Journal of Clinical Investigation Open access	25 Oct 2007	167
13	Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease Johannes Grosse, Violeta Chiţu, Andreas Marquardt et al. · Blood Open access	5 Jan 2006	148
14	Characterization of a Conserved Structural Determinant Controlling Protein Kinase Sensitivity to Selective Inhibitors Stephanie Blencke, Birgit Zech, Ola Engkvist et al. · Chemistry & Biology Open access	May 2004	143
15	Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice Jan Freark de Boer, Marleen Schonewille, Marije Boesjes et al. · Gastroenterology Open access	6 Jan 2017	142
16	Novel Chemical Class of pUL97 Protein Kinase-Specific Inhibitors with Strong Anticytomegaloviral Activity Thomas Herget, Martina Freitag, Monika Morbitzer et al. · Antimicrobial Agents and Chemotherapy Open access	25 Oct 2004	142
17	Evaluation of AGR2 and AGR3 as candidate genes for inflammatory bowel disease Wu Zheng, Philip C Rosenstiel, Klaus Huse et al. · Genes and Immunity	13 Oct 2005	131
18	The Tyrosine Kinase Inhibitor STI571 Induces Cellular Clearance of PrPSc in Prion-infected Cells Alexa Ertmer, Sabine Gilch, Seong‐Wook Yun et al. · Journal of Biological Chemistry Open access	10 Jul 2004	131
19	Automated Yeast Two-hybrid Screening for Nuclear Receptor-interacting Proteins M. Albers, Harald D. Kranz, Ingo Kober et al. · Molecular & Cellular Proteomics Open access	16 Dec 2004	127
20	Mutation of Threonine 766 in the Epidermal Growth Factor Receptor Reveals a Hotspot for Resistance Formation against Selective Tyrosine Kinase Inhibitors Stephanie Blencke, Axel Ullrich, Henrik Daub · Journal of Biological Chemistry Open access	Apr 2003	115
21	The protein kinase pUL97 of human cytomegalovirus interacts with and phosphorylates the DNA polymerase processivity factor pUL44 Manfred Marschall, Martina Freitag, Patricia Suchy et al. · Virology Open access	27 May 2003	109
22	Proteome-wide Identification of Cellular Targets Affected by Bisindolylmaleimide-type Protein Kinase C Inhibitors Dirk Brehmer, Klaus Godl, Birgit Zech et al. · Molecular & Cellular Proteomics Open access	9 Feb 2004	107
23	Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice Sadim Jawhar, Oliver Wirths, Stephan Schilling et al. · Journal of Biological Chemistry Open access	11 Dec 2010	103
24	Synthetic Farnesoid X Receptor Agonists Induce High-Density Lipoprotein-Mediated Transhepatic Cholesterol Efflux in Mice and Monkeys and Prevent Atherosclerosis in Cholesteryl Ester Transfer Protein Transgenic Low-Density Lipoprotein Receptor (−/−) Mice Eva Hambruch, Shinobu Miyazaki‐Anzai, Ulrike K. Hahn et al. · Journal of Pharmacology and Experimental Therapeutics Open access	24 Aug 2012	99
25	A Novel Principle for Partial Agonism of Liver X Receptor Ligands M. Albers, Beatrix Blume, Thomas Schlueter et al. · Journal of Biological Chemistry Open access	15 Dec 2005	94
26	The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions Holger Cynis et al. · EMBO Molecular Medicine Open access	20 Jul 2011	93
27	Identification of cellular deoxyhypusine synthase as a novel target for antiretroviral therapy Ilona Hauber, Dorian Bevec, Jochen Heukeshoven et al. · Journal of Clinical Investigation Open access	3 Jan 2005	92
28	The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer Verena Thewes et al. · Oncogene	20 Mar 2017	89
29	The small SLC43 family: Facilitator system l amino acid transporters and the orphan EEG1 Susanna Bodoy, Dimitrios Fotiadis, Claudia Stoeger et al. · Molecular Aspects of Medicine Open access	23 Dec 2012	86
30	T‐type amino acid transporter TAT1 (Slc16a10) is essential for extracellular aromatic amino acid homeostasis control Luca Mariotta, Tamara Ramadan, Dustin Singer et al. · The Journal of Physiology Open access	9 Oct 2012	86
31	Mutations in Gasdermin 3 Cause Aberrant Differentiation of the Hair Follicle and Sebaceous Gland Declan Patrick Lunny, Erica Weed, Patrick M. Nolan et al. · Journal of Investigative Dermatology Open access	28 Feb 2005	84
32	FXR Controls the Tumor Suppressor NDRG2 and FXR Agonists Reduce Liver Tumor Growth and Metastasis in an Orthotopic Mouse Xenograft Model Ulrich Deuschle, Julia B. Schüler, Andreas Schulz et al. · PLoS ONE Open access	9 Oct 2012	83
33	Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis Xiaohua Xue, Pejman Soroosh, Aimee De Leon-Tabaldo et al. · Scientific Reports Open access	Dec 2016	78
34	MS4A12 Is a Colon-Selective Store-Operated Calcium Channel Promoting Malignant Cell Processes Michael Koslowski, Uğur Şahin, Karl Dhaene et al. · Cancer Research	May 2008	77
35	Nonsteroidal FXR Ligands: Current Status and Clinical Applications Christian Gege, Eva Hambruch, Nina Hambruch et al. · Handbook of experimental pharmacology Book chapter	2019	76
36	Inhibitors of human cytomegalovirus replication drastically reduce the activity of the viral protein kinase pUL97 Manfred Marschall, Matthias Stein-Gerlach, Martina Freitag et al. · Journal of General Virology	Jun 2001	76
37	FXR agonists for NASH: How are they different and what difference do they make? Claus Kremoser · Journal of Hepatology	10 May 2021	75
38	Inhibition of glutaminyl cyclase prevents pGlu‐Aβ formation after intracortical/hippocampal microinjection in vivo/in situ Stephan Schilling, Thomas Appl, Torsten Hoffmann et al. · Journal of Neurochemistry	8 Jul 2008	74
39	Direct targeting of human cytomegalovirus protein kinase pUL97 by kinase inhibitors is a novel principle for antiviral therapy Manfred Marschall, Matthias Stein-Gerlach, Martina Freitag et al. · Journal of General Virology	May 2002	73
40	The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model Philipp Schwabl, Eva Hambruch, Grant R. Budas et al. · Biomedicines Open access	9 Jan 2021	69
41	Knocking on FXR's Door:The "Hammerhead"-Structure Series of FXRs Agonists - Amphiphilic Isoxazoles with Potent In Vitro and In Vivo Activities Christian Gege, Olaf D. Kinzel, Christoph Steeneck et al. · Current Topics in Medicinal Chemistry	13 Nov 2014	68
42	Efficient and fast targeted production of murine models based on ENU mutagenesis Martin A. Augustin et al. · Mammalian Genome	Jun 2005	67
43	Large-scale mapping of mutations affecting zebrafish development Robert Geisler et al. · BMC Genomics Open access	9 Jan 2007	67
44	RORγt inhibitors as potential back-ups for the phase II candidate VTP-43742 from Vitae Pharmaceuticals: patent evaluation of WO2016061160 and US20160122345 Christian Gege · Expert Opinion on Therapeutic Patents	17 Nov 2016	66
45	Glutaminyl cyclase contributes to the formation of focal and diffuse pyroglutamate (pGlu)-Aβ deposits in hippocampus via distinct cellular mechanisms Maike Hartlage‐Rübsamen, Markus Morawski, Alexander Waniek et al. · Acta Neuropathologica Open access	7 Feb 2011	65
46	Role of Protein Kinase G in Growth and Glutamine Metabolism of Mycobacterium bovis BCG Liem Nguyen, Anne Walburger, Edith N. G. Houben et al. · Journal of Bacteriology Open access	3 Aug 2005	64
47	Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists Ulrich R. Abel, Thomas Schlüter, Andreas Schulz et al. · Bioorganic & Medicinal Chemistry Letters Open access	20 Jun 2010	60
48	Mannose receptor-mediated gene delivery into antigen presenting dendritic cells. Sandra S. Diebold, Christian Plank, Matthew L. Cotten et al. · Somatic Cell and Molecular Genetics	2002	60
49	Dietary α-tocopherol and atorvastatin reduce high-fat-induced lipid accumulation and down-regulate CD36 protein in the liver of guinea pigs Maren Catherina Podszun, Nadine Grebenstein, Astrid Spruss et al. · The Journal of Nutritional Biochemistry	20 Feb 2014	55
50	The 3′‐UTR of the mRNA coding for the major protein kinase C substrate MARCKS contains a novel CU‐rich element interacting with the mRNA stabilizing factors HuD and HuR Georg Wein, Marek Rössler, Roland Klug et al. · European Journal of Biochemistry Open access	19 Dec 2002	48

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.