Most cited papers from Princess Máxima Center

Princess Máxima Center

What are the most cited papers from Princess Máxima Center?

The most cited paper from Princess Máxima Center is "The 2021 WHO Classification of Tumors of the Central Nervous System: a summary" (David N. Louis, Arie Perry, Pieter Wesseling et al., 2021), with 12,579 citations. Next come "Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities" (4,545) and "DNA methylation-based classification of central nervous system tumours" (3,228).

Published TypeFieldAccessAuthorsCitations

Showing 50 of 60 papers. Every paper with more than 392 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	The 2021 WHO Classification of Tumors of the Central Nervous System: a summary David N. Louis, Arie Perry, Pieter Wesseling et al. · Neuro-Oncology Open access	3 May 2021	12,579
2	Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities Roel Nusse, Hans C. Clevers · Cell Open access	Jun 2017	4,545
3	DNA methylation-based classification of central nervous system tumours David Capper et al. · Nature Open access143 authors	13 Mar 2018	3,228
4	Cancer stem cells revisited Eduard Batlle, Hans C. Clevers · Nature Medicine Open access	Oct 2017	2,900
5	The Human Cell Atlas Aviv Regev et al. · eLife Open access	5 Dec 2017	2,441
6	Organoids in cancer research Jarno Drost, Hans C. Clevers · Nature reviews. Cancer ReviewOpen access	24 Apr 2018	1,820
7	The landscape of genomic alterations across childhood cancers ICGC PedBrain-Seq Project et al. · Nature Open access	28 Feb 2018	1,654
8	Neoadjuvant immunotherapy leads to pathological responses in MMR-proficient and MMR-deficient early-stage colon cancers Myriam Chalabi et al. · Nature Medicine Open access	Apr 2020	1,437
9	A single-cell transcriptomic atlas characterizes ageing tissues in the mouse Nicole Almanzar et al. · Nature Open access134 authors	15 Jul 2020	1,373
10	Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli Cayetano Pleguezuelos‐Manzano et al. · Nature Open access101 authors	27 Feb 2020	1,232
11	A common classification framework for neuroendocrine neoplasms: an International Agency for Research on Cancer (IARC) and World Health Organization (WHO) expert consensus proposal Guido Rindi et al. · Modern Pathology Open access	23 Aug 2018	1,162
12	Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer Hervé Tiriac et al. · Cancer Discovery Open access	31 May 2018	1,139
13	Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids Krijn K. Dijkstra et al. · Cell Open access	9 Aug 2018	1,129
14	Long‐term expanding human airway organoids for disease modeling Norman Sachs et al. · The EMBO Journal Open access	14 Jan 2019	1,113
15	Tales from the crypt: new insights into intestinal stem cells Helmuth Gehart, Hans C. Clevers · Nature Reviews Gastroenterology & Hepatology ReviewOpen access	14 Nov 2018	1,056
16	European Society of Endocrinology Clinical Practice Guidelines on the management of adrenocortical carcinoma in adults, in collaboration with the European Network for the Study of Adrenal Tumors Martin Faßnacht, Olaf M Dekkers, Tobias Else et al. · European Journal of Endocrinology Open access	24 Jul 2018	970
17	The central role of DNA damage in the ageing process Björn Schumacher, Joris Pothof, Jan Vijg et al. · Nature Open access	28 Apr 2021	945
18	Patient-derived organoids can predict response to chemotherapy in metastatic colorectal cancer patients Salo Ooft et al. · Science Translational Medicine Open access	9 Oct 2019	865
19	An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity Oded Kopper et al. · Nature Medicine Open access	22 Apr 2019	864
20	Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids Huili Hu, Helmuth Gehart, Benedetta Artegiani et al. · Cell Open access	Nov 2018	863
21	Disease Modeling in Stem Cell-Derived 3D Organoid Systems Devanjali Dutta, Inha Heo, Hans C. Clevers · Trends in Molecular Medicine ReviewOpen access	21 Mar 2017	849
22	WHO 2016 Classification of gliomas Pieter Wesseling, David Capper · Neuropathology and Applied Neurobiology Open access	17 Aug 2017	838
23	Reparative inflammation takes charge of tissue regeneration Michael Karin, Hans C. Clevers · Nature Open access	2016	786
24	MutationalPatterns: comprehensive genome-wide analysis of mutational processes Francis Blokzijl, Roel Janssen, Ruben van Boxtel et al. · Genome Medicine Open access	25 Apr 2018	748
25	A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening Helen H.N. Yan et al. · Cell stem cell Open access	18 Oct 2018	742
26	Ageing hallmarks exhibit organ-specific temporal signatures Nicholas Schaum et al. · Nature Open access161 authors	15 Jul 2020	725
27	The PD-1/PD-L1-Checkpoint Restrains T cell Immunity in Tumor-Draining Lymph Nodes Floris F. Dammeijer et al. · Cancer Cell Open access	Oct 2020	704
28	Interrogating open issues in cancer precision medicine with patient-derived xenografts Annette T. Byrne et al. · Nature reviews. Cancer ReviewOpen access	20 Jan 2017	685
29	De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data Dominic Grün, Mauro J. Muraro, Jean-Charles Boisset et al. · Cell stem cell Open access	25 Jun 2016	680
30	Establishment of patient-derived cancer organoids for drug-screening applications Else Driehuis, Kai Kretzschmar, Hans C. Clevers · Nature Protocols Open access	14 Sep 2020	678
31	EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours Émilie Le Rhun, Michael Weller, Dieta Brandsma et al. · Annals of Oncology Open access	5 May 2017	649
32	Longitudinal molecular trajectories of diffuse glioma in adults Floris P Barthel et al. · Nature Open access163 authors	20 Nov 2019	616
33	EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with brain metastasis from solid tumours Émilie Le Rhun et al. · Annals of Oncology Open access	6 Aug 2021	610
34	Neuroblastoma is composed of two super-enhancer-associated differentiation states Tim van Groningen et al. · Nature Genetics Open access	26 Jun 2017	587
35	Intra-tumour diversification in colorectal cancer at the single-cell level Sophie F. Roerink, Nobuo Sasaki, Henry Lee-Six et al. · Nature Open access	Apr 2018	585
36	High-resolution 3D imaging of fixed and cleared organoids Johanna F. Dekkers, María Alieva, Lianne M. Wellens et al. · Nature Protocols Open access	3 May 2019	584
37	Tumor-Infiltrating Lymphocyte Therapy or Ipilimumab in Advanced Melanoma Maartje W. Rohaan et al. · New England Journal of Medicine Open access	7 Dec 2022	577
38	Sarcoma classification by DNA methylation profiling Christian Koelsche et al. · Nature Communications Open access111 authors	21 Jan 2021	561
39	cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and grading David N. Louis et al. · Brain Pathology Open access	19 Apr 2020	543
40	Glioma progression is shaped by genetic evolution and microenvironment interactions Frederick S. Varn et al. · Cell Open access147 authors	31 May 2022	530
41	Human Organoids: Tools for Understanding Biology and Treating Diseases Frans Schutgens, Hans C. Clevers · Annual Review of Pathology Mechanisms of Disease ReviewOpen access	24 Sep 2019	525
42	Pembrolizumab versus placebo as adjuvant therapy in completely resected stage IIB or IIC melanoma (KEYNOTE-716): a randomised, double-blind, phase 3 trial Jason J Luke et al. · The Lancet Open access	Apr 2022	500
43	Extracellular matrix hydrogel derived from decellularized tissues enables endodermal organoid culture Giovanni Giuseppe Giobbe et al. · Nature Communications Open access	11 Dec 2019	496
44	Sleep characteristics across the lifespan in 1.1 million people from the Netherlands, United Kingdom and United States: a systematic review and meta-analysis Desana Kocevska et al. · Nature Human Behaviour ReviewOpen access	16 Nov 2020	492
45	Organoids: Modeling Development and the Stem Cell Niche in a Dish Kai Kretzschmar, Hans C. Clevers · Developmental Cell Open access	Sep 2016	491
46	Pancreatic cancer organoids recapitulate disease and allow personalized drug screening Else Driehuis et al. · Proceedings of the National Academy of Sciences Open access	9 Dec 2019	487
47	Use of CRISPR-modified human stem cell organoids to study the origin of mutational signatures in cancer Jarno Drost, Ruben van Boxtel, Francis Blokzijl et al. · Science Open access	15 Sep 2017	481
48	MHC Class I Downregulation in Cancer: Underlying Mechanisms and Potential Targets for Cancer Immunotherapy Annelisa M. Cornel, Iris L. Mimpen, Stefan Nierkens · Cancers Open access	2 Jul 2020	477
49	Chemotherapy Side-Effects: Not All DNA Damage Is Equal Winnie M. C. van den Boogaard, Daphne S. J. Komninos, Wilbert P. Vermeij · Cancers Open access	26 Jan 2022	468
50	Tubuloids derived from human adult kidney and urine for personalized disease modeling Frans Schutgens et al. · Nature Biotechnology Open access	Mar 2019	462

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.