| 1 |
The RNA Sensor RIG-I Dually Functions as an Innate Sensor and Direct Antiviral Factor for Hepatitis B Virus
Seiichi Sato, Kai Li, Takeshi Kameyama et al. · Immunity
Open access |
19 Dec 2014 |
411 |
| 2 |
Influence of hepatitis B virus genotypes on the intra‐ and extracellular expression of viral DNA and antigens†‡
Masaya Sugiyama, Yasuhito Tanaka, Takanobu Kato et al. · Hepatology
Open access |
27 Sep 2006 |
290 |
| 3 |
MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis
Tomohiro Ogawa, Masaru Enomoto, Hideki Fujii et al. · Gut
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20 Jan 2012 |
255 |
| 4 |
Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cells
Eriko Fujita, Yuko Tanabe, Akira Shiota et al. · Proceedings of the National Academy of Sciences
Open access |
19 Feb 2008 |
251 |
| 5 |
Suppression of hepatic stellate cell activation by microRNA-29b
Yumiko Sekiya, Tomohiro Ogawa, Katsutoshi Yoshizato et al. · Biochemical and Biophysical Research Communications
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24 Jul 2011 |
169 |
| 6 |
Generation of Novel Chimeric Mice with Humanized Livers by Using Hemizygous cDNA-uPA/SCID Mice
Chise Tateno, Yosuke Kawase, Yoshimi Tobita et al. · PLoS ONE
Open access |
4 Nov 2015 |
142 |
| 7 |
Suppression of type I collagen production by microRNA-29b in cultured human stellate cells
Tomohiro Ogawa, Masashi Iizuka, Yumiko Sekiya et al. · Biochemical and Biophysical Research Communications
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13 Nov 2009 |
133 |
| 8 |
Novel Robust in Vitro Hepatitis B Virus Infection Model Using Fresh Human Hepatocytes Isolated from Humanized Mice
Yuji Ishida, Chihiro Yamasaki, Ami Yanagi et al. · American Journal Of Pathology
Open access |
21 Mar 2015 |
110 |
| 9 |
MiR-29a Assists in Preventing the Activation of Human Stellate Cells and Promotes Recovery From Liver Fibrosis in Mice
Yoshinari Matsumoto, Saori Itami, Masahiko Kuroda et al. · Molecular Therapy
Open access |
2 Aug 2016 |
107 |
| 10 |
Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection
Klaus Klumpp, Takashi Shimada, Lena Allweiss et al. · Gastroenterology
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24 Oct 2017 |
100 |
| 11 |
Essential role of gastric gland mucin in preventing gastric cancer in mice
Fumitoshi Karasawa, Akira Shiota, Yukinobu Goso et al. · Journal of Clinical Investigation
Open access |
6 Feb 2012 |
100 |
| 12 |
Differentiation Stage-Specific Requirement in Hypoxia-Inducible Factor-1α–Regulated Glycolytic Pathway during Murine B Cell Development in Bone Marrow
Hidefumi Kojima, Ayano Kobayashi, Daisuke Sakurai et al. · The Journal of Immunology
Open access |
30 Nov 2009 |
99 |
| 13 |
Promotion of Liver and Lung Tumorigenesis in DEN-Treated Cytoglobin-Deficient Mice
Lê Thị Thanh Thủy, Takashi Morita, Kayo Yoshida et al. · American Journal Of Pathology
Open access |
14 Jun 2011 |
94 |
| 14 |
Enhanced flexibility of place discrimination learning by targeting striatal cholinergic interneurons
Kana Okada, Kayo Nishizawa, Ryoji Fukabori et al. · Nature Communications
Open access |
6 May 2014 |
92 |
| 15 |
Phagocytic cells contribute to the antibody-mediated elimination of pulmonary-infected SARS coronavirus
Fumihiko Yasui, Michinori Kohara, Masahiro Kitabatake et al. · Virology
Open access |
4 Mar 2014 |
88 |
| 16 |
Chimeric mice with humanized liver
Miki Katoh, Chise Tateno, Katsutoshi Yoshizato et al. · Toxicology
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26 Nov 2007 |
87 |
| 17 |
In vivo drug metabolism model for human cytochrome P450 enzyme using chimeric mice with humanized liver
Miki Katoh, Toshiro Sawada, Yoshinori Soeno et al. · Journal of Pharmaceutical Sciences
Open access |
18 Oct 2006 |
87 |
| 18 |
From frog integument to human skin: dermatological perspectives from frog skin biology
Iain S. Haslam, Eric W. Roubos, Maria Luisa Mangoni et al. · Biological reviews/Biological reviews of the Cambridge Philosophical Society
Review |
3 Dec 2013 |
84 |
| 19 |
Down‐regulation of cyclin E1 expression by microrna‐195 accounts for interferon‐β‐induced inhibition of hepatic stellate cell proliferation
Yumiko Sekiya, Tomohiro Ogawa, Masashi Iizuka et al. · Journal of Cellular Physiology
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29 Dec 2010 |
82 |
| 20 |
A novel TK-NOG based humanized mouse model for the study of HBV and HCV infections
Keiichi Kosaka, Nobuhiko Hiraga, Michio Imamura et al. · Biochemical and Biophysical Research Communications
Open access |
15 Oct 2013 |
82 |
| 21 |
Induction of microRNA-214-5p in human and rodent liver fibrosis
Masashi Iizuka, Tomohiro Ogawa, Masaru Enomoto et al. · Fibrogenesis & Tissue Repair
Open access |
Aug 2012 |
81 |
| 22 |
Generation and Characterization of Severe Combined Immunodeficiency Rats
Tomoji Mashimo, Akiko Takizawa, Junya Kobayashi et al. · Cell Reports
Open access |
Sep 2012 |
78 |
| 23 |
Rapid emergence of telaprevir resistant hepatitis C virus strain from wildtype clone in vivo
Nobuhiko Hiraga, Michio Imamura, Hiromi Abe et al. · Hepatology
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30 May 2011 |
74 |
| 24 |
In Vitro Evaluation of Cytochrome P450 and Glucuronidation Activities in Hepatocytes Isolated from Liver-Humanized Mice
Chihiro Yamasaki, Miho Kataoka, Yumiko O. KATO et al. · Drug Metabolism and Pharmacokinetics
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2010 |
72 |
| 25 |
Hepatitis C Virus Impairs p53 via Persistent Overexpression of 3β-Hydroxysterol Δ24-Reductase
Tomohiro Nishimura, Michinori Kohara, Kosuke Izumi et al. · Journal of Biological Chemistry
Open access |
28 Oct 2009 |
68 |
| 26 |
Novel pH-sensitive multifunctional envelope-type nanodevice for siRNA-based treatments for chronic HBV infection
Naoki Yamamoto, Yusuke Sato, Tsubasa Munakata et al. · Journal of Hepatology
Open access |
26 Oct 2015 |
67 |
| 27 |
Morphological and microarray analyses of human hepatocytes from xenogeneic host livers
Chise Tateno, Fuyuki Miya, Kenjiro Wake et al. · Laboratory Investigation
Open access |
12 Nov 2012 |
67 |
| 28 |
Humanization of Excretory Pathway in Chimeric Mice with Humanized Liver
Hirotoshi Okumura, Miki Katoh, Takeshi Sawada et al. · Toxicological Sciences
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18 Jan 2007 |
66 |
| 29 |
Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver
Hiroyuki Motoyama, Tohru Komiya, Lê Thị Thanh Thủy et al. · Laboratory Investigation
Open access |
2 Dec 2013 |
65 |
| 30 |
Cytoglobin Deficiency Promotes Liver Cancer Development from Hepatosteatosis through Activation of the Oxidative Stress Pathway
Lê Thị Thanh Thủy, Yoshinari Matsumoto, Tuong Thi Van Thuy et al. · American Journal Of Pathology
Open access |
7 Feb 2015 |
65 |
| 31 |
Transmission of HBV DNA Mediated by Ceramide-Triggered Extracellular Vesicles
Takahiro Sanada, Yuichi Hirata, Yutaka Naito et al. · Cellular and Molecular Gastroenterology and Hepatology
Open access |
24 Oct 2016 |
62 |
| 32 |
Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes
Takashi Takano, Kyoko Tsukiyama–Kohara, Masahiro Hayashi et al. · Journal of Hepatology
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23 Dec 2010 |
62 |
| 33 |
Titration of hepatitis B virus infectivity in the sera of pre‐acute and late acute phases of HBV infection: Transmission experiments to chimeric mice with human liver repopulated hepatocytes
Ayako Tabuchi, Junko Tanaka, Keiko Katayama et al. · Journal of Medical Virology
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21 Oct 2008 |
61 |
| 34 |
Absence of cytoglobin promotes multiple organ abnormalities in aged mice
Lê Thị Thanh Thủy, Tuong Thi Van Thuy, Yoshinari Matsumoto et al. · Scientific Reports
Open access |
5 May 2016 |
59 |
| 35 |
Direct Cytopathic Effects of Particular Hepatitis B Virus Genotypes in Severe Combined Immunodeficiency Transgenic With Urokinase-Type Plasminogen Activator Mouse With Human Hepatocytes
Masaya Sugiyama, Yasuhito Tanaka, Fuat Kurbanov et al. · Gastroenterology
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30 Oct 2008 |
59 |
| 36 |
Growth Hormone-Dependent Pathogenesis of Human Hepatic Steatosis in a Novel Mouse Model Bearing a Human Hepatocyte-Repopulated Liver
Chise Tateno, Miho Kataoka, Rie Utoh et al. · Endocrinology
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8 Feb 2011 |
59 |
| 37 |
Evaluation of mRNA expression of human drug-metabolizing enzymes and transporters in chimeric mouse with humanized liver
Masuhiro Nishimura, Hiroki YOSHITSUGU, Tsuyoshi Yokoi et al. · Xenobiotica
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Sep 2005 |
58 |
| 38 |
Molecular Epidemiology and Interferon Susceptibility of the Natural Recombinant Hepatitis C Virus Strain RF1_2k/1b
Fuat Kurbanov, Yasuhito Tanaka, Elena V. Chub et al. · The Journal of Infectious Diseases
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17 Oct 2008 |
55 |
| 39 |
The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice
Montserrat A. de la Rosa Rodriguez, Go Sugahara, Guido J. E. J. Hooiveld et al. · BMC Genomics
Open access |
7 Jun 2018 |
54 |
| 40 |
Progressive polyuria without vasopressin neuron loss in a mouse model for familial neurohypophysial diabetes insipidus
Masayuki Hayashi, Hiroshi Arima, Noriyuki Ozaki et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
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19 Mar 2009 |
52 |
| 41 |
Acute hepatitis B virus infection in humanized chimeric mice has multiphasic viral kinetics
Yuji Ishida, Tje Lin Chung, Michio Imamura et al. · Hepatology
Open access |
23 Mar 2018 |
51 |
| 42 |
Predictability of plasma concentration–time curves in humans using single-species allometric scaling of chimeric mice with humanized liver
Seigo Sanoh, Yoichi Naritomi, Mami Fujimoto et al. · Xenobiotica
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3 Mar 2015 |
51 |
| 43 |
Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies
Masakazu Kakuni, Chihiro Yamasaki, Asato Tachibana et al. · International Journal of Molecular Sciences
Open access |
20 Dec 2013 |
51 |
| 44 |
Chimeric Mice with Hepatocyte-humanized Liver as an Appropriate Model to Study Human Peroxisome Proliferator–activated Receptor-α
Chise Tateno, Toshinobu Yamamoto, Rie Utoh et al. · Toxicologic Pathology
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8 Aug 2014 |
49 |
| 45 |
Elimination of hepatitis C virus by short term NS3-4A and NS5B inhibitor combination therapy in human hepatocyte chimeric mice
Eiji Ohara, Nobuhiko Hiraga, Michio Imamura et al. · Journal of Hepatology
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27 Oct 2010 |
49 |
| 46 |
Arginine vasopressin neuronal loss results from autophagy-associated cell death in a mouse model for familial neurohypophysial diabetes insipidus
Daisuke Hagiwara, Hiroshi Arima, Yoshiaki Morishita et al. · Cell Death and Disease
Open access |
27 Mar 2014 |
49 |
| 47 |
Predictability of Metabolism of Ibuprofen and Naproxen Using Chimeric Mice with Human Hepatocytes
Seigo Sanoh, Aya Horiguchi, Kazumi Sugihara et al. · Drug Metabolism and Disposition
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31 Aug 2012 |
47 |
| 48 |
Striatal Indirect Pathway Contributes to Selection Accuracy of Learned Motor Actions
Kayo Nishizawa, Ryoji Fukabori, Kana Okada et al. · Journal of Neuroscience
Open access |
26 Sep 2012 |
46 |
| 49 |
Chimeric mice with a humanized liver as an animal model of troglitazone-induced liver injury
Masakazu Kakuni, Mayu Morita, Kentaro Matsuo et al. · Toxicology Letters
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10 Aug 2012 |
46 |
| 50 |
Severe necroinflammatory reaction caused by natural killer cell-mediated Fas/Fas ligand interaction and dendritic cells in human hepatocyte chimeric mouse
Akihito Okazaki, Nobuhiko Hiraga, Michio Imamura et al. · Hepatology
Open access |
13 Feb 2012 |
45 |