Most cited papers from Probiodrug (Germany)

Probiodrug (Germany)

What are the most cited papers from Probiodrug (Germany)?

The most cited paper from Probiodrug (Germany) is "Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β" (Justin M. Nussbaum, Stephan Schilling, Holger Cynis et al., 2012), with 437 citations. Next come "Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology" (357) and "Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats" (334).

Published TypeFieldAccessCitations

Showing 50 of 61 papers. Every paper with more than 58 citations is listed.

Most cited papers, sortable by citations and release date
#	Paper
1	Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β Justin M. Nussbaum, Stephan Schilling, Holger Cynis et al. · Nature Open access	May 2012	437
2	Glutaminyl cyclase inhibition attenuates pyroglutamate Aβ and Alzheimer's disease–like pathology Stephan Schilling, Ulrike Zeitschel, Torsten Hoffmann et al. · Nature Medicine	28 Sep 2008	357
3	Dipeptidyl Peptidase IV Inhibitor Treatment Stimulates β-Cell Survival and Islet Neogenesis in Streptozotocin-Induced Diabetic Rats John Andrew Pospisilik, Jennifer Martin, Timothy Doty et al. · Diabetes Open access	Mar 2003	334
4	The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism Michael H. Engel, Torsten Hoffmann, Leona Wagner et al. · Proceedings of the National Academy of Sciences Open access	10 Apr 2003	307
5	On the Seeding and Oligomerization of pGlu-Amyloid Peptides (in vitro) Stephan Schilling, Thomas Lauber, Michael Schaupp et al. · Biochemistry	20 Sep 2006	259
6	Crystal structure of the incretin-bound extracellular domain of a G protein-coupled receptor C. Parthier, Martin Kleinschmidt, Piotr Neumann et al. · Proceedings of the National Academy of Sciences Open access	21 Aug 2007	236
7	Long-Term Treatment With the Dipeptidyl Peptidase IV Inhibitor P32/98 Causes Sustained Improvements in Glucose Tolerance, Insulin Sensitivity, Hyperinsulinemia, and β-Cell Glucose Responsiveness in VDF (fa/fa) Zucker Rats John Andrew Pospisilik, Sara G. Stafford, H-U. Demuth et al. · Diabetes	Apr 2002	233
8	Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides Dagmar Schlenzig, Susanne Manhart, Yeliz Cinar et al. · Biochemistry	11 Jun 2009	229
9	Dipeptidyl peptidase IV inhibitors: how do they work as new antidiabetic agents? Christopher H.S. McIntosh, Hans‐Ulrich Demuth, John Andrew Pospisilik et al. · Regulatory Peptides	30 Jul 2004	195
10	Type 2 diabetes—Therapy with dipeptidyl peptidase IV inhibitors Hans‐Ulrich Demuth, Christopher H.S. McIntosh, Raymond A. Pederson · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics	10 Jun 2005	193
11	Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions Stephan Schilling, Torsten Hoffmann, Susanne Manhart et al. · FEBS Letters Open access	22 Mar 2004	176
12	Intraneuronal pyroglutamate-Abeta 3–42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model Oliver Wirths, Henning Breyhan, Holger Cynis et al. · Acta Neuropathologica Open access	22 Jun 2009	174
13	Glucose-Dependent Insulinotropic Polypeptide Promotes β-(INS-1) Cell Survival via Cyclic Adenosine Monophosphate-Mediated Caspase-3 Inhibition and Regulation of p38 Mitogen-Activated Protein Kinase Jan A. Ehses, Vanbric R. Casilla, Tim Doty et al. · Endocrinology	24 Jun 2003	162
14	Long-Term Treatment With Dipeptidyl Peptidase IV Inhibitor Improves Hepatic and Peripheral Insulin Sensitivity in the VDF Zucker Rat John Andrew Pospisilik, Sara G. Stafford, Hans‐Ulrich Demuth et al. · Diabetes Open access	Sep 2002	139
15	Expression of the stem cell self-renewal gene Hiwi and risk of tumour-related death in patients with soft-tissue sarcoma Helge W. Taubert, Thomas Greither, Deepak Kaushal et al. · Oncogene	4 Sep 2006	138
16	Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer’s disease: results of a randomized, double-blind, placebo-controlled phase 2a study Philip Scheltens, Merja Hallikainen, Timo Grimmer et al. · Alzheimer s Research & Therapy Open access	11 Oct 2018	133
17	Pyroglutamate-3 Amyloid-β Deposition in the Brains of Humans, Non-Human Primates, Canines, and Alzheimer Disease–Like Transgenic Mouse Models Jeffrey L. Frost, Kevin X. Le, Holger Cynis et al. · American Journal Of Pathology Open access	7 Jun 2013	132
18	Dipeptidyl Peptidase IV-Resistant [ d -Ala2]Glucose-Dependent Insulinotropic Polypeptide (GIP) Improves Glucose Tolerance in Normal and Obese Diabetic Rats Simon A. Hinke, Richard W. Gelling, Raymond A. Pederson et al. · Diabetes	Mar 2002	131
19	Reversal of islet GIP receptor down-regulation and resistance to GIP by reducing hyperglycemia in the Zucker rat Shalea Piteau, Amy Olver, Su‐jin Kim et al. · Biochemical and Biophysical Research Communications	30 Aug 2007	130
20	Dipeptidyl Peptidase IV (DPIV/CD26) Degradation of Glucagon Simon A. Hinke, John Andrew Pospisilik, Hans-Ulrich Demuth et al. · Journal of Biological Chemistry Open access	Feb 2000	120
21	Amyloidogenic Processing of Amyloid Precursor Protein: Evidence of a Pivotal Role of Glutaminyl Cyclase in Generation of Pyroglutamate-Modified Amyloid-β Holger Cynis, Eike Scheel, Takaomi C. Saido et al. · Biochemistry	21 Jun 2008	120
22	Soil microbiological and biochemical properties affected by plant growth and different long-term fertilisation Livia Böhme, Frank Böhme · European Journal of Soil Biology	29 Sep 2005	116
23	Inhibition of CD26/Dipeptidyl Peptidase IV Enhances CCL11/Eotaxin-Mediated Recruitment of Eosinophils In Vivo Ulf Forssmann, Carsten Stoetzer, Michael Stephan et al. · The Journal of Immunology	Jul 2008	115
24	Glutaminyl Cyclase in Human Cortex: Correlation with (pGlu)-Amyloid-β Load and Cognitive Decline in Alzheimer's Disease Markus Morawski, Stephan Schilling, Moritz Kreuzberger et al. · Journal of Alzheimer s Disease Open access	24 Jan 2014	109
25	Metformin Effects on Dipeptidylpeptidase IV Degradation of Glucagon-like Peptide-1 Simon A. Hinke, Kerstin Kühn‐Wache, Torsten Hoffmann et al. · Biochemical and Biophysical Research Communications	Mar 2002	105
26	Glutaminyl cyclases from animals and plants: a case of functionally convergent protein evolution Stephan Schilling, Claus H. Wasternack, Hans‐Ulrich Demuth · Biological Chemistry	Aug 2008	105
27	Selective Hippocampal Neurodegeneration in Transgenic Mice Expressing Small Amounts of Truncated Aβ Is Induced by Pyroglutamate–Aβ Formation Anca Alexandru, Wolfgang Jagla, Sigrid Graubner et al. · Journal of Neuroscience Open access	7 Sep 2011	103
28	Overexpression of Glutaminyl Cyclase, the Enzyme Responsible for Pyroglutamate Aβ Formation, Induces Behavioral Deficits, and Glutaminyl Cyclase Knock-out Rescues the Behavioral Phenotype in 5XFAD Mice Sadim Jawhar, Oliver Wirths, Stephan Schilling et al. · Journal of Biological Chemistry Open access	11 Dec 2010	103
29	Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion Ingo Schulz, Ulrike Zeitschel, Thomas J Rudolph et al. · Journal of Neurochemistry	30 Jun 2005	102
30	Modulation of inositol 1,4,5‐triphosphate concentration by prolyl endopeptidase inhibition Ingo Schulz, Bernd Gerhartz, Antje Neubauer et al. · European Journal of Biochemistry Open access	Dec 2002	99
31	The First Potent Inhibitors for Human Glutaminyl Cyclase: Synthesis and Structure−Activity Relationship Mirko Buchholz, Ulrich F. Heiser, Stephan Schilling et al. · Journal of Medicinal Chemistry Open access	16 Dec 2005	97
32	Neuropeptide Y (NPY) cleaving enzymes: Structural and functional homologues of dipeptidyl peptidase 4 Nadine Frerker, Leona Wagner, Raik Wolf et al. · Peptides	17 Jan 2007	97
33	The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions Holger Cynis et al. · EMBO Molecular Medicine Open access	20 Jul 2011	93
34	Regulation of Expression and Function of Dipeptidyl Peptidase 4 (DP4), DP8/9, and DP10 in Allergic Responses of the Lung in Rats Jutta Schade, Michael Stephan, Andreas Schmiedl et al. · Journal of Histochemistry & Cytochemistry Open access	15 Oct 2007	90
35	Identification of Human Glutaminyl Cyclase as a Metalloenzyme Stephan Schilling, André J. Niestroj, Jens‐Ulrich Rahfeld et al. · Journal of Biological Chemistry Open access	Dec 2003	90
36	Induction of an Extracellular Cyclic Nucleotide Phosphodiesterase as an Accessory Ribonucleolytic Activity during Phosphate Starvation of Cultured Tomato Cells Steffen Abel, Thorsten Nürnberger, Volker Ahnert et al. · PLANT PHYSIOLOGY Open access	Feb 2000	87
37	Inhibition of glutaminyl cyclase alters pyroglutamate formation in mammalian cells Holger Cynis, Stephan Schilling, Mandy Bodnár et al. · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics	17 Aug 2006	86
38	N‐Terminal pyroglutamate formation of Aβ38 and Aβ40 enforces oligomer formation and potency to disrupt hippocampal long‐term potentiation Dagmar Schlenzig, Raik Rönicke, Holger Cynis et al. · Journal of Neurochemistry	29 Feb 2012	85
39	Alternative pathways for production of β-amyloid peptides of Alzheimer's disease VIVIAN Y. H. HOOK, Israël Schechter, Hans‐Ulrich Demuth et al. · Biological Chemistry Open access	Aug 2008	84
40	Passive Immunization against Pyroglutamate-3 Amyloid-β Reduces Plaque Burden in Alzheimer-Like Transgenic Mice: A Pilot Study Jeffrey L. Frost, Bin Liu, Martin Kleinschmidt et al. · Neurodegenerative Diseases Open access	2012	83
41	Isolation of an Isoenzyme of Human Glutaminyl Cyclase: Retention in the Golgi Complex Suggests Involvement in the Protein Maturation Machinery Holger Cynis, Jens‐Ulrich Rahfeld, Anett Stephan et al. · Journal of Molecular Biology	17 Apr 2008	83
42	Identification of a bioactive domain in the amino-terminus of glucose-dependent insulinotropic polypeptide (GIP) Simon A. Hinke, Susanne Manhart, Nathalie Pamir et al. · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology	May 2001	82
43	Open-loop control of the biomass concentration within the growth phase of recombinant protein production processes Marco Jenzsch, Stefan Gnoth, Matthias Beck et al. · Journal of Biotechnology	16 Jun 2006	80
44	Effects of dipeptidyl peptidase IV on the satiety actions of peptide YY Suraj Unniappan, Christopher H.S. McIntosh, Hans Ulrich Demuth et al. · Diabetologia Open access	26 Jun 2006	80
45	Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer’s Disease—Studies on Relation to Effective Target Occupancy Torsten Hoffmann, Antje Meyer, Ulrich F. Heiser et al. · Journal of Pharmacology and Experimental Therapeutics Open access	27 Apr 2017	76
46	Pyroglutamate Amyloid β (Aβ) Aggravates Behavioral Deficits in Transgenic Amyloid Mouse Model for Alzheimer Disease Jessica L. Wittnam, Erik Portelius, Henrik Zetterberg et al. · Journal of Biological Chemistry Open access	21 Jan 2012	76
47	Inhibition of glutaminyl cyclase prevents pGlu‐Aβ formation after intracortical/hippocampal microinjection in vivo/in situ Stephan Schilling, Thomas Appl, Torsten Hoffmann et al. · Journal of Neurochemistry	8 Jul 2008	74
48	Metabolism of glucagon by dipeptidyl peptidase IV (CD26) John Andrew Pospisilik, Simon A. Hinke, Raymond A. Pederson et al. · Regulatory Peptides	2001	71
49	Evidence for a crucial role of neutrophil‐derived serine proteases in the inactivation of interleukin‐6 at sites of inflammation Ute Bank, Bernadette Küpper, Dirk Reinhold et al. · FEBS Letters Open access	15 Nov 1999	70
50	Structure–Activity Relationships of Benzimidazole-Based Glutaminyl Cyclase Inhibitors Featuring a Heteroaryl Scaffold Daniel Ramsbeck, Mirko Buchholz, Birgit Maria Koch et al. · Journal of Medicinal Chemistry Open access	25 Jul 2013	66

Citations are OpenAlex's own counts, from its 2026-09-23 snapshot, so the ranking can differ from Google Scholar or Web of Science. A paper is listed for an institution when any of its authors gave it as an affiliation; retracted papers and papers whose citation count cannot be traced to citing works are left out, and a preprint and the article it became are shown once. Release dates are OpenAlex's: where a source gave only a month or a year, that is what is shown. How the lists are chosen.